Carol Otey

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint B35 neuroblastoma cells: an easily transfected, cultured cell model of central nervous system neurons
    Carol A Otey
    Departments of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Methods Cell Biol 71:287-304. 2003
  2. ncbi request reprint A critical role for palladin in astrocyte morphology and response to injury
    Malika Boukhelifa
    Department of Cell and Molecular Physiology, The UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell Neurosci 23:661-8. 2003
  3. pmc Isoform-specific upregulation of palladin in human and murine pancreas tumors
    Silvia M Goicoechea
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina, USA
    PLoS ONE 5:e10347. 2010
  4. pmc Characterization of palladin, a novel protein localized to stress fibers and cell adhesions
    M M Parast
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Cell Biol 150:643-56. 2000
  5. ncbi request reprint Alpha-actinin revisited: a fresh look at an old player
    Carol A Otey
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7545, USA
    Cell Motil Cytoskeleton 58:104-11. 2004
  6. pmc Cytoplasmic Ig-domain proteins: cytoskeletal regulators with a role in human disease
    Carol A Otey
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cell Motil Cytoskeleton 66:618-34. 2009
  7. pmc Simultaneous stretching and contraction of stress fibers in vivo
    Lynda J Peterson
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Biol Cell 15:3497-508. 2004
  8. ncbi request reprint The palladin/myotilin/myopalladin family of actin-associated scaffolds
    Carol A Otey
    Department of Cell and Molecular Physiology and the Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Int Rev Cytol 246:31-58. 2005
  9. ncbi request reprint Connexin 43 is localized with actin in tenocytes
    Michelle E Wall
    Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cell Motil Cytoskeleton 64:121-30. 2007
  10. ncbi request reprint Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins
    Zenon Rajfur
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC, USA
    Nat Cell Biol 4:286-93. 2002

Collaborators

Detail Information

Publications24

  1. ncbi request reprint B35 neuroblastoma cells: an easily transfected, cultured cell model of central nervous system neurons
    Carol A Otey
    Departments of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Methods Cell Biol 71:287-304. 2003
    ..All of these protocols have been written for researchers who have some skill in basic cell culture techniques, but previous experience with cultured neurons is not required...
  2. ncbi request reprint A critical role for palladin in astrocyte morphology and response to injury
    Malika Boukhelifa
    Department of Cell and Molecular Physiology, The UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Cell Neurosci 23:661-8. 2003
    ..These results suggest that palladin upregulation following injury may be a key step in the acquisition of the reactive astrocyte morphology...
  3. pmc Isoform-specific upregulation of palladin in human and murine pancreas tumors
    Silvia M Goicoechea
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina, USA
    PLoS ONE 5:e10347. 2010
    ..Thus, palladin may have a potential use in the early diagnosis of PDA and may have much broader significance in understanding metastatic behavior...
  4. pmc Characterization of palladin, a novel protein localized to stress fibers and cell adhesions
    M M Parast
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Cell Biol 150:643-56. 2000
    ..At longer times after antisense treatment, fibroblasts became fully rounded. These results suggest that palladin is required for the normal organization of the actin cytoskeleton and focal adhesions...
  5. ncbi request reprint Alpha-actinin revisited: a fresh look at an old player
    Carol A Otey
    Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599 7545, USA
    Cell Motil Cytoskeleton 58:104-11. 2004
  6. pmc Cytoplasmic Ig-domain proteins: cytoskeletal regulators with a role in human disease
    Carol A Otey
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cell Motil Cytoskeleton 66:618-34. 2009
    ..Cell Motil. Cytoskeleton 2009. (c) 2009 Wiley-Liss, Inc...
  7. pmc Simultaneous stretching and contraction of stress fibers in vivo
    Lynda J Peterson
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Biol Cell 15:3497-508. 2004
    ..In the periphery, the banding patterns for both proteins were shorter, whereas in central regions, where stretching occurred, the bands were wider...
  8. ncbi request reprint The palladin/myotilin/myopalladin family of actin-associated scaffolds
    Carol A Otey
    Department of Cell and Molecular Physiology and the Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Int Rev Cytol 246:31-58. 2005
    ..Since mutations in myotilin result in two forms of muscle disease, an essential role for this family member in organizing the skeletal muscle sarcomere is implied...
  9. ncbi request reprint Connexin 43 is localized with actin in tenocytes
    Michelle E Wall
    Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cell Motil Cytoskeleton 64:121-30. 2007
    ..Connexins may associate with actin to stabilize gap junctions at the plasma membrane, ensuring that tenocytes remain coupled during periods of prolonged or intense mechanical loading...
  10. ncbi request reprint Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins
    Zenon Rajfur
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC, USA
    Nat Cell Biol 4:286-93. 2002
    ..Thus, alpha-actinin is essential for the binding of microfilaments to integrins in the FA. CALI-induced changes in alpha-actinin result in the breakage of that link and the subsequent retraction of the stress fibre...
  11. pmc The role of palladin in actin organization and cell motility
    Silvia M Goicoechea
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    Eur J Cell Biol 87:517-25. 2008
    ..Recently, a mutation in the human palladin gene was implicated in an unusually penetrant form of inherited pancreatic cancer, which has stimulated new ideas about the role of palladin in invasive cancer...
  12. ncbi request reprint Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin
    Richard D S Dixon
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    J Biol Chem 283:6222-31. 2008
    ..In addition, our results suggest a potential role for palladin in generating specialized, actin-based cell morphologies via both direct actin cross-linking activity and indirect scaffolding activity...
  13. ncbi request reprint Identification of palladin isoforms and characterization of an isoform-specific interaction between Lasp-1 and palladin
    Andrew S Rachlin
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    J Cell Sci 119:995-1004. 2006
    ....
  14. ncbi request reprint Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells
    Silvia Goicoechea
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, NC, USA
    J Cell Sci 119:3316-24. 2006
    ....
  15. ncbi request reprint The proline-rich protein palladin is a binding partner for profilin
    Malika Boukhelifa
    Department of Cell and Molecular Physiology and Neuroscience Center, University of North Carolina at Chapel Hill, 27599 7545, USA
    FEBS J 273:26-33. 2006
    ..Our results suggest that palladin may play an important role in recruiting profilin to sites of actin dynamics...
  16. ncbi request reprint Palladin is a novel binding partner for Ena/VASP family members
    Malika Boukhelifa
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 27599 7545, USA
    Cell Motil Cytoskeleton 58:17-29. 2004
    ..These results suggest that the recently described actin-associated protein palladin may play an important role in recruiting VASP to sites of actin filament growth, anchorage, and crosslinking...
  17. ncbi request reprint Movement of stress fibers away from focal adhesions identifies focal adhesions as sites of stress fiber assembly in stationary cells
    Nicole Endlich
    Department of Anatomy and Cell Biology, Ernst Moritz Arndt University, D 17487 Greifswald, Germany
    Cell Motil Cytoskeleton 64:966-76. 2007
    ..Our finding of SF assembly at FAs has important implications for SF formation, force transmission, and tension distribution within the actin cytoskeletal network of stationary cells...
  18. pmc Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism
    Kay L Pogue-Geile
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS Med 3:e516. 2006
    ..In this study, our goal was to discover the identity of the familial pancreatic cancer gene on 4q32 and determine the function of that gene...
  19. ncbi request reprint Modulation of corneal fibroblast contractility within fibrillar collagen matrices
    Mridula Vishwanath
    Department of Ophthalmology, Southwestern Medical Center, Dallas, Texas 75390 9057, USA
    Invest Ophthalmol Vis Sci 44:4724-35. 2003
    ..To investigate the migratory and contractile behavior of isolated human corneal fibroblasts in fibrillar collagen matrices...
  20. ncbi request reprint Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration
    Li Jin
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908 0736, USA
    Circ Res 100:817-25. 2007
    ....
  21. ncbi request reprint Human adipose-derived adult stem cells upregulate palladin during osteogenesis and in response to cyclic tensile strain
    Michelle E Wall
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695 7115, USA
    Am J Physiol Cell Physiol 293:C1532-8. 2007
    ..Silencing the palladin gene, however, did not affect hADAS cells' commitment down the osteogenic lineage...
  22. ncbi request reprint Molecular analysis of the interaction between palladin and alpha-actinin
    Mikko Rönty
    Biomedicum Helsinki, Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    FEBS Lett 566:30-4. 2004
    ..Using transfection-based targeting assays, we show that palladin is involved in targeting of alpha-actinin to specific subcellular foci indicating a functional interplay between the two actin-associated proteins...
  23. ncbi request reprint Isoform-specific regulation of the actin-organizing protein palladin during TGF-beta1-induced myofibroblast differentiation
    Mikko J Rönty
    Neuroscience Program and Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    J Invest Dermatol 126:2387-96. 2006
    ..They also provide for the first time information about the signaling cascades involved in the regulation of palladin expression...

Research Grants12

  1. Role of Palladin in Regulating Astrocytes
    Carol Otey; Fiscal Year: 2002
    ..A long-term goal of this research is to provide new therapeutic approaches for controlling the astrocytic response and glial scar formation in vivo. ..
  2. Role of Palladin in Regulating Astrocytes
    Carol Otey; Fiscal Year: 2006
    ..A long-term goal of this research is to provide new therapeutic approaches for controlling the astrocytic response and glial scar formation in vivo. ..
  3. Biochemical Regulation of Actin Cytoskeleton Assembly
    Carol Otey; Fiscal Year: 2002
    ....
  4. Molecular Function of Palladin's Ig Domains in Cell Adhesion and Motility
    Carol Otey; Fiscal Year: 2009
    ..Thus, understanding the precise molecular function of palladin is likely to yield insights into the cellular mechanisms that control both essential functions in normal cells, and dysfunctions that result in pathological cell behavior. ..
  5. Role of Palladin in Regulating Astrocytes
    Carol Otey; Fiscal Year: 2006
    ..A long-term goal of this research is to provide new therapeutic approaches for controlling the astrocytic response and glial scar formation in vivo. ..
  6. Role of Palladin in Regulating Astrocytes
    Carol Otey; Fiscal Year: 2005
    ..A long-term goal of this research is to provide new therapeutic approaches for controlling the astrocytic response and glial scar formation in vivo. ..
  7. Biochemical Regulation of Actin Cytoskeleton Assembly
    Carol Otey; Fiscal Year: 2005
    ....
  8. Role of Palladin in Regulating Astrocytes
    Carol Otey; Fiscal Year: 2004
    ..A long-term goal of this research is to provide new therapeutic approaches for controlling the astrocytic response and glial scar formation in vivo. ..
  9. Biochemical Regulation of Actin Cytoskeleton Assembly
    Carol Otey; Fiscal Year: 2004
    ....
  10. Role of Palladin in Regulating Astrocytes
    Carol Otey; Fiscal Year: 2003
    ..A long-term goal of this research is to provide new therapeutic approaches for controlling the astrocytic response and glial scar formation in vivo. ..
  11. Biochemical Regulation of Actin Cytoskeleton Assembly
    Carol Otey; Fiscal Year: 2003
    ....
  12. Molecular Function of Palladin's Ig Domains in Cell Adhesion and Motility
    Carol A Otey; Fiscal Year: 2010
    ..Thus, understanding the precise molecular function of palladin is likely to yield insights into the cellular mechanisms that control both essential functions in normal cells, and dysfunctions that result in pathological cell behavior. ..