Patrick J Pagano
Affiliation: University of Pittsburgh
Cifuentes Pagano M, Meijles D, Pagano P. Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors. Curr Pharm Des. 2015;21:6023-35 pubmed
Sahoo S, Meijles D, Pagano P. NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?. Clin Sci (Lond). 2016;130:317-35 pubmed publisher
..In addition, we briefly describe emerging Nox therapies and their potential in improving the health of the elderly population. ..
RodrÃguez A, CsÃ¡nyi G, Ranayhossaini D, Feck D, Blose K, Assatourian L, et al
. MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2015;35:430-8 pubmed publisher
..The data also characterize a new Nox1 inhibitor as a potential therapy for treatment of vascular dysfunction in hypertension. ..
Al Ghouleh I, Rodriguez A, Pagano P, Csanyi G. Proteomic analysis identifies an NADPH oxidase 1 (Nox1)-mediated role for actin-related protein 2/3 complex subunit 2 (ARPC2) in promoting smooth muscle cell migration. Int J Mol Sci. 2013;14:20220-35 pubmed publisher
..Importantly, gene silencing of ARPC2 suppressed H2O2-stimulated VSMC migration. These results demonstrate for the first time that Nox1-mediated VSMC migration involves ARPC2 as a downstream signaling target. ..
Mukawera E, Chartier S, Williams V, Pagano P, Lapointe R, Grandvaux N. Redox-modulating agents target NOX2-dependent IKKÎµ oncogenic kinase expression and proliferation in human breast cancer cell lines. Redox Biol. 2015;6:9-18 pubmed publisher
..Taken together, our results suggest that redox-modulating compounds targeting NOX2 could present a particular therapeutic interest in combination therapy against breast carcinomas exhibiting IKKÎµ amplification. ..
Meijles D, Pagano P. Nox and Inflammation in the Vascular Adventitia. Hypertension. 2016;67:14-9 pubmed publisher
Al Ghouleh I, Meijles D, Mutchler S, Zhang Q, Sahoo S, Gorelova A, et al
. Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype. Proc Natl Acad Sci U S A. 2016;113:E5308-17 pubmed publisher
Li Y, Pagano P. Microvascular NADPH oxidase in health and disease. Free Radic Biol Med. 2017;109:33-47 pubmed publisher
Ghouleh I, Sahoo S, Meijles D, Amaral J, de Jesus D, Sembrat J, et al
. Endothelial Nox1 oxidase assembly in human pulmonary arterial hypertension; driver of Gremlin1-mediated proliferation. Clin Sci (Lond). 2017;131:2019-2035 pubmed publisher
..These findings also support targeting of Nox1 as a viable therapeutic option to combat PAH. ..