Research Topics
| R L PageSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Antiarrhythmic effects of azimilide in paroxysmal supraventricular tachycardia: efficacy and dose-responseRichard L Page
Department of Medicine, Cardiovascular Division, University of Texas Southwestern Medical Center, Parkland Memorial Hospital, Dallas, Tex 75390 9047, USA
Am Heart J 143:643-9. 2002..Its effect on paroxysmal supraventricular tachycardia (PSVT) has not been reported...
Arrhythmias occurring during pregnancyRichard L Page
Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9047, USA
Card Electrophysiol Rev 6:136-9. 2002
Biphasic versus monophasic shock waveform for conversion of atrial fibrillation: the results of an international randomized, double-blind multicenter trialRichard L Page
Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
J Am Coll Cardiol 39:1956-63. 2002..This study compared a biphasic waveform with a conventional monophasic waveform for cardioversion of atrial fibrillation (AF)...
Use of automated external defibrillators by a U.S. airlineR L Page
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390 9047, USA
N Engl J Med 343:1210-6. 2000..Passengers who have ventricular fibrillation aboard commercial aircraft rarely survive, owing to the delay in obtaining emergency care and defibrillation...
Baroreflex gain predicts blood pressure recovery during simulated ventricular tachycardia in humansM H Hamdan
University of Texas, Southwestern Medical Center, Dallas, Texas, USA
Circulation 100:381-6. 1999..We hypothesize that the magnitude of sympathoexcitation and thus arterial baroreflex gain is an important determinant of the hemodynamic outcome of VT...
Biventricular pacing decreases sympathetic activity compared with right ventricular pacing in patients with depressed ejection fractionM H Hamdan
University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA
Circulation 102:1027-32. 2000..We hypothesized that BV pacing results in improved hemodynamics and a decrease in sympathetic nerve activity (SNA) compared with single-site pacing...
Selective parasympathetic denervation following posteroseptal ablation for either atrioventricular nodal reentrant tachycardia or accessory pathwaysM H Hamdan
University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Division of Cardiology, 75216, USA
Am J Cardiol 85:875-8, A9. 2000..Arterial baroreflex gain was significantly reduced after radiofrequency ablation (p = 0.046), whereas coronary sinus epinephrine and norepinephrine levels did not change significantly compared with preablation levels...
Effect of carvedilol on survival and hemodynamics in patients with atrial fibrillation and left ventricular dysfunction: retrospective analysis of the US Carvedilol Heart Failure Trials ProgramJ A Joglar
Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
Am Heart J 142:498-501. 2001..Thus it is necessary to establish therapy to improve the outcome in this high-risk population...
Antiarrhythmic effects of azimilide in atrial fibrillation: efficacy and dose-response. Azimilide Supraventricular Arrhythmia Program 3 (SVA-3) InvestigatorsE L Pritchett
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
J Am Coll Cardiol 36:794-802. 2000..The purpose of this study was to assess the effectiveness of azimilide, a class III antiarrhythmic drug, in reducing the frequency of symptomatic arrhythmia recurrences in patients with atrial fibrillation, atrial flutter or both...
Effects of azimilide on heart rate and ECG conduction intervals during sinus rhythm in patients with a history of atrial fibrillationEdward L C Pritchett
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
J Clin Pharmacol 42:388-94. 2002..It was concluded that in patients with a history of atrial fibrillation or flutter, azimilide was associated with statistically significant increases in RR, QT, QTc(Bazett), and QTc(Fridericia) when patients were in sinus rhythm...
Asymptomatic or "silent" atrial fibrillation: frequency in untreated patients and patients receiving azimilideRichard L Page
Cardiovascular Division, Clinical Cardiac Electrophysiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, USA
Circulation 107:1141-5. 2003....
Effect of P-wave timing during supraventricular tachycardia on the hemodynamic and sympathetic neural responseM H Hamdan
University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Dallas, TX 75216, USA
Circulation 103:96-101. 2001....
Automated external defibrillators: technical considerations and clinical promiseT S Takata
Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Room CS7.102, 5323 Harry Hines Boulevard, Dallas, TX 75390-9047, USA
Ann Intern Med 135:990-8. 2001..Since the experience continues to be positive, AEDs are being used in increasingly diverse community locations, and public awareness is growing. The American Heart Association's initiative is progressing rapidly...
Antiarrhythmic drugs in pregnancyJ A Joglar
The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
Curr Opin Cardiol 16:40-5. 2001..Conservative therapies should be used when appropriate. Several drug options exist for most maternal and fetal arrhythmias...
Azimilide for the treatment of atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardia: results of a randomized trial and insights on the concordance of symptoms and recurrent arrhythmiasRichard L Page
Division of Cardiology, University of Washington School of Medicine, Seattle, Washington 98195 6422, USA
J Cardiovasc Electrophysiol 19:172-7. 2008..This study was designed to confirm efficacy of 125 mg daily azimilide...
The hot can: ICD failure presenting as severe shoulder painJ A Joglar
Department of Internal Medicine Cardiology, Clinical Cardiac Electrophysiology, University of Texas Southwestern Medical Center, Rm CS7 102, 5323 Harry Hines Blvd, Dallas, TX 75390 9047, USA
Pacing Clin Electrophysiol 24:396-7. 2001..The duration of the painful episode was equal to the estimated ICD battery life under this low impedance condition...
Approach to the diagnosis and initial management of the stable adult patient with a wide complex tachycardiaZachary D Goldberger
Department of Internal Medicine, University of Washington Medical Center, VA Puget Sound Health Care System, Seattle, Washington, USA
Am J Cardiol 101:1456-66. 2008....
Drug therapy for atrial fibrillation: where do we go from here?Richard L Page
Division of Cardiology, University of Washington School of Medicine, 1959 NE Pacific Street, Room AA502, Health Sciences Bldg, Box 356422, Seattle 98195 6422, USA
Nat Rev Drug Discov 4:899-910. 2005..In this review we describe present-day medical options and developments of future therapies to treat atrial fibrillation and maintain normal sinus rhythm...
Clinical practice. Newly diagnosed atrial fibrillationRichard L Page
Cardiology Division, Department of Internal Medicine, University of Washington School of Medicine, Seattle 98195-6422, USA
N Engl J Med 351:2408-16. 2004
Atrioventricular junction ablation followed by resynchronization therapy in patients with congestive heart failure and atrial fibrillation (AVERT-AF) study designMohamed H Hamdan
Department of Internal Medicine, Division of Cardiology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132 2401, USA
Pacing Clin Electrophysiol 29:1081-8. 2006..Patients_enrollment will begin in summer 2006 and is expected to be completed in 2008. The results of this trial should help define the best treatment option for this common arrhythmia in patients with left ventricular dysfunction...
Pharmacological therapy of atrial fibrillationKristen K Patton
University of Washington Medical Center, Division of Cardiology, 1959 NE Pacific Street, Box 356422, Seattle, WA 98122, USA
Expert Opin Investig Drugs 16:169-79. 2007..This review concentrates on both the classical and novel pharmacological therapies aimed at maintaining sinus rhythm...
Frequency and outcome of arrhythmias complicating admission during pregnancy: experience from a high-volume and ethnically-diverse obstetric serviceJian Ming Li
Division of Cardiology, Department of Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN 55417, USA
Clin Cardiol 31:538-41. 2008..Arrhythmias are reported during pregnancy, although hospitalization for these infrequent events is not fully characterized. The frequency and outcome of arrhythmias during pregnancy are unknown...
Seasonal variation of mortality in the Antiarrhythmics Versus Implantable Defibrillators (AVID) study registryRichard L Page
Department of Internal Medicine, Cardiology Division, University of Washington School of Medicine, Seattle, 98195, USA
Heart Rhythm 1:435-40. 2004..We postulated that the pattern of death would be nonrandom with respect to temporal variables...
American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society scientific statement on noninvasive risk stratification techniques for identifying patients at risk for sudden cardiac death: a scientific statement from the AmericaJeffrey J Goldberger
American Heart Association, Public Information, Dallas, TX 75231-4596, USA
Circulation 118:1497-1518. 2008
Effects of resynchronization therapy on sympathetic activity in patients with depressed ejection fraction and intraventricular conduction delay due to ischemic or idiopathic dilated cardiomyopathyMohamed H Hamdan
University of Texas Southwestern Medical Center, and Dallas Veterans Affairs Medical Center, Dallas, Texas 75216, USA
Am J Cardiol 89:1047-51. 2002..If the current findings are also present with chronic biventricular pacing, then this form of therapy may have a positive impact on mortality...
Serotonin reuptake inhibitor (Paxil) does not prevent the vasovagal reaction associated with carotid sinus massage and/or lower body negative pressure in healthy volunteersTheodore S Takata
University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Dallas, Tex 75390-9047, USA
Circulation 106:1500-4. 2002..CONCLUSIONS: Paxil decreases arterial BRS but does not prevent the presyncope associated with LBNP. The effect of Paxil on the autonomic reflexes in patients with neurally mediated syncope remains unclear...
Effect of atrial fibrillation and an irregular ventricular response on sympathetic nerve activity in human subjectsStephen L Wasmund
University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Dallas, TX 75390-9047, USA
Circulation 107:2011-5. 2003..Our findings suggest that restoring NSR or regularity might be beneficial, particularly in patients with heart failure...
ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Valentin Fuster
Circulation 114:e257-354. 2006
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology CommValentin Fuster
J Am Coll Cardiol 48:854-906. 2006
Efficacy of azimilide for the maintenance of sinus rhythm in patients with paroxysmal atrial fibrillation in the presence and absence of structural heart diseaseCharles R Kerr
St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Am J Cardiol 98:215-8. 2006..56, p=0.11), and overall group (hazard ratio 1.22, 95% confidence interval 1.00 to 1.49, p=0.053). No patient died. In conclusion, azimilide showed a nonsignificant trend toward efficacy in maintaining sinus rhythm in patients with AF...
Antiarrhythmic efficacy of azimilide in patients with atrial fibrillation. Maintenance of sinus rhythm after conversion to sinus rhythmEdward L C Pritchett
Duke University Medical Center, Durham, NC, USA
Am Heart J 151:1043-9. 2006..In patients with atrial fibrillation, it has shown excellent efficacy in some previous trials and minimal efficacy in others...
Rationale and design of ATHENA: A placebo-controlled, double-blind, parallel arm Trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular Hospitalization or death from any cause in patiENts with Atrial fibrillation/atriaStefan H Hohnloser
J W Goethe University, Department of Cardiology, Frankfurt, Germany
J Cardiovasc Electrophysiol 19:69-73. 2008..There is a continued need for new antiarrhythmic drugs to treat the ever-increasing number of patients with this arrhythmia. Dronedarone is a new antiarrhythmic compound currently being developed for treatment of AF...
Symptoms at the time of arrhythmia recurrence in patients receiving azimilide for control of atrial fibrillation or flutter: results from randomized trialsStuart J Connolly
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Am Heart J 146:489-93. 2003..There was another effect of azimilide: an average reduction of 0.38 symptoms (P <.01) that was independent of heart rate. CONCLUSION: Azimilide (125 mg/day) reduces the number of symptoms reported at the time of AF recurrence...
Efficacy and safety of sustained-release propafenone (propafenone SR) for patients with atrial fibrillationEdward L C Pritchett
Duke University Medical Center, Durham, North Carolina, USA
Am J Cardiol 92:941-6. 2003..Adverse effects leading to withdrawal were higher in the propafenone SR 425-mg twice daily group than in any other group. Thus, propafenone SR has important and statistically significant antiarrhythmic effects in patients with AF...
Quality of life in the antiarrhythmics versus implantable defibrillators trial: impact of therapy and influence of adverse symptoms and defibrillator shocksEleanor B Schron
Clinical Trials Group, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
Circulation 105:589-94. 2002..Adverse symptoms were associated with reduced self-perceived QoL in both groups, and sporadic shocks were associated with reduced QoL in ICD recipients...
Medical management of atrial fibrillation: future directionsRichard L Page
Department of Internal Medicine Cardiology Division, University of Washington School of Medicine, Seattle, Washington 98195 6422, USA
Heart Rhythm 4:S91-4. 2007..It is hoped that efforts to develop new drugs, including those with preferential effects on the atrium, will provide therapy with greater efficacy and safety...
ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European SocietDouglas P Zipes
Eur Heart J 27:2099-140. 2006
2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: 2007 Writing Group to Review New Evidence anSpencer B King
Circulation 117:261-95. 2008
2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice GuidelinesElliott M Antman
J Am Coll Cardiol 51:210-47. 2008
Electrocardiographic predictors of arrhythmic death and total mortality in the multicenter unsustained tachycardia trialPeter J Zimetbaum
Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Boston, Mass 02215, USA
Circulation 110:766-9. 2004..We assessed the prognostic significance of ECG markers of conduction abnormalities and left ventricular hypertrophy in the Multicenter Unsustained Tachycardia Trial (MUSTT)...
ACC/AHA/HRS 2008 guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: executive summaryAndrew E Epstein
Heart Rhythm 5:934-55. 2008
American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death. A scientific statement from the AmericaJeffrey J Goldberger
J Am Coll Cardiol 52:1179-99. 2008
2008 focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee toRobert O Bonow
J Am Coll Cardiol 52:e1-142. 2008
Automated external defibrillator use by police responders: where do we go from here?Jose A Joglar
Circulation 106:1030-3. 2002
Short QT: when does it matter?Mohan N Viswanathan
Circulation 116:686-8. 2007
[ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation--excutive summary]Valentin Fuster
Rev Port Cardiol 26:383-446. 2007
Early recurrence of atrial fibrillation: does the shock waveform matter?Jose A Joglar
J Cardiovasc Electrophysiol 15:898-900. 2004
Biphasic versus monophasic shock waveform for conversion of atrial fibrillationRobert W Rho
The University of Washington School of Medicine, Seattle, WA 98195 6422, USA
Card Electrophysiol Rev 7:290-1. 2003..We recommend starting with biphasic energy of 100 J for atrial fibrillation of less than 48 hours duration, but using higher energies (150 J, 200 J or greater) when AF has been present for longer periods...
Asymptomatic atrial fibrillationRobert W Rho
Department of Medicine (Division of Cardiology, University of Washington School of Medicine, Seattle, WA, 98195-6422, USA
Prog Cardiovasc Dis 48:79-87. 2005..This manuscript provides an overview of the clinical entity of asymptomatic AF including the epidemiology, clinical significance, and the implications it has on the daily management of patients suffering from AF...
Antiarrhythmic drugs for all patients with an ICD?Richard L Page
JAMA 295:211-3. 2006
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation-executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology CommiValentin Fuster
American College of Cardiology, Bethesda, MD 20814, USA
Eur Heart J 27:1979-2030. 2006
New-onset paroxysmal atrial fibrillation: is permanence inevitable?Kristen K Patton
Am Heart J 149:388-90. 2005
ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology ComDouglas P Zipes
J Am Coll Cardiol 48:e247-346. 2006
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee foValentin Fuster
France
Europace 8:651-745. 2006
The automated external defibrillator: critical link in the chain of survivalKarthik Ramaswamy
Division of Cardiovascular Medicine (Clinical Cardiac Electrophysiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
Annu Rev Med 54:235-43. 2003..Use of the AED by trained nontraditional first responders (e.g., firefighters, police officers, flight crews) has improved survival rates in a variety of settings and forms the basis for public-access defibrillation...
2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice guidelinesSpencer B King
J Am Coll Cardiol 51:172-209. 2008
