Vasantha Padmanabhan

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Neuroendocrine control of follicle-stimulating hormone (FSH) secretion. I. Direct evidence for separate episodic and basal components of FSH secretion
    V Padmanabhan
    Reproductive Sciences Program, University of Michigan, Ann Arbor 48109 0404, USA
    Endocrinology 138:424-32. 1997
  2. pmc Animal models of the polycystic ovary syndrome phenotype
    Vasantha Padmanabhan
    Department of Pediatrics, Obstetrics and Gynecology, Molecular and Integrative Physiology, and Environmental Health Sciences, The University of Michigan, 300 North Ingalls, Room 1138, Ann Arbor, MI, United States
    Steroids 78:734-40. 2013
  3. pmc Sheep models of polycystic ovary syndrome phenotype
    Vasantha Padmanabhan
    Departments of Pediatrics, Obstetrics and Gynecology, Molecular and Integrative Physiology, The University of Michigan, 300 North Ingalls, Room 1138, Ann Arbor, MI, United States
    Mol Cell Endocrinol 373:8-20. 2013
  4. doi request reprint Developmental programming: impact of prenatal testosterone excess on insulin sensitivity, adiposity, and free fatty acid profile in postpubertal female sheep
    A Veiga-Lopez
    Department of Pediatrics and Reproductive Sciences Program, University of Michigan, 300 North Ingalls Building, Room 1137, Ann Arbor, Michigan 48109 0404, USA
    Endocrinology 154:1731-42. 2013
  5. pmc Delivery type not associated with global methylation at birth
    Shama Virani
    Department of Pediatrics, The University of Michigan, Ann Arbor, MI, USA
    Clin Epigenetics 4:8. 2012
  6. pmc Contributions of androgen and estrogen to fetal programming of ovarian dysfunction
    David H Abbott
    National Primate Research Center, Department of Ob Gyn, Endocrinology Reproductive Physiology Training Program, University of Wisconsin, Madison, WI 53715, USA
    Reprod Biol Endocrinol 4:17. 2006
  7. ncbi request reprint Neuroendocrine vs. paracrine control of follicle-stimulating hormone
    V Padmanabhan
    Department of Pediatrics and the Reproductive Sciences Program, University of Michigan, Ann Arbor, MI 48109 0404, USA
    Arch Med Res 32:533-43. 2001
  8. ncbi request reprint Prenatal testosterone excess programs reproductive and metabolic dysfunction in the female
    Vasantha Padmanabhan
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 0404, USA
    Mol Cell Endocrinol 246:165-74. 2006
  9. pmc Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females
    V Padmanabhan
    Department of Pediatrics and Reproductive Sciences Program, University of Michigan, 300 North Ingalls Building, Ann Arbor, Michigan 48109 0404, USA
    Endocrinology 151:595-605. 2010
  10. doi request reprint Developmental reprogramming of reproductive and metabolic dysfunction in sheep: native steroids vs. environmental steroid receptor modulators
    V Padmanabhan
    Department of Pediatrics and the Reproductive Sciences Program, The University of Michigan, Ann Arbor, MI48109, USA
    Int J Androl 33:394-404. 2010

Research Grants

  1. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
  2. Bisphenol-A and Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2011
  3. Bisphenol-A and Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2010
  4. Reproductive Consequences of Prenatal Androgenization
    Vasantha Padmanabhan; Fiscal Year: 2005
  5. NEUROENDOCRINE CONTROL OF FSH
    Vasantha Padmanabhan; Fiscal Year: 2001

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Neuroendocrine control of follicle-stimulating hormone (FSH) secretion. I. Direct evidence for separate episodic and basal components of FSH secretion
    V Padmanabhan
    Reproductive Sciences Program, University of Michigan, Ann Arbor 48109 0404, USA
    Endocrinology 138:424-32. 1997
    ....
  2. pmc Animal models of the polycystic ovary syndrome phenotype
    Vasantha Padmanabhan
    Department of Pediatrics, Obstetrics and Gynecology, Molecular and Integrative Physiology, and Environmental Health Sciences, The University of Michigan, 300 North Ingalls, Room 1138, Ann Arbor, MI, United States
    Steroids 78:734-40. 2013
    ..The current review summarizes the phenotypes of current animal models exposed to excess steroid during the prenatal and early postnatal period and how they compare with the phenotype seen in women with PCOS. ..
  3. pmc Sheep models of polycystic ovary syndrome phenotype
    Vasantha Padmanabhan
    Departments of Pediatrics, Obstetrics and Gynecology, Molecular and Integrative Physiology, The University of Michigan, 300 North Ingalls, Room 1138, Ann Arbor, MI, United States
    Mol Cell Endocrinol 373:8-20. 2013
    ....
  4. doi request reprint Developmental programming: impact of prenatal testosterone excess on insulin sensitivity, adiposity, and free fatty acid profile in postpubertal female sheep
    A Veiga-Lopez
    Department of Pediatrics and Reproductive Sciences Program, University of Michigan, 300 North Ingalls Building, Room 1137, Ann Arbor, Michigan 48109 0404, USA
    Endocrinology 154:1731-42. 2013
    ....
  5. pmc Delivery type not associated with global methylation at birth
    Shama Virani
    Department of Pediatrics, The University of Michigan, Ann Arbor, MI, USA
    Clin Epigenetics 4:8. 2012
    ..abstract:..
  6. pmc Contributions of androgen and estrogen to fetal programming of ovarian dysfunction
    David H Abbott
    National Primate Research Center, Department of Ob Gyn, Endocrinology Reproductive Physiology Training Program, University of Wisconsin, Madison, WI 53715, USA
    Reprod Biol Endocrinol 4:17. 2006
    ..Understanding the quality of the fetal female sex steroid hormone environment is thus becoming increasingly important in improving our knowledge of mechanisms underlying a variety of female reproductive pathologies...
  7. ncbi request reprint Neuroendocrine vs. paracrine control of follicle-stimulating hormone
    V Padmanabhan
    Department of Pediatrics and the Reproductive Sciences Program, University of Michigan, Ann Arbor, MI 48109 0404, USA
    Arch Med Res 32:533-43. 2001
    ..This review focuses on the recent advances made in the neuroendocrine and paracrine regulation of FSH synthesis/secretion/heterogeneity and pinpoints areas of gaps in our knowledge...
  8. ncbi request reprint Prenatal testosterone excess programs reproductive and metabolic dysfunction in the female
    Vasantha Padmanabhan
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 0404, USA
    Mol Cell Endocrinol 246:165-74. 2006
    ....
  9. pmc Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females
    V Padmanabhan
    Department of Pediatrics and Reproductive Sciences Program, University of Michigan, 300 North Ingalls Building, Ann Arbor, Michigan 48109 0404, USA
    Endocrinology 151:595-605. 2010
    ..The findings are of relevance in the context of developmental programming of insulin resistance by prenatal steroids and excess weight gain...
  10. doi request reprint Developmental reprogramming of reproductive and metabolic dysfunction in sheep: native steroids vs. environmental steroid receptor modulators
    V Padmanabhan
    Department of Pediatrics and the Reproductive Sciences Program, The University of Michigan, Ann Arbor, MI48109, USA
    Int J Androl 33:394-404. 2010
    ..These findings provide evidence in support of developmental origin of adult reproductive and metabolic diseases and highlight the risk posed by exposure to environmental endocrine disrupting chemicals...
  11. doi request reprint Maternal bisphenol-A levels at delivery: a looming problem?
    V Padmanabhan
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109 0404, USA
    J Perinatol 28:258-63. 2008
    ..The objective was to determine whether bisphenol-A (BPA) is found in maternal circulation of pregnant women in the US population and is related to gestational length and birth weight...
  12. pmc Prenatal exposure to excess testosterone modifies the developmental trajectory of the insulin-like growth factor system in female sheep
    Erica J Crespi
    Reproductive Sciences Program, 300 N Ingalls Bldg, Rm 1109 SW, Ann Arbor, MI 48109 0404, USA
    J Physiol 572:119-30. 2006
    ....
  13. ncbi request reprint Hypothalamic, pituitary and gonadal regulation of FSH
    V Padmanabhan
    Department of Pediatrics, and the Reproductive Sciences Program, University of Michigan, Ann Arbor, MI 48109, USA
    Reprod Suppl 59:67-82. 2002
    ....
  14. ncbi request reprint Is there an FSH-releasing factor?
    V Padmanabhan
    Department of Pediatrics and the Reproductive Sciences Program, University of Michigan, Ann Arbor, MI 48109, USA
    Reproduction 121:21-30. 2001
    ....
  15. ncbi request reprint Neuroendocrine control of follicle-stimulating hormone (FSH) secretion: III. Is there a gonadotropin-releasing hormone-independent component of episodic FSH secretion in ovariectomized and luteal phase ewes?
    Vasantha Padmanabhan
    Department of Pediatrics, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Endocrinology 144:1380-92. 2003
    ..These studies provide the first direct evidence of the existence of an acute GnRH I-independent component of episodic FSH secretion...
  16. ncbi request reprint Neuroendocrine control of follicle-stimulating hormone (FSH) secretion: II. Is follistatin-induced suppression of FSH secretion mediated via changes in activin availability and does it involve changes in gonadotropin-releasing hormone secretion?
    Vasantha Padmanabhan
    Department of Pediatrics, Reproductive Sciences Program, University of Michigan, Ann Arbor, MI 48109 0404, USA
    Biol Reprod 66:1395-402. 2002
    ..The slower clearance of total follistatin and the lack of follistatin effects on GnRH secretion suggest that changes in activin bioavailability dictate the level of pituitary FSH secretion and that this is a pituitary-specific effect...
  17. pmc Developmental programming: gestational testosterone treatment alters fetal ovarian gene expression
    Lacey J Luense
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Endocrinology 152:4974-83. 2011
    ....
  18. pmc Developmental origin of reproductive and metabolic dysfunctions: androgenic versus estrogenic reprogramming
    Vasantha Padmanabhan
    Department of Pediatrics, The University of Michigan, Ann Arbor, Michigan, USA
    Semin Reprod Med 29:173-86. 2011
    ....
  19. ncbi request reprint Developmental programming: impact of prenatal testosterone excess on pre- and postnatal gonadotropin regulation in sheep
    Mohan Manikkam
    Department of Pediatrics, the Reproductive Sciences Program, and the Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, Michigan 48109 0404, USA
    Biol Reprod 78:648-60. 2008
    ....
  20. ncbi request reprint Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep
    Mohan Manikkam
    Department of Pediatrics, University of Michigan, 300 North Ingalls Building, Room 1109 SW, Ann Arbor, MI 48109 0404, USA
    Endocrinology 145:790-8. 2004
    ..These findings support the concept that fetal growth retardation and postnatal catch-up growth, early markers of future adult diseases, can also be programmed by prenatal exposure to excess sex steroids...
  21. pmc Neuroendocrine control of FSH secretion: IV. Hypothalamic control of pituitary FSH-regulatory proteins and their relationship to changes in FSH synthesis and secretion
    Tejinder P Sharma
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 0404, USA
    Biol Reprod 86:171. 2012
    ..Perhaps the effects of GnRH pulse frequency on FSH is due to changes in the balance of free versus bound amounts of these FSH regulatory proteins or to the involvement of other regulators not monitored in this study...
  22. pmc Developmental programming: exogenous gonadotropin treatment rescues ovulatory function but does not completely normalize ovarian function in sheep treated prenatally with testosterone
    Teresa L Steckler
    Departments of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 0404, USA
    Biol Reprod 79:686-95. 2008
    ....
  23. pmc Developmental programming: impact of prenatal exposure to bisphenol-A and methoxychlor on steroid feedbacks in sheep
    Bachir Abi Salloum
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Toxicol Appl Pharmacol 268:300-8. 2013
    ..These findings suggest that the postpubertal reproductive defects seen in these animals may have stemmed from ovarian defects and the steroidal signals emanating from them...
  24. pmc Developmental programming: excess weight gain amplifies the effects of prenatal testosterone excess on reproductive cyclicity--implication for polycystic ovary syndrome
    Teresa L Steckler
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 0404, USA
    Endocrinology 150:1456-65. 2009
    ..These findings agree with the increased prevalence of anovulation observed in obese women with polycystic ovary syndrome and indicate that excess postnatal weight gain amplifies reproductive disruptions caused by prenatal T excess...
  25. ncbi request reprint Fetal programming: prenatal testosterone treatment leads to follicular persistence/luteal defects; partial restoration of ovarian function by cyclic progesterone treatment
    Mohan Manikkam
    Department of Pediatrics, University of Michigan, Ann Arbor, 48109 0404, USA
    Endocrinology 147:1997-2007. 2006
    ..Cyclic P treatment was able to only partially restore follicular dynamics, but this may be related to the low replacement concentrations of P achieved...
  26. pmc Developmental programming: postnatal steroids complete prenatal steroid actions to differentially organize the GnRH surge mechanism and reproductive behavior in female sheep
    Leslie M Jackson
    Reproductive Sciences Program, University of Michigan, Ann Arbor, Michigan, USA
    Endocrinology 154:1612-23. 2013
    ..These findings support the hypothesis that the feedback controls of the GnRH surge are sensitive to programming by prenatal and postnatal steroids in a precocial species...
  27. pmc Developmental programming: contribution of prenatal androgen and estrogen to estradiol feedback systems and periovulatory hormonal dynamics in sheep
    Almudena Veiga-Lopez
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 0404, USA
    Biol Reprod 80:718-25. 2009
    ..The findings may be of translational relevance since daughters of mothers with hyperandrogenism are at risk of increased exposure to androgens...
  28. ncbi request reprint Developmental programming: differential effects of prenatal exposure to bisphenol-A or methoxychlor on reproductive function
    Mozhgan Savabieasfahani
    Department of Pediatrics, 300 North Ingalls Building, Room 1109 SW, Ann Arbor, University of Michigan 48109 0404, USA
    Endocrinology 147:5956-66. 2006
    ..05) in BPA sheep. These findings suggest that prenatal BPA and MXC exposure have long-term differential effects on a variety of reproductive endocrine parameters that could impact fertility...
  29. pmc Developmental programming: prenatal testosterone excess disrupts anti-Müllerian hormone expression in preantral and antral follicles
    Almudena Veiga-Lopez
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 5404, USA
    Fertil Steril 97:748-56. 2012
    ..To investigate the impact of prenatal T excess on the expression of key ovarian regulators implicated in follicular recruitment and persistence using a large animal model of polycystic ovarian syndrome (PCOS)...
  30. ncbi request reprint Fetal programming: testosterone exposure of the female sheep during midgestation disrupts the dynamics of its adult gonadotropin secretion during the periovulatory period
    Mozhgan Savabieasfahani
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biol Reprod 72:221-9. 2005
    ....
  31. pmc Developmental programming: insulin sensitizer treatment improves reproductive function in prenatal testosterone-treated female sheep
    Almudena Veiga-Lopez
    Department of Pediatrics and Reproductive Sciences Program, University of Michigan, Ann Arbor, Michigan 48109 0404, USA
    Endocrinology 151:4007-17. 2010
    ..These findings provide evidence that insulin sensitizer treatment prevents further deterioration of the reproductive axis in prenatal T-treated sheep, a finding of translational relevance to women with polycystic ovary syndrome...
  32. ncbi request reprint Developmental programming: follicular persistence in prenatal testosterone-treated sheep is not programmed by androgenic actions of testosterone
    Teresa Steckler
    Department of Pediatrics, University of Michigan, 300 North Ingalls Building, Room 1109, Ann Arbor, Michigan 48109 0404, USA
    Endocrinology 148:3532-40. 2007
    ....
  33. ncbi request reprint Fetal programming: prenatal androgen disrupts positive feedback actions of estradiol but does not affect timing of puberty in female sheep
    Tejinder Pal Sharma
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Biol Reprod 66:924-33. 2002
    ..The present findings indicate that disruption of the surge system can account for the fertility problems that occur during adulthood in prenatally androgenized sheep...
  34. pmc Developmental programming: prenatal and postnatal contribution of androgens and insulin in the reprogramming of estradiol positive feedback disruptions in prenatal testosterone-treated sheep
    Bachir Abi Salloum
    Department of Pediatrics and Reproductive Sciences Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Endocrinology 153:2813-22. 2012
    ....
  35. ncbi request reprint Diurnal changes in FSH-regulatory peptides and their relationship to gonadotrophins in pubertal girls
    Carol M Foster
    Department of Pediatrics Endocrinology and Reproductive Sciences Program, University of Michigan, Ann Arbor, MI 48109 0718, USA
    Hum Reprod 20:543-8. 2005
    ..We hypothesized that day/night variations in FSH serum concentrations would be associated with diurnal variation in FSH-regulatory peptides...
  36. ncbi request reprint GnRH agonist stimulation of the pituitary-gonadal axis in children: age and sex differences in circulating inhibin-B and activin-A
    Daniel D Elsholz
    Department of Pediatrics, Division of Endocrinology, University of Michigan, Ann Arbor, MI 48109 0646, USA
    Hum Reprod 19:2748-58. 2004
    ..Inhibin-B decreases and activin increases FSH secretion in adults. We investigated whether an FSH-inhibin/activin feedback loop exists before or during puberty...
  37. pmc Developmental programming: gestational bisphenol-A treatment alters trajectory of fetal ovarian gene expression
    Almudena Veiga-Lopez
    Department of Pediatrics and Reproductive Sciences Program, University of Michigan, 300 North Ingalls Building, Room 1138, Ann Arbor, Michigan 48109 5404, USA
    Endocrinology 154:1873-84. 2013
    ....
  38. ncbi request reprint Long-term exposure of female sheep to physiologic concentrations of estradiol: effects on the onset and maintenance of reproductive function, pregnancy, and social development in female offspring
    Karl D Malcolm
    Reproductive Sciences Program, University of Michigan, Ann Arbor, Michigan 48109 0404, USA
    Biol Reprod 75:844-52. 2006
    ..Despite these disruptive steroid actions, ovarian cyclicity and fertility are not invariably compromised, pointing to an impressive resiliency of the reproductive axis to insult by exogenous estrogenic compounds...
  39. pmc Developmental programming: impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep
    Almudena Veiga-Lopez
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 5404, USA
    Biol Reprod 84:87-96. 2011
    ....
  40. ncbi request reprint Fetal programming: excess prenatal testosterone reduces postnatal luteinizing hormone, but not follicle-stimulating hormone responsiveness, to estradiol negative feedback in the female
    Hirendra N Sarma
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Endocrinology 146:4281-91. 2005
    ..Collectively, these findings support the hypothesis that prenatal exposure to excess T decreases postnatal responsiveness to E2 inhibitory feedback of LH/GnRH secretion to contribute to the development of hypergonadotropism...
  41. doi request reprint Prenatal testosterone and dihydrotestosterone exposure disrupts ovine testicular development
    Charles L Bormann
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Reproduction 142:167-73. 2011
    ....
  42. ncbi request reprint Sex differences in FSH-regulatory peptides in pubertal age boys and girls and effects of sex steroid treatment
    Carol M Foster
    Department of Pediatrics Endocrinology and the Reproductive Sciences Program, University of Michigan, Ann Arbor, MI 48109, USA
    Hum Reprod 19:1668-76. 2004
    ..FSH concentrations are higher in girls than in boys before puberty. We hypothesized that steroid-mediated changes in FSH-regulatory proteins underlie the sex differences in FSH secretion and pubertal timing...
  43. pmc Juvenile rank can predict male-typical adult mating behavior in female sheep treated prenatally with testosterone
    Eila K Roberts
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
    Biol Reprod 80:737-42. 2009
    ..We conclude that the effect of prenatal testosterone exposure on adult male-specific but not female-specific mating behavior is modulated by juvenile social experiences...
  44. doi request reprint Prenatal testosterone treatment alters LH and testosterone responsiveness to GnRH agonist in male sheep
    Sergio E Recabarren
    Reproductive Sciences Program, Departments of Obstetrics and Gynecology, Pediatrics and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    Biol Res 40:329-38. 2007
    ..05). Our findings suggest that prenatal T treatment advances the developmental trajectory of gonadal responsiveness to GnRH in male offspring...
  45. ncbi request reprint Programming of GnRH feedback controls timing puberty and adult reproductive activity
    Douglas L Foster
    Reproductive Sciences Program, Departments of Obstetrics and Gynecology, Pediatrics, and Physiology, University of Michigan, Ann Arbor, MI 48109 0404, United States
    Mol Cell Endocrinol 254:109-19. 2006
    ....
  46. pmc Antimüllerian hormone levels are independently related to ovarian hyperandrogenism and polycystic ovaries
    Robert L Rosenfield
    Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA
    Fertil Steril 98:242-9. 2012
    ..To determine the relationship of antimüllerian hormone (AMH) levels to polycystic ovaries and ovarian androgenic function...
  47. pmc Differential effects of aging on activin A and its binding protein, follistatin, across the menopause transition
    Nancy E Reame
    School of Nursing, University of Michigan, Ann Arbor, Michigan, USA
    Fertil Steril 88:1003-5. 2007
    ....
  48. ncbi request reprint Acidic mix of FSH isoforms are better facilitators of ovarian follicular maturation and E2 production than the less acidic
    Christine R West
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Endocrinology 143:107-16. 2002
    ..The C-FSH ewes had more estrogenic follicles than the GnRH and N-FSH groups (P < 0.05). Our findings show that C-FSH clears more slowly than N-FSH, and C-FSH is a better facilitator of follicular development and maturation than N-FSH...
  49. ncbi request reprint Fetal programming: prenatal testosterone treatment causes intrauterine growth retardation, reduces ovarian reserve and increases ovarian follicular recruitment
    Teresa Steckler
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 0404, USA
    Endocrinology 146:3185-93. 2005
    ..The extent to which metabolic changes associated with intrauterine growth retardation contribute toward altered trajectory of ovarian folliculogenesis remains to be determined...
  50. doi request reprint Differential effects of prenatal testosterone timing and duration on phenotypic and behavioral masculinization and defeminization of female sheep
    Eila K Roberts
    Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 1043, USA
    Biol Reprod 79:43-50. 2008
    ....
  51. pmc Insight into the neuroendocrine site and cellular mechanism by which cortisol suppresses pituitary responsiveness to gonadotropin-releasing hormone
    Kellie M Breen
    Reproductive Sciences Program, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    Endocrinology 149:767-73. 2008
    ..Collectively, these observations provide evidence that cortisol acts via the type II GR within the pituitary gland to elicit a rapid decrease in responsiveness to GnRH, independent of changes in expression of the GnRH receptor...
  52. pmc Developmental programming: differential effects of prenatal testosterone excess on insulin target tissues
    Shadia E Nada
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 5404, USA
    Endocrinology 151:5165-73. 2010
    ..These changes are consistent with the hypothesis that prenatal T excess disrupts the insulin sensitivity of peripheral tissues, with liver and muscle being insulin resistant and adipose tissue insulin sensitive...
  53. pmc Insulin resistance influences central opioid activity in polycystic ovary syndrome
    Alison Berent-Spillson
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA
    Fertil Steril 95:2494-8. 2011
    ....
  54. pmc Bisphenol A and chronic disease risk factors in US children
    Donna S Eng
    Division of Pediatric Endocrinology, University of Michigan, Ann Arbor, MI, USA
    Pediatrics 132:e637-45. 2013
    ..To evaluate the relationship between urinary bisphenol A (BPA) levels and measures of adiposity and chronic disease risk factors for a nationally representative US pediatric sample...
  55. ncbi request reprint The role of endogenous growth hormone-releasing hormone in acromegaly
    Eleni V Dimaraki
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Endocrinol Metab 91:2185-90. 2006
    ..Some indirect evidence suggests hypothalamic control of GH secretion in acromegaly...
  56. ncbi request reprint Developmental programming: deficits in reproductive hormone dynamics and ovulatory outcomes in prenatal, testosterone-treated sheep
    A Veiga-Lopez
    Department of Pediatrics, and the Reproductive Sciences Program, University of Michigan, Ann Arbor, Michigan 48109 0404, USA
    Biol Reprod 78:636-47. 2008
    ....
  57. ncbi request reprint Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone
    Sergio E Recabarren
    Laboratory of Animal Physiology and Endocrinology, Faculty of Veterinary Medicine, Univ of Concepción, Chillan, Chile
    Am J Physiol Endocrinol Metab 289:E801-6. 2005
    ..Our findings suggest that prenatal T treatment leads to offspring with reduced birth weight and impaired insulin sensitivity in early postnatal life...
  58. pmc Developmental origin of health and disease
    Peter W Nathanielsz
    J Physiol 572:3-4. 2006
  59. ncbi request reprint Prenatal programming of reproductive neuroendocrine function: fetal androgen exposure produces progressive disruption of reproductive cycles in sheep
    Rachel A Birch
    Laboratory of Neuroendocrinology, Department of Neurobiology, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Endocrinology 144:1426-34. 2003
    ..Our findings reveal that exposure to androgens in utero causes a progressive loss of cyclic function in adulthood...
  60. ncbi request reprint Prepubertal administration of estradiol valerate disrupts cyclicity and leads to cystic ovarian morphology during adult life in the rat: role of sympathetic innervation
    Alzira Rosa-E-Silva
    Department of Physiology, Universidad de Sao Paulo, Brazil
    Endocrinology 144:4289-97. 2003
    ..These findings provide evidence that EV exposure during juvenile life leads to long-lasting deleterious reproductive consequences via activation of the sympathetic ovarian nerve...
  61. pmc Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeys
    David H Abbott
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    Biol Reprod 79:154-63. 2008
    ..Thus, in this nonhuman primate model, differential programming of the fetal hypothalamo-pituitary unit with concomitant hyperandrogenism provides evidence to suggest developmental origins of LH and androgen excess in adulthood...
  62. ncbi request reprint In utero programming of sexually differentiated gonadotrophin releasing hormone (GnRH) secretion
    Jane E Robinson
    Laboratory of Neuroendocrinology, The Babraham Institute, Cambridge CB2 4AT, UK
    Domest Anim Endocrinol 23:43-52. 2002
    ..The consequences of in utero androgen exposure are reflected in a progressive and dramatic impairment of fertility in the ovary-intact ewe...
  63. ncbi request reprint Prenatal exposure of the ovine fetus to androgens sexually differentiates the steroid feedback mechanisms that control gonadotropin releasing hormone secretion and disrupts ovarian cycles
    Jane E Robinson
    Laboratory of Neuroendocrinology, Babraham Institute, Babraham, Cambridge, United Kingdom
    Arch Sex Behav 31:35-41. 2002
    ..These data indicate that a relatively short exposure to male hormones during in utero life permanently alters the neural mechanisms that control reproduction and leads progressively to a state of infertility...
  64. ncbi request reprint Assessment of ovarian reserve by using the follicle-stimulating hormone isoform distribution pattern to predict the outcome of in vitro fertilization
    Gerard S Letterie
    Northwest Center for Reproductive Sciences, Seattle, Washington 98119, USA
    Fertil Steril 86:1547-9. 2006
    ..Changes in FSH isoforms occur at temporally specific times during the menstrual cycle and reproductive lifespan. Changes in ratio in FSH isoforms may provide a sensitive test of ovarian reserve before IVF...
  65. ncbi request reprint Participation of vasoactive intestinal polypeptide in ovarian steroids production during the rat estrous cycle and in the development of estradiol valerate-induced polycystic ovary
    Claudio Parra
    Lab Neurobioquímica, Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago, Chile
    Reproduction 133:147-54. 2007
    ..These results strongly suggest that intraovarian VIP participates in the control of estradiol secretion during the rat estrous cycle and possibly in the maintenance of increased ovarian estradiol secretory activity of EV-treated rats...
  66. ncbi request reprint Hypertension caused by prenatal testosterone excess in female sheep
    Andrew J King
    Deparetment of Pharmacology and Toxicology, B440 Life Sciences, Michigan State University, East Lansing, MI 48824, USA
    Am J Physiol Endocrinol Metab 292:E1837-41. 2007
    ..This first-ever use of radiotelemetric blood pressure recordings in sheep demonstrates that mild hypertension, a risk factor reported in some women with PCOS, is also a feature of the sheep model of PCOS produced by prenatal T treatment...
  67. ncbi request reprint Environment and origin of disease
    Vasantha Padmanabhan
    Rev Endocr Metab Disord 8:67-9. 2007
  68. pmc Polycystic ovary syndrome and its developmental origins
    Daniel A Dumesic
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Rev Endocr Metab Disord 8:127-41. 2007
    ....

Research Grants19

  1. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
    ....
  2. Bisphenol-A and Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2011
    ..The findings will be of relevance to the threat estrogenic environmental disruptors pose at current exposure levels to reproductive health. ..
  3. Bisphenol-A and Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2010
    ..The findings will be of relevance to the threat estrogenic environmental disruptors pose at current exposure levels to reproductive health. ..
  4. Reproductive Consequences of Prenatal Androgenization
    Vasantha Padmanabhan; Fiscal Year: 2005
    ..Specifically it will establish that discrete, experimentally induced androgen excess of fetal sheep provides the first clear etiology for hyperandrogenic anovulation in adulthood. ..
  5. NEUROENDOCRINE CONTROL OF FSH
    Vasantha Padmanabhan; Fiscal Year: 2001
    ....