Andrew K Ottens

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Rapid discovery of putative protein biomarkers of traumatic brain injury by SDS-PAGE-capillary liquid chromatography-tandem mass spectrometry
    William E Haskins
    Center of Neuroproteomics and Biomarkers Research, Department of Neuroscience, University of Florida, Gainesville, Florida 32610, USA
    J Neurotrauma 22:629-44. 2005
  2. ncbi request reprint Neuroproteomics in neurotrauma
    Andrew K Ottens
    Center of Neuroproteomics and Biomarkers Research, McKnight Brain Institute, University of Florida, Gainesville, FL, USA
    Mass Spectrom Rev 25:380-408. 2006
  3. pmc Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry
    Andrew K Ottens
    Department of Psychiatry, Centers for Neuroproteomics and Biomarker Research and Traumatic Brain Injury Studies at the McKnight Brain Institute of the University of Florida, Gainesville, Florida 32610 0256, USA
    J Neurochem 104:1404-14. 2008
  4. ncbi request reprint Novel neuroproteomic approaches to studying traumatic brain injury
    Andrew K Ottens
    Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research at the McKnight Brain Institute of the University of Florida, PO Box 100256, Gainesville, FL 32610, USA
    Prog Brain Res 161:401-18. 2007
  5. ncbi request reprint Calpain-mediated collapsin response mediator protein-1, -2, and -4 proteolysis after neurotoxic and traumatic brain injury
    Zhiqun Zhang
    Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    J Neurotrauma 24:460-72. 2007
  6. ncbi request reprint Novel differential neuroproteomics analysis of traumatic brain injury in rats
    Firas H Kobeissy
    Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, McKnight Brain Institute of the University of Florida, Gainesville, USA
    Mol Cell Proteomics 5:1887-98. 2006
  7. ncbi request reprint A multidimensional differential proteomic platform using dual-phase ion-exchange chromatography-polyacrylamide gel electrophoresis/reversed-phase liquid chromatography tandem mass spectrometry
    Andrew K Ottens
    Center for Neuroproteomics and Biomarker Research, University of Florida, Gainesville, Florida 32610, USA
    Anal Chem 77:4836-45. 2005
  8. doi request reprint Psychoproteomic analysis of rat cortex following acute methamphetamine exposure
    Firas H Kobeissy
    Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, College of Medicine, McKnight Brain Institute of the University of Florida, Gainesville, Florida 32610, USA
    J Proteome Res 7:1971-83. 2008
  9. doi request reprint Calmodulin-binding proteome in the brain
    Zhiqun Zhang
    Department of Psychiatry, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 566:181-90. 2009
  10. ncbi request reprint Proteomic identification of biomarkers of traumatic brain injury
    Kevin K W Wang
    McKnight Brain Institute, University of Florida, L4 100, PO Box 100256, 100 S Newell Drive, Gainesville, FL 32610, USA
    Expert Rev Proteomics 2:603-14. 2005

Research Grants

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Rapid discovery of putative protein biomarkers of traumatic brain injury by SDS-PAGE-capillary liquid chromatography-tandem mass spectrometry
    William E Haskins
    Center of Neuroproteomics and Biomarkers Research, Department of Neuroscience, University of Florida, Gainesville, Florida 32610, USA
    J Neurotrauma 22:629-44. 2005
    ..e., TBI) without a priori knowledge of the molecules involved...
  2. ncbi request reprint Neuroproteomics in neurotrauma
    Andrew K Ottens
    Center of Neuroproteomics and Biomarkers Research, McKnight Brain Institute, University of Florida, Gainesville, FL, USA
    Mass Spectrom Rev 25:380-408. 2006
    ..Ultimately, knowledge attained through neuroproteomics could lead to clinical diagnostics and therapeutics to lessen the burden of neurotrauma on society...
  3. pmc Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry
    Andrew K Ottens
    Department of Psychiatry, Centers for Neuroproteomics and Biomarker Research and Traumatic Brain Injury Studies at the McKnight Brain Institute of the University of Florida, Gainesville, Florida 32610 0256, USA
    J Neurochem 104:1404-14. 2008
    ..3 kDa fragment. Ultimately, the novel methodology described here can be used to study MBP dynamics and other similar proteolytic events of relevance to brain injury and other CNS processes...
  4. ncbi request reprint Novel neuroproteomic approaches to studying traumatic brain injury
    Andrew K Ottens
    Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research at the McKnight Brain Institute of the University of Florida, PO Box 100256, Gainesville, FL 32610, USA
    Prog Brain Res 161:401-18. 2007
    ..This chapter explores the use of neuroproteomics in the study of TBI and the validation of identified putative biomarkers for subsequent clinical translation into novel injury diagnostics...
  5. ncbi request reprint Calpain-mediated collapsin response mediator protein-1, -2, and -4 proteolysis after neurotoxic and traumatic brain injury
    Zhiqun Zhang
    Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    J Neurotrauma 24:460-72. 2007
    ..It is possible that the calpain-mediated truncation of CRMPs following TBI may be an inhibiting factor for post-injury neurite regeneration...
  6. ncbi request reprint Novel differential neuroproteomics analysis of traumatic brain injury in rats
    Firas H Kobeissy
    Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, McKnight Brain Institute of the University of Florida, Gainesville, USA
    Mol Cell Proteomics 5:1887-98. 2006
    ..Results from this work provide insight into mechanisms of traumatic brain injury and yield putative biochemical markers to potentially facilitate patient management by monitoring the severity, progression, and treatment of injury...
  7. ncbi request reprint A multidimensional differential proteomic platform using dual-phase ion-exchange chromatography-polyacrylamide gel electrophoresis/reversed-phase liquid chromatography tandem mass spectrometry
    Andrew K Ottens
    Center for Neuroproteomics and Biomarker Research, University of Florida, Gainesville, Florida 32610, USA
    Anal Chem 77:4836-45. 2005
    ..When combined with RPLC-MSMS for protein identification, an additional quantification step is performed for internal validation, confirming a 2-fold or greater change in 89% of identified differential targets...
  8. doi request reprint Psychoproteomic analysis of rat cortex following acute methamphetamine exposure
    Firas H Kobeissy
    Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, College of Medicine, McKnight Brain Institute of the University of Florida, Gainesville, Florida 32610, USA
    J Proteome Res 7:1971-83. 2008
    ..Lastly, we used these differentially expressed protein subsets to construct a "psychoproteomic" spectrum map in an effort to uncover potential protein interactions relevant to acute METH neurotoxicity...
  9. doi request reprint Calmodulin-binding proteome in the brain
    Zhiqun Zhang
    Department of Psychiatry, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 566:181-90. 2009
    ..The general methods described here can be applied to study possible alternations of calmodulin-binding proteome in neurological, neurodegenerative, and psychiatric disorders...
  10. ncbi request reprint Proteomic identification of biomarkers of traumatic brain injury
    Kevin K W Wang
    McKnight Brain Institute, University of Florida, L4 100, PO Box 100256, 100 S Newell Drive, Gainesville, FL 32610, USA
    Expert Rev Proteomics 2:603-14. 2005
    ..Lastly, the most important sequela of any proteomically identified TBI biomarker is validation in preclinical or clinical samples...

Research Grants2

  1. Dynamics of the Traumatic Brain Injury Degradome.
    Andrew Ottens; Fiscal Year: 2007
    ..An understanding of these events will foster development of novel diagnostics and therapeutics to reduce the burden of brain trauma on society. ..