Research Topics
| Carol OteySummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
B35 neuroblastoma cells: an easily transfected, cultured cell model of central nervous system neuronsCarol A Otey
Departments of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Methods Cell Biol 71:287-304. 2003..All of these protocols have been written for researchers who have some skill in basic cell culture techniques, but previous experience with cultured neurons is not required...- A critical role for palladin in astrocyte morphology and response to injuryMalika Boukhelifa
Department of Cell and Molecular Physiology, The UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Mol Cell Neurosci 23:661-8. 2003..These results suggest that palladin upregulation following injury may be a key step in the acquisition of the reactive astrocyte morphology... 
Isoform-specific upregulation of palladin in human and murine pancreas tumorsSilvia M Goicoechea
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, North Carolina, USA
PLoS ONE 5:e10347. 2010..Thus, palladin may have a potential use in the early diagnosis of PDA and may have much broader significance in understanding metastatic behavior...
Characterization of palladin, a novel protein localized to stress fibers and cell adhesionsM M Parast
Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
J Cell Biol 150:643-56. 2000..At longer times after antisense treatment, fibroblasts became fully rounded. These results suggest that palladin is required for the normal organization of the actin cytoskeleton and focal adhesions...- Cytoplasmic Ig-domain proteins: cytoskeletal regulators with a role in human diseaseCarol A Otey
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Cell Motil Cytoskeleton 66:618-34. 2009..Cell Motil. Cytoskeleton 2009. (c) 2009 Wiley-Liss, Inc... - Alpha-actinin revisited: a fresh look at an old playerCarol A Otey
Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC 27599-7545, USA
Cell Motil Cytoskeleton 58:104-11. 2004 - Simultaneous stretching and contraction of stress fibers in vivoLynda J Peterson
Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mol Biol Cell 15:3497-508. 2004..In the periphery, the banding patterns for both proteins were shorter, whereas in central regions, where stretching occurred, the bands were wider... - The palladin/myotilin/myopalladin family of actin-associated scaffoldsCarol A Otey
Department of Cell and Molecular Physiology and the Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Int Rev Cytol 246:31-58. 2005..Since mutations in myotilin result in two forms of muscle disease, an essential role for this family member in organizing the skeletal muscle sarcomere is implied... - Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteinsZenon Rajfur
Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC, USA
Nat Cell Biol 4:286-93. 2002..Thus, alpha-actinin is essential for the binding of microfilaments to integrins in the FA. CALI-induced changes in alpha-actinin result in the breakage of that link and the subsequent retraction of the stress fibre... - The role of palladin in actin organization and cell motilitySilvia M Goicoechea
Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
Eur J Cell Biol 87:517-25. 2008..Recently, a mutation in the human palladin gene was implicated in an unusually penetrant form of inherited pancreatic cancer, which has stimulated new ideas about the role of palladin in invasive cancer... 
Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actinRichard D S Dixon
Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
J Biol Chem 283:6222-31. 2008..In addition, our results suggest a potential role for palladin in generating specialized, actin-based cell morphologies via both direct actin cross-linking activity and indirect scaffolding activity...- Connexin 43 is localized with actin in tenocytesMichelle E Wall
Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Cell Motil Cytoskeleton 64:121-30. 2007..Connexins may associate with actin to stabilize gap junctions at the plasma membrane, ensuring that tenocytes remain coupled during periods of prolonged or intense mechanical loading... - Identification of palladin isoforms and characterization of an isoform-specific interaction between Lasp-1 and palladinAndrew S Rachlin
Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
J Cell Sci 119:995-1004. 2006.... - Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cellsSilvia Goicoechea
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, NC, USA
J Cell Sci 119:3316-24. 2006.... - Palladin is a novel binding partner for Ena/VASP family membersMalika Boukhelifa
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, 27599 7545, USA
Cell Motil Cytoskeleton 58:17-29. 2004..These results suggest that the recently described actin-associated protein palladin may play an important role in recruiting VASP to sites of actin filament growth, anchorage, and crosslinking... - The proline-rich protein palladin is a binding partner for profilinMalika Boukhelifa
Department of Cell and Molecular Physiology and Neuroscience Center, University of North Carolina at Chapel Hill, 27599 7545, USA
FEBS J 273:26-33. 2006..Our results suggest that palladin may play an important role in recruiting profilin to sites of actin dynamics... - Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanismKay L Pogue-Geile
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
PLoS Med 3:e516. 2006..In this study, our goal was to discover the identity of the familial pancreatic cancer gene on 4q32 and determine the function of that gene... - Modulation of corneal fibroblast contractility within fibrillar collagen matricesMridula Vishwanath
Department of Ophthalmology, Southwestern Medical Center, Dallas, Texas 75390-9057, USA
Invest Ophthalmol Vis Sci 44:4724-35. 2003..Sarcomeric shortening of stress fibers in contracting corneal fibroblasts is also demonstrated for the first time... - Movement of stress fibers away from focal adhesions identifies focal adhesions as sites of stress fiber assembly in stationary cellsNicole Endlich
Department of Anatomy and Cell Biology, Ernst Moritz Arndt University, D 17487 Greifswald, Germany
Cell Motil Cytoskeleton 64:966-76. 2007..Our finding of SF assembly at FAs has important implications for SF formation, force transmission, and tension distribution within the actin cytoskeletal network of stationary cells... - Molecular analysis of the interaction between palladin and alpha-actininMikko Rönty
Biomedicum Helsinki, Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
FEBS Lett 566:30-4. 2004..Using transfection-based targeting assays, we show that palladin is involved in targeting of alpha-actinin to specific subcellular foci indicating a functional interplay between the two actin-associated proteins... - Human adipose-derived adult stem cells upregulate palladin during osteogenesis and in response to cyclic tensile strainMichelle E Wall
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695 7115, USA
Am J Physiol Cell Physiol 293:C1532-8. 2007..Silencing the palladin gene, however, did not affect hADAS cells' commitment down the osteogenic lineage... - Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migrationLi Jin
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908 0736, USA
Circ Res 100:817-25. 2007.... - Isoform-specific regulation of the actin-organizing protein palladin during TGF-beta1-induced myofibroblast differentiationMikko J Rönty
Neuroscience Program and Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
J Invest Dermatol 126:2387-96. 2006..They also provide for the first time information about the signaling cascades involved in the regulation of palladin expression...
Research Grants
- Molecular Function of Palladin's Ig Domains in Cell Adhesion and MotilityCarol Otey; Fiscal Year: 2009..Thus, understanding the precise molecular function of palladin is likely to yield insights into the cellular mechanisms that control both essential functions in normal cells, and dysfunctions that result in pathological cell behavior. ..
- Role of Palladin in Regulating AstrocytesCarol Otey; Fiscal Year: 2006..A long-term goal of this research is to provide new therapeutic approaches for controlling the astrocytic response and glial scar formation in vivo. ..
- Biochemical Regulation of Actin Cytoskeleton AssemblyCarol Otey; Fiscal Year: 2005....
- Molecular Function of Palladin's Ig Domains in Cell Adhesion and MotilityCarol A Otey; Fiscal Year: 2010..Thus, understanding the precise molecular function of palladin is likely to yield insights into the cellular mechanisms that control both essential functions in normal cells, and dysfunctions that result in pathological cell behavior. ..