L Packer

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol
    L Packer
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Free Radic Biol Med 27:704-24. 1999
  2. ncbi request reprint Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling
    L Packer
    Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720 3200, USA
    J Nutr 131:369S-73S. 2001
  3. ncbi request reprint Antioxidant regulation of phorbol ester-induced adhesion of human Jurkat T-cells to endothelial cells
    S Roy
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Free Radic Biol Med 25:229-41. 1998
  4. ncbi request reprint Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione
    C K Sen
    Department of Molecular and Cell Biology, University of California Berkeley 94720 3200, USA
    Biochem Biophys Res Commun 218:148-53. 1996
  5. ncbi request reprint Monochloramine inhibits phorbol ester-inducible neutrophil respiratory burst activation and T cell interleukin-2 receptor expression by inhibiting inducible protein kinase C activity
    T Ogino
    Department of Molecular and Cellular Biology, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    J Biol Chem 272:26247-52. 1997
  6. ncbi request reprint Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa B activation in skeletal muscle-derived L6 cells
    C K Sen
    Department of Molecular and Cell Biology, University of California at Berkeley 94720, USA
    Biochem Biophys Res Commun 237:645-9. 1997
  7. ncbi request reprint Protective effects of anethole dithiolethione against oxidative stress-induced cytotoxicity in human Jurkat T cells
    S Khanna
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Biochem Pharmacol 56:61-9. 1998
  8. ncbi request reprint mRNA expression profile of a human cancer cell line in response to Ginkgo biloba extract: induction of antioxidant response and the Golgi system
    K Gohil
    Department of Molecular and Cell Biology, Lawrence Berkeley National Laboratory University of California, 94720, USA
    Free Radic Res 33:831-49. 2000
  9. ncbi request reprint Thiol chelation of Cu2+ by dihydrolipoic acid prevents human low density lipoprotein peroxidation
    J K Lodge
    Department of Molecular and Cell Biology, University of California at Berkeley, 94720 3200, USA
    Free Radic Biol Med 25:287-97. 1998
  10. ncbi request reprint A positively charged alpha-lipoic acid analogue with increased cellular uptake and more potent immunomodulatory activity
    C K Sen
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720 3200, USA
    Biochem Biophys Res Commun 247:223-8. 1998

Detail Information

Publications25

  1. ncbi request reprint Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol
    L Packer
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Free Radic Biol Med 27:704-24. 1999
    ..PYC effects redox-sensitive signal transduction pathways and alters gene expression. Aspects of PYC's activity are presented and discussed together with possible future implications and directions in the field of flavonoid research...
  2. ncbi request reprint Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling
    L Packer
    Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720 3200, USA
    J Nutr 131:369S-73S. 2001
    ..Important novel antiproliferative and neuroprotective effects of tocotrienols, which may be independent of their antioxidant activity, have also been described...
  3. ncbi request reprint Antioxidant regulation of phorbol ester-induced adhesion of human Jurkat T-cells to endothelial cells
    S Roy
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Free Radic Biol Med 25:229-41. 1998
    ..The inhibitory effect of low concentration of alpha-lipaote alone or in combination with alpha-tocopherol on agonist-induced adhesion processes observed in this study may be of potential therapeutic value...
  4. ncbi request reprint Inhibition of NF-kappa B activation in human T-cell lines by anetholdithiolthione
    C K Sen
    Department of Molecular and Cell Biology, University of California Berkeley 94720 3200, USA
    Biochem Biophys Res Commun 218:148-53. 1996
    ..H2O2 induced lipid peroxidation in Wurzburg cells was remarkably inhibited by ADT pretreatment. ADT, a pro-glutathione antioxidant, was observed to be capable of modulating NF-kappa B activation...
  5. ncbi request reprint Monochloramine inhibits phorbol ester-inducible neutrophil respiratory burst activation and T cell interleukin-2 receptor expression by inhibiting inducible protein kinase C activity
    T Ogino
    Department of Molecular and Cellular Biology, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    J Biol Chem 272:26247-52. 1997
    ..These results show that NH2Cl inhibits PKC-mediated cellular responses through inhibition of the inducible PKC activity...
  6. ncbi request reprint Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa B activation in skeletal muscle-derived L6 cells
    C K Sen
    Department of Molecular and Cell Biology, University of California at Berkeley 94720, USA
    Biochem Biophys Res Commun 237:645-9. 1997
    ....
  7. ncbi request reprint Protective effects of anethole dithiolethione against oxidative stress-induced cytotoxicity in human Jurkat T cells
    S Khanna
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Biochem Pharmacol 56:61-9. 1998
    ..In conclusion, ADT proved to be a potent cytoprotective thiol antioxidant with multifaceted mechanisms of action, suggesting that the drug has a remarkable therapeutic potential...
  8. ncbi request reprint mRNA expression profile of a human cancer cell line in response to Ginkgo biloba extract: induction of antioxidant response and the Golgi system
    K Gohil
    Department of Molecular and Cell Biology, Lawrence Berkeley National Laboratory University of California, 94720, USA
    Free Radic Res 33:831-49. 2000
    ..These in vitro studies using GeneChips demonstrated a promising strategy for identifying nutritional supplement induced cellular responses that may have a role in counteracting chronic human diseases...
  9. ncbi request reprint Thiol chelation of Cu2+ by dihydrolipoic acid prevents human low density lipoprotein peroxidation
    J K Lodge
    Department of Molecular and Cell Biology, University of California at Berkeley, 94720 3200, USA
    Free Radic Biol Med 25:287-97. 1998
    ..DHLA, thus, has both pro- and antioxidant properties depending upon the ratio of Cu2+:DHLA and the pH. These results provide an additional mechanism of thiol-mediated formation of radicals and metal chelation...
  10. ncbi request reprint A positively charged alpha-lipoic acid analogue with increased cellular uptake and more potent immunomodulatory activity
    C K Sen
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720 3200, USA
    Biochem Biophys Res Commun 247:223-8. 1998
    ..At 5 microM LA-Plus, but not LA, protected against both spontaneous and etoposide induced apoptosis in rat thymocytes. LA-Plus is thus an improved form of LA with increased therapeutic potential...
  11. ncbi request reprint Effect of benzoyl peroxide on antioxidant status, NF-kappaB activity and interleukin-1alpha gene expression in human keratinocytes
    G Valacchi
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Toxicology 165:225-34. 2001
    ..These results demonstrate that BP induces an inflammatory reaction mediated by oxidative stress by a pathway independent of the redox-sensitive transcription factor NF-kappaB...
  12. ncbi request reprint Modulation of cellular reducing equivalent homeostasis by alpha-lipoic acid. Mechanisms and implications for diabetes and ischemic injury
    S Roy
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, U S A
    Biochem Pharmacol 53:393-9. 1997
    ....
  13. ncbi request reprint Penetration and distribution of alpha-tocopherol, alpha- or gamma-tocotrienols applied individually onto murine skin
    M G Traber
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Lipids 33:87-91. 1998
    ..Hence, applied vitamin E penetrates rapidly through the skin, but the highest concentrations are found in the uppermost 5 microns...
  14. ncbi request reprint Methods to assess free radicals and oxidative stress in biological systems
    G Rimbach
    Department of Molecular and Cell Biology, University of California at Berkeley 94720 3200, USA
    Arch Tierernahr 52:203-22. 1999
    ..Information obtained from the hyperfine splitting of the spin-trapped adduct can provide identification and quantification of the originally generated free radicals...
  15. ncbi request reprint Induction of glutathione synthesis in human keratinocytes by Ginkgo biloba extract (EGb761)
    G Rimbach
    Department of Molecular and Cell Biology, University of California, Berkeley, USA
    Biofactors 15:39-52. 2001
    ....
  16. ncbi request reprint Vitamin C, uric acid, and glutathione gradients in murine stratum corneum and their susceptibility to ozone exposure
    S U Weber
    Department of Molecular and Cell Biology, University of California, Berkeley, USA
    J Invest Dermatol 113:1128-32. 1999
    ..01). This report demonstrates the previously unrecognized role of hydrophilic antioxidants in the stratum corneum and provides further evidence that O3 induces oxidative stress in this outer skin layer...
  17. ncbi request reprint Macromolecular carbonyls in human stratum corneum: a biomarker for environmental oxidant exposure?
    J J Thiele
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    FEBS Lett 422:403-6. 1998
    ..43 +/- 0.06 nmol/cm2) vs. lower arm (0.32 +/- 0.04, mean +/- S.E.M., n = 11; P < 0.003) and lower back (0.26 +/- 0.02) vs. buttock (0.21 +/- 0.02; n = 6, P < 0.01) indicating in vivo oxidative damage...
  18. ncbi request reprint Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells
    C K Sen
    Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    J Biol Chem 275:13049-55. 2000
    ..At a concentration 4-10-fold lower than levels detected in plasma of supplemented humans, tocotrienol regulated unique signal transduction processes that were not sensitive to comparable concentrations of tocopherol...
  19. ncbi request reprint From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited
    B Rihn
    Membrane Bioenergetics Group, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Phytother Res 15:76-8. 2001
    ..Interestingly, PBE was shown to downregulate both calgranulin A and B genes which are known to be upregulated in psoriasis and various dermatoses. Thus, PBE could be considered in human dermatoses...
  20. ncbi request reprint Inhibitory effect of alpha-lipoic acid and its positively charged amide analogue on nitric oxide production in RAW 264.7 macrophages
    Q Guo
    Department of Molecular and Cell Biology, University of California, 251 Life Sciences Addition, Berkeley, CA 94720-3200, USA
    Biochem Pharmacol 61:547-54. 2001
    ....
  21. ncbi request reprint Fas mediated apoptosis of human Jurkat T-cells: intracellular events and potentiation by redox-active alpha-lipoic acid
    C K Sen
    Biological Technologies, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Cell Death Differ 6:481-91. 1999
    ..This work provides first evidence showing that inducible caspase 3 activity may be pharmacologically up-regulated by reducing agents such as dihydrolipoic acid...
  22. ncbi request reprint Guanidino compounds generate reactive oxygen species
    A Mori
    Department of Molecular and Cell Biology, University of California at Berkeleley 94720 3200, USA
    Biochem Mol Biol Int 40:135-43. 1996
    ..Arginine may have a similar role in the pathogenesis of hyperarginemia...
  23. ncbi request reprint Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development
    Y Terasawa
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94110, USA
    J Lipid Res 40:1967-77. 1999
    ..secretion in mouse yolk sac during embryonic development...
  24. ncbi request reprint Protein binding of procyanidins: studies using polyacrylamide gel electrophoresis and French maritime pine bark extract
    H Moini
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3200, USA
    Methods Enzymol 335:333-7. 2001
    ..Data presented suggest that PBE and EGb 761 have protein-binding properties, which, in addition to their redox-based effects, could provide a biochemical basis for their action in biological systems...
  25. ncbi request reprint Impact of ultraviolet radiation and ozone on the transepidermal water loss as a function of skin temperature in hairless mice
    J J Thiele
    Department of Molecular and Cell Biology, University of California, Berkeley, California, USA
    Skin Pharmacol Appl Skin Physiol 16:283-90. 2003
    ..Furthermore, experimental evidence clearly suggests that future studies applying TEWL measurements in animal models should be performed under carefully controlled skin temperature conditions...