D H Overstreet

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint The flinders sensitive line rat model of depression--25 years and still producing
    David H Overstreet
    Center for Alcohol Studies and Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Pharmacol Rev 65:143-55. 2013
  2. doi request reprint Modeling depression in animal models
    David H Overstreet
    Department of Psychiatry and Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Methods Mol Biol 829:125-44. 2012
  3. pmc Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors
    David H Overstreet
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, 3009 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 77:405-13. 2004
  4. ncbi request reprint Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression
    David H Overstreet
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 175:303-9. 2004
  5. ncbi request reprint Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression
    David H Overstreet
    Center for Alcohol Studies, CB 7178, 3009 Thurston Bowles Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Eur J Pharmacol 492:195-201. 2004
  6. ncbi request reprint Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression
    David H Overstreet
    Department of Psychiatry, Center for Alcohol Studies, CB 7178, 3009 Thurston Bowles Bldg, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Eur J Pharmacol 497:49-53. 2004
  7. ncbi request reprint Antidepressant-like effects of the vasopressin V1b receptor antagonist SSR149415 in the Flinders Sensitive Line rat
    David H Overstreet
    Department of Psychiatry and Bowles Center for Alcohol Studies, CB 7178, 429 Taylor Bldg, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 82:223-7. 2005
  8. pmc Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley rats
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, 3009 Thurston Bowles Bldg, CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 81:122-30. 2005
  9. ncbi request reprint The Flinders Sensitive Line rat: a selectively bred putative animal model of depression
    David H Overstreet
    Department of Psychiatry, Skipper Bowler Center for Alcohol Studies, University of North Carolina at Chapel Hill, CB 7178, Thurston Bowles Bldg 3009, Chapel Hill, NC 27599 7178, USA
    Neurosci Biobehav Rev 29:739-59. 2005
  10. pmc Reduction in repeated ethanol-withdrawal-induced anxiety-like behavior by site-selective injections of 5-HT1A and 5-HT2C ligands
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 187:1-12. 2006

Collaborators

Detail Information

Publications77

  1. doi request reprint The flinders sensitive line rat model of depression--25 years and still producing
    David H Overstreet
    Center for Alcohol Studies and Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Pharmacol Rev 65:143-55. 2013
    ..It has been recently shown that each of these drugs feeds through G protein-coupled receptors to potassium-gated channels. Thus, an abnormality in the potassium channel could underlie the depressed-like behavior of the FSL rats...
  2. doi request reprint Modeling depression in animal models
    David H Overstreet
    Department of Psychiatry and Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Methods Mol Biol 829:125-44. 2012
    ..It is concluded that the behavioral tests used to infer depressed-like behavior in rats will continue to provide useful data if the appropriate animals and proper methods are used...
  3. pmc Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors
    David H Overstreet
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, 3009 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 77:405-13. 2004
    ..These findings indicate that the CRF system and CRF(1) receptors play key roles in the adaptive change responsible for the anxiety-like behavior induced by repeated withdrawals from chronic ethanol...
  4. ncbi request reprint Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression
    David H Overstreet
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 175:303-9. 2004
    ..Nemifitide is a novel peptide analog of melanocyte-inhibiting factor (MIF) that has been reported to relieve depressive symptoms in a very short period...
  5. ncbi request reprint Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression
    David H Overstreet
    Center for Alcohol Studies, CB 7178, 3009 Thurston Bowles Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Eur J Pharmacol 492:195-201. 2004
    ..These findings indicate that citalopram and CP154,526, a CRF(1) receptor antagonist, have both antidepressant and anxiolytic effects that can be detected in an experimental model of depression only and not in "normal" control animals...
  6. ncbi request reprint Antidepressant-like effects of CRF1 receptor antagonist SSR125543 in an animal model of depression
    David H Overstreet
    Department of Psychiatry, Center for Alcohol Studies, CB 7178, 3009 Thurston Bowles Bldg, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Eur J Pharmacol 497:49-53. 2004
    ..Together, these findings indicate that the CRF(1) receptor antagonist SSR125543 has both antidepressant- and anxiolytic-like effects in the Flinders Sensitive Line rats...
  7. ncbi request reprint Antidepressant-like effects of the vasopressin V1b receptor antagonist SSR149415 in the Flinders Sensitive Line rat
    David H Overstreet
    Department of Psychiatry and Bowles Center for Alcohol Studies, CB 7178, 429 Taylor Bldg, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 82:223-7. 2005
    ..These findings confirm the antidepressant-like potential of SSR149415 and suggest that it may also have anxiolytic effects. It is likely that the strategy of testing selective vasopressin V1b receptor antagonists will be fruitful...
  8. pmc Pharmacological modulation of repeated ethanol withdrawal-induced anxiety-like behavior differs in alcohol-preferring P and Sprague-Dawley rats
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, 3009 Thurston Bowles Bldg, CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 81:122-30. 2005
    ....
  9. ncbi request reprint The Flinders Sensitive Line rat: a selectively bred putative animal model of depression
    David H Overstreet
    Department of Psychiatry, Skipper Bowler Center for Alcohol Studies, University of North Carolina at Chapel Hill, CB 7178, Thurston Bowles Bldg 3009, Chapel Hill, NC 27599 7178, USA
    Neurosci Biobehav Rev 29:739-59. 2005
    ..Thus, the FSL rat model of depression exhibits some behavioral, neurochemical, and pharmacological features that have been reported in depressed individuals and has been very effective in detecting antidepressants...
  10. pmc Reduction in repeated ethanol-withdrawal-induced anxiety-like behavior by site-selective injections of 5-HT1A and 5-HT2C ligands
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 187:1-12. 2006
    ..Anxiety-like behavior resulting from repeated withdrawals from chronic ethanol diets is counteracted by systemic administration of a 5-HT2C receptor antagonist or a 5-HT1A receptor partial agonist...
  11. ncbi request reprint Modulation of high alcohol drinking in the inbred Fawn-Hooded (FH/Wjd) rat strain: implications for treatment
    David H Overstreet
    Bowles Center for Alcohol Studies and Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    Addict Biol 11:356-73. 2006
    ....
  12. ncbi request reprint Depressive-like behavior and high alcohol drinking co-occur in the FH/WJD rat but appear to be under independent genetic control
    David H Overstreet
    Department of Psychiatry and Center for Alcohol Studies, University of North Carolina, CB 7178, Chapel Hill, NC 27599 7178, USA
    Neurosci Biobehav Rev 31:103-14. 2007
    ..These findings suggest that although depressive-like behavior and high alcohol intake co-occur in the FH/Wjd rat, they are independently regulated...
  13. ncbi request reprint The Open Field Test for two
    David H Overstreet
    Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    J Psychopharmacol 21:140. 2007
  14. pmc Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P rats
    David H Overstreet
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 31:1473-81. 2007
    ..Because anxiety is often regarded as a precipitating factor in relapsing alcoholics, we decided to examine the consequences of stressing alcohol-preferring P rats on both voluntary alcohol drinking and withdrawal-induced anxiety...
  15. doi request reprint Confirmation of antidepressant potential of the selective beta3 adrenoceptor agonist amibegron in an animal model of depression
    David H Overstreet
    Department of Psychiatry and Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 89:623-6. 2008
    ..Thus, amibegron had a selective antidepressant-like effect in this study, confirming its antidepressant potential...
  16. pmc A selective ALDH-2 inhibitor reduces anxiety in rats
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, United States
    Pharmacol Biochem Behav 94:255-61. 2009
    ..Thus, a non-addictive selective inhibitor of ALDH-2 has both anxiolytic and antidipsotropic properties, which may be dependent, in part on the involvement of the GABA-benzodiazepine system...
  17. pmc Nerve growth factor (NGF) has novel antidepressant-like properties in rats
    David H Overstreet
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 94:553-60. 2010
    ..Thus, NGF has antidepressant-like effects but does not appear to have biochemical actions typical of other antidepressants...
  18. ncbi request reprint NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists
    David H Overstreet
    Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, 3009 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 75:619-25. 2003
    ..A reduction in [3H]flunitrazepam binding was also seen at this concentration. These findings are consistent with NPI-031G being a weak benzodiazepine site antagonist...
  19. ncbi request reprint Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists
    David H Overstreet
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7178, USA
    Behav Genet 32:335-48. 2002
    ..Their usefulness in detecting potential antidepressant drugs and the relationship between mood disorders and drug abuse will be discussed...
  20. pmc Accentuated decrease in social interaction in rats subjected to repeated ethanol withdrawals
    David H Overstreet
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Alcohol Clin Exp Res 26:1259-68. 2002
    ..In this article, the effects of a three-cycle model of ethanol exposure and withdrawal on the social interaction test of anxiety are summarized...
  21. ncbi request reprint Organophosphate pesticides, cholinergic function and cognitive performance in advanced age
    D H Overstreet
    Bowles Center for Alcohol Studies and Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7178, USA
    Neurotoxicology 21:75-81. 2000
    ..However, the findings in an animal model of dietary-induced cholinergic hypofunction developed by Roger Russell and colleagues may shed light on this question...
  22. ncbi request reprint Herbal remedies for alcoholism: promises and possible pitfalls
    David H Overstreet
    Bowles Center for Alchohol Studies DHO, University of North Carolina, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 27:177-85. 2003
    ..W. Lee; (4) St. John's Wort extract reduces alcohol intake in FH and P rats, by Amir Rezvani and David Overstreet; and (5) extracts reduce alcohol intake in Marchigian Sardinian alcohol-preferring rats, by Maurizio Massi...
  23. ncbi request reprint A genetic rat model of cholinergic hypersensitivity: implications for chemical intolerance, chronic fatigue, and asthma
    D H Overstreet
    Department of Psychiatry and Center for Alcohol Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
    Ann N Y Acad Sci 933:92-102. 2001
    ..An elucidation of these mechanisms may provide useful clues to those involved in chemical intolerance in humans...
  24. ncbi request reprint Involvement of 5-HT1A receptors in animal tests of anxiety and depression: evidence from genetic models
    David H Overstreet
    Bowles Center for Alcoholic Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
    Stress 6:101-10. 2003
    ..Further study with additional tests of anxiety are needed to confirm this intriguing relationship...
  25. pmc A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in rats
    David H Overstreet
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 167:344-52. 2003
    ..The deficits in social interaction behavior following withdrawal from continuous ethanol exposure can be reduced following acute treatments with 5-HT(2C) antagonists or 5-HT(1A) agonists...
  26. ncbi request reprint Further selection of rat lines differing in 5-HT-1A receptor sensitivity: behavioral and functional correlates
    D H Overstreet
    Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine at Chapel Hill 27599 7178, USA
    Psychiatr Genet 6:107-17. 1996
    ..The pattern of binding results suggests that these behavioral correlates of 8-OH-DPAT selection may be related to changes in cortical 5-HT-1A receptors rather than raphe autoreceptors...
  27. ncbi request reprint Selective breeding of 5-HT(1A) receptor-mediated responses: application to emotion and receptor action
    D J Knapp
    Bowles Center for Alcohol Studies and Department of Psychiatry, CB 7178, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Pharmacol Biochem Behav 67:701-8. 2000
    ....
  28. pmc Enduring effects of prenatal cocaine administration on emotional behavior in rats
    D H Overstreet
    Department of Psychiatry, 3011 Thurston Bowles Bldg, CB 7178, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Physiol Behav 70:149-56. 2000
    ..These findings indicate that when emotional behavior is altered by prenatal cocaine administration, the effects are enduring...
  29. pmc Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitization
    Mae M Huang
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    J Pharmacol Exp Ther 332:298-307. 2010
    ..These results indicate that CRF released by stress acts on CRF-1 receptors within specific brain regions to produce a cumulative adaptation that sensitizes anxiety-like behavior during withdrawal from chronic ethanol exposure...
  30. pmc Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats
    Tiffany A Wills
    Neurobiology Curriculum, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 33:455-63. 2009
    ..Current experiments determined if adolescent rats exhibit sensitized anxiety-like behavior, the duration of this effect, if drug pretreatments blocked these effects, and if these effects differed from those seen in adults...
  31. ncbi request reprint Brain 5-HT1A receptor autoradiography and hypothermic responses in rats bred for differences in 8-OH-DPAT sensitivity
    D J Knapp
    Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Brain Res 782:1-10. 1998
    ....
  32. ncbi request reprint The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism
    Amir H Rezvani
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Psychiatr Genet 12:1-16. 2002
    ..We conclude that the FH/Wjd rat is a genetic animal model of depression and alcoholism, but that the two measures reflective of these states are under separate genetic controls...
  33. pmc Differential dietary ethanol intake and blood ethanol levels in adolescent and adult rats: effects on anxiety-like behavior and seizure thresholds
    Tiffany A Wills
    Neurobiology Curriculum, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 32:1350-60. 2008
    ..While adolescent rats have differential responses to both acute and chronic ethanol treatments, the potential differences in the effects of repeated withdrawals in this population have yet to be determined...
  34. ncbi request reprint Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression
    David H Overstreet
    Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599 7178, United States
    Pharmacol Biochem Behav 96:206-10. 2010
    ..Moreover, they suggest that saredutant might also act as an add-on therapy for individuals who are not fully responding to their antidepressant treatment...
  35. pmc Gestational ethanol and nicotine exposure: effects on maternal behavior, oxytocin, and offspring ethanol intake in the rat
    M S McMurray
    The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7096, USA
    Neurotoxicol Teratol 30:475-86. 2008
    ..Oxytocin's possible involvement in the mediation of these effects is highlighted...
  36. ncbi request reprint Selectively bred male rat lines differ in naïve and experienced sexual behavior
    A Sura
    Department of Urology, University of North Carolina, 451 Burnett-Womack Building, CB #7235, Chapel Hill, NC 27599, USA
    Physiol Behav 72:13-20. 2001
    ..5-HT(1A) receptors are involved in the regulation of resumption of sexual behavior after ejaculation...
  37. ncbi request reprint Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats
    Amir H Rezvani
    Department of Psychiatry, Duke University, Durham, NC, USA
    Alcohol Clin Exp Res 31:57-63. 2007
    ..Furthermore, unlike the benzodiazepines, JNJ-5234801 does not have an adverse interaction with ethanol even at doses 20 to 40 times the minimal effective dose in the rat elevated plus maze (MED=1.0 mg/kg, p.o.)...
  38. ncbi request reprint Effects of sweetened ethanol solutions on ethanol self-administration and blood ethanol levels
    D B Matthews
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7178, USA
    Pharmacol Biochem Behav 68:13-21. 2001
    ..These results indicate that sucrose can significantly alter blood ethanol levels and that chronic self-administration of a sweetened ethanol solution for 6 weeks does not produce ethanol dependence...
  39. ncbi request reprint Anticholinesterase (DFP) toxicity antagonism by chronic donepezil: a potential nerve agent treatment
    David S Janowsky
    Department of Psychiatry, CB 7175, Medical Research Building A, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7175, USA
    Pharmacol Biochem Behav 81:917-22. 2005
    ..Although these phenomena are not the same as lethality, they may be parallel phenomena, and our results may have therapeutic implications for the treatment of nerve agent toxicity...
  40. pmc Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal
    Darin J Knapp
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7178, USA
    Alcohol Clin Exp Res 31:582-95. 2007
    ..The present investigation assessed whether pretreatment of rats with agents targeting receptor systems thought to be important in treating relapse in alcoholic patients would prevent sensitization of anxiety-like behavior...
  41. pmc Stress sensitization of ethanol withdrawal-induced reduction in social interaction: inhibition by CRF-1 and benzodiazepine receptor antagonists and a 5-HT1A-receptor agonist
    George R Breese
    Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Neuropsychopharmacology 29:470-82. 2004
    ....
  42. ncbi request reprint Plant derivatives in the treatment of alcohol dependency
    Amir H Rezvani
    Department of Psychiatry, Duke University Medical Center, Box 3412, Durham, NC 27710, USA
    Pharmacol Biochem Behav 75:593-606. 2003
    ..However, their role in the future of pharmacotherapy for alcoholism will depend upon the outcome of carefully conducted clinical trials...
  43. pmc The amygdala regulates the antianxiety sensitization effect of flumazenil during repeated chronic ethanol or repeated stress
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7158, USA
    Alcohol Clin Exp Res 31:1872-82. 2007
    ..This investigation explored the potential role of several brain regions (amygdala, raphe, inferior colliculus, nucleus accumbens, and paraventricular hypothalamus) for these actions of flumazenil...
  44. ncbi request reprint Antagonism of anticholinesterase (DFP) toxicity by donepezil plus scopolamine: a preliminary study
    David S Janowsky
    Department of Psychiatry, University of North Carolina, CB 7175, Medical Research Building A, Chapel Hill, NC 27599 7175, USA
    Pharmacol Biochem Behav 77:337-43. 2004
    ..Therefore, these preliminary findings are encouraging, but many additional studies are needed to establish the effectiveness of donepezil as a prophylactic agent against irreversible cholinesterase inhibition by DFP...
  45. pmc Simultaneous prenatal ethanol and nicotine exposure affect ethanol consumption, ethanol preference and oxytocin receptor binding in adolescent and adult rats
    Sarah K Williams
    Curriculum in Neurobiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neurotoxicol Teratol 31:291-302. 2009
    ..Prenatal exposure to these drugs sex-specifically decreased ethanol preference behavior in offspring unlike reports for either drug separately. The possible role of oxytocin in reduction of ethanol consumption behavior is highlighted...
  46. pmc Modulation of ethanol withdrawal-induced anxiety-like behavior during later withdrawals by treatment of early withdrawals with benzodiazepine/gamma-aminobutyric acid ligands
    Darin J Knapp
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:553-63. 2005
    ..The studies reported herein examined the effects of gamma-aminobutyric acid-modulating drugs on social interaction behavior-an established model of anxiety-in rats exposed to repeated cycles of ethanol treatment and withdrawal...
  47. pmc SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats
    Darin J Knapp
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Alcohol 32:101-11. 2004
    ..Because anxiety may be a complicating factor in alcohol withdrawal and relapse, future studies of this type are needed to provide focus for the effort to define selective and novel antianxiety agents for these disorders...
  48. pmc Repeated lipopolysaccharide (LPS) or cytokine treatments sensitize ethanol withdrawal-induced anxiety-like behavior
    George R Breese
    Department of Psychiatry, UNC School of Medicine, Chapel Hill, NC, USA
    Neuropsychopharmacology 33:867-76. 2008
    ..Together, these findings indicate that increased cytokine activity induces adaptive change that supports sensitization of ethanol withdrawal-induced anxiety that may be linked to GABA(A)-receptor function...
  49. pmc Conceptual framework for the etiology of alcoholism: a "kindling"/stress hypothesis
    George R Breese
    Bowles Center for Alcohol Studies, Department of Psychiatry, University of North Carolina School of Medicine, 3007 Thurston Bowles Building CB 7178, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 178:367-80. 2005
    ..The rationale for proposing the "kindling"/stress hypothesis is to provide a conceptual basis for the insidious development and maintenance of alcohol abuse...
  50. pmc Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist
    George R Breese
    Bowles Center for Alcohol Studies, Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7178, USA
    Neuropsychopharmacology 30:1662-9. 2005
    ....
  51. pmc Stress enhancement of craving during sobriety: a risk for relapse
    George R Breese
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:185-95. 2005
    ..Collectively, the presentations provided convincing support for an involvement of stress in the cause of relapse and continuing alcohol abuse and suggested novel pharmacological approaches for treating relapse induced by stress...
  52. ncbi request reprint Attenuation of alcohol consumption by a novel nontoxic ibogaine analogue (18-methoxycoronaridine) in alcohol-preferring rats
    A H Rezvani
    Skipper Bowles Center for Alcohol Studies and Department of Psychiatry, The University of North Carolina School of Medicine at Chapel Hill, 27599 7178, USA
    Pharmacol Biochem Behav 58:615-9. 1997
    ....
  53. doi request reprint Electroacupuncture reduces voluntary alcohol intake in alcohol-preferring rats via an opiate-sensitive mechanism
    David H Overstreet
    Bowles Center for Alcohol Studies, UNC School of Medicine, Chapel Hill, NC 27599 7178, USA
    Neurochem Res 33:2166-70. 2008
    ....
  54. ncbi request reprint The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats
    Jason P Schroeder
    Department of Psychiatry and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 179:262-70. 2005
    ..Recent research indicates that blockade of mGluR5 modifies the reinforcing properties of ethanol...
  55. pmc Similar anxiety-like responses in male and female rats exposed to repeated withdrawals from ethanol
    David H Overstreet
    Department of Psychiatry, Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Thurston Bowles Building 3009, CB 7178, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 78:459-64. 2004
    ..Thus, there are no sex differences in the three-cycle multiple-withdrawal paradigm, but there may be differences after briefer exposures...
  56. doi request reprint Abstinence from moderate alcohol self-administration alters progenitor cell proliferation and differentiation in multiple brain regions of male and female P rats
    Jun He
    Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Alcohol Clin Exp Res 33:129-38. 2009
    ..The goal of the current investigation was to study cellular alterations on neuro- and cell-genesis during abstinence following alcohol self-administration using alcohol-preferring rats (P rats)...
  57. ncbi request reprint The neuropeptide-Y Y5 receptor antagonist L-152,804 decreases alcohol self-administration in inbred alcohol-preferring (iP) rats
    Jason P Schroeder
    Department of Psychiatry and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599, USA
    Alcohol 36:179-86. 2005
    ..For this reason, NPY Y5 receptor antagonists may be useful in medical management of alcohol abuse and alcoholism in the human population...
  58. pmc Pro-apoptotic Par-4 and dopamine D2 receptor in temporal cortex in schizophrenia, bipolar disorder and major depression
    Leisa A Glantz
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Schizophr Res 118:292-9. 2010
    ..Changes in the Par-4/D2DR signaling pathway represent a novel mechanism that may link apoptotic and dopamine signaling pathways in major depression and schizophrenia...
  59. ncbi request reprint Dimensional complexity of the neuronal activity in a rat model of depression
    Eliyahu Dremencov
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Neuroreport 15:1983-6. 2004
    ..Our results suggest that nonlinear analyses can detect dysregulation of the mesolimbic dopaminergic system and shed light on the pathophysiology of depression...
  60. ncbi request reprint Variability of the mesolimbic neuronal activity in a rat model of depression
    Alexander Friedman
    Department of Bio Informatics, Jerusalem College of Technology, Jerusalem, Israel
    Neuroreport 16:513-6. 2005
    ..Impaired variance of the length of interspike intervals in this area may correspond to the pathophysiology of depression, and hence be a possible marker for the analysis of the efficiency of antidepressant treatment...
  61. ncbi request reprint Comment on "preclinical models: status of basic research in depression"
    David H Overstreet
    Biol Psychiatry 53:268-70; author reply 270. 2003
  62. ncbi request reprint Reduced 5-HT3 receptor binding and lower baseline plus maze anxiety in the alcohol-preferring inbred fawn-hooded rat
    Julie G Hensler
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, MC 7764, 7707 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Pharmacol Biochem Behav 77:281-9. 2004
    ..Further research into 5-HT(3) receptor function in the alcohol-preferring FH/Wjd rats is needed to elucidate the relationship among 5-HT(3) receptors, alcohol drinking, and anxiety...
  63. ncbi request reprint The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression
    Eliyahu Dremencov
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 28:141-7. 2004
    ..The authors conclude that the 5-HT-dopamine interaction is critical to the fast-onset action of antidepressant treatment...
  64. ncbi request reprint 5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression
    Michal Shayit
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    Brain Res 980:100-8. 2003
    ..This may contribute to a better understanding of the involvement of the serotonergic system in depression, and lead to pharmacological interventions aiming to modulate 5-HT regulation...
  65. ncbi request reprint Analysis of alcohol-related phenotypes in F2 progeny derived from FH/Wjd and ACI/N rat strains reveals independent measures and sex differences
    Biswanath Patra
    Department of Pediatrics, University of Arkansas for Medical Sciences, ACHRI, 1120 Marshall Street, Slot 512 40B, Little Rock, AR 72202, USA
    Behav Brain Res 177:37-44. 2007
    ..0001) greater effect on forced alcohol intake than the FH father. It is concluded from these analyses that alcohol-related phenotypes are segregating independently and may be influenced by maternal and sex factors...
  66. ncbi request reprint Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment
    Eliyahu Dremencov
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Neuropharmacology 48:34-42. 2005
    ....
  67. ncbi request reprint The reward system and maternal behavior in an animal model of depression: a microdialysis study
    Yael Lavi-Avnon
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    Psychopharmacology (Berl) 196:281-91. 2008
    ..In this study, we examined the rewarding value of mother-infant interaction for FSL dams...
  68. ncbi request reprint Abnormal patterns of maternal behavior in a genetic animal model of depression
    Yael Lavi-Avnon
    Department of Psychology and the Gonda Goldschmied Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, 52900, Israel
    Physiol Behav 84:607-15. 2005
    ..Possible explanations, especially regarding the FSL dams' reward system are discussed...
  69. ncbi request reprint Brain 5-HT synthesis in the Flinders Sensitive Line rat model of depression: an autoradiographic study
    Shu Hasegawa
    Cone Neurosurgical Research Laboratory, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Que, Canada
    Neurochem Int 48:358-66. 2006
    ..These results suggest that significantly reduced 5-HT synthesis in the raphe nuclei and limbic areas in FSL rats may contribute to their depressive features...
  70. ncbi request reprint Decoding of dopaminergic mesolimbic activity and depressive behavior
    Alexander Friedman
    Leslie Susan Gonda Goldschmied Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    J Mol Neurosci 32:72-9. 2007
    ..Decoding the functionality of the dopaminergic system may help in development of future antidepressant drugs...
  71. ncbi request reprint Further genetic characterization of the fawn-hooded (FH/Wjd) rat, an animal model of comorbid depression and alcoholism
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychiatr Genet 17:77-83. 2007
    ..Recent comparisons of the parental strains with F1 and F2 intercrosses revealed that the alcohol and saccharin intakes were positively correlated with each other but not with immobility...
  72. ncbi request reprint Two different putative genetic animal models of childhood depression
    Oz Malkesman
    Interdisciplinary Program in the Brain Sciences, Bar Ilan University, Ramat Gan
    Biol Psychiatry 59:17-23. 2006
    ..In an attempt to model childhood depression, we examined whether existing genetic animal models of depression in adult rats are also valid in prepubertal rats...
  73. ncbi request reprint The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression
    Rachel Maayan
    Biological Psychiatry Laboratory, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, Petah Tikva, Israel
    Eur Neuropsychopharmacol 15:253-62. 2005
    ..The present study supports our assumption that high basal levels of DHEA/S play a role in the resistance to ECS and maybe ECT in humans...
  74. ncbi request reprint Serotonin produces an enhanced outward current recorded at rat dorsal lateral septal neurons from the Flinders Sensitive Line of rats, a genetically-selected animal model of depression
    Baojian Yu
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 300 University Boulevard, Galveston, TX 77555 1031, USA
    Neurosci Lett 339:235-8. 2003
    ..Our results suggest that within a particular population of DLSN neurons from rats exhibiting a known phenotype of depression a post-synaptic 5-HT(1A) receptor is functionally hyper-responsive compared to controls...
  75. ncbi request reprint Impaired cardiac and sympathetic autonomic control in rats differing in acetylcholine receptor sensitivity
    James R Padley
    Hypertension and Stroke Research Laboratories, Dept of Physiology, University of Sydney, NSW Australia
    Am J Physiol Heart Circ Physiol 289:H1985-92. 2005
    ..In contrast, AChR sensitivity results in autonomic and respiratory abnormalities arising from alterations in central muscarinic and or other neurotransmitter receptors...
  76. ncbi request reprint Toxicity study of an antidipsotropic Chinese herbal mixture in rats: NPI-028
    Daniel E Keyler
    Center for Addiction and Alternative Medicine Research, Natural Products and Toxicology Laboratories, Minneapolis Medical Research Foundation, MN 55404, USA
    J Altern Complement Med 8:175-83. 2002
    ..To determine the potential toxicity and safety of the Chinese herbal medicine NPI-028 in rats following subchronic (3-month) exposure via daily oral consumption...
  77. ncbi request reprint Reduced primary antibody responses in a genetic animal model of depression
    Elliot M Friedman
    Psychology Department, Bronfman Science Center, Williams College, Williamstown, MA 01267, USA
    Psychosom Med 64:267-73. 2002
    ..This study tested the hypothesis that the Flinders Sensitive Line (FSL) rat, a promising genetic animal model of depression, would exhibit reductions in antigen-specific primary antibody responses to immunization...