Gary Owens

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation
    Yueting Shang
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 181:461-73. 2008
  2. pmc Detection of histone modifications at specific gene loci in single cells in histological sections
    Delphine Gomez
    Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Nat Methods 10:171-7. 2013
  3. pmc Xenotropic MLV envelope proteins induce tumor cells to secrete factors that promote the formation of immature blood vessels
    Meera Murgai
    Robert M, Berne Cardiovascular Research Center, University of Virginia, School of Medicine Charlottesville, Charlottesville, VA 22908, USA
    Retrovirology 10:34. 2013
  4. pmc Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C repressor element in the SM22α promoter mediates transcriptional silencing during SMC phenotypic switching in vivo
    Morgan Salmon
    University of Virginia, School of Medicine, Robert M Berne Cardiovascular Research Center, PO Box 801394, Charlottesville, VA 22908 1394, USA
    Circ Res 111:685-96. 2012
  5. ncbi request reprint Molecular regulation of vascular smooth muscle cell differentiation in development and disease
    Gary K Owens
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia School of Medicine, 415 Lane Rd, Medical Research Building 5, Rm 1220, PO Box 801394, Charlottesville, VA 22908, USA
    Physiol Rev 84:767-801. 2004
  6. ncbi request reprint Combinatorial control of smooth muscle-specific gene expression
    Meena S Kumar
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Rd, MR5 Room 1220, PO Box 801394, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 23:737-47. 2003
  7. ncbi request reprint Forced expression of myocardin is not sufficient for induction of smooth muscle differentiation in multipotential embryonic cells
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, MR5 Room 1220, 415 Lane Road, PO Box 801394, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 24:1596-601. 2004
  8. ncbi request reprint Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins
    Meena S Kumar
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Rd, MR5 Room 1220, PO Box 801394, Charlottesville, VA 22908, USA
    Circ Res 92:840-7. 2003
  9. pmc PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins
    Keiko Kawai-Kowase
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Road, MR5, Room 1220, P O Box 801394, Charlottesville, VA 22908, USA
    Mol Cell Biol 25:8009-23. 2005
  10. ncbi request reprint Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression
    Yan Liu
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 280:9719-27. 2005

Collaborators

Detail Information

Publications50

  1. pmc Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation
    Yueting Shang
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 181:461-73. 2008
    ..Our results demonstrate that Pitx2 functions to regulate the early stages of SMC differentiation...
  2. pmc Detection of histone modifications at specific gene loci in single cells in histological sections
    Delphine Gomez
    Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Nat Methods 10:171-7. 2013
    ..This methodology has promise for broad applications in the study of epigenetic mechanisms in complex multicellular tissues in development and disease...
  3. pmc Xenotropic MLV envelope proteins induce tumor cells to secrete factors that promote the formation of immature blood vessels
    Meera Murgai
    Robert M, Berne Cardiovascular Research Center, University of Virginia, School of Medicine Charlottesville, Charlottesville, VA 22908, USA
    Retrovirology 10:34. 2013
    ..There is also no direct evidence that XMRV infection has any functional effects that contribute to tumor pathogenesis...
  4. pmc Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C repressor element in the SM22α promoter mediates transcriptional silencing during SMC phenotypic switching in vivo
    Morgan Salmon
    University of Virginia, School of Medicine, Robert M Berne Cardiovascular Research Center, PO Box 801394, Charlottesville, VA 22908 1394, USA
    Circ Res 111:685-96. 2012
    ..However, the mechanisms regulating the activity of the G/C Repressor are unknown, although we have previously shown that phenotypic switching of cultured SMC is dependent on Krupple-like factor (KLF)4...
  5. ncbi request reprint Molecular regulation of vascular smooth muscle cell differentiation in development and disease
    Gary K Owens
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia School of Medicine, 415 Lane Rd, Medical Research Building 5, Rm 1220, PO Box 801394, Charlottesville, VA 22908, USA
    Physiol Rev 84:767-801. 2004
    ..The goal of this review is to summarize the current state of our knowledge in this area and to attempt to identify some of the key unresolved challenges and questions that require further study...
  6. ncbi request reprint Combinatorial control of smooth muscle-specific gene expression
    Meena S Kumar
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Rd, MR5 Room 1220, PO Box 801394, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 23:737-47. 2003
    ..Finally, we discuss the implications of chromatin remodeling on SMC differentiation...
  7. ncbi request reprint Forced expression of myocardin is not sufficient for induction of smooth muscle differentiation in multipotential embryonic cells
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, MR5 Room 1220, 415 Lane Road, PO Box 801394, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 24:1596-601. 2004
    ..The aim of the present study was to determine whether myocardin alone is sufficient to induce SMC lineage in multipotential stem cells as evidenced by activation of the entire SMC differentiation program...
  8. ncbi request reprint Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins
    Meena S Kumar
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Rd, MR5 Room 1220, PO Box 801394, Charlottesville, VA 22908, USA
    Circ Res 92:840-7. 2003
    ....
  9. pmc PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins
    Keiko Kawai-Kowase
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Road, MR5, Room 1220, P O Box 801394, Charlottesville, VA 22908, USA
    Mol Cell Biol 25:8009-23. 2005
    ..These results provide novel evidence that PIAS1 modulates transcriptional activation of SMC marker genes through cooperative interactions with both SRF and class I bHLH proteins...
  10. ncbi request reprint Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression
    Yan Liu
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 280:9719-27. 2005
    ....
  11. pmc PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns
    James A Thomas
    Department of Molecular Physiology and Biological Physics, Univeresity of Virginia, Charlottesville, VA, USA
    Am J Physiol Heart Circ Physiol 296:H442-52. 2009
    ..These findings demonstrate a novel activity for PDGF-DD in SMC biology and highlight the potential contribution of this molecule to SMC phenotypic modulation in the setting of disturbed blood flow...
  12. pmc Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration
    Olga A Cherepanova
    Department of Molecular Physiology and Biological Physics, University of Virginia, Robert M Berne Cardiovascular Research Center, Charlottesville, VA 22908, USA
    Circ Res 104:609-18. 2009
    ....
  13. ncbi request reprint Platelet-derived growth factor-BB represses smooth muscle cell marker genes via changes in binding of MKL factors and histone deacetylases to their promoters
    Tadashi Yoshida
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia, MR5 Rm 1220, 415 Lane Road, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 292:C886-95. 2007
    ....
  14. ncbi request reprint Transforming growth factor-beta1 signaling contributes to development of smooth muscle cells from embryonic stem cells
    Sanjay Sinha
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia, 415 Lane Rd, MR5, Rm 1220, PO Box 801394, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 287:C1560-8. 2004
    ..These results are the first to provide direct evidence that TGF-beta1 signaling through Smad2 and Smad3 plays an important role in the development of SMCs from totipotential ESCs...
  15. pmc Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo
    Oliver G McDonald
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Invest 116:36-48. 2006
    ..Taken together, these findings provide novel evidence that SMC-selective epigenetic control of SRF binding to chromatin plays a key role in regulation of SMC gene expression in response to pathophysiological stimuli in vivo...
  16. ncbi request reprint Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression
    Qiong Gan
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Circ Res 101:883-92. 2007
    ..Results also indicate that the MCAT element-mutated SM alpha-actin promoter-enhancer is a useful tool to direct gene expression selectively in differentiated SMCs...
  17. ncbi request reprint Programming smooth muscle plasticity with chromatin dynamics
    Oliver G McDonald
    Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, VA 22903, USA
    Circ Res 100:1428-41. 2007
    ....
  18. pmc Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle
    Rebecca A Deaton
    Department of Molecular Physiology and Biophysics, Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA
    Am J Physiol Heart Circ Physiol 296:H1027-37. 2009
    ..Taken together, the results suggest a novel role for Sp1 in increasing the expression of KLF4 in phenotypically modulated SMCs...
  19. ncbi request reprint Myocardin and Prx1 contribute to angiotensin II-induced expression of smooth muscle alpha-actin
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Circ Res 94:1075-82. 2004
    ..Taken together, these results support a model in which Ang II-induced increases in expression of SM alpha-actin are mediated through Prx1-dependent increases in SRF binding to CArG elements and subsequent recruitment of myocardin...
  20. ncbi request reprint Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908 0736, USA
    Circ Res 92:856-64. 2003
    ..Taken together, results provide compelling evidence that myocardin plays a key role as a transcriptional coactivator of SMC marker genes through CArG-dependent mechanisms...
  21. ncbi request reprint Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes
    Frederic Dandre
    Cardiovascular Research Center, University of Virginia, PO Box 801394, Charlottesville, VA 22908 1394, USA
    Am J Physiol Heart Circ Physiol 286:H2042-51. 2004
    ..Taken together, results of these experiments provide novel insights regarding possible mechanisms whereby PDGF-BB and Ets-1 may contribute to SMC phenotypic switching associated with vascular injury...
  22. pmc 5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo
    Jennifer A Hendrix
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 115:418-27. 2005
    ....
  23. pmc Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids
    Tadashi Yoshida
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia, MR5 Room 1226, 415 Lane Road, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 295:C1175-82. 2008
    ..Coimmunoprecipitation assays showed that Klf4 interacted with HDAC5. Results provide evidence that Klf4, Elk-1, and HDACs coordinately mediate POVPC-induced suppression of SMC differentiation marker genes...
  24. pmc The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies
    Li Jin
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 284:2121-30. 2009
    ..All together, these results suggest that Palladin is essential for expression of the full complement of contractile proteins necessary for optimal force development of SMCs derived from EBs...
  25. pmc Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Rd, Charlottesville, VA 22908, USA
    Circ Res 102:1548-57. 2008
    ..Taken together, we have demonstrated that Klf4 plays a critical role in regulating expression of SMC differentiation markers and proliferation of SMCs in vivo in response to vascular injury...
  26. pmc Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype
    Brian R Wamhoff
    Department of Medicine, Cardiovascular Division, University of Virginia, Charlottesville, VA 22901, USA
    Arterioscler Thromb Vasc Biol 28:1454-61. 2008
    ..The role of sphingosine-1-phosphate (S1P) receptors in acute vascular injury and smooth muscle cell (SMC) phenotypic modulation is not completely resolved...
  27. pmc Smooth muscle phenotypic modulation is an early event in aortic aneurysms
    Gorav Ailawadi
    Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 138:1392-9. 2009
    ..However, little is known of the role of smooth muscle cells in aortic aneurysms. We hypothesized that smooth muscle cells undergo phenotypic modulation early in the development of aortic aneurysms...
  28. ncbi request reprint Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells
    Keiko Kawai-Kowase
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Road, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 292:C59-69. 2007
    ....
  29. ncbi request reprint ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse development
    Demetra Perlegas
    Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 801394, Charlottesville, VA 22908 1394, USA
    Am J Physiol Heart Circ Physiol 288:H96-102. 2005
    ..Taken together, results indicate that functional AT(2)R are expressed in fetal aorta and mediate reduced force development but do not significantly contribute to regulation of SMC differentiation...
  30. ncbi request reprint Smooth muscle-targeted knockout of connexin43 enhances neointimal formation in response to vascular injury
    Yongbo Liao
    Department of Anesthesiology, University of Virginia, Charlottesville, VA, USA
    Arterioscler Thromb Vasc Biol 27:1037-42. 2007
    ..We hypothesized that connexins might play a role in the smooth muscle cell response to vascular injury...
  31. ncbi request reprint Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor
    C Huie Lin
    Department of Molecular Physiology and Biological Physics, University of Virginia, Box 800736, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 292:C1617-24. 2007
    ..e., recruitment of SL1. Moreover, studies provide critical new data regarding multiple additional UBF phosphorylation sites that will require further characterization by the field...
  32. pmc Lost in transdifferentiation
    Mark H Hoofnagle
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 113:1249-51. 2004
    ..cells with preexisting SMCs, a possibility raised by results of studies of adult stem cells in animal models of liver regeneration ? Or could this be bona fide transdifferentiation that recapitulates the pathologic processes in humans?..
  33. pmc Bone marrow-derived cell-specific chemokine (C-C motif) receptor-2 expression is required for arteriolar remodeling
    Meghan M Nickerson
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 29:1794-801. 2009
    ....
  34. ncbi request reprint A transforming growth factor-beta control element required for SM alpha-actin expression in vivo also partially mediates GKLF-dependent transcriptional repression
    Yan Liu
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:48004-11. 2003
    ....
  35. pmc Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 285:21175-84. 2010
    ..In vivo chromatin immunoprecipitation assays on the heart revealed that Klf4 bound to the promoter region of the Gata4 gene. Results provide novel evidence that Klf4 plays a key role in late fetal and/or postnatal cardiac development...
  36. ncbi request reprint Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity
    Gary K Owens
    Department of Molecular Physiology and Bological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Novartis Found Symp 283:174-91; discussion 191-3, 238-41. 2007
    ..We postulate that the latter epigenetic changes may provide a mechanism for 'cell lineage memory' during reversible phenotypic switching of vascular SMCs...
  37. ncbi request reprint Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells
    Sanjay Sinha
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, 22908 0736, USA
    Stem Cells 24:1678-88. 2006
    ....
  38. ncbi request reprint Mobilization of bone marrow-derived cells enhances the angiogenic response to hypoxia without transdifferentiation into endothelial cells
    Thomas J O'Neill
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908 0736, USA
    Circ Res 97:1027-35. 2005
    ..The results of this study suggest a potentially beneficial action of BMCs during hypoxia through paracrine release of growth factors but not transdifferentiation into ECs...
  39. ncbi request reprint Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro
    Nataliya A Pidkovka
    University of Virginia, Cardiovascular Research Center, Department of Molecular Physiology and Biophysics, 415 Lane Road, Charlottesville, VA 22908, USA
    Circ Res 101:792-801. 2007
    ..These results may have important novel implications for the mechanisms by which oxPLs contribute to the pathogenesis of atherosclerosis...
  40. ncbi request reprint Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells
    Qiong Gan
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    Stem Cells 25:2-9. 2007
    ..Finally, we consider how these rapid histone modification exchanges become progressively more stable as ESCs undergo differentiation and maturation into specialized cell lineages...
  41. pmc Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes
    Mark H Hoofnagle
    Department of Molecular Physiology and Biological Physic, University of Virginia, Charlottesville, Virginia, USA
    Am J Physiol Heart Circ Physiol 300:H1707-21. 2011
    ....
  42. ncbi request reprint Molecular determinants of vascular smooth muscle cell diversity
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908, USA
    Circ Res 96:280-91. 2005
    ....
  43. ncbi request reprint Origin of neointimal smooth muscle: we've come full circle
    Mark H Hoofnagle
    Arterioscler Thromb Vasc Biol 26:2579-81. 2006
  44. pmc PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells
    Christopher A Davis
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    Mol Cell Biol 26:2626-36. 2006
    ..We conclude that PRISM acts as a novel epigenetic regulator of SMC phenotypic plasticity by suppressing differentiation and maintaining the proliferative potential of vascular SMCs...
  45. pmc Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element
    James J Tomasek
    Department of Cell Biology, BMSB 553, The University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, Oklahoma 73104, USA
    Am J Pathol 166:1343-51. 2005
    ..Taken together, these results provide the first in vivo evidence for the importance of the intronic CArG and TCE cis-elements in the regulation of alpha-SMA expression in myofibroblasts in granulation tissue...
  46. ncbi request reprint Excitation-transcription coupling in arterial smooth muscle
    Brian R Wamhoff
    Biomedical Sciences, Veterinary School of Medicine, University of Missouri, Columbia, MO, USA
    Circ Res 98:868-78. 2006
    ..In addition, we discuss the potential role of IK channels and TRPC in ET-coupling as potential mediators of SMC phenotypic modulation, ie, negatively regulate SMC differentiation marker genes, in vascular disease...
  47. pmc Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice
    William G C Horsnell
    Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    PLoS Pathog 3:e1. 2007
    ..brasiliensis expulsion by coordinating T helper 2 cytokine responses, goblet hyperplasia, and acetylcholine responsiveness, which drive smooth muscle cell contractions...
  48. ncbi request reprint Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression
    G C Teg Pipes
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Dev Biol 288:502-13. 2005
    ....
  49. ncbi request reprint Vascular hypertrophy in angiotensin II-induced hypertension is mediated by vascular smooth muscle cell-derived H2O2
    Yong Zhang
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 46:732-7. 2005
    ..4+/-2.0 versus 43.2+/-7.6 microm; P<0.001). These results demonstrate that vascular SMC-derived hydrogen peroxide plays an important role in angiotensin II-induced hypertrophy of the arterial wall...
  50. pmc Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation
    Kevin L Du
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 23:2425-37. 2003
    ..Taken together, these data demonstrate that myocardin plays an important role in the SRF-dependent transcriptional program that regulates SMC development and differentiation...

Research Grants42

  1. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary K Owens; Fiscal Year: 2010
    ....
  2. Derivation of Smooth Muscle Lineages from Stem Cells
    Gary Owens; Fiscal Year: 2004
    ....
  3. SHORT-TERM TRAINING FOR MINORITY STUDENTS
    Gary Owens; Fiscal Year: 2006
    ..Reviews of the program by past participants have been outstanding and have contributed significantly to the continued interest in our program...
  4. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary Owens; Fiscal Year: 2007
    ....
  5. Short-Term Training to Increase Diversity in Health-Related Research
    Gary Owens; Fiscal Year: 2007
    ..Reviews of the program by past participants have been outstanding and have contributed significantly to the continued interest in our program. ..
  6. MEDICAL SCIENTIST TRAINING PROGRAM
    Gary Owens; Fiscal Year: 2007
    ....
  7. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary Owens; Fiscal Year: 2009
    ....
  8. KLF4-Dependent Regulation of SMC Differentiation and Phenotypic Switching
    Gary K Owens; Fiscal Year: 2010
    ..Studies in this proposal will provide novel insights into mechanisms that control SMC differentiation in development and disease and may lead to new and more effective therapies. ..
  9. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary Owens; Fiscal Year: 2003
    ..abstract_text> ..
  10. KLF4-Dependent Regulation of SMC Differentiation and Phenotypic Switching
    Gary K Owens; Fiscal Year: 2011
    ..Studies in this proposal will provide novel insights into mechanisms that control SMC differentiation in development and disease and may lead to new and more effective therapies. ..
  11. GROWTH AND DIFFERENTIATION OF VASCULAR SMOOTH MUSCLE
    Gary Owens; Fiscal Year: 1992
    ....
  12. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary Owens; Fiscal Year: 2001
    ..abstract_text> ..
  13. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary Owens; Fiscal Year: 2002
    ..abstract_text> ..
  14. Role of Oxidized Phospholipids in Phenotypic Switching of Smooth Muscle Cells (SM
    Gary Owens; Fiscal Year: 2009
    ....
  15. Epigenetic Control of Smooth Muscle Cell Lineage and Phenotypic Switching
    Gary Owens; Fiscal Year: 2009
    ..Studies will define fundamental mechanisms that control differentiation of SMC, and are likely to lead to novel therapies for treatment of diseases in which SMC phenotypic switching plays a major role. ..
  16. GROWTH AND DIFFERENTIATION OF VASCULAR SMOOTH MUSCLE
    Gary Owens; Fiscal Year: 1991
    ....
  17. Role of Oxidized Phospholipids in Phenotypic Switching of Smooth Muscle Cells (SM
    Gary K Owens; Fiscal Year: 2010
    ....
  18. Epigenetic Control of Smooth Muscle Cell Lineage and Phenotypic Switching
    Gary K Owens; Fiscal Year: 2010
    ..Studies will define fundamental mechanisms that control differentiation of SMC, and are likely to lead to novel therapies for treatment of diseases in which SMC phenotypic switching plays a major role. ..
  19. Vascular Biology Gordon Research Conference
    Gary Owens; Fiscal Year: 2003
    ..abstract_text> ..
  20. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary Owens; Fiscal Year: 2004
    ..abstract_text> ..
  21. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary Owens; Fiscal Year: 2005
    ..abstract_text> ..
  22. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary Owens; Fiscal Year: 2000
    ..In addition, studies are likely to identify DNA regulatory sequences that confer SMC specific expression which could be used for construction of vectors for SMC specific gene knockouts and/or targeting gene therapies to the vasculature. ..
  23. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary Owens; Fiscal Year: 1999
    ..In addition, studies are likely to identify DNA regulatory sequences that confer SMC specific expression which could be used for construction of vectors for SMC specific gene knockouts and/or targeting gene therapies to the vasculature. ..
  24. REGULATION OF SMOOTH MUSCLE MYOSIN GENE EXPRESSION
    Gary Owens; Fiscal Year: 2007
    ..abstract_text> ..
  25. GROWTH AND DIFFERENTIATION OF VASCULAR SMOOTH MUSCLE
    Gary Owens; Fiscal Year: 1993
    ....
  26. GROWTH AND DIFFERENTIATION OF VASCULAR SMOOTH MUSCLE
    Gary Owens; Fiscal Year: 1990
    ....
  27. MOLECULAR REGULATION OF SMOOTH MUSCLE DIFFERENTIATION
    Gary Owens; Fiscal Year: 2006
    ....