Daniel PackSummaryAffiliation: University of Illinois Country: USA Publications
Research Grants
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Detail Information
Publications
Design and development of polymers for gene deliveryDaniel W Pack
Department of Chemical and Biomolecular Engineering, University of Illinois, Box C 3, 600 South Mathews Avenue, Urbana, IL 61801, USA
Nat Rev Drug Discov 4:581-93. 2005..With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative polymer chemists, it is likely that polymer-based gene-delivery systems will become an important tool for human gene therapy...- Dendrons with spermine surface groups as potential building blocks for nonviral vectors in gene therapyJohn G Hardy
Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
Bioconjug Chem 17:172-8. 2006.... - Use of thermodynamic parameters for design of double-walled microsphere fabrication methodsEmily J Pollauf
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, USA
Biomaterials 27:2898-906. 2006..Appropriate choices of solvents and initial polymer concentrations resulted in DWMS with the desired polyphosphoester shells and piroxicam located selectively in PLG cores... - Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactionsNathan P Gabrielson
Department of Chemical and Biomolecular Engineering and Department of Bioengineering, University of Illinois, Urbana, Illinois 61801, USA
Biomacromolecules 7:2427-35. 2006..Overall, the data suggest that the increased gene delivery activity may be attributable to an appropriate balance between polymer buffering capacity and strength of polymer/DNA interactions... - Monodisperse liquid-filled biodegradable microcapsulesCory Berkland
Department of Chemical and Petroleum Engineering, 2030 Becker Dr, Lawrence, Kansas 66047, USA
Pharm Res 24:1007-13. 2007..We report an extension of Precision Particle Fabrication (PPF) technology for the production of monodisperse liquid-filled microcapsules containing an oil or aqueous core and contrast these results to double-walled microspheres... - Macromolecule release from monodisperse PLG microspheres: control of release rates and investigation of release mechanismCory Berkland
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
J Pharm Sci 96:1176-91. 2007..Monodisperse microspheres may represent a new delivery system for therapeutic proteins and DNA and provide enhanced control of delivery rates using simple injectable depot formulations... - Biochemical investigation of active intracellular transport of polymeric gene-delivery vectorsDavid M Drake
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
J Pharm Sci 97:1399-413. 2008..Further, the strong decrease in transfection efficiency caused by ATPase inhibitors that possess inhibitory activity against kinesin implies an unexpected role for these motors in gene delivery... 
Influence of particle size and antacid on release and stability of plasmid DNA from uniform PLGA microspheresNeelesh K Varde
Department of Chemical and Biomolecular Engineering, University of Illinois, 600 S Mathews Ave, Urbana, IL 61801 USA
J Control Release 124:172-80. 2007..Our studies show that the incorporation of antacid into the microsphere structure has potential in addressing some of the major problems associated with DNA encapsulation and release in PLGA microspheres...- Engineering of a stable retroviral gene delivery vector by directed evolutionHalong N Vu
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
Mol Ther 16:308-14. 2008..The improved stability of the variant MLVs will provide more facile virus production and increased transduction efficiency... - Small-molecule release from poly(D,L-lactide)/poly(D,L-lactide-co-glycolide) composite microparticlesEmily J Pollauf
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois, USA
J Pharm Sci 94:2013-22. 2005..Combining PDLL(PLG) microcapsules of different shell thicknesses allows nearly constant release rates to be attained for a period of 6 weeks... - On the kinetics of polyplex endocytic trafficking: implications for gene delivery vector designM Laird Forrest
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
Mol Ther 6:57-66. 2002..Additionally, PEI does not appear to buffer endocytic compartments, but requires exposure to an acidic environment for efficient gene delivery... - In vitro degradation of polyanhydride/polyester core-shell double-wall microspheresEmily J Pollauf
Department of Chemical and Biomolecular Engineering, University of Illinois, Box C-3, 600 S. Mathews Ave, Urbana, IL 61801, USA
Int J Pharm 301:294-303. 2005..Nevertheless, the relatively thin (approximately 5 microm) PCPH shells could not prevent water penetration, and the PLG cores completely eroded by 6 weeks of incubation... - Precise control of PLG microsphere size provides enhanced control of drug release rateCory Berkland
Department of Chemical Engineering, University of Illinois, MC-712, Box C-3, 600 South Mathews Avenue, Urbana, IL 61801, USA
J Control Release 82:137-47. 2002..Mixing of uniform microspheres, as well as control of microsphere size distribution, may provide an improved methodology to tailor small-molecule drug-release kinetics from simple, biodegradable-polymer microparticles... - PLG microsphere size controls drug release rate through several competing factorsCory Berkland
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
Pharm Res 20:1055-62. 2003..CONCLUSION: Microsphere size affects drug release not only through changes in diffusion rates but also through secondary effects including drug distribution in the particle, polymer degradation rate, and microsphere erosion rates... - A degradable polyethylenimine derivative with low toxicity for highly efficient gene deliveryM Laird Forrest
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
Bioconjug Chem 14:934-40. 2003..These easily synthesized polymers are some of the most efficient polymeric vectors reported to date and provide a versatile platform for investigation of the effects of polymer structure and degradation rate on gene delivery efficiency... - Partial acetylation of polyethylenimine enhances in vitro gene deliveryM Laird Forrest
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, USA
Pharm Res 21:365-71. 2004..Future studies will address these possibilities in more detail... - Uniform double-walled polymer microspheres of controllable shell thicknessCory Berkland
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, USA
J Control Release 96:101-11. 2004.... - Controlling surface nano-structure using flow-limited field-injection electrostatic spraying (FFESS) of poly(D,L-lactide-co-glycolide)Cory Berkland
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, USA
Biomaterials 25:5649-58. 2004..FFESS technology provides a simple yet powerful technique for fabricating biomedical devices with a precisely defined nano-structure potentially capable of utilizing a broad range of biocompatible polymeric materials... - Cyclodextrin-polyethylenimine conjugates for targeted in vitro gene deliveryM Laird Forrest
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
Biotechnol Bioeng 89:416-23. 2005..Because of the relative ease with which CD-binding moieties may be attached to various types of ligands, CD-PEI may be a generally useful material for testing novel cell-specific targeting compounds... - Modeling small-molecule release from PLG microspheres: effects of polymer degradation and nonuniform drug distributionChandrashekar Raman
Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, United States
J Control Release 103:149-58. 2005..The model also incorporates the effect of nonuniform drug distribution within the microspheres, which is obtained from confocal fluorescence microscopy. The model results agree well with experiments despite using only one fit parameter... - HER-2-mediated endocytosis of magnetic nanospheres and the implications in cell targeting and particle magnetizationShy Chyi Wuang
Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260
Biomaterials 29:2270-9. 2008..The combination of these cell-targeting magnetic carriers with chemotherapeutic agents will be highly advantageous for the preferential killing of cancer cells in hyperthermia treatment...
Research Grants
- Design of Microparticles for Precision Drug DeliveryDaniel Pack; Fiscal Year: 2004..abstract_text> ..
- Precision Microparticles for Controlled Protein DeliveryDaniel Pack; Fiscal Year: 2007..Through precision particle fabrication, this project will result in novel fundamental insights into mechanisms controlling release as well as provide a method for enhanced control of release rates. ..
- Precision Microparticles for Controlled Protein DeliveryDaniel Pack; Fiscal Year: 2009..Through precision particle fabrication, this project will result in novel fundamental insights into mechanisms controlling release as well as provide a method for enhanced control of release rates. ..
- Effects of Uptake Mechanism on Polyplex Design CriteriaDaniel W Pack; Fiscal Year: 2010..This project aims to build fundamental understanding of vectors and their interaction with cells that will aid in design of the advanced vectors required to move human gene therapy from the laboratory to the clinic. ..