D Paddon-Jones

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Role of dietary protein in the sarcopenia of aging
    Douglas Paddon-Jones
    Department of Physical Therapy, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Clin Nutr 87:1562S-1566S. 2008
  2. ncbi request reprint Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Exp Gerontol 41:215-9. 2006
  3. ncbi request reprint Protein, weight management, and satiety
    Douglas Paddon-Jones
    Department of Physical Therapy, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Clin Nutr 87:1558S-1561S. 2008
  4. pmc Amino acid metabolism and inflammatory burden in ovarian cancer patients undergoing intense oncological therapy
    E L Dillon
    Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    Clin Nutr 26:736-43. 2007
  5. ncbi request reprint Aging does not impair the anabolic response to a protein-rich meal
    T Brock Symons
    Division of Rehabilitation Sciences, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Clin Nutr 86:451-6. 2007
  6. ncbi request reprint Acute adaptation to low volume eccentric exercise
    D Paddon-Jones
    School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, 4072, Australia
    Med Sci Sports Exerc 33:1213-9. 2001
  7. ncbi request reprint The catabolic effects of prolonged inactivity and acute hypercortisolemia are offset by dietary supplementation
    Douglas Paddon-Jones
    Metabolism Unit, 815 Market Street, Galveston, Texas
    J Clin Endocrinol Metab 90:1453-9. 2005
  8. ncbi request reprint Differential expression of muscle damage in humans following acute fast and slow velocity eccentric exercise
    D Paddon-Jones
    School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia
    J Sci Med Sport 8:255-63. 2005
  9. ncbi request reprint Interplay of stress and physical inactivity on muscle loss: Nutritional countermeasures
    Douglas Paddon-Jones
    The University of Texas Medical Branch, Galveston, TX 77550, USA
    J Nutr 136:2123-6. 2006
  10. ncbi request reprint Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 91:4836-41. 2006

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Role of dietary protein in the sarcopenia of aging
    Douglas Paddon-Jones
    Department of Physical Therapy, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Clin Nutr 87:1562S-1566S. 2008
    ..However, renal function decreases with age, and high protein intake is contraindicated in individuals with renal disease. Assessment of renal function is recommended for older individuals before they adopt a higher-protein diet...
  2. ncbi request reprint Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Exp Gerontol 41:215-9. 2006
    ..088+/-0.011% h-1 (EAA) and 0.066+/-0.004% h-1 (WY), (P<0.05). While both EAA and WY supplements stimulated muscle protein synthesis, EAAs may provide a more energetically efficient nutritional supplement for elderly individuals...
  3. ncbi request reprint Protein, weight management, and satiety
    Douglas Paddon-Jones
    Department of Physical Therapy, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Clin Nutr 87:1558S-1561S. 2008
    ..Nevertheless, any potential benefits associated with a moderately elevated protein intake must be evaluated in the light of customary dietary practices and individual variability...
  4. pmc Amino acid metabolism and inflammatory burden in ovarian cancer patients undergoing intense oncological therapy
    E L Dillon
    Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    Clin Nutr 26:736-43. 2007
    ..Our considerable data showing the strong anabolic potential of amino acids (AA) led us to test whether AA can acutely stimulate muscle protein synthesis in cancer patients (CA) undergoing intense chemotherapy...
  5. ncbi request reprint Aging does not impair the anabolic response to a protein-rich meal
    T Brock Symons
    Division of Rehabilitation Sciences, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Clin Nutr 86:451-6. 2007
    ..However, the ability of an actual protein-rich food to stimulate anabolism in the young and the elderly has not been explored...
  6. ncbi request reprint Acute adaptation to low volume eccentric exercise
    D Paddon-Jones
    School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, 4072, Australia
    Med Sci Sports Exerc 33:1213-9. 2001
    ..The purpose of this study was to determine whether a nondamaging, low repetition, low volume eccentric exercise bout could also provide a protective/adaptive effect...
  7. ncbi request reprint The catabolic effects of prolonged inactivity and acute hypercortisolemia are offset by dietary supplementation
    Douglas Paddon-Jones
    Metabolism Unit, 815 Market Street, Galveston, Texas
    J Clin Endocrinol Metab 90:1453-9. 2005
    ..04%.h(-1)) and post-BR (EXP, 0.111 +/- 0.015, and CON, 0.05 +/- 0.002%.h(-1)). Unlike a typical clinical meal, AA/CHO supplementation stimulated net muscle protein synthesis despite acute hypercortisolemia and prolonged inactivity...
  8. ncbi request reprint Differential expression of muscle damage in humans following acute fast and slow velocity eccentric exercise
    D Paddon-Jones
    School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia
    J Sci Med Sport 8:255-63. 2005
    ..The contraction velocity of an acute bout of eccentric exercise differentially influences the magnitude and time course of several indirect markers of muscle damage...
  9. ncbi request reprint Interplay of stress and physical inactivity on muscle loss: Nutritional countermeasures
    Douglas Paddon-Jones
    The University of Texas Medical Branch, Galveston, TX 77550, USA
    J Nutr 136:2123-6. 2006
    ..This review focuses on the role of amino acid supplementation in the maintenance of skeletal muscle mass during age-related and clinically mandated inactivity...
  10. ncbi request reprint Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 91:4836-41. 2006
    ..We recently demonstrated that 28-d bed rest in healthy volunteers results in a moderate loss of lean leg mass and strength...
  11. pmc Dietary protein recommendations and the prevention of sarcopenia
    Douglas Paddon-Jones
    Department of Physical Therapy, Division of Rehabilitation Sciences The University of Texas Medical Branch 301 University Blvd Galveston, Texas 77555 1144, USA
    Curr Opin Clin Nutr Metab Care 12:86-90. 2009
    ..To draw attention to recent work on the role of protein and the amount of protein needed with each meal to preserve skeletal muscle mass in ageing...
  12. ncbi request reprint Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestion
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77550, USA
    Am J Physiol Endocrinol Metab 288:E761-7. 2005
    ..2 +/- 8.5 nmol x min(-1) x 100 ml leg volume(-1). These data indicate that CAA supplementation produces a greater anabolic effect than ingestion of intact protein but does not interfere with the normal metabolic response to a meal...
  13. ncbi request reprint Amino acid ingestion improves muscle protein synthesis in the young and elderly
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 286:E321-8. 2004
    ..Despite differences in the time course of plasma phenylalanine kinetics and a greater residual IC phenylalanine concentration, amino acid supplementation acutely stimulated muscle protein synthesis in both young and elderly individuals...
  14. ncbi request reprint Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest
    Douglas Paddon-Jones
    Metabolism Unit, 815 Market Street, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 89:4351-8. 2004
    ..8 +/- 1.4 kg; CON, -17.8 +/- 4.4 kg). Essential amino acid and carbohydrate supplementation may represent a viable intervention for individuals at risk of sarcopenia due to immobility or prolonged bedrest...
  15. ncbi request reprint Short-term beta-hydroxy-beta-methylbutyrate supplementation does not reduce symptoms of eccentric muscle damage
    D Paddon-Jones
    School of Human Movement Studies at The University of Queensland, Brisbane, Australia
    Int J Sport Nutr Exerc Metab 11:442-50. 2001
    ..We examined the effects of short-term beta-hydroxy-beta-methylbutyrate (HMB) supplementation on symptoms of muscle damage following an acute bout of eccentric exercise...
  16. ncbi request reprint Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids
    Douglas Paddon-Jones
    Department of Surgery, University of Texas Medical Branch and Metabolism Unit, Shriners Burns Hospital, 815 Market Street, Galveston, TX 77550, USA
    Am J Physiol Endocrinol Metab 284:E946-53. 2003
    ..180 min) in the C + AA group. Thus, although differences in protein metabolism were evident, EAA ingestion improved muscle protein anabolism during acute hypercortisolemia and may help minimize muscle loss following debilitating injury...
  17. ncbi request reprint Adaptation to chronic eccentric exercise in humans: the influence of contraction velocity
    D Paddon-Jones
    Department of Surgery, University of Texas Medical Branch, Galveston 77550, USA
    Eur J Appl Physiol 85:466-71. 2001
    ..Possible mechanisms include greater cumulative damage to contractile tissues or stress induced by slow eccentric muscle contractions...
  18. ncbi request reprint Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise
    M Sheffield-Moore
    Department of Surgery, General Clinical Research Center, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston 77550, USA
    Am J Physiol Endocrinol Metab 287:E513-22. 2004
    ..Aging per se does not diminish the protein metabolic capacity of the elderly to respond to acute aerobic exercise...
  19. pmc The anabolic response to resistance exercise and a protein-rich meal is not diminished by age
    T B Symons
    Division of Rehabilitation Sciences, The University of Texas Medical Branch, Galveston, Texas 77555 1144, USA
    J Nutr Health Aging 15:376-81. 2011
    ..To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age...
  20. ncbi request reprint Mixed muscle and hepatic derived plasma protein metabolism is differentially regulated in older and younger men following resistance exercise
    M Sheffield-Moore
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    Am J Physiol Endocrinol Metab 288:E922-9. 2005
    ..Moreover, our data suggest that with age may come a greater need to salvage or make available amino acids from exercise-induced muscle protein breakdown to mount an acute-phase response...
  21. pmc Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity
    T B Symons
    The Univ of Texas Medical Branch, 301 Univ Blvd, Galveston, TX 77555 1144, USA
    J Appl Physiol 107:34-8. 2009
    ....
  22. ncbi request reprint Differential anabolic effects of testosterone and amino acid feeding in older men
    Arny A Ferrando
    Departments of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 88:358-62. 2003
    ..Taken together, however, these diverse stimulatory effects can increase lean body mass and muscle strength over time...
  23. ncbi request reprint Bed rest and myopathies
    Arny A Ferrando
    Department of Surgery, University of Texas Medical Branch, Shrine Hospital for Children, Galveston, Texas 77550, USA
    Curr Opin Clin Nutr Metab Care 9:410-5. 2006
    ..Changes in protein metabolism with bed rest alone and during physiological stress are discussed. Nutritional and hormonal interventions that ameliorate the loss of skeletal muscle are highlighted...
  24. ncbi request reprint Androgen therapy induces muscle protein anabolism in older women
    Melinda Sheffield-Moore
    University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0569, USA
    J Clin Endocrinol Metab 91:3844-9. 2006
    ..Normal healthy men and women undergo a gradual loss of skeletal muscle mass and strength with advancing age. While androgens are protein anabolic in older men, the metabolic effects in older women are poorly understood...
  25. pmc Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle
    Blake B Rasmussen
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    J Clin Invest 110:1687-93. 2002
    ..07 nmol/g during hyperglycemia with hyperinsulinemia. We conclude that hyperglycemia with hyperinsulinemia increases malonyl-CoA, inhibits functional CPT-1 activity, and shunts LCFA away from oxidation and toward storage in human muscle...
  26. pmc Plasma triglycerides are not related to tissue lipids and insulin sensitivity in elderly following PPAR-alpha agonist treatment
    Melanie G Cree
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555, United States
    Mech Ageing Dev 128:558-65. 2007
    ..2+/-0.05, insulin resistant). Furthermore, there was no change in IMCL or LFAT. These results indicate that whereas fenofibrate significantly lowers plasma lipids it neither affects insulin sensitivity nor intracellular lipids in elderly...
  27. ncbi request reprint Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia
    Peter N Uchakin
    Department of Internal Medicine, Mercer University School of Medicine, 1550 College Street, Macon, GA, USA
    Aviat Space Environ Med 78:608-12. 2007
    ..Hypokinesia is associated with spaceflight and prolonged illnesses and may lead to secondary immune deficiency...
  28. ncbi request reprint Amino acid supplementation for reversing bed rest and steroid myopathies
    Douglas Paddon-Jones
    Department of Surgery, University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, TX, USA
    J Nutr 135:1809S-1812S. 2005
    ..It may be necessary to concomitantly reduce the catabolic influence of cortisol or provide another anabolic stimulus...
  29. ncbi request reprint Potential ergogenic effects of arginine and creatine supplementation
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch and Metabolism Unit, Shriners Hospitals for Children, Galveston, TX 77550, USA
    J Nutr 134:2888S-2894S; discussion 2895S. 2004
    ..The purpose of this review is to summarize the role of arginine and its metabolite creatine in the context of a nutrition supplement for use in conjunction with an exercise stimulus in both healthy and patient populations...