H S Oz

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Application of prodrugs to inflammatory diseases of the gut
    Helieh S Oz
    Center for Oral Health Research, College of Dentistry and Department of Internal Medicine, University of Kentucky, Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Molecules 13:452-74. 2008
  2. pmc Animal models for periodontal disease
    Helieh S Oz
    Center for Oral Health Research, College of Dentistry, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Biomed Biotechnol 2011:754857. 2011
  3. pmc Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model
    Helieh S Oz
    Center for the Oral Health Research and Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Transl Res 150:122-9. 2007
  4. pmc Methionine deficiency and hepatic injury in a dietary steatohepatitis model
    Helieh S Oz
    Center for the Oral Health Research, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Dig Dis Sci 53:767-76. 2008
  5. doi request reprint Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity
    Helieh S Oz
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Dig Dis Sci 53:2980-8. 2008
  6. pmc Pattern recognition scavenger receptors, SR-A and CD36, have an additive role in the development of colitis in mice
    Helieh S Oz
    Center for Oral Health Research, College of Dentistry, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Dig Dis Sci 54:2561-7. 2009
  7. pmc Nutrition intervention: a strategy against systemic inflammatory syndrome
    Helieh S Oz
    Center for Oral Health Research, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    JPEN J Parenter Enteral Nutr 33:380-9. 2009
  8. pmc A novel murine model for chronic inflammatory alveolar bone loss
    H S Oz
    Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40536, USA
    J Periodontal Res 45:94-9. 2010
  9. doi request reprint A model for chronic mucosal inflammation in IBD and periodontitis
    Helieh S Oz
    MN310 Center for Oral Health Research, College of Dentistry and Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Dig Dis Sci 55:2194-202. 2010
  10. ncbi request reprint The macrophage pattern recognition scavenger receptors SR-A and CD36 protect against microbial induced pregnancy loss
    Helieh S Oz
    Center for Oral Health Research, MN310 College of Dentistry and Internal Medicine, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Inflamm Res 60:93-7. 2011

Research Grants

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Application of prodrugs to inflammatory diseases of the gut
    Helieh S Oz
    Center for Oral Health Research, College of Dentistry and Department of Internal Medicine, University of Kentucky, Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Molecules 13:452-74. 2008
    ..This review describes the progress in digestive tract prodrug design and delivery in light of gut metabolic activities...
  2. pmc Animal models for periodontal disease
    Helieh S Oz
    Center for Oral Health Research, College of Dentistry, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Biomed Biotechnol 2011:754857. 2011
    ..A practical and highly reproducible model that truly mimics the natural pathogenesis of human periodontal disease has yet to be developed...
  3. pmc Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model
    Helieh S Oz
    Center for the Oral Health Research and Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Transl Res 150:122-9. 2007
    ..These abnormalities were attenuated in prodrug-treated mice. In conclusion, these data strongly support the novel action of the PTCA against colitis, which further supports a possible therapeutic application for IBD patients...
  4. pmc Methionine deficiency and hepatic injury in a dietary steatohepatitis model
    Helieh S Oz
    Center for the Oral Health Research, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Dig Dis Sci 53:767-76. 2008
    ..These data support a pivotal role for methionine in the pathogenesis of the dietary model of Meth-choline-deficient (MCD) steatohepatitis (NASH)...
  5. doi request reprint Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity
    Helieh S Oz
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Dig Dis Sci 53:2980-8. 2008
    ..05) and the depletion of rGSH (P < 0.05). In conclusion, GrTP supplementation attenuated hepatotoxicity by normalizing Cox-2 and Bcl-2 activation, suggesting a potential use for GrTP in treatng APAP toxicity...
  6. pmc Pattern recognition scavenger receptors, SR-A and CD36, have an additive role in the development of colitis in mice
    Helieh S Oz
    Center for Oral Health Research, College of Dentistry, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Dig Dis Sci 54:2561-7. 2009
    ....
  7. pmc Nutrition intervention: a strategy against systemic inflammatory syndrome
    Helieh S Oz
    Center for Oral Health Research, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    JPEN J Parenter Enteral Nutr 33:380-9. 2009
    ....
  8. pmc A novel murine model for chronic inflammatory alveolar bone loss
    H S Oz
    Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY 40536, USA
    J Periodontal Res 45:94-9. 2010
    ..Alveolar bone loss was assessed on the defleshed skull using morphometric measures for area of bone resorption...
  9. doi request reprint A model for chronic mucosal inflammation in IBD and periodontitis
    Helieh S Oz
    MN310 Center for Oral Health Research, College of Dentistry and Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Dig Dis Sci 55:2194-202. 2010
    ..We hypothesized that mucosal injury after "oral delivery" of dextran sulfate sodium (DSS) or TNBS for an extended period of 18 weeks is reflected by chronic inflammatory responses in a time-dependent fashion...
  10. ncbi request reprint The macrophage pattern recognition scavenger receptors SR-A and CD36 protect against microbial induced pregnancy loss
    Helieh S Oz
    Center for Oral Health Research, MN310 College of Dentistry and Internal Medicine, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Inflamm Res 60:93-7. 2011
    ..We hypothesized that bacterial penetration of the maternal mucosal surfaces and replication in embryonic fluids compromise the fetal status and can result in miscarriage...
  11. pmc Glutathione-enhancing agents protect against steatohepatitis in a dietary model
    Helieh S Oz
    Department of Internal Medicine, Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Biochem Mol Toxicol 20:39-47. 2006
    ..Rats fed (ad libitum) amino acid based methionine-choline deficient (MCD) diet were further gavaged with (1) vehicle (MCD), (2) S-adenosylmethionine (SAMe), or (3) 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid (PTCA)...
  12. ncbi request reprint Antioxidants as novel therapy in a murine model of colitis
    Helieh S Oz
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Nutr Biochem 16:297-304. 2005
    ..In conclusion, three structurally dissimilar antioxidants provided protection against DSS-induced colitis in this murine model, supporting a possible role for antioxidant therapy in IBD patients...
  13. ncbi request reprint Metallothionein overexpression does not protect against inflammatory bowel disease in a murine colitis model
    Helieh S Oz
    Department of Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Med Sci Monit 11:BR69-73. 2005
    ..We evaluated whether modulation of metallothionein (MT, and subsequent oxidative stress) would influence the development and progression of colitis...
  14. ncbi request reprint Diverse antioxidants protect against acetaminophen hepatotoxicity
    Helieh S Oz
    Department of Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Biochem Mol Toxicol 18:361-8. 2004
    ..This is the first report that GrTP and oral administration of PTCA and SAMe can provide protection against APAP injury in this model...
  15. ncbi request reprint Green tea polyphenol extract attenuates inflammation in interleukin-2-deficient mice, a model of autoimmunity
    G W Varilek
    Graduate Program in Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA
    J Nutr 131:2034-9. 2001
    ..These results show that GrTP attenuated inflammation in IL-2(-/-) mice and suggest a role for GrTP in treating chronic inflammatory diseases such as inflammatory bowel disease...
  16. ncbi request reprint Efficacy of a transforming growth factor beta 2 containing nutritional support formula in a murine model of inflammatory bowel disease
    Helieh S Oz
    Department of Medicine, Section of Gastroenterology Nutrition, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Am Coll Nutr 23:220-6. 2004
    ..The objective of this study was to determine whether a diet containing TGF-beta 2 modulates intestinal injury and immune responses in an Interleukin-10 knockout (IL-10-/-) mouse model of IBD...
  17. ncbi request reprint Effect of CD40 ligand and other immunomodulators on Pneumocystis carinii infection in rat model
    H S Oz
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Microb Pathog 29:187-90. 2000
    ..carinii infection. In contrast, daily administration of FLT3L, IL-15 or G-CSF provided no protection against P. carinii infection...
  18. ncbi request reprint Osteopontin deficiency protects mice from Dextran sodium sulfate-induced colitis
    Jian Zhong
    Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY 40536 0084, USA
    Inflamm Bowel Dis 12:790-6. 2006
    ..From this evidence, we investigated in the present study whether OPN deficiency protects mice against dextran sodium sulfate (DSS)-induced colitis...
  19. ncbi request reprint The leptin defense against wasting is abolished in the IL-2-deficient mouse model of inflammatory bowel disease
    Lisa M Gaetke
    Department of Nutrition and Food Science, University of Kentucky, Lexington, KY 40506, USA
    J Nutr 132:893-6. 2002
    ..These data show abnormal leptin responses in IL-2(-/-) mice with increased leptin concentrations disproportionate to fat mass and prevention of the normal decline in leptin with food restriction...
  20. ncbi request reprint Anti-TNF-alpha antibody normalizes serum leptin in IL-2 deficient mice
    Lisa M Gaetke
    Department of Nutrition and Food Science, University of Kentucky, and the Lexington Veterans Administration Medical Center, Lexington 40506 0054, USA
    J Am Coll Nutr 22:415-20. 2003
    ..The objective of this study was to examine whether increased tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine, contributes to the abnormally elevated leptin in IL-2(-/-) mice...
  21. ncbi request reprint The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6
    F Yang
    Graduate Program in Nutritional Sciences, University of Kentucky and Veterans Administration Medical Center, Lexington, Kentucky, USA
    Mol Pharmacol 60:528-33. 2001
    ..In conclusion, EGCG is an effective inhibitor of IKK activity. This may explain, at least in part, some of the reported anti-inflammatory and anticancer effects of green tea...
  22. ncbi request reprint A rat model for combined Trypanosoma cruzi and Pneumocystis carinii infection
    H S Oz
    Department of Internal Medicine, MN 649, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Microb Pathog 29:363-5. 2000
    ..In addition, T. cruzi infection independently does not provoke P. carinii pneumonia in this model. Finally, patients with Chagas' disease treated with corticosteroids may be at risk for PCP and should be considered for chemoprophylaxis...
  23. ncbi request reprint Search for Pneumocystis carinii DNA in upper and lower respiratory tract of humans
    H S Oz
    Department of Internal Medicine, University of Kentucky Medical Center, 40536, Lexington, KY, USA
    Diagn Microbiol Infect Dis 37:161-4. 2000
    ..All patients with PCP, and none without PCP, had P. carinii DNA in BAL, sputum or both. The study indicates the prevalence of P. carinii DNA is low or absent in oropharyngeal secretions in the absence of PCP...
  24. ncbi request reprint Effects of immunomodulators on acute Trypanosoma Cruzi infection in mice
    Helieh S Oz
    Department of Medicine, Division of GI Hepatology, University of Louisville, Louisville, KY 40202, USA
    Med Sci Monit 8:BR208-11. 2002
    ..In this study, effects of immunomodulators with diverse properties were examined on the course of an acute and lethal Trypanosoma cruzi infection...

Research Grants1

  1. Green Tea Polyphenols: A Novel Approach to IBD
    HELIEH OZ; Fiscal Year: 2004
    ..abstract_text> ..