Patrick J Pagano
Affiliation: University of Pittsburgh
de Jesus D, DeVallance E, Li Y, Falabella M, Guimaraes D, Shiva S, et al
. Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration. Redox Biol. 2019;22:101138 pubmed publisher
..These findings reveal a new signaling pathway by which Nox1 via induction of CREB and Gremlin1 signaling contributes to vascular remodeling and provide preclinical indication of its significance in PAH. ..
Li Y, Cifuentes Pagano E, DeVallance E, de Jesus D, Sahoo S, Meijles D, et al
. NADPH oxidase 2 inhibitors CPP11G and CPP11H attenuate endothelial cell inflammation & vessel dysfunction and restore mouse hind-limb flow. Redox Biol. 2019;22:101143 pubmed publisher
..These studies identify a proximal role for Nox2 in propagated inflammatory signaling and support therapeutic value of Nox2 inhibitors in inflammatory disease. ..
Cifuentes Pagano M, Meijles D, Pagano P. Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors. Curr Pharm Des. 2015;21:6023-35 pubmed
Sahoo S, Meijles D, Pagano P. NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?. Clin Sci (Lond). 2016;130:317-35 pubmed publisher
..In addition, we briefly describe emerging Nox therapies and their potential in improving the health of the elderly population. ..
RodrÃguez A, CsÃ¡nyi G, Ranayhossaini D, Feck D, Blose K, Assatourian L, et al
. MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2015;35:430-8 pubmed publisher
..The data also characterize a new Nox1 inhibitor as a potential therapy for treatment of vascular dysfunction in hypertension. ..
Al Ghouleh I, Rodriguez A, Pagano P, Csanyi G. Proteomic analysis identifies an NADPH oxidase 1 (Nox1)-mediated role for actin-related protein 2/3 complex subunit 2 (ARPC2) in promoting smooth muscle cell migration. Int J Mol Sci. 2013;14:20220-35 pubmed publisher
..Importantly, gene silencing of ARPC2 suppressed H2O2-stimulated VSMC migration. These results demonstrate for the first time that Nox1-mediated VSMC migration involves ARPC2 as a downstream signaling target. ..
Mukawera E, Chartier S, Williams V, Pagano P, Lapointe R, Grandvaux N. Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines. Redox Biol. 2015;6:9-18 pubmed publisher
..Taken together, our results suggest that redox-modulating compounds targeting NOX2 could present a particular therapeutic interest in combination therapy against breast carcinomas exhibiting IKKε amplification. ..
Meijles D, Pagano P. Nox and Inflammation in the Vascular Adventitia. Hypertension. 2016;67:14-9 pubmed publisher
Al Ghouleh I, Meijles D, Mutchler S, Zhang Q, Sahoo S, Gorelova A, et al
. Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype. Proc Natl Acad Sci U S A. 2016;113:E5308-17 pubmed publisher