Pablo M Paez

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx
    Pablo M Paez
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles Medical School, Los Angeles, California 90095, USA
    J Neurosci 29:6663-76. 2009
  2. pmc Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene
    Pablo M Paez
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, California 90095 7332, USA
    J Neurosci 31:3625-37. 2011
  3. doi request reprint Golli myelin basic proteins stimulate oligodendrocyte progenitor cell proliferation and differentiation in remyelinating adult mouse brain
    Pablo M Paez
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7332, USA
    Glia 60:1078-93. 2012
  4. doi request reprint Regulation of L-type Ca++ currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteins
    Daniel Fulton
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, 90095, USA
    Glia 58:1292-303. 2010
  5. pmc Multiple kinase pathways regulate voltage-dependent Ca2+ influx and migration in oligodendrocyte precursor cells
    Pablo M Paez
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurosci 30:6422-33. 2010
  6. ncbi request reprint Increased expression of golli myelin basic proteins enhances calcium influx into oligodendroglial cells
    Pablo M Paez
    Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles Geffen Medical School, Los Angeles, California 90095, USA
    J Neurosci 27:12690-9. 2007
  7. pmc STAT3-mediated astrogliosis protects myelin development in neonatal brain injury
    Hiroko Nobuta
    Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, CA, USA
    Ann Neurol 72:750-65. 2012
  8. pmc The multiple roles of myelin protein genes during the development of the oligodendrocyte
    Daniel Fulton
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA
    ASN Neuro 2:e00027. 2010
  9. pmc Impact of simulated microgravity on oligodendrocyte development: implications for central nervous system repair
    Araceli Espinosa-Jeffrey
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Intellectual and Developmental Disabilities Research Center, Los Angeles, California, United States of America
    PLoS ONE 8:e76963. 2013

Collaborators

  • Ji Ming Feng
  • David H Rowitch
  • Daniel Fulton
  • Anthony T Campagnoni
  • Araceli Espinosa-Jeffrey
  • Jean de Vellis
  • Vilma Spreuer
  • Hiroko Nobuta
  • VerĂ³nica T Cheli
  • Ina Wanner
  • Eric J Huang
  • Rose A Korsak
  • James A Waschek
  • Armine Manukyan
  • Michael V Sofroniew
  • Hongmei Dong
  • Jiaxi Li
  • Cristina A Ghiani
  • Harry V Vinters
  • Christopher S Colwell
  • Vance Handley
  • Robin Fisher

Detail Information

Publications10

  1. pmc Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx
    Pablo M Paez
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles Medical School, Los Angeles, California 90095, USA
    J Neurosci 29:6663-76. 2009
    ..These data define a new molecule that regulates Ca(2+) homeostasis in OPCs, and are the first to demonstrate that voltage-gated Ca(2+) channels can regulate an OPC function, such as migration...
  2. pmc Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene
    Pablo M Paez
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, California 90095 7332, USA
    J Neurosci 31:3625-37. 2011
    ..More important, we have shown that extracellular Ca(2+) uptake through TRPC1 is an essential component in the mechanism of OPC proliferation...
  3. doi request reprint Golli myelin basic proteins stimulate oligodendrocyte progenitor cell proliferation and differentiation in remyelinating adult mouse brain
    Pablo M Paez
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7332, USA
    Glia 60:1078-93. 2012
    ....
  4. doi request reprint Regulation of L-type Ca++ currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteins
    Daniel Fulton
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, 90095, USA
    Glia 58:1292-303. 2010
    ..These data on L-type Ca(2+) channels and process development provide in situ evidence for the influence of golli on VOCCs, and offer an explanation for the hypomyelination observed in the brains of golli-KO mice...
  5. pmc Multiple kinase pathways regulate voltage-dependent Ca2+ influx and migration in oligodendrocyte precursor cells
    Pablo M Paez
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurosci 30:6422-33. 2010
    ..These kinases modulate voltage-operated Ca(2+) uptake in OPCs and participate in the modulation of process extension and migration...
  6. ncbi request reprint Increased expression of golli myelin basic proteins enhances calcium influx into oligodendroglial cells
    Pablo M Paez
    Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles Geffen Medical School, Los Angeles, California 90095, USA
    J Neurosci 27:12690-9. 2007
    ..Our observations are consistent with the hypothesis that golli proteins, as a part of a protein complex, modulate Ca2+ influx at the plasma membrane and along OL processes...
  7. pmc STAT3-mediated astrogliosis protects myelin development in neonatal brain injury
    Hiroko Nobuta
    Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, CA, USA
    Ann Neurol 72:750-65. 2012
    ..Despite the heterogeneous nature of this condition, reactive astrogliosis and microgliosis are frequently observed. Thus, molecular mechanisms by which glia activation contribute to WMI were investigated...
  8. pmc The multiple roles of myelin protein genes during the development of the oligodendrocyte
    Daniel Fulton
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA
    ASN Neuro 2:e00027. 2010
    ..In the present review, the newly emerging functions of these myelin proteins will be described, and these will then be discussed in the context of their contribution to oligodendroglial development...
  9. pmc Impact of simulated microgravity on oligodendrocyte development: implications for central nervous system repair
    Araceli Espinosa-Jeffrey
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Intellectual and Developmental Disabilities Research Center, Los Angeles, California, United States of America
    PLoS ONE 8:e76963. 2013
    ..To our knowledge, this is the first report on the gravitational modulation of oligodendrocyte intrinsic plasticity to increase their progenies. ..