Patrick J Pagano


Affiliation: University of Pittsburgh
Country: USA


  1. de Jesus D, DeVallance E, Li Y, Falabella M, Guimaraes D, Shiva S, et al. Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration. Redox Biol. 2019;22:101138 pubmed publisher
    ..These findings reveal a new signaling pathway by which Nox1 via induction of CREB and Gremlin1 signaling contributes to vascular remodeling and provide preclinical indication of its significance in PAH. ..
  2. Li Y, Cifuentes Pagano E, DeVallance E, de Jesus D, Sahoo S, Meijles D, et al. NADPH oxidase 2 inhibitors CPP11G and CPP11H attenuate endothelial cell inflammation & vessel dysfunction and restore mouse hind-limb flow. Redox Biol. 2019;22:101143 pubmed publisher
    ..These studies identify a proximal role for Nox2 in propagated inflammatory signaling and support therapeutic value of Nox2 inhibitors in inflammatory disease. ..
  3. Cifuentes Pagano M, Meijles D, Pagano P. Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors. Curr Pharm Des. 2015;21:6023-35 pubmed
  4. Sahoo S, Meijles D, Pagano P. NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?. Clin Sci (Lond). 2016;130:317-35 pubmed publisher
    ..In addition, we briefly describe emerging Nox therapies and their potential in improving the health of the elderly population. ..
  5. Rodríguez A, Csányi G, Ranayhossaini D, Feck D, Blose K, Assatourian L, et al. MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2015;35:430-8 pubmed publisher
    ..The data also characterize a new Nox1 inhibitor as a potential therapy for treatment of vascular dysfunction in hypertension. ..
  6. Al Ghouleh I, Rodriguez A, Pagano P, Csanyi G. Proteomic analysis identifies an NADPH oxidase 1 (Nox1)-mediated role for actin-related protein 2/3 complex subunit 2 (ARPC2) in promoting smooth muscle cell migration. Int J Mol Sci. 2013;14:20220-35 pubmed publisher
    ..Importantly, gene silencing of ARPC2 suppressed H2O2-stimulated VSMC migration. These results demonstrate for the first time that Nox1-mediated VSMC migration involves ARPC2 as a downstream signaling target. ..
  7. Mukawera E, Chartier S, Williams V, Pagano P, Lapointe R, Grandvaux N. Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines. Redox Biol. 2015;6:9-18 pubmed publisher
    ..Taken together, our results suggest that redox-modulating compounds targeting NOX2 could present a particular therapeutic interest in combination therapy against breast carcinomas exhibiting IKKε amplification. ..
  8. Meijles D, Pagano P. Nox and Inflammation in the Vascular Adventitia. Hypertension. 2016;67:14-9 pubmed publisher
  9. Al Ghouleh I, Meijles D, Mutchler S, Zhang Q, Sahoo S, Gorelova A, et al. Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype. Proc Natl Acad Sci U S A. 2016;113:E5308-17 pubmed publisher

More Information


  1. Li Y, Pagano P. Microvascular NADPH oxidase in health and disease. Free Radic Biol Med. 2017;109:33-47 pubmed publisher
  2. Ghouleh I, Sahoo S, Meijles D, Amaral J, de Jesus D, Sembrat J, et al. Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation. Clin Sci (Lond). 2017;131:2019-2035 pubmed publisher
    ..These findings also support targeting of Nox1 as a viable therapeutic option to combat PAH. ..
  3. Meijles D, Sahoo S, Al Ghouleh I, Amaral J, Bienes Martínez R, Knupp H, et al. The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1. Sci Signal. 2017;10: pubmed publisher
    ..Together, our results provide insights into the functional interplay between TSP1 and Nox1 in the regulation of endothelial senescence and suggest potential targets for controlling the aging process at the molecular level. ..