Paine M, Criss A, Watkins P. Two major grapefruit juice components differ in intestinal CYP3A4 inhibition kinetic and binding properties. Drug Metab Dispos. 2004;32:1146-53 pubmed
..Results also emphasize the importance of appropriate substrate selection when designing inhibition studies involving dietary constituents...
Paine M, Criss A, Watkins P. Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition. J Pharmacol Exp Ther. 2005;312:1151-60 pubmed
..g., lime juice) could produce a substrate-dependent interaction with drugs consumed concomitantly, but a substrate-independent interaction with drugs taken several hours after food consumption. ..
Paine M, Leung L, Watkins P. New insights into drug absorption: studies with sirolimus. Ther Drug Monit. 2004;26:463-7 pubmed
..This new insight into the intestinal elimination of sirolimus, which was not identified using traditional drug metabolism/transport screening methods, may represent another source for the limited absorption of sirolimus. ..