Research Topics
Species | L PackerSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenolL Packer
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
Free Radic Biol Med 27:704-24. 1999..PYC effects redox-sensitive signal transduction pathways and alters gene expression. Aspects of PYC's activity are presented and discussed together with possible future implications and directions in the field of flavonoid research...- Molecular aspects of alpha-tocotrienol antioxidant action and cell signallingL Packer
Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720 3200, USA
J Nutr 131:369S-73S. 2001..Important novel antiproliferative and neuroprotective effects of tocotrienols, which may be independent of their antioxidant activity, have also been described... - Antioxidant regulation of phorbol ester-induced adhesion of human Jurkat T-cells to endothelial cellsS Roy
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
Free Radic Biol Med 25:229-41. 1998..The inhibitory effect of low concentration of alpha-lipaote alone or in combination with alpha-tocopherol on agonist-induced adhesion processes observed in this study may be of potential therapeutic value... - Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthioneC K Sen
Department of Molecular and Cell Biology, University of California Berkeley 94720 3200, USA
Biochem Biophys Res Commun 218:148-53. 1996..H2O2 induced lipid peroxidation in Wurzburg cells was remarkably inhibited by ADT pretreatment. ADT, a pro-glutathione antioxidant, was observed to be capable of modulating NF-kappa B activation... - Monochloramine inhibits phorbol ester-inducible neutrophil respiratory burst activation and T cell interleukin-2 receptor expression by inhibiting inducible protein kinase C activityT Ogino
Department of Molecular and Cellular Biology, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
J Biol Chem 272:26247-52. 1997..These results show that NH2Cl inhibits PKC-mediated cellular responses through inhibition of the inducible PKC activity... - Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa B activation in skeletal muscle-derived L6 cellsC K Sen
Department of Molecular and Cell Biology, University of California at Berkeley 94720, USA
Biochem Biophys Res Commun 237:645-9. 1997.... - Protective effects of anethole dithiolethione against oxidative stress-induced cytotoxicity in human Jurkat T cellsS Khanna
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
Biochem Pharmacol 56:61-9. 1998..In conclusion, ADT proved to be a potent cytoprotective thiol antioxidant with multifaceted mechanisms of action, suggesting that the drug has a remarkable therapeutic potential... - mRNA expression profile of a human cancer cell line in response to Ginkgo biloba extract: induction of antioxidant response and the Golgi systemK Gohil
Department of Molecular and Cell Biology, Lawrence Berkeley National Laboratory University of California, 94720, USA
Free Radic Res 33:831-49. 2000..These in vitro studies using GeneChips demonstrated a promising strategy for identifying nutritional supplement induced cellular responses that may have a role in counteracting chronic human diseases... - Thiol chelation of Cu2+ by dihydrolipoic acid prevents human low density lipoprotein peroxidationJ K Lodge
Department of Molecular and Cell Biology, University of California at Berkeley, 94720 3200, USA
Free Radic Biol Med 25:287-97. 1998..DHLA, thus, has both pro- and antioxidant properties depending upon the ratio of Cu2+:DHLA and the pH. These results provide an additional mechanism of thiol-mediated formation of radicals and metal chelation... - A positively charged alpha-lipoic acid analogue with increased cellular uptake and more potent immunomodulatory activityC K Sen
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720 3200, USA
Biochem Biophys Res Commun 247:223-8. 1998..At 5 microM LA-Plus, but not LA, protected against both spontaneous and etoposide induced apoptosis in rat thymocytes. LA-Plus is thus an improved form of LA with increased therapeutic potential... - Effect of benzoyl peroxide on antioxidant status, NF-kappaB activity and interleukin-1alpha gene expression in human keratinocytesG Valacchi
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
Toxicology 165:225-34. 2001..These results demonstrate that BP induces an inflammatory reaction mediated by oxidative stress by a pathway independent of the redox-sensitive transcription factor NF-kappaB... - Modulation of cellular reducing equivalent homeostasis by alpha-lipoic acid. Mechanisms and implications for diabetes and ischemic injuryS Roy
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, U S A
Biochem Pharmacol 53:393-9. 1997.... - Penetration and distribution of alpha-tocopherol, alpha- or gamma-tocotrienols applied individually onto murine skinM G Traber
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
Lipids 33:87-91. 1998..Hence, applied vitamin E penetrates rapidly through the skin, but the highest concentrations are found in the uppermost 5 microns... - Methods to assess free radicals and oxidative stress in biological systemsG Rimbach
Department of Molecular and Cell Biology, University of California at Berkeley 94720 3200, USA
Arch Tierernahr 52:203-22. 1999..Information obtained from the hyperfine splitting of the spin-trapped adduct can provide identification and quantification of the originally generated free radicals... - Induction of glutathione synthesis in human keratinocytes by Ginkgo biloba extract (EGb761)G Rimbach
Department of Molecular and Cell Biology, University of California, Berkeley, USA
Biofactors 15:39-52. 2001.... - Vitamin C, uric acid, and glutathione gradients in murine stratum corneum and their susceptibility to ozone exposureS U Weber
Department of Molecular and Cell Biology, University of California, Berkeley, USA
J Invest Dermatol 113:1128-32. 1999..01). This report demonstrates the previously unrecognized role of hydrophilic antioxidants in the stratum corneum and provides further evidence that O3 induces oxidative stress in this outer skin layer... - Macromolecular carbonyls in human stratum corneum: a biomarker for environmental oxidant exposure?J J Thiele
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
FEBS Lett 422:403-6. 1998..43 +/- 0.06 nmol/cm2) vs. lower arm (0.32 +/- 0.04, mean +/- S.E.M., n = 11; P < 0.003) and lower back (0.26 +/- 0.02) vs. buttock (0.21 +/- 0.02; n = 6, P < 0.01) indicating in vivo oxidative damage... - Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cellsC K Sen
Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
J Biol Chem 275:13049-55. 2000..At a concentration 4-10-fold lower than levels detected in plasma of supplemented humans, tocotrienol regulated unique signal transduction processes that were not sensitive to comparable concentrations of tocopherol... - From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisitedB Rihn
Membrane Bioenergetics Group, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
Phytother Res 15:76-8. 2001..Interestingly, PBE was shown to downregulate both calgranulin A and B genes which are known to be upregulated in psoriasis and various dermatoses. Thus, PBE could be considered in human dermatoses... - Inhibitory effect of alpha-lipoic acid and its positively charged amide analogue on nitric oxide production in RAW 264.7 macrophagesQ Guo
Department of Molecular and Cell Biology, University of California, 251 Life Sciences Addition, Berkeley, CA 94720-3200, USA
Biochem Pharmacol 61:547-54. 2001.... - Fas mediated apoptosis of human Jurkat T-cells: intracellular events and potentiation by redox-active alpha-lipoic acidC K Sen
Biological Technologies, Lawrence Berkeley National Laboratory, Berkeley, California, USA
Cell Death Differ 6:481-91. 1999..This work provides first evidence showing that inducible caspase 3 activity may be pharmacologically up-regulated by reducing agents such as dihydrolipoic acid... - Guanidino compounds generate reactive oxygen speciesA Mori
Department of Molecular and Cell Biology, University of California at Berkeleley 94720 3200, USA
Biochem Mol Biol Int 40:135-43. 1996..Arginine may have a similar role in the pathogenesis of hyperarginemia... - Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic developmentY Terasawa
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94110, USA
J Lipid Res 40:1967-77. 1999..secretion in mouse yolk sac during embryonic development... - Protein binding of procyanidins: studies using polyacrylamide gel electrophoresis and French maritime pine bark extractH Moini
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3200, USA
Methods Enzymol 335:333-7. 2001..Data presented suggest that PBE and EGb 761 have protein-binding properties, which, in addition to their redox-based effects, could provide a biochemical basis for their action in biological systems... - Impact of ultraviolet radiation and ozone on the transepidermal water loss as a function of skin temperature in hairless miceJ J Thiele
Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
Skin Pharmacol Appl Skin Physiol 16:283-90. 2003..Furthermore, experimental evidence clearly suggests that future studies applying TEWL measurements in animal models should be performed under carefully controlled skin temperature conditions...