Research Topics
Species | Stephanie T PageSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL functionStephanie T Page
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 97:1598-605. 2012....- Dutasteride reduces prostate size and prostate specific antigen in older hypogonadal men with benign prostatic hyperplasia undergoing testosterone replacement therapyStephanie T Page
Department of Medicine, University of Washington, Seattle, Washington, USA
J Urol 186:191-7. 2011.... 
Physiologic role and regulation of intratesticular sex steroidsStephanie T Page
Division of Metabolism, Nutrition and Endocrinology, University of Washington Medical Center, Seattle, Washington 98195, USA
Curr Opin Endocrinol Diabetes Obes 18:217-23. 2011..To summarize recent advances in our understanding of the role and regulation of intratesticular androgens, and their metabolites, in human spermatogenesis...- Dihydrotestosterone administration does not increase intraprostatic androgen concentrations or alter prostate androgen action in healthy men: a randomized-controlled trialStephanie T Page
Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine, Box 357138, 1959 NE Pacific Street, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 96:430-7. 2011..Exogenous androgens raise serum DHT concentrations, but their effects on the prostate are not clear... - Higher testosterone levels are associated with increased high-density lipoprotein cholesterol in men with cardiovascular disease: results from the Massachusetts Male Aging StudyStephanie T Page
Department of Medicine, University of Washington, 1959 NE Pacific, Seattle, WA 98195, USA
Asian J Androl 10:193-200. 2008..To study the relationship between circulating androgens (total testosterone [TT], free testosterone [fT] and dihydrotestosterone [DHT]) and high-density lipoprotein cholesterol (HDL-C) in men with and without cardiovascular disease (CVD)... - Tissue selectivity of the anabolic steroid, 19-nor-4-androstenediol-3beta,17beta-diol in male Sprague Dawley rats: selective stimulation of muscle mass and bone mineral density relative to prostate massStephanie T Page
Division of Endocrinology and Metabolism, Department of Medicine, University of Washington Medical Center, 1959 NE Pacific, Seattle, WA 98195, USA
Endocrinology 149:1987-93. 2008..Anabolic steroids such as 3beta,19-NA should be studied further to determine their mechanisms of tissue selectivity and effects in men... 
Nanomilled oral testosterone plus dutasteride effectively normalizes serum testosterone in normal men with induced hypogonadismStephanie T Page
Center for Research in Reproduction and Contraception, Division of General Internal Medicine and Endocrinology, Metabolism, and Nutrition, Department of Medicine, University of Washington Medical School, Seattle, WA, USA
J Androl 29:222-7. 2008..NmT allows for tablet formulation, and its pharmacokinetics were not affected by food, demonstrating the feasibility of oral nanomilled T as a promising and practical twice-daily therapy for the treatment of male hypogonadism...- Advances in male contraceptionStephanie T Page
Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
Endocr Rev 29:465-93. 2008.... - Intratesticular androgens and spermatogenesis during severe gonadotropin suppression induced by male hormonal contraceptive treatmentStephanie T Page
Department of Medicine, University of Washington, Seattle, Washington, USA
J Androl 28:734-41. 2007..Additional studies to identify factors involved in persistent spermatogenesis despite gonadotropin suppression are warranted... - Testosterone gel combined with depomedroxyprogesterone acetate is an effective male hormonal contraceptive regimen and is not enhanced by the addition of a GnRH antagonistStephanie T Page
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Clin Endocrinol Metab 91:4374-80. 2006.... - Persistent intraprostatic androgen concentrations after medical castration in healthy menStephanie T Page
University of Washington Medical Center, Division of Metabolism, Endocrinology and Nutrition, Box 357138, 1959 NE Pacific, Seattle, WA 98195
J Clin Endocrinol Metab 91:3850-6. 2006..Studies of men with prostate cancer have suggested that prostatic androgens are preserved in the setting of castration. Tissue androgens might stimulate prostate growth, producing adverse clinical consequences... - Testosterone administration suppresses adiponectin levels in menStephanie T Page
Department of Medicine, University of Washington Medical Center, Division of Endocrinology and Metabolism, 1959 NE Pacific, Box 357138, Seattle, WA 98195, USA
J Androl 26:85-92. 2005..Furthermore, supraphysiologic T administration results in decreased adiponectin levels. Our data support the hypothesis that T, its metabolites, or both directly suppress adipocyte production of adiponectin... - The androgen receptor gene CAG repeat polymorphism does not predict increased risk of heart disease: longitudinal results from the Massachusetts Male Ageing StudyStephanie T Page
Department of Medicine, University of Washington, Seattle, WA, USA
Clin Endocrinol (Oxf) 65:333-9. 2006..Longer, less androgenic CAG repeats have been associated with higher high-density lipoprotein (HDL) levels, which might protect against HD. Therefore, we hypothesized that CAG repeat length contributes to HD risk in men... - Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum TStephanie T Page
Wesley Woods Health Center, 1841 Clifton Road Northeast, Atlanta, Georgia 30329 5102, USA
J Clin Endocrinol Metab 90:1502-10. 2005.... - A new combination of testosterone and nestorone transdermal gels for male hormonal contraceptionNiloufar Ilani
Department of Medicine, Harbor University of California, Los Angeles, Medical Center and Los Angeles Biomedical Research Institute, 1000 West Carson Street, Torrance, California 90509, USA
J Clin Endocrinol Metab 97:3476-86. 2012..Combinations of testosterone (T) and nestorone (NES; a nonandrogenic progestin) transdermal gels may suppress spermatogenesis and prove appealing to men for contraception... - Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trialMara Y Roth
Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Fertil Steril 99:132-9. 2013..To study the potential role for using serum biomarkers, including insulin-like factor 3 (INSL3), 17α-hydroxyprogesterone, antimüllerian hormone, and inhibin B, as correlates of intratesticular T (IT-T) concentrations in men... - Acceptability of a combination testosterone gel and depomedroxyprogesterone acetate male contraceptive regimenJohn K Amory
Department of Medicine, University of Washington, Box 326429, Seattle, WA 98195, USA
Contraception 75:218-23. 2007.... - Pharmacokinetics of 2 novel formulations of modified-release oral testosterone alone and with finasteride in normal men with experimental hypogonadismChristin N Snyder
University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
J Androl 31:527-35. 2010..This formulation might have efficacy for the treatment of testosterone deficiency... - Impact of male hormonal contraception on prostate androgens and androgen action in healthy men: a randomized, controlled trialElahe A Mostaghel
Division of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Clin Endocrinol Metab 97:2809-17. 2012..Male hormonal contraception (MHC) combines hypothalamic-pituitary-gonadal axis blockade with exogenous androgen delivery to maintain extragonadal androgen end-organ effects. Concern exists that MHC may adversely impact prostate health... - Pharmacokinetics of modified slow-release oral testosterone over 9 days in normal men with experimental hypogonadismAda Lee
Center for Research in Reproduction and Contraception, Divisions of General Internal Medicine and Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington Medical School, Seattle, WA, USA
J Androl 33:420-6. 2012..This formulation of oral testosterone may have efficacy for the treatment of testosterone deficiency... - Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: a randomized clinical trialBradley D Anawalt
Department of Medicine, University of Washington School of Medicine, Seattle, WA 98108, USA
J Androl 26:405-13. 2005.... - Acute sex steroid withdrawal increases cholesterol efflux capacity and HDL-associated clusterin in menKatya B Rubinow
Center for Research in Reproduction and Contraception, Division of Metabolism, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98109, United States
Steroids 77:454-60. 2012..Further investigation of the effects of sex steroids on HDL composition and function may help resolve the apparently conflicting data regarding testosterone, HDL-C, and CVD risk... - Combined transdermal testosterone gel and the progestin nestorone suppresses serum gonadotropins in menVahid Mahabadi
Department of Medicine, Division of Endocrinology, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, California 90509, USA
J Clin Endocrinol Metab 94:2313-20. 2009..Nestorone (NES), a progestin without estrogenic or androgenic activity, when combined with T may be an excellent candidate for male contraception... - Elevated end-of-treatment serum INSL3 is associated with failure to completely suppress spermatogenesis in men receiving male hormonal contraceptionJohn K Amory
Department of Medicine, University of Washington, 1959 NE Pacific, Seattle, WA 98195, USA
J Androl 28:548-54. 2007..INSL3 may play a role in preventing complete suppression of spermatogenesis in some men on hormonal contraceptive regimens. This finding suggests that INSL3 may be a potential target for male contraceptive development... - The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young menJohn K Amory
Department of Medicine, University of Washington, Seattle, Washington, USA
J Urol 179:2333-8. 2008..Because androgens affect bone, lipids, hematopoiesis, prostate and sexual function, we determined the impact of 5alpha-reductase inhibitors on these end points... - Drug insight: Recent advances in male hormonal contraceptionJohn K Amory
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Nat Clin Pract Endocrinol Metab 2:32-41. 2006..One of these testosterone and progestogen combination regimens might soon bring the promise of male hormonal contraception to fruition... - Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancerElahe A Mostaghel
Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Cancer Res 67:5033-41. 2007..Optimal clinical efficacy will require testing of novel approaches targeting complete suppression of systemic and intracrine contributions to the prostatic androgen microenvironment... - Pharmacokinetics and pharmacodynamics of oral testosterone enanthate plus dutasteride for 4 weeks in normal men: implications for male hormonal contraceptionJohn K Amory
Center for Research in Reproduction and Contraception, University of Washington, Box 356429, 1959 NE Pacific St, Seattle, WA 98195, USA
J Androl 29:260-71. 2008..The administration of 800 mg oral TE daily combined with dutasteride for 28 days significantly suppresses gonadotropins without untoward side effects and might have utility as part of a male hormonal contraceptive regimen... - Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in gonadotropin-suppressed normal men receiving various dosages of human chorionic gonadotropinJohn K Amory
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Fertil Steril 89:380-6. 2008..To determine if serum concentrations of testosterone precursors would correlate with intratesticular testosterone (ITT) concentration measured directly by testicular aspiration and allow for a less invasive means of inferring ITT... - Effect of medical castration on CD4+ CD25+ T cells, CD8+ T cell IFN-gamma expression, and NK cells: a physiological role for testosterone and/or its metabolitesStephanie T Page
Department of Medicine, University of Washington, Seattle, WA, USA
Am J Physiol Endocrinol Metab 290:E856-63. 2006..In addition, sex steroids suppress NK cell proliferation. This study supports a complex physiological role for T and/or its metabolites in immune regulation... - Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacityKatya B Rubinow
Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
J Lipid Res 53:1376-83. 2012..These effects appear independent of testosterone conversion to dihydrotestosterone. Further research is needed to determine how changes in HDL protein content affect CVD risk in men... - Treatment of male infertility secondary to morbid obesityMara Y Roth
Division of Metabolism, Endocrinology and Nutrition, University of Washington School of Medicine, Seattle, WA 98195 6246, USA
Nat Clin Pract Endocrinol Metab 4:415-9. 2008..5 kg/m(2)). Before referral to the clinic, the patient had been treated with testosterone therapy for 4 months for hypogonadism. This treatment had caused his initially low sperm concentration to fall to undetectable levels... - Oral testosterone in oil: pharmacokinetic effects of 5alpha reduction by finasteride or dutasteride and food intake in menJohn K Amory
University of Washington, Box 356429, 1959 NE Pacific St, Seattle, WA 98195, USA
J Androl 27:72-8. 2006..Additional studies of the combination of oral T in oil with 5alpha-reductase inhibitors as a novel form of oral T therapy are warranted... - Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamicsJohn Kenneth Amory
Department of Medicine, Division of General Internal Medicine and Endocrinology, Center for Research in Reproduction and Contraception, University of Washington, Seattle, WA 98195, USA
Cancer Chemother Pharmacol 64:641-5. 2009..We hypothesized that GIPET enhancement would allow for the safe oral dosing of acyline for the treatment of prostate cancer... - Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variantShihua Sun
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
J Clin Invest 120:2715-30. 2010.... - Analysis of testosterone and dihydrotestosterone from biological fluids as the oxime derivatives using high-performance liquid chromatography/tandem mass spectrometryThomas F Kalhorn
Mass Spectrometry Center, Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195 7610, USA
Rapid Commun Mass Spectrom 21:3200-6. 2007..Given its high reproducibility, sensitivity, and relative simplicity, this assay should be of use in determining androgen levels in biospecimens, particularly in settings where sample quantity or steroid concentration are low... - Transdermal androgen therapy to augment EPO in the treatment of anemia of chronic renal diseaseAndrew T Brockenbrough
Division of Nephrology, Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington Medical School, Seattle, WA, USA
Am J Kidney Dis 47:251-62. 2006..Additionally, by increasing hemoglobin levels, testosterone replacement may allow for a dose reduction in recombinant human erythropoietin (rHuEPO), thereby reducing cost... - Oxidative DNA damage in the prostate may predispose men to a higher risk of prostate cancerJennifer D Wu
Department of Medicine, University of Washington, Seattle, WA, USA
Transl Oncol 2:39-45. 2009.... - Male pattern baldness and prostate cancer risk in a population-based case-control studyJonathan L Wright
Department of Urology, University of Washington School of Medicine, Seattle, WA, United States
Cancer Epidemiol 34:131-5. 2010..Studies exploring the relationship between the two conditions have been inconclusive. Using a population-based, case-control study of PCa, we explore the relationship between early-onset MPB and PCa risk... - Is there a relationship between sex hormones and erectile dysfunction? Results from the Massachusetts Male Aging StudyVarant Kupelian
New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA
J Urol 176:2584-8. 2006..Simultaneously, age related changes occur in male endocrine functioning. We examined the association between erectile dysfunction and total testosterone, bioavailable testosterone, sex hormone-binding globulin and luteinizing hormone... - Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese menVarant Kupelian
New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
J Clin Endocrinol Metab 91:843-50. 2006..The purpose of this analysis was to determine whether low serum sex hormone levels or clinical androgen deficiency (AD) predict the development of MetS... - Do statins affect androgen levels in men? Results from the Boston area community health surveySusan A Hall
New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA
Cancer Epidemiol Biomarkers Prev 16:1587-94. 2007.... - DHEA and testosterone in the elderlyStephanie T Page
N Engl J Med 356:635; author reply 637. 2007 - Sex steroids and all-cause and cause-specific mortality in menAndre B Araujo
New England Research Institutes, 9 Galen St, Watertown, MA 02472, USA
Arch Intern Med 167:1252-60. 2007..Sex steroid levels are related to metabolic outcomes that could convey higher risk of premature death... - 10th Summit Meeting consensus: recommendations for regulatory approval for hormonal male contraceptionPertti Aaltonen
Schering AG, Berlin, Germany
J Androl 28:362-3. 2007
Research Grants
- Hormonal and molecular consequences of androgen replacement on the prostateStephanie Page; Fiscal Year: 2007..Nelson, MD, Associate Professor of Medicine (Oncology), University of Washington School of Medicine will co-mentor this award. ..
- Dose-response relationships between circulating and intraprostatic androgens in mStephanie T Page; Fiscal Year: 2010..An improved understanding of the impact of testosterone on the prostate will help inform the risk:benefit ratio of testosterone therapies in older men. ..