R Pahwa

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi request reprint Basic algorithms for the programming of deep brain stimulation in Parkinson's disease
    Jens Volkmann
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 21:S284-9. 2006
  2. ncbi request reprint Prevalence of bone mineral density screening in Parkinson's disease clinic outpatients
    Marty L Eng
    Mov Disord 21:2265-6. 2006
  3. ncbi request reprint Understanding Parkinson's disease: an update on current diagnostic and treatment strategies
    Rajesh Pahwa
    J Am Med Dir Assoc 7:4-10. 2006
  4. doi request reprint Randomized trial of IPX066, carbidopa/levodopa extended release, in early Parkinson's disease
    Rajesh Pahwa
    University of Kansas Medical Center, Kansas City, KS, USA Electronic address
    Parkinsonism Relat Disord 20:142-8. 2014
  5. ncbi request reprint Preoperative clinical predictors of response to bilateral subthalamic stimulation in patients with Parkinson's disease
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Stereotact Funct Neurosurg 83:80-3. 2005
  6. ncbi request reprint Mirtazapine in essential tremor: a double-blind, placebo-controlled pilot study
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Mov Disord 18:584-7. 2003
  7. ncbi request reprint Bilateral subthalamic stimulation in patients with Parkinson disease: long-term follow up
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurosurg 99:71-7. 2003
  8. ncbi request reprint Ropinirole therapy for Parkinson's disease
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Blvd, Kansas City, KS 66160, USA
    Expert Rev Neurother 4:581-8. 2004
  9. ncbi request reprint Thalamic stimulation for midbrain tremor after partial hemangioma resection
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mov Disord 17:404-7. 2002
  10. ncbi request reprint Options in the treatment of motor fluctuations and dyskinesias in Parkinson's disease: a brief review
    Rajesh Pahwa
    Parkinson s Disease and Movement Disorder Center, University of Kansas Medical Center, 3599 Rainbow Boulevard, Mailstop 2012, Kansas City, KS 66160, USA
    Neurol Clin 22:S35-52. 2004

Research Grants

Detail Information

Publications85

  1. ncbi request reprint Basic algorithms for the programming of deep brain stimulation in Parkinson's disease
    Jens Volkmann
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 21:S284-9. 2006
    ..The basic programming algorithms for thalamic, subthalamic, and pallidal stimulation in PD are explained and summarized in flowcharts...
  2. ncbi request reprint Prevalence of bone mineral density screening in Parkinson's disease clinic outpatients
    Marty L Eng
    Mov Disord 21:2265-6. 2006
  3. ncbi request reprint Understanding Parkinson's disease: an update on current diagnostic and treatment strategies
    Rajesh Pahwa
    J Am Med Dir Assoc 7:4-10. 2006
    ..With chronic levodopa therapy, patients ultimately experience a wearing off in levodopa response and other motor complications. Management of wearing off is a significant challenge in the treatment of patients with advanced PD...
  4. doi request reprint Randomized trial of IPX066, carbidopa/levodopa extended release, in early Parkinson's disease
    Rajesh Pahwa
    University of Kansas Medical Center, Kansas City, KS, USA Electronic address
    Parkinsonism Relat Disord 20:142-8. 2014
    ..The objective was to assess the efficacy, safety, and impact on quality of life of IPX066 in the treatment of levodopa-naive Parkinson's disease (PD) patients...
  5. ncbi request reprint Preoperative clinical predictors of response to bilateral subthalamic stimulation in patients with Parkinson's disease
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Stereotact Funct Neurosurg 83:80-3. 2005
    ..Younger age and a response to a supra-threshold levodopa challenge have been reported to predict a favorable response to bilateral subthalamic nucleus (STN) stimulation...
  6. ncbi request reprint Mirtazapine in essential tremor: a double-blind, placebo-controlled pilot study
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Mov Disord 18:584-7. 2003
    ..We conclude that the majority of the ET patients do not benefit from mirtazapine. Mirtazapine has significant adverse effects and should be used cautiously in ET patients...
  7. ncbi request reprint Bilateral subthalamic stimulation in patients with Parkinson disease: long-term follow up
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurosurg 99:71-7. 2003
    ..Bilateral subthalamic nucleus (STN) stimulation is increasingly used in patients with advanced Parkinson disease (PD). This study was performed to evaluate the long-term efficacy and safety of bilateral STN stimulation in cases of PD...
  8. ncbi request reprint Ropinirole therapy for Parkinson's disease
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Blvd, Kansas City, KS 66160, USA
    Expert Rev Neurother 4:581-8. 2004
    ..A once-daily formulation of ropinirole is currently in development that has the potential for greater convenience, improved tolerability and greater efficacy...
  9. ncbi request reprint Thalamic stimulation for midbrain tremor after partial hemangioma resection
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mov Disord 17:404-7. 2002
    ..We describe a patient with disabling medication-resistant midbrain tremor developed after partial hemangioma resection, who responded to deep brain stimulation of the thalamus...
  10. ncbi request reprint Options in the treatment of motor fluctuations and dyskinesias in Parkinson's disease: a brief review
    Rajesh Pahwa
    Parkinson s Disease and Movement Disorder Center, University of Kansas Medical Center, 3599 Rainbow Boulevard, Mailstop 2012, Kansas City, KS 66160, USA
    Neurol Clin 22:S35-52. 2004
  11. ncbi request reprint Essential tremor: differential diagnosis and current therapy
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160 7314, USA
    Am J Med 115:134-42. 2003
    ..Patients with medication-resistant tremor may benefit from thalamotomy or deep brain stimulation of the thalamus. The use of medical and surgical therapies can provide benefit in up to 80% of patients with essential tremor...
  12. ncbi request reprint Subcutaneous apomorphine in patients with advanced Parkinson's disease: a dose-escalation study with randomized, double-blind, placebo-controlled crossover evaluation of a single dose
    Rajesh Pahwa
    University of Kansas Medical Center, 3599 Rainbow Blvd, Kansas City, KS 66160, USA
    J Neurol Sci 258:137-43. 2007
    ..To further explore the efficacy and safety of subcutaneous apomorphine (APO) in treating off episodes in APO-naïve patients with advanced Parkinson's disease (PD)...
  13. ncbi request reprint Ropinirole 24-hour prolonged release: randomized, controlled study in advanced Parkinson disease
    R Pahwa
    University of Kansas Medical Center, Kansas City, KS 66160, USA
    Neurology 68:1108-15. 2007
    ..To evaluate the efficacy of ropinirole 24-hour prolonged release (ropinirole 24-hour) as an adjunct to levodopa in patients with Parkinson disease (PD) and motor fluctuations...
  14. ncbi request reprint Bilateral thalamic stimulation for the treatment of essential tremor
    R Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City 66160, USA
    Neurology 53:1447-50. 1999
    ..To determine the safety and efficacy of bilateral thalamic stimulation in the treatment of essential tremor (ET)...
  15. ncbi request reprint Long-term evaluation of deep brain stimulation of the thalamus
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurosurg 104:506-12. 2006
    ..The aim of this study was to evaluate the long-term safety and efficacy of DBS of the ventralis intermedius nucleus (VIM) of the thalamus for PD and ET...
  16. ncbi request reprint Quantitative assessments of the effect of bilateral subthalamic stimulation on multiple aspects of sensorimotor function for patients with Parkinson's disease
    W Liu
    Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7601, USA
    Parkinsonism Relat Disord 11:503-8. 2005
    ..Future studies need to determine whether or not there is a potential negative effect of STN DBS on the postural control...
  17. ncbi request reprint Onset of dyskinesia with adjunct ropinirole prolonged-release or additional levodopa in early Parkinson's disease
    Ray L Watts
    Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Mov Disord 25:858-66. 2010
    ..Ropinirole prolonged-release delayed the onset of dyskinesia with comparable efficacy to increased doses of levodopa in early PD patients not optimally controlled with levodopa...
  18. pmc Long term safety and efficacy of unilateral deep brain stimulation of the thalamus for parkinsonian tremor
    K E Lyons
    University of Miami Medical Center, Department of Neurology, 1501 NW 9th Avenue, Miami, Florida 33136, USA
    J Neurol Neurosurg Psychiatry 71:682-4. 2001
    ..In conclusion, unilateral DBS of the thalamus has long term efficacy for treatment of tremor due to Parkinson's disease...
  19. ncbi request reprint Health-related quality of life in Parkinson's disease after pallidotomy and deep brain stimulation
    K Straits-Troster
    Department of Veterans Affairs Medical Center, Kansas City, USA
    Brain Cogn 42:399-416. 2000
    ..Results suggest that neurosurgical interventions for PD improve disabling PD motor symptoms and also improve several domains of quality of life...
  20. ncbi request reprint Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor
    W C Koller
    Department of Neurology, University of Miami Medical Center, 1501 NW 9th Ave, Miami, FL 33136, USA
    Mov Disord 16:464-8. 2001
    ..However, this therapy is compromised by loss of efficacy in some patients and device complications which increase the risk of additional surgical procedures...
  21. ncbi request reprint Magnitude of microelectrode refinement in pallidotomy and thalamotomy
    B D Milligan
    Imaging Resource Center, University of Kansas Medical Center, Kansas City 66160, USA
    Stereotact Funct Neurosurg 76:2-18. 2001
    ..Lesions were consistently localized anterior and superior to the starting point and a refined starting point algorithm may reduce the number of microelectrode recording tracts...
  22. ncbi request reprint Interactions between deep brain stimulation and levodopa in Parkinson's disease
    J G Nutt
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Neurology 57:1835-42. 2001
    ..To quantify the effects of deep brain stimulation (DBS) of globus pallidus interna (GPi) and subthalamic nucleus (STN) on motor fluctuations and dyskinesia in PD and to determine how the response to levodopa was modified by DBS...
  23. doi request reprint Study of istradefylline in patients with Parkinson's disease on levodopa with motor fluctuations
    Robert A Hauser
    Department of Neurology, University of South Florida, Tampa, Florida 33606, USA
    Mov Disord 23:2177-85. 2008
    ..We conclude that istradefylline is well tolerated and significantly reduces OFF time as an adjunct to levodopa in PD subjects with motor fluctuations...
  24. ncbi request reprint Surgical treatment of Parkinson's disease
    W C Koller
    Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7314, USA
    J Neurol Sci 167:1-10. 1999
    ..This procedure may control all PD symptoms, and the dose of levodopa can often be dramatically reduced. Neurotransplantation is a promising surgical approach to PD. However, further investigation is needed to optimize this approach...
  25. ncbi request reprint Pharmacokinetic-pharmacodynamic crossover comparison of two levodopa extension strategies
    Peter A LeWitt
    Department of Neurology, Henry Ford Hospital and Wayne State University School of Medicine, Detroit, Michigan, USA
    Mov Disord 24:1319-24. 2009
    ..803), and "on state with nontroublesome dyskinesia" was 18% for CLE and 7% for CL-CR (P = 0.03). Despite less "off" time with CLE, both formulations demonstrated similar mean PK values and marked intersubject PK variability...
  26. ncbi request reprint Bilateral subthalamic stimulation improves gait initiation in patients with Parkinson's disease
    W Liu
    Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7601, USA
    Gait Posture 23:492-8. 2006
    ..It is concluded that DBS significantly improved the performance of patients with advanced PD in gait initiation...
  27. ncbi request reprint Long-term benefits in quality of life provided by bilateral subthalamic stimulation in patients with Parkinson disease
    Kelly E Lyons
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurosurg 103:252-5. 2005
    ....
  28. ncbi request reprint Subthalamic nucleus stimulation in Parkinson's disease patients intolerant to levodopa
    Kelly E Lyons
    University of Kansas Medical Center, Department of Neurology, Kansas City, KS 66160, USA
    Stereotact Funct Neurosurg 85:169-74. 2007
    ..In conclusion, although levodopa responsiveness is the best predictor for outcome after STN DBS, carefully selected PD patients intolerant to levodopa can have significant improvement...
  29. ncbi request reprint Effects of bilateral subthalamic nucleus stimulation on sleep, daytime sleepiness, and early morning dystonia in patients with Parkinson disease
    Kelly E Lyons
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Neurosurg 104:502-5. 2006
    ....
  30. ncbi request reprint Practice Parameter: treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology
    R Pahwa
    University of Kansas Medical Center, Kansas City, USA
    Neurology 66:983-95. 2006
    ..5. Preoperative response to levodopa predicts better outcome after DBS of the STN (Level B)...
  31. ncbi request reprint An open-label conversion study of pramipexole to ropinirole prolonged release in Parkinson's disease
    Kelly E Lyons
    Department of Neurology, Parkinson s Disease and Movement Disorder Center, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mov Disord 24:2121-7. 2009
    ..A conversion ratio of 1 mg of pramipexole to 4 mg of ropinirole PR resulted in the fewest discontinuations of ropinirole PR, the fewest dose adjustments and the largest percentage of subjects that preferred ropinirole PR...
  32. ncbi request reprint Open-label trial regarding the use of acupuncture and yin tui na in Parkinson's disease outpatients: a pilot study on efficacy, tolerability, and quality of life
    Marty L Eng
    University of Kansas Medical Center, University of Kansas, School of Pharmacy, Department of Pharmacy Practice, Kansas City, KS 66160 7231, USA
    J Altern Complement Med 12:395-9. 2006
    ..This study evaluates the effects of sequential tui na massage, acupuncture, and instrument-delivered qigong for patients with Parkinson disease (PD) over a 6-month period...
  33. doi request reprint Pharmacotherapy of essential tremor : an overview of existing and upcoming agents
    Kelly E Lyons
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    CNS Drugs 22:1037-45. 2008
    ..Several new drugs, including 1-octanol, sodium oxybate, dimethoxymethyl-diphenyl-barbituric acid (T-2000) and carisbamate, are currently under investigation for the treatment of essential tremor...
  34. ncbi request reprint Levodopa-related wearing-off in Parkinson's disease: identification and management
    Rajesh Pahwa
    Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Blvd, Kansas City, KS 66160, USA
    Curr Med Res Opin 25:841-9. 2009
    ..The initial complication is commonly wearing-off, which is the re-emergence of motor and non-motor symptoms before the next scheduled levodopa dose...
  35. doi request reprint Orally disintegrating selegiline in Parkinson patients with dopamine agonist-related adverse effects
    Kelly E Lyons
    University of Kansas Medical Center, Kansas City, KS 66160, USA
    Clin Neuropharmacol 33:5-10. 2010
    ....
  36. ncbi request reprint Use of brain MRI after deep brain stimulation hardware implantation
    Jules M Nazzaro
    Department of Neurosurgery, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Int J Neurosci 120:176-83. 2010
    ..Rather, our data may contribute to further defining safe MRI scanning parameters that might ultimately be adopted in future product labeling as more centers report in detail their experiences...
  37. doi request reprint Head positioning and risk of pneumocephalus, air embolism, and hemorrhage during subthalamic deep brain stimulation surgery
    Jules M Nazzaro
    Department of Neurosurgery, University of Kansas Medical Center, Kansas City, 66160, USA
    Acta Neurochir (Wien) 152:2047-52. 2010
    ....
  38. ncbi request reprint Pramipexole vs levodopa as initial treatment for Parkinson disease: a 4-year randomized controlled trial
    Robert G Holloway
    Department of Neurology, University of Rochester, 1351 Mt Hope Avenue, Suite 220, Rochester, NY 14620, USA
    Arch Neurol 61:1044-53. 2004
    ..The best way to initiate dopaminergic therapy for early Parkinson disease remains unclear...
  39. ncbi request reprint Surgical and hardware complications of subthalamic stimulation: a series of 160 procedures
    Kelly E Lyons
    Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Blvd, Mailstop 2012, Kansas City, KS 66160, USA
    Neurology 63:612-6. 2004
    ..To assess the surgical and hardware complications in a series of 81 consecutive patients undergoing subthalamic (STN) deep brain stimulation (DBS) for Parkinson disease (PD)...
  40. ncbi request reprint Double-blind controlled study of methazolamide in the treatment of essential tremor
    K Busenbark
    Department of Neurology, University of Kansas Medical Center, Kansas City 66160 7314
    Neurology 43:1045-7. 1993
    ..Side effects, paresthesias, sedation, headaches, and gastrointestinal symptoms were common. Only two patients elected to remain on the drug after the study. Methazolamide has only limited efficacy in the treatment of essential tremor...
  41. ncbi request reprint Development and initial validation of a screening tool for Parkinson disease surgical candidates
    M S Okun
    Department of Neurology, University of Florida McKnight Brain Institute, 100 S Newell Dr, 3rd Fl, rm L3 100, PO Box 100236, Gainesville, FL 32610, USA
    Neurology 63:161-3. 2004
    ..Part II was a multicenter study to assess the correlation of FLASQ-PD scores. The results of this study suggest that the FLASQ-PD may be a useful triage tool for screening PD patients for DBS surgery...
  42. ncbi request reprint Deep brain stimulation and essential tremor
    Kelly E Lyons
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Clin Neurophysiol 21:2-5. 2004
    ..Deep brain stimulation of the thalamus is a safe and efficacious procedure and should be considered in patients with ET who experience medication-resistant disabling tremor...
  43. ncbi request reprint Benefits and risks of pharmacological treatments for essential tremor
    Kelly E Lyons
    University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Drug Saf 26:461-81. 2003
    ..The use of medication and/or surgery can provide adequate tremor control in the majority of the patients...
  44. doi request reprint Treatment of early Parkinson's disease. Part 1
    Tanya Simuni
    Department of Neurology, Northwestern University, Parkinson s Disease and Movement Disorders Center, Chicago, Ill 60611, USA
    Eur Neurol 61:193-205. 2009
    ..Safety and tolerability data are also reviewed. Part 2 of the article reviews key findings relevant to the assessment of potential neuroprotective therapies and the treatment of non-motor symptoms...
  45. doi request reprint Treatment of early Parkinson's disease. Part 2
    Tanya Simuni
    Department of Neurology, Northwestern University, Parkinson s Disease and Movement Disorders Center, Chicago, Ill, USA
    Eur Neurol 61:206-15. 2009
    ..Part 2 of the article, presented here, reviews key data relevant to the assessment of potential neuroprotective therapies and the treatment of non-motor symptoms...
  46. ncbi request reprint Freezing of gait after bilateral subthalamic nucleus stimulation for Parkinson's disease
    Justin T Davis
    University of Kansas Medical Center, Department of Neurology, 3599 Rainbow Blvd, Kansas City, KS 66160, USA
    Clin Neurol Neurosurg 108:461-4. 2006
    ..To determine the long-term effect of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on freezing of gait in Parkinson's disease patients...
  47. ncbi request reprint Levetiracetam is not effective for essential tremor
    Rodger J Elble
    Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL 62794 9643, USA
    Clin Neuropharmacol 30:350-6. 2007
    ..To determine if levetiracetam is efficacious in the treatment of essential tremor...
  48. ncbi request reprint Stimulation of the motor cortex for disabling essential tremor
    Kelly E Lyons
    Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Blvd, Mailstop 2012, Kansas City, KS 66160, USA
    Clin Neurol Neurosurg 108:564-7. 2006
    ..To examine the safety and efficacy of targeted stimulation of the motor cortex as a treatment for essential tremor (ET)...
  49. ncbi request reprint Conversion from sustained release carbidopa/levodopa to carbidopa/levodopa/entacapone (stalevo) in Parkinson disease patients
    Kelly E Lyons
    Department of Neurology, University of Kansas Medical Center, Kansas City, 66160, USA
    Clin Neuropharmacol 29:73-6. 2006
    ....
  50. ncbi request reprint Deep brain stimulation in Parkinson's disease
    Kelly E Lyons
    Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Boulevard, Mailstop 2012, Kansas City, KS 66160, USA
    Curr Neurol Neurosci Rep 4:290-5. 2004
    ..Complications associated with DBS are related to the experience of the surgical center. Referring physicians and patients should be aware of the number of surgical procedures and complication rates of any prospective surgical center...
  51. ncbi request reprint Neuropathologic findings in essential tremor
    E D Louis
    GH Sergievsky Center, Department of Neurology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 66:1756-9. 2006
    ..Six cases (60%) had Lewy bodies vs 2 controls (16.7%) (odds ratio 7.5, 95% CI 1.04 to 54.1; p = 0.035). Four of these six had an atypical distribution of brainstem Lewy bodies. ET may be pathologically heterogeneous...
  52. doi request reprint Utility of the NeuroTrax computerized battery for cognitive screening in Parkinson's disease: comparison with the MMSE and the MoCA
    B Hanna-Pladdy
    Landon Center on Aging, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Int J Neurosci 120:538-43. 2010
    ..While the MoCA is sensitive, it may be too stringent in overclassifying PD patients as impaired...
  53. ncbi request reprint Postural tremor suppression is dependent on thalamic stimulation frequency
    Mwiza Ushe
    Department of Neurology, Washington University, St Louis, Missouri, USA
    Mov Disord 21:1290-2. 2006
    ....
  54. ncbi request reprint Quality of life in Essential Tremor Questionnaire (QUEST): development and initial validation
    Alexander I Troster
    Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7025, USA
    Parkinsonism Relat Disord 11:367-73. 2005
    ..We sought to develop an ET-specific measure that might be more sensitive, acceptable to patients, relatively brief, and easily used...
  55. ncbi request reprint Effect of stimulation frequency on tremor suppression in essential tremor
    Mwiza Ushe
    Department of Neurology, Washington University in St Louis, St Louis, Missouri, USA
    Mov Disord 19:1163-8. 2004
    ..Second, thalamic DBS provides tremor benefit in a graded manner and is not an all-or-nothing phenomenon...
  56. ncbi request reprint Efficacy and tolerability of levetiracetam in Parkinson disease patients with levodopa-induced dyskinesia
    Kelly E Lyons
    Department of Neurology, University of Kansas Medical Center, Kansas City, 66160, USA
    Clin Neuropharmacol 29:148-53. 2006
    ..This open-label study was performed to evaluate the efficacy and tolerability of levetiracetam for levodopa-induced dyskinesia and its effect on motor functioning and quality of life in Parkinson disease (PD) patients...
  57. pmc A review of ropinirole prolonged release in Parkinson's disease
    Muhammad M Nashatizadeh
    Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Clin Interv Aging 4:179-86. 2009
    ..This manuscript briefly reviews the current pharmacological treatment options for PD and provides a more detailed review of the currently available data regarding ropinirole prolonged release as a treatment option for PD...
  58. ncbi request reprint Long-term efficacy of globus pallidus stimulation for the treatment of Parkinson's disease
    Kelly E Lyons
    Department of Neurology, University of Miami Medical Center, Miami, Fla, USA
    Stereotact Funct Neurosurg 79:214-20. 2002
    ..To determine the long-term efficacy and safety of globus pallidus internus (GPi) stimulation for Parkinson's disease (PD)...
  59. pmc Impact of belief in neuroprotection on therapeutic intervention in Parkinson's disease
    Rodger J Elble
    Department of Neurology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Mov Disord 25:1082-6. 2010
    ..We found the investigators' level of confidence in these agents had no effect on the time to symptomatic therapy or on the change in UPDRS during 12 months of treatment...
  60. ncbi request reprint Early diagnosis of Parkinson's disease: recommendations from diagnostic clinical guidelines
    Rajesh Pahwa
    University of Kansas Medical Center, 3599 Rainbow Blvd, Kansas City, KS 66160, USA
    Am J Manag Care 16:S94-9. 2010
    ..This article reviews and summarizes published recommendations for the clinical diagnosis of PD...
  61. pmc Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease
    David K Simon
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 11:53. 2010
    ..We investigated the potential contribution of mtDNA variants or mutations to the risk of PD...
  62. doi request reprint Cancer incidence in a trial of an antiapoptotic agent for Parkinson's disease
    Steven R Schwid
    Department of Neurology, University of Rochester, Rochester, New York, USA
    Mov Disord 25:1801-8. 2010
    ..Melanoma occurrence in our PD patients was greater than predicted compared with the general population and was unrelated to dopaminergic therapy. Clinical surveillance of PD patients for melanoma may be warranted...
  63. doi request reprint Deep brain stimulation and tremor
    Kelly E Lyons
    Parkinson s Disease and Movement Disorder Center, Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Neurotherapeutics 5:331-8. 2008
    ....
  64. ncbi request reprint Electronic motor function diary for patients with Parkinson's disease: a feasibility study
    Kelly E Lyons
    Parkinson s Disease and Movement Disorder Center, Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Blvd, Mailstop 2012, Kansas City, KS 66160, USA
    Parkinsonism Relat Disord 13:304-7. 2007
    ..Electronic diaries could be operated by PD patients, provided valuable information about response patterns and resulted in average response compliance of approximately 1h...
  65. ncbi request reprint Pulse width is associated with cognitive decline after thalamic stimulation for essential tremor
    Steven Paul Woods
    Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Box 356560, 1959 NE Pacific Street, Seattle, WA 98195 6560, USA
    Parkinsonism Relat Disord 9:295-300. 2003
    ..Findings indicate that although relatively higher PW settings might afford optimal tremor control in some patients, the corresponding risk of mild, probably often subclinical, cognitive morbidity must be weighed accordingly...
  66. ncbi request reprint Validity of clinical and patient ratings of tremor disability among older adults
    Duane A Lundervold
    Department of Psychology, Central Missouri State University, 1111 Lovinger Hall, Warrensburg, MO 64093, USA
    Parkinsonism Relat Disord 10:15-8. 2003
    ....
  67. ncbi request reprint Transtelephonic home blood pressure to assess the monoamine oxidase-B inhibitor rasagiline in Parkinson disease
    William B White
    Division of Hypertension and Clinical Pharmacology, Pat and Jim Calhoun Cardiology Center and Clinical Trials Unit, University of Connecticut, Farmington, Connecticut 06030 3940, USA
    Hypertension 52:587-93. 2008
    ..3%, 2.6%, and 2.9% of the placebo, 0.5-mg, and 1.0-mg rasagiline groups, respectively. These data demonstrate that rasagiline did not induce postprandial hypertension in patients with Parkinson disease who were on an unrestricted diet...
  68. ncbi request reprint Effect of motor improvement on quality of life following subthalamic stimulation is mediated by changes in depressive symptomatology
    Alexander I Troster
    Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    Stereotact Funct Neurosurg 80:43-7. 2003
    ..Because depression is a potent correlate of QOL, and STN-DBS may be associated with changes in mood, this study sought to determine whether QOL improvement is a direct or indirect consequence of motor improvement...
  69. ncbi request reprint Deep brain stimulation: preoperative issues
    Anthony E Lang
    Department of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 21:S171-96. 2006
    ..It outlines answers to a series of questions developed to address all aspects of deep brain stimulation preoperative decision-making...
  70. ncbi request reprint Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes
    Galit Kleiner-Fisman
    Parkinson s Disease Research Education and Clinical Center, Philadelphia VA Hospital, Philadelphia, Pennsylvania 19104, USA
    Mov Disord 21:S290-304. 2006
    ..These data provide an estimate of the magnitude of the treatment effects and emphasize the need for controlled and randomized studies...
  71. ncbi request reprint Neuropathological changes in essential tremor: 33 cases compared with 21 controls
    Elan D Louis
    GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, USA
    Brain 130:3297-307. 2007
    ..The majority have cerebellar changes without Lewy bodies; a smaller proportion has brainstem Lewy bodies. The clinical differences between cases with versus without Lewy bodies require additional study...
  72. ncbi request reprint Safety and efficacy of newly formulated selegiline orally disintegrating tablets as an adjunct to levodopa in the management of 'off' episodes in patients with Parkinson's disease
    Mark F Lew
    Keck University of Southern California School of Medicine, Los Angeles, CA 90033, USA
    Curr Med Res Opin 23:741-50. 2007
    ..This study assessed adjunctive Zelapar (selegiline orally disintegrating tablet (ODT)) for managing off episodes and for long-term safety...
  73. ncbi request reprint Advanced Parkinson disease treated with rotigotine transdermal system: PREFER Study
    Peter A LeWitt
    Clinical Neuroscience Center, Southfield, MI 48034, USA
    Neurology 68:1262-7. 2007
    ..In patients experiencing motor fluctuations, a major treatment challenge is the reduction of "off" time, particularly upon awakening. Rotigotine (Neupro) is a novel dopaminergic agonist with 24-hour transdermal delivery...
  74. ncbi request reprint Parkin mutations and susceptibility alleles in late-onset Parkinson's disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 53:624-9. 2003
    ..These findings suggest that mutations in Parkin contribute to the common form of PD and that heterozygous mutations, especially those lying in exon 7, act as susceptibility alleles for late-onset form of Parkinson disease...
  75. pmc Age at onset in two common neurodegenerative diseases is genetically controlled
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 70:985-93. 2002
    ..62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases...
  76. ncbi request reprint Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Hum Mol Genet 12:3259-67. 2003
    ..This is provocative given reports of the possible role of inflammation in these two neurodegenerative disorders...
  77. ncbi request reprint Bilateral pallidotomy for severe dystonia in an 18-month-old child with glutaric aciduria
    Goran Rakocevic
    National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA
    Stereotact Funct Neurosurg 82:80-3. 2004
    ..The surgery improved dystonic symptoms, especially pain in this child with minor complications related to the procedure. Pallidotomy is a reasonable option for children with dystonic symptoms secondary to glutaric aciduria...
  78. ncbi request reprint Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families
    Lianna Ishihara
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    Mov Disord 22:55-61. 2007
    ....
  79. ncbi request reprint A founding LRRK2 haplotype shared by Tunisian, US, European and Middle Eastern families with Parkinson's disease
    L Warren
    Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park, NC 27709, USA
    Parkinsonism Relat Disord 14:77-80. 2008
    ..The most recent common founder of the mutation was dated to 2600 (95% CI: 1950-3850) years ago although additional studies are warranted to ensure an accurate age estimate for this mutation...
  80. pmc Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease
    Joelle M van der Walt
    Department of Medicine, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 72:804-11. 2003
    ..45; 95% CI 0.22-0.93; P=.03). Our results suggest that ND3 is an important factor in PD susceptibility among white individuals and could help explain the role of complex I in PD expression...
  81. ncbi request reprint Association study of Parkin gene polymorphisms with idiopathic Parkinson disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC
    Arch Neurol 60:975-80. 2003
    ..However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD...
  82. pmc Reduced Purkinje cell number in essential tremor: a postmortem study
    Jordan E Axelrad
    Gertrude H Sergievsky Center, Columbia University, New York, New York, USA
    Arch Neurol 65:101-7. 2008
    ..In recent postmortem studies, we documented increased numbers of torpedoes (Purkinje cell axonal swellings) in ET patients without Lewy bodies. Purkinje cell loss, however, has never been rigorously assessed...
  83. pmc Serum urate as a predictor of clinical and radiographic progression in Parkinson disease
    Michael A Schwarzschild
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, USA
    Arch Neurol 65:716-23. 2008
    ..To determine whether concentration of serum urate, a purine metabolite and potent antioxidant that has been linked to a reduced risk of Parkinson disease (PD), predicts prognosis in PD...

Research Grants4

  1. KU Center for Neuroprotection in Parkinson's Disease
    Rajesh Pahwa; Fiscal Year: 2002
    ..The University of Kansas Parkinson's Disease Center is willing and dedicated to adhere to a common protocol and to cooperate with other centers and NINDS in the conduct of both pilot studies and the main efficacy study. ..
  2. KU Center for Neuroprotection in Parkinson's Disease
    Rajesh Pahwa; Fiscal Year: 2006
    ..The University of Kansas Parkinson's Disease Center is willing and dedicated to adhere to a common protocol and to cooperate with other centers and NINDS in the conduct of both pilot studies and the main efficacy study. ..
  3. KU Center for Neuroprotection in Parkinson's Disease
    Rajesh Pahwa; Fiscal Year: 2007
    ..The University of Kansas Parkinson's Disease Center is willing and dedicated to adhere to a common protocol and to cooperate with other centers and NINDS in the conduct of both pilot studies and the main efficacy study. ..