Research Topics
Species | C D OwensSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Statins and other agents for vascular inflammationChristopher D Owens
University of California San Francisco Medical Center, San Francisco, CA 94148, USA
J Vasc Surg 56:1799-806. 2012..The results of these trials will provide key data to help us understand the relationship between inflammation and vascular risk...
An integrated biochemical prediction model of all-cause mortality in patients undergoing lower extremity bypass surgery for advanced peripheral artery diseaseChristopher D Owens
Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, Calif 94148, USA
J Vasc Surg 56:686-95. 2012..This study tested the hypothesis that baseline biochemical parameters would add clinically meaningful predictive information in patients undergoing lower extremity bypass operations...
Assessing drug elution technologies in the superficial femoral arteryC D Owens
Division of Vascular and Endovascular Surgery, University of California San Francisco, San Francisco, CA 94143, USA
Panminerva Med 53:37-49. 2011..While these offer promise in improving outcomes following lower extremity intervention, caution is warranted until the safety of these new technologies can be ensured...
Endothelial function predicts positive arterial-venous fistula remodeling in subjects with stage IV and V chronic kidney diseaseChristopher D Owens
Division of Vascular and Endovascular Surgery, University of California, San Francisco, CA 94143 0222, USA
J Vasc Access 11:329-34. 2010..However, factors influencing remodeling of AVF are poorly understood. We hypothesized that AVF remodeling was an endothelium-dependent process...
JAK2 V617F mutation, mesenteric vein thrombosis, and myeloproliferative disordersChristopher D Owens
Division of Vascular and Endovascular Surgery, University of California San Francisco, San Francisco, CA 94143, USA
J Vasc Surg 52:205-7. 2010..This article reports a patient who presented with mesenteric vein thrombosis and relatively normal peripheral blood counts. He was diagnosed with essential thrombocythemia after he tested positive for the JAK2 V617F mutation...
Novel adipokines, high molecular weight adiponectin and resistin, are associated with outcomes following lower extremity revascularization with autogenous veinChristopher D Owens
Division of Vascular and Endovascular Surgery, University of California, San Francisco, Calif, USA
J Vasc Surg 51:1152-9. 2010..We hypothesized that serum biomarkers of insulin resistance and inflammation would identify a subgroup at elevated risk for graft failure, limb loss, and mortality...
Adaptive changes in autogenous vein grafts for arterial reconstruction: clinical implicationsChristopher D Owens
Division of Vascular and Endovascular Surgery, University of California San Francisco, San Francisco, CA 94143, USA
J Vasc Surg 51:736-46. 2010..This review summarizes recent translational efforts to understand the structural and functional properties of human vein grafts and places it within the context of the rich existing literature of vein graft failure...
In vivo human lower extremity saphenous vein bypass grafts manifest flow mediated vasodilationChristopher D Owens
Division of Vascular and Endovascular Surgery, University of California San Francisco, San Francisco, CA 94143 0222, USA
J Vasc Surg 50:1063-70. 2009..We hypothesized that mature SVGs would exhibit endothelium-dependent, flow-mediated vasodilation (FMD). We further hypothesized that endothelium-derived nitric oxide (NO) was an important mediator...
Comparative analysis of autogenous infrainguinal bypass grafts in African Americans and Caucasians: the association of race with graft function and limb salvageDavid K Chew
Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Vasc Surg 42:695-701. 2005..The purpose of this study was to compare the results of autogenous infrainguinal bypasses in AAs and Caucasians to determine the association of race with graft function and limb salvage...
Technical factors affecting autogenous vein graft failure: observations from a large multicenter trialAndres Schanzer
Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
J Vasc Surg 46:1180-90; discussion 1190. 2007..We utilized data from a prospective, multicenter trial to identify technical variables that were significantly associated with early and midterm results of autogenous LEB for limb salvage...
Lower extremity vein graft failure: a translational approachChristopher D Owens
Division of Vascular and Endovascular Surgery, Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Vasc Med 13:63-74. 2008..This article reviews the definition and diagnosis of vein graft failure and summarizes our current efforts to understand the mechanisms of normal and abnormal vein graft adaptation to the arterial environment...
Statins are independently associated with reduced mortality in patients undergoing infrainguinal bypass graft surgery for critical limb ischemiaAndres Schanzer
Division of Vascular and Endovascular Surgery, University of Massachusetts, Worcester, MA, USA
J Vasc Surg 47:774-781. 2008..Patients with critical limb ischemia (CLI) have a large atherosclerotic burden with related high mortality. The effect of such therapies in this population is largely inferred and unproven...
Risk factors for lower-extremity vein graft failureThomas S Monahan
Division of Vascular and Endovascular Surgery, University of California, San Francisco, CA 94143 0222, USA
Semin Vasc Surg 22:216-26. 2009..Therapy with statins is indicated in patients with peripheral atherosclerosis and may have beneficial effects on vein graft function, although further studies are needed in this area...
Risk factors for failure of lower-extremity revascularization procedures: are they different for bypass and percutaneous procedures?Christopher D Owens
Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, USA
Semin Vasc Surg 21:143-53. 2008....
C-reactive protein and vein graft disease: evidence for a direct effect on smooth muscle cell phenotype via modulation of PDGF receptor-betaKaren J Ho
Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Physiol Heart Circ Physiol 295:H1132-H1140. 2008..Clinically relevant levels of CRP can stimulate SMC migration by a mechanism that may involve upregulation and activation of PDGFRbeta...
