JOSEPH PAGANO

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Role of the ubiquitin system and tumor viruses in AIDS-related cancer
    Julia Shackelford
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    BMC Biochem 8:S8. 2007
  2. ncbi request reprint Infectious agents and cancer: criteria for a causal relation
    Joseph S Pagano
    Lineberger Comprehensive Cancer Center and Departments of Medicine and Microbiology, University of North Carolina at Chapel Hill, Campus Box 7295, Mason Farm Road, Chapel Hill, NC 27599 7295, USA
    Semin Cancer Biol 14:453-71. 2004
  3. pmc Epstein-Barr virus-encoded protein kinase (BGLF4) is involved in production of infectious virus
    Edward Gershburg
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB 7295, Chapel Hill, NC 27599 7295, USA
    J Virol 81:5407-12. 2007
  4. ncbi request reprint Ubiquitin editing enzyme UCH L1 and microtubule dynamics: implication in mitosis
    Anjali Bheda
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
    Cell Cycle 9:980-94. 2010
  5. pmc Interferon regulatory factor 7 is negatively regulated by the Epstein-Barr virus immediate-early gene, BZLF-1
    Angela M Hahn
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, 27599, USA
    J Virol 79:10040-52. 2005
  6. pmc Effects of maribavir and selected indolocarbazoles on Epstein-Barr virus protein kinase BGLF4 and on viral lytic replication
    Edward Gershburg
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Antimicrob Agents Chemother 48:1900-3. 2004
  7. pmc Hyperphosphorylation of EBNA2 by Epstein-Barr virus protein kinase suppresses transactivation of the LMP1 promoter
    Wei Yue
    Department of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, Campus Box 7295, Chapel Hill, NC 27599, USA
    J Virol 79:5880-5. 2005
  8. pmc Phosphorylation of the Epstein-Barr virus (EBV) DNA polymerase processivity factor EA-D by the EBV-encoded protein kinase and effects of the L-riboside benzimidazole 1263W94
    Edward Gershburg
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Virol 76:998-1003. 2002
  9. pmc Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit
    Shunbin Ning
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Virol 77:9359-68. 2003
  10. pmc The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity
    Christopher B Whitehurst
    Departments of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Virol 83:4345-53. 2009

Research Grants

Collaborators

Detail Information

Publications35

  1. pmc Role of the ubiquitin system and tumor viruses in AIDS-related cancer
    Julia Shackelford
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    BMC Biochem 8:S8. 2007
    ..Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com)...
  2. ncbi request reprint Infectious agents and cancer: criteria for a causal relation
    Joseph S Pagano
    Lineberger Comprehensive Cancer Center and Departments of Medicine and Microbiology, University of North Carolina at Chapel Hill, Campus Box 7295, Mason Farm Road, Chapel Hill, NC 27599 7295, USA
    Semin Cancer Biol 14:453-71. 2004
    ..In the meantime study of tumorigenic infectious agents will continue to illuminate molecular oncogenic processes...
  3. pmc Epstein-Barr virus-encoded protein kinase (BGLF4) is involved in production of infectious virus
    Edward Gershburg
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB 7295, Chapel Hill, NC 27599 7295, USA
    J Virol 81:5407-12. 2007
    ..Our results provide evidence that EBV PK plays an important role in nuclear egress of the virus and ultimately is crucial for lytic virus replication...
  4. ncbi request reprint Ubiquitin editing enzyme UCH L1 and microtubule dynamics: implication in mitosis
    Anjali Bheda
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
    Cell Cycle 9:980-94. 2010
    ....
  5. pmc Interferon regulatory factor 7 is negatively regulated by the Epstein-Barr virus immediate-early gene, BZLF-1
    Angela M Hahn
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, 27599, USA
    J Virol 79:10040-52. 2005
    ..Thus, EBV may subvert cellular antiviral responses and immune detection by blocking the activation of IFN-alpha4, IFN-beta, and Tap-2 by IRF-7 through the medium of BZLF-1 as a negative regulator...
  6. pmc Effects of maribavir and selected indolocarbazoles on Epstein-Barr virus protein kinase BGLF4 and on viral lytic replication
    Edward Gershburg
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Antimicrob Agents Chemother 48:1900-3. 2004
    ..However, maribavir and another indolocarbazole, NGIC-I, do inhibit EBV DNA synthesis, suggesting that although these last compounds inhibit both HCMV and EBV, they seem to operate through differ-ent pathways...
  7. pmc Hyperphosphorylation of EBNA2 by Epstein-Barr virus protein kinase suppresses transactivation of the LMP1 promoter
    Wei Yue
    Department of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, Campus Box 7295, Chapel Hill, NC 27599, USA
    J Virol 79:5880-5. 2005
    ..This is the first report about the effect of EBV PK on the function of one of its target proteins and regulation of EBNA2 phosphorylation during the EBV lytic cycle...
  8. pmc Phosphorylation of the Epstein-Barr virus (EBV) DNA polymerase processivity factor EA-D by the EBV-encoded protein kinase and effects of the L-riboside benzimidazole 1263W94
    Edward Gershburg
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Virol 76:998-1003. 2002
    ....
  9. pmc Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit
    Shunbin Ning
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Virol 77:9359-68. 2003
    ..Together with the previous data that LMP1 can induce IRF7 expression and facilitate IRF7 phosphorylation and nuclear translocation, these results suggest a positive regulatory circuit between IRF7 and LMP1...
  10. pmc The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity
    Christopher B Whitehurst
    Departments of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Virol 83:4345-53. 2009
    ..These results indicate that the EBV deubiquitinating enzyme interacts with, deubiquitinates, and influences the activity of the EBV RR. This is the first verified protein target of the EBV deubiquitinating enzyme...
  11. pmc Mitosis-specific hyperphosphorylation of Epstein-Barr virus nuclear antigen 2 suppresses its function
    Wei Yue
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Virol 78:3542-52. 2004
    ..1. Finally, endogenous LMP-1 mRNA levels in M phase are around 55% of those in asynchronously growing cells. These results suggest that regulation of gene expression during type III latency may be regulated in a cell-cycle-related manner...
  12. pmc Maribavir inhibits epstein-barr virus transcription in addition to viral DNA replication
    Fu Zhang Wang
    Departments of Microbiology and Immunology and Medicine, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    J Virol 83:12108-17. 2009
    ..The results emphasize the different modes of action of the two drugs and suggest that the action of MBV may be linked to indirect effects on the transcription of EBV genes through the interaction of BGLF4 with multiple viral proteins...
  13. ncbi request reprint Epstein-Barr virus infections: prospects for treatment
    Edward Gershburg
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Antimicrob Chemother 56:277-81. 2005
    ..A number of experimental approaches for treatment of EBV-related malignancies that are not susceptible to conventional antiviral drug treatment are also discussed...
  14. pmc cdc2/cyclin B1-dependent phosphorylation of EBNA2 at Ser243 regulates its function in mitosis
    Wei Yue
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    J Virol 80:2045-50. 2006
    ..Our data implicate EBNA2 Ser243 as a cdc2/cyclin B1 site of phosphorylation important for EBNA2's cotranscriptional function in mitosis...
  15. ncbi request reprint EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells
    Satoru Kondo
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cancer Res 66:9870-7. 2006
    ..Thus, Siah1 is implicated in the regulation of HIF1alpha and is involved in a recently appreciated aspect of EBV-mediated tumorigenesis, namely, the angiogenesis process triggered by LMP1...
  16. ncbi request reprint Epstein-Barr virus induces invasion and metastasis factors
    Naohiro Wakisaka
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    Anticancer Res 23:2133-8. 2003
    ..Alteration of cellular phenotype independent of transforming effects may be a property of other tumor viruses...
  17. ncbi request reprint Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma
    Toshiyuki Horikawa
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Res 67:1970-8. 2007
    ..These results suggest that induction of Twist by a human viral oncoprotein LMP1 directly contributes to the metastatic nature of NPC...
  18. ncbi request reprint Targeting of host-cell ubiquitin pathways by viruses
    Julia Shackelford
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Essays Biochem 41:139-56. 2005
    ....
  19. pmc Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9
    Gretchen L Bentz
    Department of Medicine and Microbiology, The University of North Carolina, Chapel Hill, NC, USA
    J Virol 85:10144-53. 2011
    ..We propose that LMP1, by interaction with Ubc9, modulates sumoylation processes, which regulate signal transduction pathways that affect phenotypic changes associated with oncogenesis...
  20. pmc Epstein-Barr virus BRLF1 inhibits transcription of IRF3 and IRF7 and suppresses induction of interferon-beta
    Gretchen L Bentz
    Lineberger Comprehensive Cancer Center, The University of North Carolina, Chapel Hill, NC, USA
    Virology 402:121-8. 2010
    ..These data suggest a new role for BRLF1 with the ability to evade host innate immune responses...
  21. ncbi request reprint Viruses and lymphomas
    Joseph S Pagano
    University of North Carolina, Chapel Hill, NC 27599 7295, USA
    N Engl J Med 347:78-9. 2002
  22. pmc Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes
    Anjali Bheda
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    PLoS ONE 4:e6764. 2009
    ....
  23. pmc Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling
    Anjali Bheda
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 4:e5955. 2009
    ....
  24. pmc Epstein-Barr virus activates beta-catenin in type III latently infected B lymphocyte lines: association with deubiquitinating enzymes
    Julia Shackelford
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    Proc Natl Acad Sci U S A 100:15572-6. 2003
    ..Activation of the beta-catenin/T cell factor pathway by EBV may contribute to the lymphoproliferation characteristic of type III latency...
  25. pmc Conserved herpesvirus protein kinases
    Edward Gershburg
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biochim Biophys Acta 1784:203-12. 2008
    ..Determination of CHPK structures will greatly facilitate this task...
  26. pmc Interferon regulatory factor 5 represses expression of the Epstein-Barr virus oncoprotein LMP1: braking of the IRF7/LMP1 regulatory circuit
    Shunbin Ning
    Lineberger Comprehensive Cancer Center, University of North Carolina, School of Medicine, Campus Box 7295, Chapel Hill, NC 27599, USA
    J Virol 79:11671-6. 2005
    ..These results indicate that IRF5 can downregulate IRF7's induction of expression of LMP1 most likely by interacting with IRF7 and provide a means of modulating a regulatory circuit between IRF7 and LMP1...
  27. ncbi request reprint Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma
    Satoru Kondo
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int J Cancer 115:368-76. 2005
    ..These results suggest that LMP1-induced MMP1 and MMP3 are closely linked and show that LMP1 activates MMP1 via an Ets binding site formed by 2G, which is a candidate marker for both risk and prognosis of NPC...
  28. pmc MUC1 induced by Epstein-Barr virus latent membrane protein 1 causes dissociation of the cell-matrix interaction and cellular invasiveness via STAT signaling
    Satoru Kondo
    Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    J Virol 81:1554-62. 2007
    ....
  29. pmc Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha
    Naohiro Wakisaka
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    Mol Cell Biol 24:5223-34. 2004
    ..The ability of EBV, and specifically its major oncoprotein, LMP1, to induce HIF-1 alpha along with other invasiveness and angiogenic factors reported previously discloses additional oncogenic properties of this tumor virus...
  30. ncbi request reprint New associations of human papillomavirus, Simian virus 40, and Epstein-Barr virus with human cancer
    May Wong
    Biological Carcinogenesis Branch, National Cancer Institute, Bethesda, MD 20892, USA
    J Natl Cancer Inst 94:1832-6. 2002
  31. ncbi request reprint Is Epstein-Barr virus transmitted sexually?
    Joseph S Pagano
    J Infect Dis 195:469-70. 2007
  32. pmc Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties
    Luwen Zhang
    NE Center for Virology, School of Biological Sciences, University of Nebraska, 1901 Vine St, Lincoln, NE 68588, USA
    J Virol 78:12987-95. 2004
    ..IRF-7-expressing NIH 3T3 cells formed tumors in athymic mice. Thus, IRF-7 has oncogenic properties and, along with LMP-1, may mediate or potentiate the EBV transformation process in the pathogenesis of EBV-associated lymphomas...
  33. ncbi request reprint Structure and function of IRF-7
    Luwen Zhang
    Nebraska Center for Virology, UNL Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    J Interferon Cytokine Res 22:95-101. 2002
    ..Other than its functions in EBV latency, IRF-7 has been identified as one of the major players in virally induced IFN production that is central to innate immunity. Thus, IRF-7 plays important roles in a variety of biologic systems...
  34. ncbi request reprint Multiple signal transducers and activators of transcription are induced by EBV LMP-1
    Luwen Zhang
    Nebraska Center for Virology, School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    Virology 323:141-52. 2004
    ....
  35. ncbi request reprint Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway
    Jin Kyu Jung
    Division of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, Korea
    Cancer Res 67:5771-8. 2007
    ..Considering that the pRb-E2F1 pathway is commonly activated in human tumors, activation of this circuit might be widespread and a potential therapeutic target...

Research Grants16

  1. BASIC MECHANISMS OF VIRAL AND CHEMICAL CARCINOGENESIS
    JOSEPH PAGANO; Fiscal Year: 2006
    ..abstract_text> ..
  2. EBV VECTORS FOR TARGETED GENE THERAPY OF B-LYMPHOMAS
    JOSEPH PAGANO; Fiscal Year: 2003
    ..Pre-established human B-lymphoma in vivo by intravenous (i.v.) injection with this system will be also evaluated in order to eliminate the disseminated B-lymphoma from various organs of the animal. ..
  3. Interferon Regulatory Factor 7 EBV Latency & Oncogenesis
    JOSEPH PAGANO; Fiscal Year: 2003
    ..Knowledge about the biological roles of IRF-7 has expanded rapidly since its discovery. Findings from this proposal will help to explain IRF-7's role in viral latency, oncogenesis and immune responses. ..
  4. INTERFERON REGULATORY FACTORS CELL CYCLE AND EBV LATENCY
    JOSEPH PAGANO; Fiscal Year: 2002
    ....
  5. New EBV Therapies for treating malignancies
    JOSEPH PAGANO; Fiscal Year: 2009
    ..abstract_text> ..