Daniel Pack

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint Design and development of polymers for gene delivery
    Daniel W Pack
    Department of Chemical and Biomolecular Engineering, University of Illinois, Box C 3, 600 South Mathews Avenue, Urbana, IL 61801, USA
    Nat Rev Drug Discov 4:581-93. 2005
  2. ncbi request reprint Dendrons with spermine surface groups as potential building blocks for nonviral vectors in gene therapy
    John G Hardy
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Bioconjug Chem 17:172-8. 2006
  3. ncbi request reprint Use of thermodynamic parameters for design of double-walled microsphere fabrication methods
    Emily J Pollauf
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, USA
    Biomaterials 27:2898-906. 2006
  4. ncbi request reprint Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions
    Nathan P Gabrielson
    Department of Chemical and Biomolecular Engineering and Department of Bioengineering, University of Illinois, Urbana, Illinois 61801, USA
    Biomacromolecules 7:2427-35. 2006
  5. ncbi request reprint Monodisperse liquid-filled biodegradable microcapsules
    Cory Berkland
    Department of Chemical and Petroleum Engineering, 2030 Becker Dr, Lawrence, Kansas 66047, USA
    Pharm Res 24:1007-13. 2007
  6. ncbi request reprint Macromolecule release from monodisperse PLG microspheres: control of release rates and investigation of release mechanism
    Cory Berkland
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
    J Pharm Sci 96:1176-91. 2007
  7. ncbi request reprint Biochemical investigation of active intracellular transport of polymeric gene-delivery vectors
    David M Drake
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
    J Pharm Sci 97:1399-413. 2008
  8. pmc Influence of particle size and antacid on release and stability of plasmid DNA from uniform PLGA microspheres
    Neelesh K Varde
    Department of Chemical and Biomolecular Engineering, University of Illinois, 600 S Mathews Ave, Urbana, IL 61801 USA
    J Control Release 124:172-80. 2007
  9. ncbi request reprint Engineering of a stable retroviral gene delivery vector by directed evolution
    Halong N Vu
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
    Mol Ther 16:308-14. 2008
  10. ncbi request reprint Small-molecule release from poly(D,L-lactide)/poly(D,L-lactide-co-glycolide) composite microparticles
    Emily J Pollauf
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois, USA
    J Pharm Sci 94:2013-22. 2005

Collaborators

  • Suzie Pun
  • Cory Berkland
  • Patrick Stayton
  • M Laird Forrest
  • Emily J Pollauf
  • Nathan P Gabrielson
  • David M Drake
  • Halong N Vu
  • Shy Chyi Wuang
  • Neelesh K Varde
  • John G Hardy
  • Chandrashekar Raman
  • Kyekyoon Kevin Kim
  • James T Koerber
  • Koon Gee Neoh
  • Deborah E Leckband
  • En Tang Kang
  • Joshua D Ramsey
  • Mauri A Kostiainen
  • David K Smith
  • Kyekyoon Kim
  • Nathan Gabrielson
  • Glenna E Meister

Detail Information

Publications21

  1. ncbi request reprint Design and development of polymers for gene delivery
    Daniel W Pack
    Department of Chemical and Biomolecular Engineering, University of Illinois, Box C 3, 600 South Mathews Avenue, Urbana, IL 61801, USA
    Nat Rev Drug Discov 4:581-93. 2005
    ..With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative polymer chemists, it is likely that polymer-based gene-delivery systems will become an important tool for human gene therapy...
  2. ncbi request reprint Dendrons with spermine surface groups as potential building blocks for nonviral vectors in gene therapy
    John G Hardy
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Bioconjug Chem 17:172-8. 2006
    ....
  3. ncbi request reprint Use of thermodynamic parameters for design of double-walled microsphere fabrication methods
    Emily J Pollauf
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, USA
    Biomaterials 27:2898-906. 2006
    ..Appropriate choices of solvents and initial polymer concentrations resulted in DWMS with the desired polyphosphoester shells and piroxicam located selectively in PLG cores...
  4. ncbi request reprint Acetylation of polyethylenimine enhances gene delivery via weakened polymer/DNA interactions
    Nathan P Gabrielson
    Department of Chemical and Biomolecular Engineering and Department of Bioengineering, University of Illinois, Urbana, Illinois 61801, USA
    Biomacromolecules 7:2427-35. 2006
    ..Overall, the data suggest that the increased gene delivery activity may be attributable to an appropriate balance between polymer buffering capacity and strength of polymer/DNA interactions...
  5. ncbi request reprint Monodisperse liquid-filled biodegradable microcapsules
    Cory Berkland
    Department of Chemical and Petroleum Engineering, 2030 Becker Dr, Lawrence, Kansas 66047, USA
    Pharm Res 24:1007-13. 2007
    ..We report an extension of Precision Particle Fabrication (PPF) technology for the production of monodisperse liquid-filled microcapsules containing an oil or aqueous core and contrast these results to double-walled microspheres...
  6. ncbi request reprint Macromolecule release from monodisperse PLG microspheres: control of release rates and investigation of release mechanism
    Cory Berkland
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
    J Pharm Sci 96:1176-91. 2007
    ..Monodisperse microspheres may represent a new delivery system for therapeutic proteins and DNA and provide enhanced control of delivery rates using simple injectable depot formulations...
  7. ncbi request reprint Biochemical investigation of active intracellular transport of polymeric gene-delivery vectors
    David M Drake
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
    J Pharm Sci 97:1399-413. 2008
    ..Further, the strong decrease in transfection efficiency caused by ATPase inhibitors that possess inhibitory activity against kinesin implies an unexpected role for these motors in gene delivery...
  8. pmc Influence of particle size and antacid on release and stability of plasmid DNA from uniform PLGA microspheres
    Neelesh K Varde
    Department of Chemical and Biomolecular Engineering, University of Illinois, 600 S Mathews Ave, Urbana, IL 61801 USA
    J Control Release 124:172-80. 2007
    ..Our studies show that the incorporation of antacid into the microsphere structure has potential in addressing some of the major problems associated with DNA encapsulation and release in PLGA microspheres...
  9. ncbi request reprint Engineering of a stable retroviral gene delivery vector by directed evolution
    Halong N Vu
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
    Mol Ther 16:308-14. 2008
    ..The improved stability of the variant MLVs will provide more facile virus production and increased transduction efficiency...
  10. ncbi request reprint Small-molecule release from poly(D,L-lactide)/poly(D,L-lactide-co-glycolide) composite microparticles
    Emily J Pollauf
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois, USA
    J Pharm Sci 94:2013-22. 2005
    ..Combining PDLL(PLG) microcapsules of different shell thicknesses allows nearly constant release rates to be attained for a period of 6 weeks...
  11. ncbi request reprint On the kinetics of polyplex endocytic trafficking: implications for gene delivery vector design
    M Laird Forrest
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
    Mol Ther 6:57-66. 2002
    ..Additionally, PEI does not appear to buffer endocytic compartments, but requires exposure to an acidic environment for efficient gene delivery...
  12. ncbi request reprint In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres
    Emily J Pollauf
    Department of Chemical and Biomolecular Engineering, University of Illinois, Box C 3, 600 S Mathews Ave, Urbana, IL 61801, USA
    Int J Pharm 301:294-303. 2005
    ..Nevertheless, the relatively thin (approximately 5 microm) PCPH shells could not prevent water penetration, and the PLG cores completely eroded by 6 weeks of incubation...
  13. ncbi request reprint Precise control of PLG microsphere size provides enhanced control of drug release rate
    Cory Berkland
    Department of Chemical Engineering, University of Illinois, MC 712, Box C 3, 600 South Mathews Avenue, Urbana, IL 61801, USA
    J Control Release 82:137-47. 2002
    ..Mixing of uniform microspheres, as well as control of microsphere size distribution, may provide an improved methodology to tailor small-molecule drug-release kinetics from simple, biodegradable-polymer microparticles...
  14. ncbi request reprint PLG microsphere size controls drug release rate through several competing factors
    Cory Berkland
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
    Pharm Res 20:1055-62. 2003
    ..We have fabricated uniform rhodamine- and piroxicam-containing microspheres, 10 to 100 microm in diameter, to better understand how microsphere size controls drug release...
  15. ncbi request reprint A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery
    M Laird Forrest
    Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Bioconjug Chem 14:934-40. 2003
    ..These easily synthesized polymers are some of the most efficient polymeric vectors reported to date and provide a versatile platform for investigation of the effects of polymer structure and degradation rate on gene delivery efficiency...
  16. ncbi request reprint Partial acetylation of polyethylenimine enhances in vitro gene delivery
    M Laird Forrest
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, USA
    Pharm Res 21:365-71. 2004
    ..To investigate the effects of the protonation properties of the polymer, we generated PEI derivatives by acetylating varying fractions of the primary and secondary amines to form secondary and tertiary amides, respectively...
  17. ncbi request reprint Uniform double-walled polymer microspheres of controllable shell thickness
    Cory Berkland
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, USA
    J Control Release 96:101-11. 2004
    ....
  18. ncbi request reprint Controlling surface nano-structure using flow-limited field-injection electrostatic spraying (FFESS) of poly(D,L-lactide-co-glycolide)
    Cory Berkland
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, USA
    Biomaterials 25:5649-58. 2004
    ..FFESS technology provides a simple yet powerful technique for fabricating biomedical devices with a precisely defined nano-structure potentially capable of utilizing a broad range of biocompatible polymeric materials...
  19. ncbi request reprint Cyclodextrin-polyethylenimine conjugates for targeted in vitro gene delivery
    M Laird Forrest
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA
    Biotechnol Bioeng 89:416-23. 2005
    ..Because of the relative ease with which CD-binding moieties may be attached to various types of ligands, CD-PEI may be a generally useful material for testing novel cell-specific targeting compounds...
  20. ncbi request reprint Modeling small-molecule release from PLG microspheres: effects of polymer degradation and nonuniform drug distribution
    Chandrashekar Raman
    Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, United States
    J Control Release 103:149-58. 2005
    ..The model also incorporates the effect of nonuniform drug distribution within the microspheres, which is obtained from confocal fluorescence microscopy. The model results agree well with experiments despite using only one fit parameter...
  21. pmc HER-2-mediated endocytosis of magnetic nanospheres and the implications in cell targeting and particle magnetization
    Shy Chyi Wuang
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260
    Biomaterials 29:2270-9. 2008
    ..The combination of these cell-targeting magnetic carriers with chemotherapeutic agents will be highly advantageous for the preferential killing of cancer cells in hyperthermia treatment...

Research Grants7

  1. Design of Microparticles for Precision Drug Delivery
    Daniel Pack; Fiscal Year: 2004
    ..abstract_text> ..
  2. Precision Microparticles for Controlled Protein Delivery
    Daniel Pack; Fiscal Year: 2007
    ..Through precision particle fabrication, this project will result in novel fundamental insights into mechanisms controlling release as well as provide a method for enhanced control of release rates. ..
  3. Precision Microparticles for Controlled Protein Delivery
    Daniel Pack; Fiscal Year: 2009
    ..Through precision particle fabrication, this project will result in novel fundamental insights into mechanisms controlling release as well as provide a method for enhanced control of release rates. ..
  4. Effects of Uptake Mechanism on Polyplex Design Criteria
    Daniel W Pack; Fiscal Year: 2010
    ..This project aims to build fundamental understanding of vectors and their interaction with cells that will aid in design of the advanced vectors required to move human gene therapy from the laboratory to the clinic. ..