K L Otipoby

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi B cells with the guts to switch
    E A Clark
    Departments of Immunology and Microbiology, University of Washington, Seattle, WA 98195, USA
    Nat Immunol 2:581-2. 2001
  2. ncbi CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1
    K L Otipoby
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 276:44315-22. 2001
  3. ncbi Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
    R J Cornall
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University, Palo Alto, California 94305, USA
    Immunity 8:497-508. 1998
  4. ncbi CD22 regulates thymus-independent responses and the lifespan of B cells
    K L Otipoby
    Department of Immunology, University of Washington Medical Center, Seattle 98195, USA
    Nature 384:634-7. 1996

Collaborators

  • Edward Clark
  • R J Cornall
  • A R Dunn
  • J G Cyster
  • M L Hibbs
  • C C Goodnow

Detail Information

Publications4

  1. ncbi B cells with the guts to switch
    E A Clark
    Departments of Immunology and Microbiology, University of Washington, Seattle, WA 98195, USA
    Nat Immunol 2:581-2. 2001
    ..Expression of mIgM was thought to be esential for the differentiation of B cells expressing antibodies of other classes. New evidence suggests isotype class switching to IgA can occur in the absence of mIgM...
  2. ncbi CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1
    K L Otipoby
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 276:44315-22. 2001
    ..We propose that the cytoplasmic tail of CD22 contains two domains that regulate signal transduction pathways initiated by the BCR and B cell fate...
  3. ncbi Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
    R J Cornall
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University, Palo Alto, California 94305, USA
    Immunity 8:497-508. 1998
    ..The biochemical basis of this complex trait involves a pathway requiring Lyn to phosphorylate CD22 and recruit SHP-1 to the CD22/BCR complex...
  4. ncbi CD22 regulates thymus-independent responses and the lifespan of B cells
    K L Otipoby
    Department of Immunology, University of Washington Medical Center, Seattle 98195, USA
    Nature 384:634-7. 1996
    ..To define the in vivo function of CD22, we generated CD22-deficient mice. Here we show that CD22 is required for normal antibody responses to thymus-independent antigens and regulates the lifespan of mature B cells...