Research Topics
Species | Richard L PageSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Clinical practice. Newly diagnosed atrial fibrillationRichard L Page
Cardiology Division, Department of Internal Medicine, University of Washington School of Medicine, Seattle 98195-6422, USA
N Engl J Med 351:2408-16. 2004
Azimilide for the treatment of atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardia: results of a randomized trial and insights on the concordance of symptoms and recurrent arrhythmiasRichard L Page
Division of Cardiology, University of Washington School of Medicine, Seattle, Washington 98195 6422, USA
J Cardiovasc Electrophysiol 19:172-7. 2008..This study was designed to confirm efficacy of 125 mg daily azimilide...
Seasonal variation of mortality in the Antiarrhythmics Versus Implantable Defibrillators (AVID) study registryRichard L Page
Department of Internal Medicine, Cardiology Division, University of Washington School of Medicine, Seattle, 98195, USA
Heart Rhythm 1:435-40. 2004..We postulated that the pattern of death would be nonrandom with respect to temporal variables...
Drug therapy for atrial fibrillation: where do we go from here?Richard L Page
Division of Cardiology, University of Washington School of Medicine, 1959 NE Pacific Street, Room AA502, Health Sciences Bldg, Box 356422, Seattle 98195 6422, USA
Nat Rev Drug Discov 4:899-910. 2005..In this review we describe present-day medical options and developments of future therapies to treat atrial fibrillation and maintain normal sinus rhythm...
Asymptomatic or "silent" atrial fibrillation: frequency in untreated patients and patients receiving azimilideRichard L Page
Cardiovascular Division, Clinical Cardiac Electrophysiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, USA
Circulation 107:1141-5. 2003....
Medical management of atrial fibrillation: future directionsRichard L Page
Department of Internal Medicine Cardiology Division, University of Washington School of Medicine, Seattle, Washington 98195 6422, USA
Heart Rhythm 4:S91-4. 2007..It is hoped that efforts to develop new drugs, including those with preferential effects on the atrium, will provide therapy with greater efficacy and safety...
Sympathoexcitation is attenuated during low level lower body negative pressure in subjects who develop pre-syncopeStephen L Wasmund
Department of Cardiology, University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Clin Auton Res 13:208-13. 2003..Our findings suggest that subjects with LBNP induced pre-syncope might have an impairment in the cardiopulmonary baroreflex gain function in the setting of a preserved arterial baroreflex gain...
Effect of atrial fibrillation and an irregular ventricular response on sympathetic nerve activity in human subjectsStephen L Wasmund
University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Dallas, TX 75390-9047, USA
Circulation 107:2011-5. 2003..Our findings suggest that restoring NSR or regularity might be beneficial, particularly in patients with heart failure...
Antiarrhythmic effects of azimilide in paroxysmal supraventricular tachycardia: efficacy and dose-responseRichard L Page
Department of Medicine, Cardiovascular Division, University of Texas Southwestern Medical Center, Parkland Memorial Hospital, Dallas, Tex 75390 9047, USA
Am Heart J 143:643-9. 2002..Its effect on paroxysmal supraventricular tachycardia (PSVT) has not been reported...
Poor baroreflex gain is a marker of heightened sympathetic activity post-tachycardia termination in humansRobert C Kowal
Division of Cardiology, Dept. of Internal Medicine, University of Texas, Southwestern Medical Center, Room C57.102, 5323 Harry Hines Blvd, Dallas, TX 75390-9047, USA
Clin Auton Res 13:443-6. 2003..04). Increased sympathetic activity following tachycardia termination could be arrhythmogenic and might play a role in the genesis of recurrent ventricular arrhythmias following tachycardia termination...
Serotonin reuptake inhibitor (Paxil) does not prevent the vasovagal reaction associated with carotid sinus massage and/or lower body negative pressure in healthy volunteersTheodore S Takata
University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Dallas, Tex 75390-9047, USA
Circulation 106:1500-4. 2002..CONCLUSIONS: Paxil decreases arterial BRS but does not prevent the presyncope associated with LBNP. The effect of Paxil on the autonomic reflexes in patients with neurally mediated syncope remains unclear...
Approach to the diagnosis and initial management of the stable adult patient with a wide complex tachycardiaZachary D Goldberger
Department of Internal Medicine, University of Washington Medical Center, VA Puget Sound Health Care System, Seattle, Washington, USA
Am J Cardiol 101:1456-66. 2008....
Wenckebach periodicity at rest that normalizes with tachycardia in a family with a NKX2.5 mutationWarren Guntheroth
Division of Cardiology, Department of Pediatrics, University of Washington, Seattle, Washington, USA
Am J Cardiol 110:1646-50. 2012..5. In addition, the physiology of WP is reviewed in these subjects and in highly conditioned athletes. In conclusion, the investigators report familial stable WP and ventricular noncompaction caused by a mutation in NKX2.5...
Atrioventricular junction ablation followed by resynchronization therapy in patients with congestive heart failure and atrial fibrillation (AVERT-AF) study designMohamed H Hamdan
Department of Internal Medicine, Division of Cardiology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132 2401, USA
Pacing Clin Electrophysiol 29:1081-8. 2006..Patients_enrollment will begin in summer 2006 and is expected to be completed in 2008. The results of this trial should help define the best treatment option for this common arrhythmia in patients with left ventricular dysfunction...
Asymptomatic atrial fibrillationRobert W Rho
Department of Medicine (Division of Cardiology, University of Washington School of Medicine, Seattle, WA, 98195-6422, USA
Prog Cardiovasc Dis 48:79-87. 2005..This manuscript provides an overview of the clinical entity of asymptomatic AF including the epidemiology, clinical significance, and the implications it has on the daily management of patients suffering from AF...
Public access defibrillationRobert W Rho
Department of Medicine, University of Washington, Seattle, WA 98195 6422, USA
Heart Fail Clin 7:269-76, ix. 2011..This article discusses the technologic features of the modern AED and the current data available on the use of AEDs in public settings...
Frequency and outcome of arrhythmias complicating admission during pregnancy: experience from a high-volume and ethnically-diverse obstetric serviceJian Ming Li
Division of Cardiology, Department of Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN 55417, USA
Clin Cardiol 31:538-41. 2008..Arrhythmias are reported during pregnancy, although hospitalization for these infrequent events is not fully characterized. The frequency and outcome of arrhythmias during pregnancy are unknown...
Pharmacological therapy of atrial fibrillationKristen K Patton
University of Washington Medical Center, Division of Cardiology, 1959 NE Pacific Street, Box 356422, Seattle, WA 98122, USA
Expert Opin Investig Drugs 16:169-79. 2007..This review concentrates on both the classical and novel pharmacological therapies aimed at maintaining sinus rhythm...
Biphasic versus monophasic shock waveform for conversion of atrial fibrillationRobert W Rho
The University of Washington School of Medicine, Seattle, WA 98195 6422, USA
Card Electrophysiol Rev 7:290-1. 2003..We recommend starting with biphasic energy of 100 J for atrial fibrillation of less than 48 hours duration, but using higher energies (150 J, 200 J or greater) when AF has been present for longer periods...
American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society scientific statement on noninvasive risk stratification techniques for identifying patients at risk for sudden cardiac death: a scientific statement from the AmericaJeffrey J Goldberger
American Heart Association, Public Information, Dallas, TX 75231-4596, USA
Circulation 118:1497-1518. 2008
Biphasic versus monophasic shock waveform for conversion of atrial fibrillation: the results of an international randomized, double-blind multicenter trialRichard L Page
Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
J Am Coll Cardiol 39:1956-63. 2002..This study compared a biphasic waveform with a conventional monophasic waveform for cardioversion of atrial fibrillation (AF)...
Effects of resynchronization therapy on sympathetic activity in patients with depressed ejection fraction and intraventricular conduction delay due to ischemic or idiopathic dilated cardiomyopathyMohamed H Hamdan
University of Texas Southwestern Medical Center, and Dallas Veterans Affairs Medical Center, Dallas, Texas 75216, USA
Am J Cardiol 89:1047-51. 2002..If the current findings are also present with chronic biventricular pacing, then this form of therapy may have a positive impact on mortality...
The automated external defibrillatorRobert W Rho
University of Washington School of Medicine, Seattle, Washington 98195 6422, USA
J Cardiovasc Electrophysiol 18:896-9. 2007..We encourage widespread implementation of PAD programs and enhanced public awareness about basic life support, with the expectation that such efforts will enhance survival of out of hospital cardiac arrest...
Pharmacological therapy for atrial fibrillation: current options and new agentsMohan N Viswanathan
University of Washington, Division of Cardiology Cardiac Electrophysiology, Seattle, WA 98195 6422, USA
Expert Opin Investig Drugs 18:417-31. 2009..This review focuses on the current and potential future pharmacological agents directed at rhythm control and maintenance of sinus rhythm...
Diabetes mellitus, glycemic control, and risk of atrial fibrillationSascha Dublin
Group Health Research Institute, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101 1448, USA
J Gen Intern Med 25:853-8. 2010..Diabetes may be an independent risk factor for atrial fibrillation. However, results from prior studies are in conflict, and no study has examined diabetes duration or glycemic control...
Rationale and design of ATHENA: A placebo-controlled, double-blind, parallel arm Trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular Hospitalization or death from any cause in patiENts with Atrial fibrillation/atriaStefan H Hohnloser
J W Goethe University, Department of Cardiology, Frankfurt, Germany
J Cardiovasc Electrophysiol 19:69-73. 2008..There is a continued need for new antiarrhythmic drugs to treat the ever-increasing number of patients with this arrhythmia. Dronedarone is a new antiarrhythmic compound currently being developed for treatment of AF...
ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European SocietDouglas P Zipes
Eur Heart J 27:2099-140. 2006
ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology ComDouglas P Zipes
J Am Coll Cardiol 48:e247-346. 2006
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology CommValentin Fuster
J Am Coll Cardiol 48:854-906. 2006
ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Valentin Fuster
Circulation 114:e257-354. 2006
The automated external defibrillator: critical link in the chain of survivalKarthik Ramaswamy
Division of Cardiovascular Medicine (Clinical Cardiac Electrophysiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
Annu Rev Med 54:235-43. 2003..Use of the AED by trained nontraditional first responders (e.g., firefighters, police officers, flight crews) has improved survival rates in a variety of settings and forms the basis for public-access defibrillation...
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology CommiValentin Fuster
American College of Cardiology, Bethesda, MD 20814, USA
Eur Heart J 27:1979-2030. 2006
Early recurrence of atrial fibrillation: does the shock waveform matter?Jose A Joglar
J Cardiovasc Electrophysiol 15:898-900. 2004
Efficacy and safety of sustained-release propafenone (propafenone SR) for patients with atrial fibrillationEdward L C Pritchett
Duke University Medical Center, Durham, North Carolina, USA
Am J Cardiol 92:941-6. 2003..Adverse effects leading to withdrawal were higher in the propafenone SR 425-mg twice daily group than in any other group. Thus, propafenone SR has important and statistically significant antiarrhythmic effects in patients with AF...
Symptoms at the time of arrhythmia recurrence in patients receiving azimilide for control of atrial fibrillation or flutter: results from randomized trialsStuart J Connolly
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am Heart J 146:489-93. 2003..There was another effect of azimilide: an average reduction of 0.38 symptoms (P <.01) that was independent of heart rate. CONCLUSION: Azimilide (125 mg/day) reduces the number of symptoms reported at the time of AF recurrence...
Antiarrhythmic drugs for all patients with an ICD?Richard L Page
JAMA 295:211-3. 2006
Antiarrhythmic efficacy of azimilide in patients with atrial fibrillation. Maintenance of sinus rhythm after conversion to sinus rhythmEdward L C Pritchett
Duke University Medical Center, Durham, NC, USA
Am Heart J 151:1043-9. 2006..In patients with atrial fibrillation, it has shown excellent efficacy in some previous trials and minimal efficacy in others...
Quality of life in the antiarrhythmics versus implantable defibrillators trial: impact of therapy and influence of adverse symptoms and defibrillator shocksEleanor B Schron
Clinical Trials Group, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
Circulation 105:589-94. 2002..Adverse symptoms were associated with reduced self-perceived QoL in both groups, and sporadic shocks were associated with reduced QoL in ICD recipients...
Effects of azimilide on heart rate and ECG conduction intervals during sinus rhythm in patients with a history of atrial fibrillationEdward L C Pritchett
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
J Clin Pharmacol 42:388-94. 2002..It was concluded that in patients with a history of atrial fibrillation or flutter, azimilide was associated with statistically significant increases in RR, QT, QTc(Bazett), and QTc(Fridericia) when patients were in sinus rhythm...
Efficacy of azimilide for the maintenance of sinus rhythm in patients with paroxysmal atrial fibrillation in the presence and absence of structural heart diseaseCharles R Kerr
St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Am J Cardiol 98:215-8. 2006..56, p=0.11), and overall group (hazard ratio 1.22, 95% confidence interval 1.00 to 1.49, p=0.053). No patient died. In conclusion, azimilide showed a nonsignificant trend toward efficacy in maintaining sinus rhythm in patients with AF...
ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 GuidelineAndrew E Epstein
Circulation 117:e350-408. 2008
ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 GuidelineAndrew E Epstein
J Am Coll Cardiol 51:e1-62. 2008
ACC/AHA/HRS 2008 Guidelines for device-based therapy of cardiac rhythm abnormalitiesAndrew E Epstein
Heart Rhythm 5:e1-62. 2008
ACC/AHA/HRS 2008 guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: executive summaryAndrew E Epstein
Heart Rhythm 5:934-55. 2008
American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death. A scientific statement from the AmericaJeffrey J Goldberger
J Am Coll Cardiol 52:1179-99. 2008
Automated external defibrillator use by police responders: where do we go from here?Jose A Joglar
Circulation 106:1030-3. 2002
Racial differences in outcome in the Multicenter UnSustained Tachycardia Trial (MUSTT): a comparison of whites versus blacksAndrea M Russo
University of Pennsylvania Health System, Presbyterian Medical Center, Philadelphia, PA 19104, USA
Circulation 108:67-72. 2003..Previous studies have shown racial differences in risk of sudden death in patients with ischemic heart disease...
2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice GuidelinesElliott M Antman
J Am Coll Cardiol 51:210-47. 2008
2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice guidelinesSpencer B King
J Am Coll Cardiol 51:172-209. 2008
ACC/AHA 2006 guideline update on perioperative cardiovascular evaluation for noncardiac surgery: focused update on perioperative beta-blocker therapy: a report of the American College of Cardiology/American Heart Association Task Force on Practice GuideliLee A Fleisher
Circulation 113:2662-74. 2006
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee foValentin Fuster
France
Europace 8:651-745. 2006
ACC/AHA 2006 guideline update on perioperative cardiovascular evaluation for noncardiac surgery: focused update on perioperative beta-blocker therapy: a report of the American College of Cardiology/American Heart Association Task Force on Practice GuideliLee A Fleisher
J Am Coll Cardiol 47:2343-55. 2006
New-onset paroxysmal atrial fibrillation: is permanence inevitable?Kristen K Patton
Am Heart J 149:388-90. 2005
Cardiac resynchronization therapy for patients with left ventricular systolic dysfunction: a systematic reviewFinlay A McAlister
The University of Alberta Evidence based Practice Center, Edmonton, Alberta, Canada
JAMA 297:2502-14. 2007..Atrial-synchronized biventricular pacemakers (cardiac resynchronization therapy [CRT]) received US Food and Drug Administration (FDA) approval for use in selected patients with LV systolic dysfunction in 2001...
[ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation--excutive summary]Valentin Fuster
Rev Port Cardiol 26:383-446. 2007
Short QT: when does it matter?Mohan N Viswanathan
Circulation 116:686-8. 2007
Relation of echocardiographic wall motion score index and response to dobutamine stress to defibrillation threshold at the time of implantation of a cardiac defibrillatorAli M Kizilbash
University of Texas Southwestern Medical Center, USA
Am J Cardiol 95:1099-101. 2005..A WMSI at rest of > or = 2.5 had a 71% positive predictive value and an 83% negative predictive value for a DFT > or = 15 J. An ischemic or biphasic response during DSE did not predict a greater DFT at implantation...
2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: developed in collaboratElliott M Antman
Circulation 117:296-329. 2008
Electrocardiographic predictors of arrhythmic death and total mortality in the multicenter unsustained tachycardia trialPeter J Zimetbaum
Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Boston, Mass 02215, USA
Circulation 110:766-9. 2004..We assessed the prognostic significance of ECG markers of conduction abnormalities and left ventricular hypertrophy in the Multicenter Unsustained Tachycardia Trial (MUSTT)...
2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: 2007 Writing Group to Review New Evidence anSpencer B King
Circulation 117:261-95. 2008
