Jaume Padilla

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk
    Jaume Padilla
    Kinesiology, Indiana University, Bloomington, Ind, USA
    J Vasc Res 46:592-600. 2009
  2. pmc Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns
    Jaume Padilla
    Dept of Biomedical Sciences Univ of Missouri, Columbia, 65211, USA
    Am J Physiol Heart Circ Physiol 298:H1128-35. 2010
  3. pmc Blood pressure regulation VIII: resistance vessel tone and implications for a pro-atherogenic conduit artery endothelial cell phenotype
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Eur J Appl Physiol 114:531-44. 2014
  4. ncbi Induction of endoplasmic reticulum stress impairs insulin-stimulated vasomotor relaxation in rat aortic rings: role of endothelin-1
    J Padilla
    Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
    J Physiol Pharmacol 64:557-64. 2013
  5. pmc Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Physiol Genomics 45:434-46. 2013
  6. pmc Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Am J Physiol Regul Integr Comp Physiol 304:R543-52. 2013
  7. pmc Differential changes in vascular mRNA levels between rat iliac and renal arteries produced by cessation of voluntary running
    Jaume Padilla
    Department of Biomedical Sciences, E102 Veterinary Medicine, 1600 East Rollins Road, University of Missouri, Columbia, MO 65211, USA
    Exp Physiol 98:337-47. 2013
  8. pmc Brachial artery vasodilatation during prolonged lower limb exercise: role of shear rate
    Jaume Padilla
    Department of Biomedical Sciences, E102 Veterinary Medicine, 1600 East Rollins Road, University of Missouri, Columbia, MO 65211, USA
    Exp Physiol 96:1019-27. 2011
  9. pmc Impact of exercise training on endothelial transcriptional profiles in healthy swine: a genome-wide microarray analysis
    Jaume Padilla
    Dept of Biomedical Sciences, E102 Veterinary Medicine, 1600 E Rollins Rd, Univ of Missouri, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 301:H555-64. 2011
  10. pmc Impact of aging on conduit artery retrograde and oscillatory shear at rest and during exercise: role of nitric oxide
    Jaume Padilla
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Hypertension 57:484-9. 2011

Collaborators

Detail Information

Publications41

  1. ncbi Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk
    Jaume Padilla
    Kinesiology, Indiana University, Bloomington, Ind, USA
    J Vasc Res 46:592-600. 2009
    ....
  2. pmc Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns
    Jaume Padilla
    Dept of Biomedical Sciences Univ of Missouri, Columbia, 65211, USA
    Am J Physiol Heart Circ Physiol 298:H1128-35. 2010
    ..Future studies should examine the complex interaction between MSNA, arterial blood pressure, and other potential modulatory factors of shear rate patterns...
  3. pmc Blood pressure regulation VIII: resistance vessel tone and implications for a pro-atherogenic conduit artery endothelial cell phenotype
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Eur J Appl Physiol 114:531-44. 2014
    ..Indeed, a vast amount of evidence supports the notion that excessive blood pressure and oscillatory shear stress are potent pro-atherogenic signals to the endothelium. ..
  4. ncbi Induction of endoplasmic reticulum stress impairs insulin-stimulated vasomotor relaxation in rat aortic rings: role of endothelin-1
    J Padilla
    Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
    J Physiol Pharmacol 64:557-64. 2013
    ..Together, these findings support the hypothesis that vascular ER stress-mediated activation of ET-1 may be an underlying cause of impaired vasomotor responsiveness to insulin and endothelial dysfunction. ..
  5. pmc Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Physiol Genomics 45:434-46. 2013
    ..In particular, our results suggest that the oxidized LDL/LOX-1/NF-κB signaling axis may be involved in the early initiation of a juvenile obesity-induced proatherogenic coronary artery phenotype...
  6. pmc Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Am J Physiol Regul Integr Comp Physiol 304:R543-52. 2013
    ..Phenotypic differences in PVAT between regions of the aorta may be relevant in light of the evidence in large animals and humans that the abdominal aorta is more vulnerable to atherosclerosis than the thoracic aorta...
  7. pmc Differential changes in vascular mRNA levels between rat iliac and renal arteries produced by cessation of voluntary running
    Jaume Padilla
    Department of Biomedical Sciences, E102 Veterinary Medicine, 1600 East Rollins Road, University of Missouri, Columbia, MO 65211, USA
    Exp Physiol 98:337-47. 2013
    ..This heterogeneous influence of short-term physical inactivity could be attributed to the distinct alteration in haemodynamic forces between arteries...
  8. pmc Brachial artery vasodilatation during prolonged lower limb exercise: role of shear rate
    Jaume Padilla
    Department of Biomedical Sciences, E102 Veterinary Medicine, 1600 East Rollins Road, University of Missouri, Columbia, MO 65211, USA
    Exp Physiol 96:1019-27. 2011
    ..These results are consistent with the hypothesis that shear stress plays a key role in signalling brachial artery vasodilatation during dynamic leg exercise...
  9. pmc Impact of exercise training on endothelial transcriptional profiles in healthy swine: a genome-wide microarray analysis
    Jaume Padilla
    Dept of Biomedical Sciences, E102 Veterinary Medicine, 1600 E Rollins Rd, Univ of Missouri, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 301:H555-64. 2011
    ....
  10. pmc Impact of aging on conduit artery retrograde and oscillatory shear at rest and during exercise: role of nitric oxide
    Jaume Padilla
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Hypertension 57:484-9. 2011
    ....
  11. pmc Long-term exercise training does not alter brachial and femoral artery vasomotor function and endothelial phenotype in healthy pigs
    Jaume Padilla
    Dept of Biomedical Sciences, W102 Veterinary Medicine, 1600 E Rollins Rd, Univ of Missouri, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 299:H379-85. 2010
    ....
  12. pmc Normalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus
    Jaume Padilla
    Kinesiology, Indiana University, Bloomington, IN, USA
    Cardiovasc Ultrasound 6:44. 2008
    ..The present study was designed to further examine the efficacy of FMD normalization to shear stress in reducing measurement variability...
  13. pmc Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats
    Jacqueline M Crissey
    Biomedical Sciences, University of Missouri, Columbia, Missouri
    Am J Physiol Regul Integr Comp Physiol 306:R596-606. 2014
    ..Collectively, we show in OLETF rats that lower adiposity leads to less AT and aortic inflammation, as well as an exercise-specific improvement in insulin-stimulated vasorelaxation...
  14. pmc Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats
    Michael D Roberts
    Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA
    Metabolism 62:1052-6. 2013
    ..We hypothesized that FNDC5 expression would be greater in obese (OLETF) versus lean (LETO) animals...
  15. doi Peripheral circulation
    M Harold Laughlin
    Department of Medical Pharmacology and Physiology, and the Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA
    Compr Physiol 2:321-447. 2012
    ....
  16. ncbi The flow-mediated dilation response to acute exercise in overweight active and inactive men
    Ryan A Harris
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, School of Health, Physical Education and Recreation, Indiana University, Bloomington, IN, USA
    Obesity (Silver Spring) 16:578-84. 2008
    ..The aim of this study was to investigate the interaction of IL-6 and TNF-alpha on endothelial function in response to acute exercise in overweight men exhibiting different physical activity profiles...
  17. ncbi The effect of acute exercise on endothelial function following a high-fat meal
    Jaume Padilla
    Department of Kinesiology, Clinical Exercise Physiology Laboratory, Indiana University, Bloomington, IN 47405, USA
    Eur J Appl Physiol 98:256-62. 2006
    ....
  18. pmc Increased brachial artery retrograde shear rate at exercise onset is abolished during prolonged cycling: role of thermoregulatory vasodilation
    Grant H Simmons
    E102 Veterinary Medicine Bldg, Univ of Missouri, Columbia, MO 65211, USA
    J Appl Physiol (1985) 110:389-97. 2011
    ..9 ± 12.5 s(-1)). We conclude that increased brachial artery retrograde SR at the onset of leg cycling subsequently returns toward baseline values due in part to thermoregulatory cutaneous vasodilation during prolonged exercise...
  19. pmc Relationship between brachial and femoral artery endothelial vasomotor function/phenotype in pigs
    Jaume Padilla
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Exp Biol Med (Maywood) 235:1287-91. 2010
    ....
  20. ncbi Reproducibility of the flow-mediated dilation response to acute exercise in overweight men
    Ryan A Harris
    Clinical Exercise Physiology Laboratory, School of Health, Physical Education and Recreation, Department of Kinesiology, Indiana University, Bloomington, IN 47404, USA
    Ultrasound Med Biol 33:1579-85. 2007
    ..The findings of the present study support the use of FMD as an outcome variable in response to acute exercise...
  21. pmc Functional adaptations in the skeletal muscle microvasculature to endurance and interval sprint training in the type 2 diabetic OLETF rat
    Jeffrey S Martin
    Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA
    J Appl Physiol (1985) 113:1223-32. 2012
    ....
  22. ncbi Variability of flow-mediated dilation measurements with repetitive reactive hyperemia
    Ryan A Harris
    Clinical Exercise Physiology Laboratory, Indiana University, Bloomington, Indiana 47404, USA
    Vasc Med 11:1-6. 2006
    ..In addition, this study found no time trends for FMD measurements during the 2-h morning period to allow for pre/post intervention FMD measurements...
  23. pmc Influence of spontaneously occurring bursts of muscle sympathetic nerve activity on conduit artery diameter
    Seth T Fairfax
    Biomedical Sciences, University of Missouri, Columbia, Missouri
    Am J Physiol Heart Circ Physiol 305:H867-74. 2013
    ....
  24. pmc Effects of endurance exercise training, metformin, and their combination on adipose tissue leptin and IL-10 secretion in OLETF rats
    Nathan T Jenkins
    Department of 1Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    J Appl Physiol (1985) 113:1873-83. 2012
    ..Overall, this study indicates that exercise training and metformin have additive influences on adipose tissue secretion and plasma concentrations of leptin and IL-10...
  25. pmc Spontaneous bursts of muscle sympathetic nerve activity decrease leg vascular conductance in resting humans
    Seth T Fairfax
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65212, USA
    Am J Physiol Heart Circ Physiol 304:H759-66. 2013
    ....
  26. ncbi Impact of acute exposure to increased hydrostatic pressure and reduced shear rate on conduit artery endothelial function: a limb-specific response
    Jaume Padilla
    Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA
    Am J Physiol Heart Circ Physiol 297:H1103-8. 2009
    ..Further efforts are needed to determine if this apparent protection of the leg vasculature against an acute hydrostatic challenge is attributable to posture-induced chronic adaptations...
  27. doi Characterization of the brachial artery shear stress following walking exercise
    Jaume Padilla
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA
    Vasc Med 13:105-11. 2008
    ..0001) which was abolished after 2 hours. Thus, we found that brachial artery SS is greatest following high-intensity walking and that the rate of decline in SS is similar across all walking intensities...
  28. pmc Unique transcriptomic signature of omental adipose tissue in Ossabaw swine: a model of childhood obesity
    Ryan G Toedebusch
    Biomedical Sciences, University of Missouri, Columbia, Missouri
    Physiol Genomics 46:362-75. 2014
    ....
  29. ncbi Heterogeneity of endothelial cell phenotype within and amongst conduit vessels of the swine vasculature
    Grant H Simmons
    Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Exp Physiol 97:1074-82. 2012
    ..Importantly, even straight vessel segments from systemic conduit arteries (e.g. brachial and carotid arteries) exhibited regional phenotypic heterogeneity; a finding not expected on the basis of local haemodynamic forces alone...
  30. doi The exercise dose affects oxidative stress and brachial artery flow-mediated dilation in trained men
    Blair D Johnson
    Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA
    Eur J Appl Physiol 112:33-42. 2012
    ..4 vs. 7.6 ± 2.7%). These data suggest that acute exercise-induced TBARS are exercise intensity-dependent whereas FMD appears to improve following energy expenditure equivalent to 30 min 50% VO(2peak), regardless of intensity or duration...
  31. ncbi A comparison between active- and reactive-hyperaemia-induced brachial artery vasodilation
    Jaume Padilla
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA
    Clin Sci (Lond) 110:387-92. 2006
    ..18+/-1.13%) treatment. In conclusion, the measurement of brachial artery vasodilation in response to active hyperaemia did not detect a change in endothelial function following a single perturbation meal, whereas reactive hyperaemia did...
  32. pmc Can the measurement of brachial artery flow-mediated dilation be applied to the acute exercise model?
    Jaume Padilla
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN, USA
    Cardiovasc Ultrasound 5:45. 2007
    ....
  33. pmc Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. II. Impact of exercise training in obesity
    Jaume Padilla
    Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri
    J Appl Physiol (1985) 116:1033-47. 2014
    ....
  34. pmc Disturbed blood flow acutely induces activation and apoptosis of the human vascular endothelium
    Nathan T Jenkins
    Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA
    Hypertension 61:615-21. 2013
    ..These data provide the first in vivo experimental evidence of disturbed blood flow-induced endothelial injury in humans...
  35. pmc Potential clinical translation of juvenile rodent inactivity models to study the onset of childhood obesity
    Michael D Roberts
    Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, 65211, USA
    Am J Physiol Regul Integr Comp Physiol 303:R247-58. 2012
    ..The use of the juvenile rodent WL or other inactivity models will continue to provide a powerful clinical translational tool that can be used for primordial prevention of human childhood obesity...
  36. pmc Norepinephrine increases NADPH oxidase-derived superoxide in human peripheral blood mononuclear cells via α-adrenergic receptors
    Shekhar H Deo
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri
    Am J Physiol Regul Integr Comp Physiol 305:R1124-32. 2013
    ..These findings indicate for the first time that NE increases superoxide production in freshly isolated primary human PBMCs via NADPH oxidase through α-adrenergic receptors, an effect facilitating monocyte adhesion to the endothelium...
  37. pmc Vascular effects of exercise: endothelial adaptations beyond active muscle beds
    Jaume Padilla
    Biomedical Sciences, University of Missouri, Columbia, Missouri, USA
    Physiology (Bethesda) 26:132-45. 2011
    ....
  38. doi Vascular consequences of a high-fat meal in physically active and inactive adults
    Blair D Johnson
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA
    Appl Physiol Nutr Metab 36:368-75. 2011
    ..9% ± 3.7% vs. 9.3% ± 3.2%). In conclusion, the differential responses following an HFM support the concept that habitual physical activity can attenuate the negative postprandial alterations that affect vascular health...
  39. doi Metformin does not enhance insulin-stimulated vasodilation in skeletal muscle resistance arteries of the OLETF rat
    Jacqueline M Crissey
    Biomedical Sciences, University of Missouri, Columbia, Missouri, USA Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
    Microcirculation 20:764-75. 2013
    ..To test the hypothesis that chronic metformin treatment enhances insulin-induced vasodilation in skeletal muscle resistance arteries and arterioles...
  40. ncbi Accumulation of physical activity reduces blood pressure in pre- and hypertension
    Jaume Padilla
    Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA
    Med Sci Sports Exerc 37:1264-75. 2005
    ....