Stephanie T Page

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 97:1598-605. 2012
  2. pmc Dutasteride reduces prostate size and prostate specific antigen in older hypogonadal men with benign prostatic hyperplasia undergoing testosterone replacement therapy
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Urol 186:191-7. 2011
  3. doi Physiologic role and regulation of intratesticular sex steroids
    Stephanie T Page
    Division of Metabolism, Nutrition and Endocrinology, University of Washington Medical Center, Seattle, Washington 98195, USA
    Curr Opin Endocrinol Diabetes Obes 18:217-23. 2011
  4. pmc Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: a randomized-controlled trial
    Stephanie T Page
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine, Box 357138, 1959 NE Pacific Street, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 96:430-7. 2011
  5. pmc Higher testosterone levels are associated with increased high-density lipoprotein cholesterol in men with cardiovascular disease: results from the Massachusetts Male Aging Study
    Stephanie T Page
    Department of Medicine, University of Washington, 1959 NE Pacific, Seattle, WA 98195, USA
    Asian J Androl 10:193-200. 2008
  6. pmc Tissue selectivity of the anabolic steroid, 19-nor-4-androstenediol-3beta,17beta-diol in male Sprague Dawley rats: selective stimulation of muscle mass and bone mineral density relative to prostate mass
    Stephanie T Page
    Division of Endocrinology and Metabolism, Department of Medicine, University of Washington Medical Center, 1959 NE Pacific, Seattle, WA 98195, USA
    Endocrinology 149:1987-93. 2008
  7. ncbi Nanomilled oral testosterone plus dutasteride effectively normalizes serum testosterone in normal men with induced hypogonadism
    Stephanie T Page
    Center for Research in Reproduction and Contraception, Division of General Internal Medicine and Endocrinology, Metabolism, and Nutrition, Department of Medicine, University of Washington Medical School, Seattle, WA, USA
    J Androl 29:222-7. 2008
  8. pmc Advances in male contraception
    Stephanie T Page
    Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Endocr Rev 29:465-93. 2008
  9. ncbi Intratesticular androgens and spermatogenesis during severe gonadotropin suppression induced by male hormonal contraceptive treatment
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Androl 28:734-41. 2007
  10. ncbi Testosterone gel combined with depomedroxyprogesterone acetate is an effective male hormonal contraceptive regimen and is not enhanced by the addition of a GnRH antagonist
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 91:4374-80. 2006

Detail Information

Publications45

  1. pmc Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 97:1598-605. 2012
    ....
  2. pmc Dutasteride reduces prostate size and prostate specific antigen in older hypogonadal men with benign prostatic hyperplasia undergoing testosterone replacement therapy
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Urol 186:191-7. 2011
    ....
  3. doi Physiologic role and regulation of intratesticular sex steroids
    Stephanie T Page
    Division of Metabolism, Nutrition and Endocrinology, University of Washington Medical Center, Seattle, Washington 98195, USA
    Curr Opin Endocrinol Diabetes Obes 18:217-23. 2011
    ..To summarize recent advances in our understanding of the role and regulation of intratesticular androgens, and their metabolites, in human spermatogenesis...
  4. pmc Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: a randomized-controlled trial
    Stephanie T Page
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine, Box 357138, 1959 NE Pacific Street, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 96:430-7. 2011
    ..Exogenous androgens raise serum DHT concentrations, but their effects on the prostate are not clear...
  5. pmc Higher testosterone levels are associated with increased high-density lipoprotein cholesterol in men with cardiovascular disease: results from the Massachusetts Male Aging Study
    Stephanie T Page
    Department of Medicine, University of Washington, 1959 NE Pacific, Seattle, WA 98195, USA
    Asian J Androl 10:193-200. 2008
    ..To study the relationship between circulating androgens (total testosterone [TT], free testosterone [fT] and dihydrotestosterone [DHT]) and high-density lipoprotein cholesterol (HDL-C) in men with and without cardiovascular disease (CVD)...
  6. pmc Tissue selectivity of the anabolic steroid, 19-nor-4-androstenediol-3beta,17beta-diol in male Sprague Dawley rats: selective stimulation of muscle mass and bone mineral density relative to prostate mass
    Stephanie T Page
    Division of Endocrinology and Metabolism, Department of Medicine, University of Washington Medical Center, 1959 NE Pacific, Seattle, WA 98195, USA
    Endocrinology 149:1987-93. 2008
    ..Anabolic steroids such as 3beta,19-NA should be studied further to determine their mechanisms of tissue selectivity and effects in men...
  7. ncbi Nanomilled oral testosterone plus dutasteride effectively normalizes serum testosterone in normal men with induced hypogonadism
    Stephanie T Page
    Center for Research in Reproduction and Contraception, Division of General Internal Medicine and Endocrinology, Metabolism, and Nutrition, Department of Medicine, University of Washington Medical School, Seattle, WA, USA
    J Androl 29:222-7. 2008
    ..NmT allows for tablet formulation, and its pharmacokinetics were not affected by food, demonstrating the feasibility of oral nanomilled T as a promising and practical twice-daily therapy for the treatment of male hypogonadism...
  8. pmc Advances in male contraception
    Stephanie T Page
    Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Endocr Rev 29:465-93. 2008
    ....
  9. ncbi Intratesticular androgens and spermatogenesis during severe gonadotropin suppression induced by male hormonal contraceptive treatment
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Androl 28:734-41. 2007
    ..Additional studies to identify factors involved in persistent spermatogenesis despite gonadotropin suppression are warranted...
  10. ncbi Testosterone gel combined with depomedroxyprogesterone acetate is an effective male hormonal contraceptive regimen and is not enhanced by the addition of a GnRH antagonist
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Endocrinol Metab 91:4374-80. 2006
    ....
  11. ncbi Persistent intraprostatic androgen concentrations after medical castration in healthy men
    Stephanie T Page
    University of Washington Medical Center, Division of Metabolism, Endocrinology and Nutrition, Box 357138, 1959 NE Pacific, Seattle, WA 98195
    J Clin Endocrinol Metab 91:3850-6. 2006
    ..Studies of men with prostate cancer have suggested that prostatic androgens are preserved in the setting of castration. Tissue androgens might stimulate prostate growth, producing adverse clinical consequences...
  12. ncbi Testosterone administration suppresses adiponectin levels in men
    Stephanie T Page
    Department of Medicine, University of Washington Medical Center, Division of Endocrinology and Metabolism, 1959 NE Pacific, Box 357138, Seattle, WA 98195, USA
    J Androl 26:85-92. 2005
    ..Furthermore, supraphysiologic T administration results in decreased adiponectin levels. Our data support the hypothesis that T, its metabolites, or both directly suppress adipocyte production of adiponectin...
  13. ncbi The androgen receptor gene CAG repeat polymorphism does not predict increased risk of heart disease: longitudinal results from the Massachusetts Male Ageing Study
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Endocrinol (Oxf) 65:333-9. 2006
    ..Longer, less androgenic CAG repeats have been associated with higher high-density lipoprotein (HDL) levels, which might protect against HD. Therefore, we hypothesized that CAG repeat length contributes to HD risk in men...
  14. ncbi Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T
    Stephanie T Page
    Wesley Woods Health Center, 1841 Clifton Road Northeast, Atlanta, Georgia 30329 5102, USA
    J Clin Endocrinol Metab 90:1502-10. 2005
    ....
  15. pmc A new combination of testosterone and nestorone transdermal gels for male hormonal contraception
    Niloufar Ilani
    Department of Medicine, Harbor University of California, Los Angeles, Medical Center and Los Angeles Biomedical Research Institute, 1000 West Carson Street, Torrance, California 90509, USA
    J Clin Endocrinol Metab 97:3476-86. 2012
    ..Combinations of testosterone (T) and nestorone (NES; a nonandrogenic progestin) transdermal gels may suppress spermatogenesis and prove appealing to men for contraception...
  16. pmc Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial
    Mara Y Roth
    Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Fertil Steril 99:132-9. 2013
    ..To study the potential role for using serum biomarkers, including insulin-like factor 3 (INSL3), 17α-hydroxyprogesterone, antimüllerian hormone, and inhibin B, as correlates of intratesticular T (IT-T) concentrations in men...
  17. ncbi Acceptability of a combination testosterone gel and depomedroxyprogesterone acetate male contraceptive regimen
    John K Amory
    Department of Medicine, University of Washington, Box 326429, Seattle, WA 98195, USA
    Contraception 75:218-23. 2007
    ....
  18. pmc Pharmacokinetics of 2 novel formulations of modified-release oral testosterone alone and with finasteride in normal men with experimental hypogonadism
    Christin N Snyder
    University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    J Androl 31:527-35. 2010
    ..This formulation might have efficacy for the treatment of testosterone deficiency...
  19. pmc Impact of male hormonal contraception on prostate androgens and androgen action in healthy men: a randomized, controlled trial
    Elahe A Mostaghel
    Division of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Clin Endocrinol Metab 97:2809-17. 2012
    ..Male hormonal contraception (MHC) combines hypothalamic-pituitary-gonadal axis blockade with exogenous androgen delivery to maintain extragonadal androgen end-organ effects. Concern exists that MHC may adversely impact prostate health...
  20. doi Pharmacokinetics of modified slow-release oral testosterone over 9 days in normal men with experimental hypogonadism
    Ada Lee
    Center for Research in Reproduction and Contraception, Divisions of General Internal Medicine and Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medical School, Seattle, WA, USA
    J Androl 33:420-6. 2012
    ..This formulation of oral testosterone may have efficacy for the treatment of testosterone deficiency...
  21. ncbi Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: a randomized clinical trial
    Bradley D Anawalt
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98108, USA
    J Androl 26:405-13. 2005
    ....
  22. pmc Acute sex steroid withdrawal increases cholesterol efflux capacity and HDL-associated clusterin in men
    Katya B Rubinow
    Center for Research in Reproduction and Contraception, Division of Metabolism, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98109, United States
    Steroids 77:454-60. 2012
    ..Further investigation of the effects of sex steroids on HDL composition and function may help resolve the apparently conflicting data regarding testosterone, HDL-C, and CVD risk...
  23. pmc Combined transdermal testosterone gel and the progestin nestorone suppresses serum gonadotropins in men
    Vahid Mahabadi
    Department of Medicine, Division of Endocrinology, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA
    J Clin Endocrinol Metab 94:2313-20. 2009
    ..Nestorone (NES), a progestin without estrogenic or androgenic activity, when combined with T may be an excellent candidate for male contraception...
  24. ncbi Elevated end-of-treatment serum INSL3 is associated with failure to completely suppress spermatogenesis in men receiving male hormonal contraception
    John K Amory
    Department of Medicine, University of Washington, 1959 NE Pacific, Seattle, WA 98195, USA
    J Androl 28:548-54. 2007
    ..INSL3 may play a role in preventing complete suppression of spermatogenesis in some men on hormonal contraceptive regimens. This finding suggests that INSL3 may be a potential target for male contraceptive development...
  25. pmc The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men
    John K Amory
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Urol 179:2333-8. 2008
    ..Because androgens affect bone, lipids, hematopoiesis, prostate and sexual function, we determined the impact of 5alpha-reductase inhibitors on these end points...
  26. ncbi Drug insight: Recent advances in male hormonal contraception
    John K Amory
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Nat Clin Pract Endocrinol Metab 2:32-41. 2006
    ..One of these testosterone and progestogen combination regimens might soon bring the promise of male hormonal contraception to fruition...
  27. ncbi Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer
    Elahe A Mostaghel
    Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Cancer Res 67:5033-41. 2007
    ..Optimal clinical efficacy will require testing of novel approaches targeting complete suppression of systemic and intracrine contributions to the prostatic androgen microenvironment...
  28. pmc Pharmacokinetics and pharmacodynamics of oral testosterone enanthate plus dutasteride for 4 weeks in normal men: implications for male hormonal contraception
    John K Amory
    Center for Research in Reproduction and Contraception, University of Washington, Box 356429, 1959 NE Pacific St, Seattle, WA 98195, USA
    J Androl 29:260-71. 2008
    ..The administration of 800 mg oral TE daily combined with dutasteride for 28 days significantly suppresses gonadotropins without untoward side effects and might have utility as part of a male hormonal contraceptive regimen...
  29. pmc Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in gonadotropin-suppressed normal men receiving various dosages of human chorionic gonadotropin
    John K Amory
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Fertil Steril 89:380-6. 2008
    ..To determine if serum concentrations of testosterone precursors would correlate with intratesticular testosterone (ITT) concentration measured directly by testicular aspiration and allow for a less invasive means of inferring ITT...
  30. ncbi Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolites
    Stephanie T Page
    Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Physiol Endocrinol Metab 290:E856-63. 2006
    ..In addition, sex steroids suppress NK cell proliferation. This study supports a complex physiological role for T and/or its metabolites in immune regulation...
  31. pmc Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity
    Katya B Rubinow
    Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    J Lipid Res 53:1376-83. 2012
    ..These effects appear independent of testosterone conversion to dihydrotestosterone. Further research is needed to determine how changes in HDL protein content affect CVD risk in men...
  32. pmc Treatment of male infertility secondary to morbid obesity
    Mara Y Roth
    Division of Metabolism, Endocrinology and Nutrition, University of Washington School of Medicine, Seattle, WA 98195 6246, USA
    Nat Clin Pract Endocrinol Metab 4:415-9. 2008
    ..5 kg/m(2)). Before referral to the clinic, the patient had been treated with testosterone therapy for 4 months for hypogonadism. This treatment had caused his initially low sperm concentration to fall to undetectable levels...
  33. ncbi Oral testosterone in oil: pharmacokinetic effects of 5alpha reduction by finasteride or dutasteride and food intake in men
    John K Amory
    University of Washington, Box 356429, 1959 NE Pacific St, Seattle, WA 98195, USA
    J Androl 27:72-8. 2006
    ..Additional studies of the combination of oral T in oil with 5alpha-reductase inhibitors as a novel form of oral T therapy are warranted...
  34. pmc Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics
    John Kenneth Amory
    Department of Medicine, Division of General Internal Medicine and Endocrinology, Center for Research in Reproduction and Contraception, University of Washington, Seattle, WA 98195, USA
    Cancer Chemother Pharmacol 64:641-5. 2009
    ..We hypothesized that GIPET enhancement would allow for the safe oral dosing of acyline for the treatment of prostate cancer...
  35. pmc Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
    Shihua Sun
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Clin Invest 120:2715-30. 2010
    ....
  36. ncbi Analysis of testosterone and dihydrotestosterone from biological fluids as the oxime derivatives using high-performance liquid chromatography/tandem mass spectrometry
    Thomas F Kalhorn
    Mass Spectrometry Center, Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195 7610, USA
    Rapid Commun Mass Spectrom 21:3200-6. 2007
    ..Given its high reproducibility, sensitivity, and relative simplicity, this assay should be of use in determining androgen levels in biospecimens, particularly in settings where sample quantity or steroid concentration are low...
  37. ncbi Transdermal androgen therapy to augment EPO in the treatment of anemia of chronic renal disease
    Andrew T Brockenbrough
    Division of Nephrology, Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington Medical School, Seattle, WA, USA
    Am J Kidney Dis 47:251-62. 2006
    ..Additionally, by increasing hemoglobin levels, testosterone replacement may allow for a dose reduction in recombinant human erythropoietin (rHuEPO), thereby reducing cost...
  38. pmc Oxidative DNA damage in the prostate may predispose men to a higher risk of prostate cancer
    Jennifer D Wu
    Department of Medicine, University of Washington, Seattle, WA, USA
    Transl Oncol 2:39-45. 2009
    ....
  39. pmc Male pattern baldness and prostate cancer risk in a population-based case-control study
    Jonathan L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, WA, United States
    Cancer Epidemiol 34:131-5. 2010
    ..Studies exploring the relationship between the two conditions have been inconclusive. Using a population-based, case-control study of PCa, we explore the relationship between early-onset MPB and PCa risk...
  40. ncbi Is there a relationship between sex hormones and erectile dysfunction? Results from the Massachusetts Male Aging Study
    Varant Kupelian
    New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA
    J Urol 176:2584-8. 2006
    ..Simultaneously, age related changes occur in male endocrine functioning. We examined the association between erectile dysfunction and total testosterone, bioavailable testosterone, sex hormone-binding globulin and luteinizing hormone...
  41. ncbi Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men
    Varant Kupelian
    New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 91:843-50. 2006
    ..The purpose of this analysis was to determine whether low serum sex hormone levels or clinical androgen deficiency (AD) predict the development of MetS...
  42. ncbi Do statins affect androgen levels in men? Results from the Boston area community health survey
    Susan A Hall
    New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA
    Cancer Epidemiol Biomarkers Prev 16:1587-94. 2007
    ....
  43. ncbi DHEA and testosterone in the elderly
    Stephanie T Page
    N Engl J Med 356:635; author reply 637. 2007
  44. ncbi Sex steroids and all-cause and cause-specific mortality in men
    Andre B Araujo
    New England Research Institutes, 9 Galen St, Watertown, MA 02472, USA
    Arch Intern Med 167:1252-60. 2007
    ..Sex steroid levels are related to metabolic outcomes that could convey higher risk of premature death...
  45. ncbi 10th Summit Meeting consensus: recommendations for regulatory approval for hormonal male contraception
    Pertti Aaltonen
    Schering AG, Berlin, Germany
    J Androl 28:362-3. 2007

Research Grants3

  1. Hormonal and molecular consequences of androgen replacement on the prostate
    Stephanie Page; Fiscal Year: 2007
    ..Nelson, MD, Associate Professor of Medicine (Oncology), University of Washington School of Medicine will co-mentor this award. ..
  2. Dose-response relationships between circulating and intraprostatic androgens in m
    Stephanie T Page; Fiscal Year: 2010
    ..An improved understanding of the impact of testosterone on the prostate will help inform the risk:benefit ratio of testosterone therapies in older men. ..