A I Pack

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues
    Ron C Anafi
    Division of Sleep Medicine and Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    BMC Genomics 14:362. 2013
  2. ncbi request reprint Novel method for high-throughput phenotyping of sleep in mice
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Physiol Genomics 28:232-8. 2007
  3. ncbi request reprint Advances in sleep-disordered breathing
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, 125 South 31st Street, Room 2120, Philadelphia, PA 19104 3403, USA
    Am J Respir Crit Care Med 173:7-15. 2006
  4. ncbi request reprint Routine polysomnography is not indicated in congestive heart failure. Con
    Allan I Pack
    Division of Sleep Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    J Clin Sleep Med 1:19-22. 2005
  5. pmc Impaired performance in commercial drivers: role of sleep apnea and short sleep duration
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 174:446-54. 2006
  6. ncbi request reprint Risk factors for excessive sleepiness in older adults
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, Philadelphia, PA 19104 3403, USA
    Ann Neurol 59:893-904. 2006
  7. ncbi request reprint Toward comprehensive interdisciplinary academic sleep centers
    Allan I Pack
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Sleep 30:383-4: discussion 385. 2007
  8. ncbi request reprint Should a pharmaceutical be approved for the broad indication of excessive sleepiness?
    Allan I Pack
    Division of Sleep Medicine, Department of Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia 19104, USA
    Am J Respir Crit Care Med 167:109-11. 2003
  9. ncbi request reprint Modafinil as adjunct therapy for daytime sleepiness in obstructive sleep apnea
    A I Pack
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 164:1675-81. 2001
  10. doi request reprint Obstructive sleep apnea and cardiovascular disease: a perspective and future directions
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3403, USA
    Prog Cardiovasc Dis 51:434-51. 2009

Detail Information

Publications83

  1. pmc Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues
    Ron C Anafi
    Division of Sleep Medicine and Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    BMC Genomics 14:362. 2013
    ..Using microarrays we compared gene expression in tissue from sleeping and sleep deprived mice euthanized at the same diurnal times...
  2. ncbi request reprint Novel method for high-throughput phenotyping of sleep in mice
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Physiol Genomics 28:232-8. 2007
    ..0 and -3.0 min per 2-h interval, respectively). This method has applications in chemical mutagenesis and for studies of molecular changes in brain with sleep/wakefulness...
  3. ncbi request reprint Advances in sleep-disordered breathing
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, 125 South 31st Street, Room 2120, Philadelphia, PA 19104 3403, USA
    Am J Respir Crit Care Med 173:7-15. 2006
    ..Thus, even though this field only began toward the end of the first century of the American Thoracic Society, substantial progress has been made, and OSA has increasingly emerged as a major public health concern...
  4. ncbi request reprint Routine polysomnography is not indicated in congestive heart failure. Con
    Allan I Pack
    Division of Sleep Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    J Clin Sleep Med 1:19-22. 2005
  5. pmc Impaired performance in commercial drivers: role of sleep apnea and short sleep duration
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 174:446-54. 2006
    ..5%, were similar in terms of their impact on objective sleepiness. Thus, addressing impairment in commercial drivers requires addressing both insufficient sleep and sleep apnea, the former being more common...
  6. ncbi request reprint Risk factors for excessive sleepiness in older adults
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, Philadelphia, PA 19104 3403, USA
    Ann Neurol 59:893-904. 2006
    ..To determine risk factors for excessive daytime sleepiness in older adults...
  7. ncbi request reprint Toward comprehensive interdisciplinary academic sleep centers
    Allan I Pack
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Sleep 30:383-4: discussion 385. 2007
  8. ncbi request reprint Should a pharmaceutical be approved for the broad indication of excessive sleepiness?
    Allan I Pack
    Division of Sleep Medicine, Department of Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia 19104, USA
    Am J Respir Crit Care Med 167:109-11. 2003
  9. ncbi request reprint Modafinil as adjunct therapy for daytime sleepiness in obstructive sleep apnea
    A I Pack
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 164:1675-81. 2001
    ..Modafinil may be a useful adjunct treatment for the management of residual daytime sleepiness in patients with obstructive sleep apnea/hypopnea syndrome who are regular users of nasal continuous positive airway pressure therapy...
  10. doi request reprint Obstructive sleep apnea and cardiovascular disease: a perspective and future directions
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3403, USA
    Prog Cardiovasc Dis 51:434-51. 2009
    ....
  11. doi request reprint Update on sleep and its disorders
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Annu Rev Med 62:447-60. 2011
    ..Hence, inadequate sleep is associated with development of obesity. OSA is also an independent risk factor for insulin resistance; treatment of OSA can improve insulin sensitivity...
  12. ncbi request reprint Central administration of a 5-HT2 receptor agonist and antagonist: lack of effect on rapid eye movement sleep and pgo waves
    L D Sanford
    Laboratory for the Study of the Brain in Sleep, Department of Animal Biology, The School of Veterinary Medicine, The University of Pennsylvania, Philadelphia, PA 19104, USA
    Sleep Res Online 1:80-6. 1998
    ....
  13. ncbi request reprint An instrument to measure functional status outcomes for disorders of excessive sleepiness
    T E Weaver
    School of Nursing, Philadelphia, Pennsylvania, USA
    Sleep 20:835-43. 1997
    ..Thus, the FOSQ can be used to determine how disorders of excessive sleepiness affect patients' abilities to conduct normal activities and the extent to which these abilities are improved by effective treatment of DOES...
  14. ncbi request reprint Magnetic resonance imaging of the upper airway structure of children with obstructive sleep apnea syndrome
    R Arens
    Division of Pulmonary Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Am J Respir Crit Care Med 164:698-703. 2001
    ..1 versus 2.7 +/- 1.2 cm(3); p < 0.05). We conclude that in children with moderate OSAS, the upper airway is restricted both by the adenoid and tonsils; however, the soft palate is also larger in this group, adding further restriction...
  15. pmc Molecular signatures of obstructive sleep apnea in adults: a review and perspective
    Erna S Arnardottir
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Sleep 32:447-70. 2009
    ..Such changes will be at least partly a consequence of chronic intermittent hypoxia and sleep fragmentation that occurs during sleep...
  16. ncbi request reprint Modafinil decreases hypersomnolence in the English bulldog, a natural animal model of sleep-disordered breathing
    K A Panckeri
    Veterinary Hospital, University of Pennsylvania, Philadelphia 19104, USA
    Sleep 19:626-31. 1996
    ..0 minutes to a value of 346.6 minutes with the drug). We obtained limited data on the effect of modafinil on SDB because the drug either greatly diminished or entirely eradicated REM sleep in all five dogs...
  17. pmc Changes in components of energy regulation in mouse cortex with increases in wakefulness
    Elena V Nikonova
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3403, USA
    Sleep 33:889-900. 2010
    ..We hypothesized that energy depletion could be a mechanism leading to difficulty maintaining wakefulness and assessed changes in components of the electron transport chain...
  18. ncbi request reprint Night-to-night variability in CPAP use over the first three months of treatment
    T E Weaver
    School of Nursing, University of Pennsylvania, Philadelphia 19104-6096, USA
    Sleep 20:278-83. 1997
    ..However, intermittent users continued to report significantly greater OSA symptoms (snoring, snorting, and apnea) posttreatment, suggesting that they continued to experience sleep disordered breathing...
  19. ncbi request reprint The effects of trazodone with L-tryptophan on sleep-disordered breathing in the English bulldog
    S C Veasey
    Center for Sleep and Respiratory Neurobiology, Division of Pulmonary and Critical Care, Department of Medicine, School of Medicine University of Pennsylvania, Philadelphia, USA
    Am J Respir Crit Care Med 160:1659-67. 1999
    ..02. Trazodone with L-tryptophan can treat sleep-disordered breathing (SDB) in an animal model of OSAHS; the effectiveness of this therapy may be related to increased upper airway dilator activity in sleep and/or enhanced slow-wave sleep...
  20. ncbi request reprint An algorithm to stratify sleep apnea risk in a sleep disorders clinic population
    I Gurubhagavatula
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Am J Respir Crit Care Med 164:1904-9. 2001
    ....
  21. ncbi request reprint Elicited pontogeniculooccipital waves and phasic suppression of diaphragm activity in sleep and wakefulness
    W K Hunt
    Laboratory for Study of the Brain in Sleep, Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Appl Physiol 84:2106-14. 1998
    ..Thus the majority of evidence argues against the existence of a common phasic-event generator in REM sleep...
  22. doi request reprint Analysis of the QTL for sleep homeostasis in mice: Homer1a is a likely candidate
    M MacKiewicz
    Department of Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Translational Research Laboratories, Philadelphia, PA 19104 3403, USA
    Physiol Genomics 33:91-9. 2008
    ..The strongest candidate gene is Homer1a, which is supported by expression differences between sleep and wakefulness and the SNP polymorphism in the upstream regulatory regions...
  23. ncbi request reprint Proteomic analysis of the effects and interactions of sleep deprivation and aging in mouse cerebral cortex
    Aaron C Pawlyk
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    J Neurochem 103:2301-13. 2007
    ..The identity and characteristics of these proteins relevant to sleep and aging are discussed...
  24. ncbi request reprint Genetic evidence for a role of CREB in sustained cortical arousal
    Laurel A Graves
    Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurophysiol 90:1152-9. 2003
    ....
  25. ncbi request reprint Sleep deprivation induces the unfolded protein response in mouse cerebral cortex
    Nirinjini Naidoo
    Division of Sleep Medicine Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 92:1150-7. 2005
    ..These changes are first observed after 6 h of induced wakefulness. Thus, prolonging wakefulness beyond a certain duration induces the UPR indicating a physiological limit to wakefulness...
  26. ncbi request reprint Differences in activity of cytochrome C oxidase in brain between sleep and wakefulness
    Elena V Nikonova
    Center for Sleep and Respiratory Neurobiology, School of Medicine, Hospital of the Univesity of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Sleep 28:21-7. 2005
    ....
  27. ncbi request reprint Consequences of comorbid insomnia symptoms and sleep-related breathing disorder in elderly subjects
    Nalaka S Gooneratne
    Division of Geriatric Medicine, Center for Sleep and Respiratory Neurobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Intern Med 166:1732-8. 2006
    ..The prevalence of sleep-related breathing disorder (SRBD) and insomnia symptoms increases considerably with advancing age, but little is known about their cooccurrence and their effects on daytime functioning when present together...
  28. ncbi request reprint Macromolecule biosynthesis: a key function of sleep
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3403, USA
    Physiol Genomics 31:441-57. 2007
    ..We postulate that during sleep there is a rebuilding of multiple key cellular components in preparation for subsequent wakefulness...
  29. pmc Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning
    Terri E Weaver
    Biobehavioral and Health Sciences Division, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
    Sleep 30:711-9. 2007
    ..This study, employing probit analyses and piecewise regression to estimate dose-response functions, estimated likelihoods of return to normal levels of sleepiness and daily functioning relative to nightly duration of CPAP...
  30. pmc Family aggregation of upper airway soft tissue structures in normal subjects and patients with sleep apnea
    Richard J Schwab
    Center for Sleep and Respiratory Neurobiology, 893 Maloney Building, University of Pennsylvania Medical Center, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Am J Respir Crit Care Med 173:453-63. 2006
    ..Sleep apnea is believed to be a genetic disorder. Thus, we hypothesized that anatomic risk factors for sleep apnea would demonstrate family aggregation...
  31. ncbi request reprint Age-related changes in adenosine metabolic enzymes in sleep/wake regulatory areas of the brain
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 991 Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Neurobiol Aging 27:351-60. 2006
    ..An increase in the activity of 5'-nucleotideases with age likely leads to an increase in adenosine levels in the brain...
  32. ncbi request reprint A role for the molecular chaperone protein BiP/GRP78 in Drosophila sleep homeostasis
    Nirinjini Naidoo
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sleep 30:557-65. 2007
    ..We then sought to establish a key role for BiP in the homeostatic process of sleep by contrasting recovery sleep in models of over- and under-expression of BiP...
  33. pmc A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans
    David M Raizen
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genetics 173:177-87. 2006
    ..In a genetic screen we have identified extragenic suppressors of this gain-of-function mutant. Thus, this mutant promises to be a useful tool for identifying downstream targets of PKG...
  34. ncbi request reprint Multiple mechanisms limit the duration of wakefulness in Drosophila brain
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Physiol Genomics 27:337-50. 2006
    ....
  35. ncbi request reprint Occupational screening for obstructive sleep apnea in commercial drivers
    Indira Gurubhagavatula
    Center for Sleep and Respiratory, Neurobiology Hospital of the University of Pennsylvania, 9th Floor, Maloney Building, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Am J Respir Crit Care Med 170:371-6. 2004
    ..26. On the other hand, excluding any apnea could not be done with reasonable accuracy unless oximetry was used. We conclude that two-stage screening is likely to be a viable means of excluding severe sleep apnea among commercial drivers...
  36. pmc Problems associated with short sleep: bridging the gap between laboratory and epidemiological studies
    Michael A Grandner
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, 125 S 31st Street, Philadelphia, PA 19104, USA
    Sleep Med Rev 14:239-47. 2010
    ....
  37. pmc Altered upper airway and soft tissue structures in the New Zealand Obese mouse
    Michael J Brennick
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 179:158-69. 2009
    ..The effect of obesity on upper airway soft tissue structure and size was examined in the New Zealand Obese (NZO) mouse and in a control lean mouse, the New Zealand White (NZW)...
  38. pmc The energy hypothesis of sleep revisited
    Matthew T Scharf
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Translational Research Building, Suite 2100, 125 S 31st Street, Philadelphia, PA 19104 3403, USA
    Prog Neurobiol 86:264-80. 2008
    ....
  39. doi request reprint Molecular mechanisms of sleep and wakefulness
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1129:335-49. 2008
    ..Identification of genes regulating sleep has the potential for translational studies to elucidate the genetics of sleep and response to sleep deprivation in humans...
  40. pmc Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling
    Nirinjini Naidoo
    Division of Sleep Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:6539-48. 2008
    ....
  41. ncbi request reprint The validity and feasibility of saliva melatonin assessment in the elderly
    Nalaka S Gooneratne
    Division of Geriatric Medicine, School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA
    J Pineal Res 34:88-94. 2003
    ..Saliva specimens provide an economical and practical method for melatonin assessment, however, in older adults, issues such as hyposalivation and low melatonin levels limit the feasibility and validity, respectively, of saliva melatonin...
  42. ncbi request reprint Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation
    Miroslaw Mackiewicz
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 85:348-57. 2003
    ..In contrast, we found no changes specifically with sleep deprivation in the activity of any enzyme in any brain region. Thus, changes in adenosine with sleep deprivation are not a consequence of alterations in adenosine enzyme activity...
  43. ncbi request reprint Modafinil maintains waking in the fruit fly drosophila melanogaster
    Joan C Hendricks
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA, USA
    Sleep 26:139-46. 2003
    ..We conclude that modafinil affects states of arousal in Drosophila in the same direction as it does in mammals. This discovery provides a tool for searching for conserved molecular mechanisms by which modafinil regulates rest and waking...
  44. ncbi request reprint Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging
    Richard J Schwab
    Center for Sleep and Respiratory Neurobiology, 893 Maloney Building, University of Pennsylvania Medical Center, 3600 Spruce Street, Philadelphia, PA 19104 4283, USA
    Am J Respir Crit Care Med 168:522-30. 2003
    ..66; 95% CI, 2.31-10.95); and (3) total soft tissue (OR, 6.95; 95% CI, 3.08-19.11). In a multivariable logistic regression analysis the volume of the tongue and lateral walls was shown to independently increase the risk of sleep apnea...
  45. ncbi request reprint Functional outcomes of excessive daytime sleepiness in older adults
    Nalaka S Gooneratne
    Division of Geriatric Medicine, School of Medicine, University of Pennsylvania, Philadelphia, USA
    J Am Geriatr Soc 51:642-9. 2003
    ..To describe the effect of self-reported excessive daytime sleepiness (EDS) on functional outcomes...
  46. pmc Estimated cost of crashes in commercial drivers supports screening and treatment of obstructive sleep apnea
    Indira Gurubhagavatula
    Center for Sleep and Respiratory Neurobiology, Division of Sleep Medicine, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, United States
    Accid Anal Prev 40:104-15. 2008
    ..These findings indicate that strategies that reduce reliance on in-laboratory polysomnography may be more cost-effective than not screening, and that treatment acceptance may need to be a condition of employment for affected drivers...
  47. doi request reprint Lethargus is a Caenorhabditis elegans sleep-like state
    David M Raizen
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 451:569-72. 2008
    ..The association of this C. elegans sleep-like state with developmental changes that occur with larval moults suggests that sleep may have evolved to allow for developmental changes...
  48. ncbi request reprint Self-efficacy in sleep apnea: instrument development and patient perceptions of obstructive sleep apnea risk, treatment benefit, and volition to use continuous positive airway pressure
    Terri E Weaver
    School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
    Sleep 26:727-32. 2003
    ..The purpose of this study was to evaluate the Self-Efficacy Measure for Sleep Apnea (SEMSA) designed to assess adherence-related cognitions...
  49. ncbi request reprint Glycogen in the brain of Drosophila melanogaster: diurnal rhythm and the effect of rest deprivation
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    J Neurochem 88:32-40. 2004
    ..0001 and p<0.0001, respectively). Glycogen in the fly brain changes in relationship to rest and activity and demonstrates a biphasic response to rest deprivation similar to that observed in mammalian astrocytes in culture...
  50. ncbi request reprint Changes in symptoms of sleep-disordered breathing during pregnancy
    Grace W Pien
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Sleep 28:1299-305. 2005
    ..Although incident snoring is common in pregnant women and has been proposed as a potential risk factor for adverse maternal-fetal outcomes, the development of sleep-disordered breathing during pregnancy has not been prospectively described...
  51. pmc A video method to study Drosophila sleep
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 125 South 31st St, Suite 2100, Philadelphia, PA 19104 3403, USA
    Sleep 31:1587-98. 2008
    ..To use video to determine the accuracy of the infrared beam-splitting method for measuring sleep in Drosophila and to determine the effect of time of day, sex, genotype, and age on sleep measurements...
  52. ncbi request reprint Review of regulations and guidelines for commercial and noncommercial drivers with sleep apnea and narcolepsy
    S J Pakola
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, USA
    Sleep 18:787-96. 1995
    ..These variations are not based on scientific data. Currently the impact of these regulations on crash rates or on the practice of sleep medicine has not been assessed...
  53. ncbi request reprint A survey screen for prediction of apnea
    G Maislin
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA
    Sleep 18:158-66. 1995
    ..79 (p < 0.0001). For BMI alone, it was 0.73, and for an index measuring the self-report of the frequency of apnea symptoms, it was 0.70. The multivariable apnea risk index has potential utility in clinical settings...
  54. pmc What are microarrays teaching us about sleep?
    Miroslaw Mackiewicz
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Trends Mol Med 15:79-87. 2009
    ..In human studies, microarrays are being applied to the identification of biomarkers for sleepiness and for the common debilitating condition of obstructive sleep apnea...
  55. pmc The role of obesity, different fat compartments and sleep apnea severity in circulating leptin levels: the Icelandic Sleep Apnea Cohort study
    E S Arnardottir
    Department of Respiratory Medicine and Sleep, Landspitali The National University Hospital of Iceland, Reykjavik, Iceland
    Int J Obes (Lond) 37:835-42. 2013
    ....
  56. ncbi request reprint Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit
    N S Freedman
    Penn Center for Sleep Disorders, Pulmonary, Allergy and Critical Care Division, Department of Medicine and the Center for Sleep and Respiratory Neurobiology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Am J Respir Crit Care Med 163:451-7. 2001
    ....
  57. ncbi request reprint Magnetic resonance imaging of the upper airway in children with Down syndrome
    E C Uong
    Division of Pulmonary Medicine, Children's Hospital of Philadelphia, and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4399, USA
    Am J Respir Crit Care Med 163:731-6. 2001
    ..This study shows that Down syndrome children without OSA do not have increased adenoid or tonsillar volume; reduced upper airway size is caused by soft tissue crowding within a smaller mid- and lower face skeleton...
  58. ncbi request reprint Simultaneous assessment of ecto- and cytosolic-5'-nucleotidase activities in brain micropunches
    M MacKiewicz
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 3600 Spruce Street, 991 Maloney Building, Philadelphia, PA 19104 4283, USA
    J Neurosci Methods 104:9-18. 2000
    ..The level of both enzymes was significantly lower in the cerebral cortex than other brain regions tested...
  59. pmc Changes in upper airway size during tidal breathing in children with obstructive sleep apnea syndrome
    Raanan Arens
    Division of Pulmonary Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
    Am J Respir Crit Care Med 171:1298-304. 2005
    ..3 +/- 2.3 years) and 10 matched control subjects (age, 5.0 +/- 2.0 years). We hypothesized that respiratory cycle fluctuations in upper airway cross-sectional area would be larger in children with OSAS...
  60. ncbi request reprint Genetic basis for sleep regulation and sleep disorders
    David M Raizen
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Neurol 26:467-83. 2006
    ..We anticipate such identification will increase our ability to assess risk for disease before symptom onset and by doing so will shift the focus from treatment to prevention of disease...
  61. ncbi request reprint Linear dimensions of the upper airway structure during development: assessment by magnetic resonance imaging
    Raanan Arens
    Division of Pulmonary Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania Medical Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    Am J Respir Crit Care Med 165:117-22. 2002
    ..Our data indicate that soft tissues, including tonsils and adenoid, surrounding the upper airway grow proportionally to the skeletal structures during the same time period...
  62. ncbi request reprint Upper airway size analysis by magnetic resonance imaging of children with obstructive sleep apnea syndrome
    Raanan Arens
    Division of Pulmonary Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Am J Respir Crit Care Med 167:65-70. 2003
    ....
  63. pmc Conservation of sleep: insights from non-mammalian model systems
    John E Zimmerman
    Center for Sleep and Respiratory Neurobiology, Department of Medicine, University of Pennsylvania School of Medicine, 125 South 31st Street, Philadelphia, PA 19104, USA
    Trends Neurosci 31:371-6. 2008
    ....
  64. ncbi request reprint Functional genomics of sleep
    Miroslaw Mackiewicz
    Department of Medicine, Division of Sleep Medicine, Center for Sleep and Respiratory Neurobiology, Hospital of the University of Pennsylvania, 991 Maloney Building, Philadelphia, PA 19104 4283, USA
    Respir Physiol Neurobiol 135:207-20. 2003
    ..The concepts outlined here for the functional genomics of sleep are applicable to respiration research...
  65. pmc AMP-activated protein kinase phosphorylation in brain is dependent on method of killing and tissue preparation
    Matthew T Scharf
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3403, USA
    J Neurochem 105:833-41. 2008
    ..These results demonstrate that alpha-AMPK phosphorylation is dependent on method of killing and tissue preparation and that alpha-AMPK phosphorylation can increase in a manner that does not reflect biological alterations...
  66. pmc Running-induced anxiety is dependent on increases in hippocampal neurogenesis
    J L Onksen
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Genes Brain Behav 11:529-38. 2012
    ..However, both the neurogenic and anxiogenic effects of wheel running were attenuated following hippocampal ATR deletion, suggesting that increased neurogenesis is an important mediator of exercise-induced anxiety...
  67. ncbi request reprint Interaction of serotonergic excitatory drive to hypoglossal motoneurons with carbachol-induced, REM sleep-like atonia
    L Kubin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA
    Sleep 19:187-95. 1996
    ..The study also demonstrates that other, non-serotonergic, mechanisms also contribute to the carbachol-induced suppression...
  68. ncbi request reprint Rest in Drosophila is a sleep-like state
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 25:129-38. 2000
    ..Finally, normal homeostatic regulation depends on the timeless but not the period central clock gene. Understanding the molecular features of Drosophila rest should shed new light on the mechanisms and function of sleep...
  69. ncbi request reprint Activity of adenosine deaminase in the sleep regulatory areas of the rat CNS
    M MacKiewicz
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Brain Res Mol Brain Res 80:252-5. 2000
    ..We postulate that adenosine deaminase plays an important role in the mechanism that controls regional concentration of adenosine in the brain and thus, it is a part of the sleep-wake regulatory mechanism...
  70. doi request reprint Identification of craniofacial risk factors for obstructive sleep apnoea using three-dimensional MRI
    L Chi
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 3624 Market Street, Suite 205, Philadelphia, PA 19104, USA
    Eur Respir J 38:348-58. 2011
    ..Enlargement of tongue is likely to be the pathogenic factor for inferior-posterior positioning of hyoid. A small and shallow mandible is an independent risk factor for OSA in males but not in females...
  71. pmc Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning
    Laurel A Graves
    Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Learn Mem 10:168-76. 2003
    ....
  72. ncbi request reprint Sleepiness and relationships in obstructive sleep apnea
    Judith L Reishtein
    School of Nursing, and Division of Sleep Medicine and Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6096, USA
    Issues Ment Health Nurs 27:319-30. 2006
    ..Intrapersonal themes included embarrassment and poor mood. This report adds specific details to previous reports of impaired relationships in OSA, and stresses the importance of assessing this critical area...
  73. pmc Exploring human/animal intersections: converging lines of evidence in comparative models of aging
    John Q Trojanowski
    School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Alzheimers Dement 4:1-5. 2008
    ..Instead, an optimal translational research model supports a bidirectional flow of information from animal models to clinical research...
  74. ncbi request reprint Pediatric parasomnias
    Thornton B A Mason
    Division of Neurology, Wood Center 6th Floor, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Sleep 30:141-51. 2007
    ..The further study of parasomnias in children may help elucidate the multi-factorial etiologies of these fascinating conditions, shedding light on the potential genetic bases as well as environmental contributions...
  75. doi request reprint Health literacy and sleep disorders: a review
    Janel E Hackney
    Department of Public Health, Health Care Center 4, 4400 Haverford Avenue, Philadelphia, PA 19104, USA
    Sleep Med Rev 12:143-51. 2008
    ..Further research needs to be done to investigate the prevalence and impact of low health literacy in patients with sleep disorders...
  76. ncbi request reprint Brain glycogen decreases with increased periods of wakefulness: implications for homeostatic drive to sleep
    Jiming Kong
    Department of Pharmacology, Division of Neurovirology, St Boniface Hospital Research Centre, University of Manitoba Faculty of Medicine, Winnipeg, Manitoba, R2H 2A6, Canada
    J Neurosci 22:5581-7. 2002
    ..The observed decreases in levels of brain glycogen may be a consequence of increased wakefulness and/or a component integral to the homeostatic drive to sleep...
  77. ncbi request reprint Claustrophobia and adherence to CPAP treatment
    Eileen R Chasens
    School of Nursing, University of Pittsburgh, USA
    West J Nurs Res 27:307-21. 2005
    ..Identification of persons with increased claustrophobia tendencies and targeted interventions may increase adherence...
  78. ncbi request reprint How much do crashes related to obstructive sleep apnea cost?
    Allan I Pack
    Sleep 27:369-70. 2004
  79. ncbi request reprint Identification of coding polymorphisms in human circadian rhythm genes PER1, PER2, PER3, CLOCK, ARNTL, CRY1, CRY2 and TIMELESS in a multi-ethnic screening panel
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    DNA Seq 19:44-9. 2008
    ..In this study, the exonic regions of the circadian rhythm genes PER1, PER2, PER3, CLOCK, ARNTL, CRY1, CRY2 and TIMELESS were re-sequenced and coding changes identified in a panel of 95 individuals varying in ethnicity...
  80. ncbi request reprint Rising to meet an unmet public health need: sleep medicine and the pulmonary community
    Susan Redline
    Am J Respir Crit Care Med 174:487-8. 2006
  81. ncbi request reprint Linkage to apnea-hypopnea index across the life-span: is this a viable strategy?
    Allan I Pack
    Am J Respir Crit Care Med 170:1260; author reply 1260-1. 2004
  82. ncbi request reprint The pipeline of investigators for sleep research--a crisis!
    Allan I Pack
    Sleep 29:1260-1. 2006
  83. ncbi request reprint Sleep-disordered breathing: access is the issue
    Allan I Pack
    Am J Respir Crit Care Med 169:666-7. 2004

Research Grants25

  1. THE MECHANISMS OF ALTERATIONS IN SLEEP WITH AGE
    Allan Pack; Fiscal Year: 2007
    ..These studies have the potential to open up new avenues for treatment of sleep disruption in older adults. ..
  2. Training Program in Sleep and Respiratory Neurobiology
    Allan Pack; Fiscal Year: 2007
    ..The training program includes structures to help with grant writing and provides career counseling. There is an active minority recruitment program with minority investigators collaborating with the Program Director in this effort. ..
  3. TRAINING IN SLEEP AND SLEEP DISORDERS
    Allan Pack; Fiscal Year: 2007
    ..All of these components of the program will utilize the extensive resources for research that have been developed by the Center for Sleep and Respiratory Neurobiology at the University of Pennsylvania. (END OF ABSTRACT) ..
  4. Family Linkage Study of Obstructive Sleep Apnea
    Allan Pack; Fiscal Year: 2007
    ..abstract_text> ..
  5. Career Development for Genomic/Genetic Studies in Lung Diseases
    Allan Pack; Fiscal Year: 2007
    ..The program is designed to be state of the art and to train the diverse scientific workforce that is required for the interdisciplinary teams of the future. (End of Abstract) ..
  6. CASE CONTROL STUDY OF INSOMNIA IN NONDEPRESSED ELDERLY
    Allan Pack; Fiscal Year: 2001
    ....
  7. TREATMENT OF SLEEP APNEA IN THE ELDERLY
    Allan Pack; Fiscal Year: 2003
    ..These data will give novel definitive information both about identification and treatment of sleep apnea in the elderly. ..
  8. MICROARRAY EXPRESSION PROFILING OF RODENT MODELS OF HUMA
    Allan Pack; Fiscal Year: 2003
    ..abstract_text> ..