MELANIE MARIA OTT

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Recruitment and activation of RSK2 by HIV-1 Tat
    Claudia Hetzer
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    PLoS ONE 2:e151. 2007
  2. pmc Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1
    Eva Herker
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    Nat Med 16:1295-8. 2010
  3. pmc Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1)
    Naoki Sakane
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America
    PLoS Pathog 7:e1002184. 2011
  4. pmc Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein
    Dorothee A Vogt
    Gladstone Institute of Virology and Immunology, San Francisco, United States of America
    PLoS Pathog 9:e1003302. 2013
  5. pmc Bromodomain proteins in HIV infection
    Daniela Boehm
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Viruses 5:1571-86. 2013
  6. pmc Three rules for HIV latency: location, location, and location
    Melanie Ott
    Gladstone Institutes, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94941, USA
    Cell Host Microbe 13:625-6. 2013
  7. pmc The control of HIV transcription: keeping RNA polymerase II on track
    Melanie Ott
    Gladstone Institutes of Virology and Immunology, University of California, San Francisco, 94158, USA
    Cell Host Microbe 10:426-35. 2011
  8. pmc SIRT1 regulates HIV transcription via Tat deacetylation
    Sara Pagans
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    PLoS Biol 3:e41. 2005

Collaborators

  • Dwayne Bisgrove
  • Qiang Zhou
  • Michael W McBurney
  • Katrin Kaehlcke
  • Eva Herker
  • Sara Pagans
  • Daniela Boehm
  • Dorothee A Vogt
  • Warner C Greene
  • Naoki Sakane
  • Claudia Hetzer
  • Angelika Pedal
  • Tien Sze Benedict Yen
  • Chia Lin Tsou
  • Gregory Camus
  • Ryan J Conrad
  • Brian R Webster
  • Masafumi Kamada
  • Martina Schnoelzer
  • Jonathan Chan
  • Hye Sook Kwon
  • Yasuhiro Mizusawa
  • Kara G Lassen
  • Arnaud Carpentier
  • Celine Hernandez
  • Charles Harris
  • Robert V Farese
  • Arielle R Rosenberg
  • Michael S Cohen
  • Kerstin Bartscherer
  • Anja Speyerer
  • Jack Taunton
  • Roy Frye
  • Brian J North
  • Manfred Jung
  • Peter Henklein
  • Alexander Dorr
  • Claudia Hetzer-Egger
  • Eric Verdin
  • Brett L Marshall
  • Henning Hruby

Detail Information

Publications8

  1. pmc Recruitment and activation of RSK2 by HIV-1 Tat
    Claudia Hetzer
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    PLoS ONE 2:e151. 2007
    ..Our data identify a novel reciprocal regulation of Tat and RSK2 function, which might serve to induce early changes in the chromatin organization of the HIV LTR...
  2. pmc Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1
    Eva Herker
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    Nat Med 16:1295-8. 2010
    ..Inhibition of DGAT1 activity or RNAi-mediated knockdown of DGAT1 severely impairs infectious virion production, implicating DGAT1 as a new target for antiviral therapy...
  3. pmc Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1)
    Naoki Sakane
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America
    PLoS Pathog 7:e1002184. 2011
    ..Small molecule inhibitors of LSD1/KDM1 show therapeutic promise by enforcing HIV latency in infected T cells...
  4. pmc Lipid droplet-binding protein TIP47 regulates hepatitis C Virus RNA replication through interaction with the viral NS5A protein
    Dorothee A Vogt
    Gladstone Institute of Virology and Immunology, San Francisco, United States of America
    PLoS Pathog 9:e1003302. 2013
    ..Collectively, our data support a model where TIP47--via its interaction with NS5A--serves as a novel cofactor for HCV infection possibly by integrating LD membranes into the membranous web...
  5. pmc Bromodomain proteins in HIV infection
    Daniela Boehm
    Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA
    Viruses 5:1571-86. 2013
    ..We end with an overview of promising new studies of bromodomain inhibitory compounds for the treatment of HIV latency. ..
  6. pmc Three rules for HIV latency: location, location, and location
    Melanie Ott
    Gladstone Institutes, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94941, USA
    Cell Host Microbe 13:625-6. 2013
    ....
  7. pmc The control of HIV transcription: keeping RNA polymerase II on track
    Melanie Ott
    Gladstone Institutes of Virology and Immunology, University of California, San Francisco, 94158, USA
    Cell Host Microbe 10:426-35. 2011
    ....
  8. pmc SIRT1 regulates HIV transcription via Tat deacetylation
    Sara Pagans
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    PLoS Biol 3:e41. 2005
    ..These results support a model in which cycles of Tat acetylation and deacetylation regulate HIV transcription. SIRT1 recycles Tat to its unacetylated form and acts as a transcriptional coactivator during Tat transactivation...

Research Grants8

  1. p90 ribosomal S6 kinase 2 (RSK2) and HIV transcription
    Melanie Ott; Fiscal Year: 2004
    ..We anticipate that these studies will substantially further our understanding of H/V pathogenesis and explore its potential as a novel target for anti-HIV therapy. ..
  2. Recruitment and activation of RSK2 by HIV Tat
    Melanie Ott; Fiscal Year: 2006
    ..We anticipate that these studies will substantially further our understanding of the role of RSK2 in HIV transcription and explore its potential as a novel target for anti-HIV therapy. ..
  3. Role of mitochondrial core protein in Hepatitis C Virus pathogenesis
    Melanie Ott; Fiscal Year: 2007
    ..We anticipate that our studies will help elucidate the mechanisms of how HCV core induces steatosis and hepatocellular carcinoma. ..
  4. Role of SIRT1 as a transcriptional coactivator of HIV-1
    Melanie Ott; Fiscal Year: 2007
    ..These studies should conclusively demonstrate whether SIRT1 is an important cellular cofactor for HIV-1 infection and a potential drug target in infected individuals. ..
  5. Role of Factor Acetylation in the Regulation of HIV Transcription
    Melanie Ott; Fiscal Year: 2009
    ..These studies are directly relevant to HIV/AIDS and may contribute to the development of novel antiviral drugs that will address public need. ..
  6. Role of Tat and SIRT1 in the T-cell Hyperactivation Syndrome Induced by HIV-1
    MELANIE MARIA OTT; Fiscal Year: 2010
    ..These studies are directly relevant to HIV/AIDS and may contribute to the development of novel antiviral drugs that will address public need. ..
  7. Role of Factor Acetylation in the Regulation of HIV Transcription
    MELANIE MARIA OTT; Fiscal Year: 2010
    ..These studies are directly relevant to HIV/AIDS and may contribute to the development of novel antiviral drugs that will address public need. ..