Brian P O'Sullivan

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Cystic fibrosis heterozygotes do not have increased platelet activation
    Inge Tarnow
    Department of Physiology and Biochemistry, University of Copenhagen, The Faculty of Life Sciences, Frederiksberg C, Denmark
    Thromb Res 121:159-62. 2007
  2. doi request reprint Pulmonary complications of systemic vasculitides
    Brian P O'Sullivan
    Department of Pediatrics, University of Mass Memorial Health Care Worcester, MA 01655, USA
    Paediatr Respir Rev 13:37-43. 2012
  3. doi request reprint Cystic fibrosis
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Lancet 373:1891-904. 2009
  4. doi request reprint The clinical approach to lung disease in patients with cystic fibrosis
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Semin Respir Crit Care Med 30:505-13. 2009
  5. ncbi request reprint The inflammatory role of platelets in cystic fibrosis
    Brian P O'Sullivan
    Department of Pediatrics, UMass Memorial Health Care, 55 Lake Avenue, North Worcester, MA 01655, USA
    Am J Respir Crit Care Med 173:483-90. 2006
  6. ncbi request reprint Platelet activation in cystic fibrosis
    Brian P O'Sullivan
    Department of Pediatrics, UMass Memorial Health Care and University of Massachusetts Medical School, Worcester, MA 01655, USA
    Blood 105:4635-41. 2005
  7. doi request reprint Inhaled aztreonam
    Brian P O'Sullivan
    Brian P O Sullivan is at the University of Massachusetts Memorial Medical Center, 55 Lake Avenue Worcester, Massachusetts 01655, USA
    Nat Rev Drug Discov 9:357-8. 2010
  8. ncbi request reprint Use of nasopharyngoscopy in the evaluation of children with noisy breathing
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School, UMass Memorial Health Care, Worcester, MA 01655, USA
    Chest 125:1265-9. 2004
  9. doi request reprint Burkholderia pseudomallei infection in a child with cystic fibrosis: acquisition in the Western Hemisphere
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA 01655, USA
    Chest 140:239-42. 2011
  10. ncbi request reprint Early pulmonary manifestation of cystic fibrosis in children with the DeltaF508/R117H-7T genotype
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatrics 118:1260-5. 2006

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Cystic fibrosis heterozygotes do not have increased platelet activation
    Inge Tarnow
    Department of Physiology and Biochemistry, University of Copenhagen, The Faculty of Life Sciences, Frederiksberg C, Denmark
    Thromb Res 121:159-62. 2007
    ..Platelet hyperreactivity in CF heterozygotes would be an important cardiovascular risk factor, since approximately 1 in 25 Caucasians is a CF carrier...
  2. doi request reprint Pulmonary complications of systemic vasculitides
    Brian P O'Sullivan
    Department of Pediatrics, University of Mass Memorial Health Care Worcester, MA 01655, USA
    Paediatr Respir Rev 13:37-43. 2012
    ..A diagnosis often can be made on the basis of clinical presentation and serologic studies, but biopsy of skin, nose, kidney, or lung may be necessary to ascertain the precise syndrome...
  3. doi request reprint Cystic fibrosis
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Lancet 373:1891-904. 2009
    ..We review clinical care for cystic fibrosis and discuss recent advances in the understanding of its pathogenesis, implementation of screening of neonates, and development of therapies aimed at treating the basic defect...
  4. doi request reprint The clinical approach to lung disease in patients with cystic fibrosis
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Semin Respir Crit Care Med 30:505-13. 2009
    ..Empowering patients in the process of providing their own care is a key to achieving this goal...
  5. ncbi request reprint The inflammatory role of platelets in cystic fibrosis
    Brian P O'Sullivan
    Department of Pediatrics, UMass Memorial Health Care, 55 Lake Avenue, North Worcester, MA 01655, USA
    Am J Respir Crit Care Med 173:483-90. 2006
    ..We hypothesize that platelet activation is important in CF lung disease and suggest research avenues that might help elucidate the role of activated platelets in CF...
  6. ncbi request reprint Platelet activation in cystic fibrosis
    Brian P O'Sullivan
    Department of Pediatrics, UMass Memorial Health Care and University of Massachusetts Medical School, Worcester, MA 01655, USA
    Blood 105:4635-41. 2005
    ..Our findings may account, at least in part, for the beneficial effects of ibuprofen in CF...
  7. doi request reprint Inhaled aztreonam
    Brian P O'Sullivan
    Brian P O Sullivan is at the University of Massachusetts Memorial Medical Center, 55 Lake Avenue Worcester, Massachusetts 01655, USA
    Nat Rev Drug Discov 9:357-8. 2010
    ....
  8. ncbi request reprint Use of nasopharyngoscopy in the evaluation of children with noisy breathing
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School, UMass Memorial Health Care, Worcester, MA 01655, USA
    Chest 125:1265-9. 2004
    ..To evaluate the practice of using nasopharyngoscopy without routine fiberoptic bronchoscopy for children presenting to a pediatric pulmonary practice with nonspecific noisy breathing...
  9. doi request reprint Burkholderia pseudomallei infection in a child with cystic fibrosis: acquisition in the Western Hemisphere
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA 01655, USA
    Chest 140:239-42. 2011
    ....
  10. ncbi request reprint Early pulmonary manifestation of cystic fibrosis in children with the DeltaF508/R117H-7T genotype
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatrics 118:1260-5. 2006
    ..Our cases highlight the importance of considering keeping so-called mild mutations on cystic fibrosis newborn screening panels and the need to follow children with these mutations closely...
  11. doi request reprint Baseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohort
    Margaret Rosenfeld
    Department of Pediatrics, Seattle Children s Hospital and University of Washington, Seattle, Washington, USA
    Pediatr Pulmonol 45:934-44. 2010
    ..The EPIC Observational Study is an ongoing prospective cohort study investigating risk factors for and clinical outcomes associated with early Pseudomonas aeruginosa (Pa) acquisition in young children with cystic fibrosis (CF)...
  12. doi request reprint Evolution of pancreatic function during the first year in infants with cystic fibrosis
    Brian P O'Sullivan
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Pediatr 162:808-812.e1. 2013
    ..To describe pancreatic function during the first year of life in infants diagnosed with cystic fibrosis (CF) using serial fecal elastase measurements...
  13. doi request reprint Oropharyngeal flora in healthy infants: observations and implications for cystic fibrosis care
    David Carlson
    Department of Pediatrics, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, Massachusetts, USA
    Pediatr Pulmonol 44:497-502. 2009
    ..The purpose of this preliminary study was to determine normal oropharyngeal flora in healthy, non-CF infants in order to help care givers better interpret culture results obtained from infants with CF...
  14. ncbi request reprint Platelet-monocyte aggregates in patients with chronic venous insufficiency remain elevated following correction of reflux
    Michael J Rohrer
    Division of Vascular Surgery and the Center for Platelet Function Studies, The University of Massachusetts Medical School, 55 Lake Avenue, North Worcester 01655, USA
    Cardiovasc Surg 10:464-9. 2002
    ..The purpose of this study was to determine whether patients with CVI maintain elevated levels of PMAs following complete surgical correction of chronic venous insufficiency...
  15. doi request reprint Using hyperpolarized 3He MRI to evaluate treatment efficacy in cystic fibrosis patients
    Yanping Sun
    Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Magn Reson Imaging 34:1206-11. 2011
    ..To use hyperpolarized (HP) (3)He MR imaging to assess functional lung ventilation in subjects with cystic fibrosis (CF) before and after treatment...
  16. ncbi request reprint Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance
    Andrew L Frelinger
    Center for Platelet Function Studies, Department of Pediatrics, UMass Memorial Medical Center, 55 Lake Ave N, Worcester, Massachusetts 01655, USA
    Circulation 113:2888-96. 2006
    ..Thrombotic events still occur in aspirin-treated patients with coronary artery disease...
  17. doi request reprint Immunophenotypic analysis of platelets
    Lori A Krueger
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Curr Protoc Cytom . 2002
    ..Detailed discussion of appropriate sample handling, reagent preparation, flow cytometric set-up, and data interpretation are provided for three independent assays...
  18. doi request reprint The platelet hyporeactivity of extremely low birth weight neonates is age-dependent
    Francis J Bednarek
    Neonatology, Department of Pediatrics, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, MA 01655, USA
    Thromb Res 124:42-5. 2009
    ..The purpose of this study was to examine the age dependency of this hyporeactivity...
  19. ncbi request reprint Combined effects of mild hypothermia and glycoprotein IIb/IIIa antagonists on platelet-platelet and leukocyte-platelet aggregation
    Andrew L Frelinger
    Center for Platelet Function Studies, Department of Pediatrics, University of Massachusetts Medical School, Worcester 01655, USA
    Am J Cardiol 92:1099-101. 2003
    ....
  20. ncbi request reprint The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin
    Andrew L Frelinger
    Center for Platelet Function Studies, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Thromb Haemost 98:192-200. 2007
    ..This inhibition is enhanced in the presence other blood cells and calcium, but not aspirin...
  21. ncbi request reprint Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis
    Kishore R Alugupalli
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655, USA
    Blood 102:2843-50. 2003
    ..These findings suggest that thrombocytopenia of relapsing fever is the result of platelet clearance after beta 3-independent bacterial attachment to circulating platelets...
  22. doi request reprint Whole blood analysis of leukocyte-platelet aggregates
    Marc R Barnard
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Curr Protoc Cytom . 2003
    ..Light scatter and at least one leukocyte-specific antibody are used to gate the desired population, and the presence of associated platelets is detected by immunostaining for abundant platelet-specific markers...
  23. ncbi request reprint Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization
    Mark I Furman
    Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Am Coll Cardiol 43:2319-25. 2004
    ....
  24. ncbi request reprint Application of flow cytometry to platelet disorders
    Matthew D Linden
    Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Semin Thromb Hemost 30:501-11. 2004
    ..Accordingly, this review summarizes the key technical and methodologic components of flow cytometric analysis of platelets, as well as specific examples of its application to diagnosis and patient care...
  25. doi request reprint Methods for the measurement of platelet function
    Alan D Michelson
    Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Cardiol 103:20A-26A. 2009
    ..Some of the factors that differentiate these tests are sample volume requirements, the use of whole blood, the presence of shear, point-of-care status, need for a technician, and expense...
  26. pmc Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors
    Hung Chang
    Center for Platelet Function Studies, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA
    Thromb Res 125:159-65. 2010
    ..Diadenosine 5',5'''-P(1),P(4)- tetraphosphate (Ap(4)A) is stored in platelet dense granules, but its effects on platelet function are not well understood...
  27. doi request reprint Platelet reactivity and the identification of acute coronary syndromes in the emergency department
    Chad E Darling
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Thromb Thrombolysis 28:31-7. 2009
    ..This review will focus on selected tests/markers of platelet function that have shown some promise with respect to the risk stratification of patients with potential ACS...
  28. doi request reprint Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial
    Jennifer S Li
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27705, USA
    Circulation 117:553-9. 2008
    ....
  29. ncbi request reprint Platelet function testing in cardiovascular diseases
    Alan D Michelson
    Center for Platelet Function Studies, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Mass 01655, USA
    Circulation 110:e489-93. 2004
  30. ncbi request reprint Aspirin resistance
    Alan D Michelson
    Department of Pediatrics, Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, 01655, USA
    Pathophysiol Haemost Thromb 35:5-9. 2006
  31. ncbi request reprint Quantification of abciximab-induced platelet inhibition is assay dependent: a comparative study in patients undergoing percutaneous coronary intervention
    Mark I Furman
    Center for Platelet Function Studies and Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am Heart J 145:e6. 2003
    ....
  32. ncbi request reprint How platelets work: platelet function and dysfunction
    Alan D Michelson
    Center for Platelet Function Studies, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Thromb Thrombolysis 16:7-12. 2003
    ..This article briefly reviews (a) how platelets normally function and (b) the clinical approach to disorders of platelet numbers and function...
  33. ncbi request reprint Evaluation of platelet function by flow cytometry
    Alan D Michelson
    Department of Pediatrics, Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, 01655, USA
    Pathophysiol Haemost Thromb 35:67-82. 2006
  34. doi request reprint P2Y12 antagonism: promises and challenges
    Alan D Michelson
    Center for Platelet Function Studies, University of Massachusetts Medical School, Room S5 846, 55 Lake Avenue North, Worcester, MA 01655, USA
    Arterioscler Thromb Vasc Biol 28:s33-8. 2008
    ..Whether this promise will be translated into clinical benefit for patients will be determined by the results of ongoing phase 3 clinical trials...
  35. ncbi request reprint Current options in platelet function testing
    Alan D Michelson
    Center for Platelet Function Studies, Division of Cardiovascular Medicine, Department of Pediatrics and Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Cardiol 98:4N-10N. 2006
    ..In patients treated with antiplatelet drugs, the degree of platelet inhibition, as determined by several of these new platelet function assays, has been shown to predict major adverse cardiac events...
  36. ncbi request reprint Survey of breast-feeding practices and outcomes in the cystic fibrosis population
    Eliza M Parker
    Department of Pediatrics, University of Massachusetts Medical School and UMass Memorial Health Care, Worcester, Massachusetts 01655, USA
    Pediatr Pulmonol 37:362-7. 2004
    ..This survey indicates that breast-feeding is not harmful to children with CF, and may be beneficial...
  37. pmc Effect of adenosine A2 receptor stimulation on platelet activation-aggregation: differences between canine and human models
    Matthew D Linden
    Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester MA 01655, United States
    Thromb Res 121:689-98. 2008
    ....
  38. doi request reprint Effects of physiologic agonists on canine whole blood flow cytometry assays of leukocyte-platelet aggregation and platelet activation
    Inge Tarnow
    Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, 7 GrĂžnnegaardsvej, DK 1870 Frederiksberg C, Denmark
    Vet Immunol Immunopathol 123:345-52. 2008
    ..In conclusion, we have developed flow cytometry assays to measure LPAs and platelet activation in canine whole blood, and have explored the effect of various physiologic agonists at different concentrations...
  39. ncbi request reprint Platelet activation and progression to complications
    Dean J Kereiakes
    Heart Center of Greater Cincinnati and Lindner Center at Christ Hospital, Cincinnati, Ohio, USA
    Rev Cardiovasc Med 7:75-81. 2006
    ..In general, optimal periprocedural outcomes require high levels of platelet inhibition. Combined administration of antiplatelet therapies may produce additive or synergistic inhibition of platelet-mediated thrombosis...
  40. ncbi request reprint Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial
    Stephen D Wiviott
    Brigham and Women s Hospital, Cardiovascular Division, 75 Francis St, Boston, MA 02115, USA
    Circulation 116:2923-32. 2007
    ..The relative antiplatelet effects of prasugrel versus high-dose clopidogrel in percutaneous coronary intervention patients are unknown...
  41. ncbi request reprint Neonatal platelet function
    Sara J Israels
    Department of Pediatrics and Child Health University of Manitoba, Winnipeg, Manitoba, Canada
    Semin Thromb Hemost 29:363-72. 2003
    ..In the immediate newborn period, this enhanced platelet adhesion may compensate for the decreased intrinsic platelet activation in healthy neonates, but may leave sick neonates at increased risk of bleeding...
  42. ncbi request reprint Therapeutic goals for effective platelet inhibition: a consensus document
    Stephen D Wiviott
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Rev Cardiovasc Med 7:214-25. 2006
    ..These novel agents such as prasugrel, AZD6140, and cangrelor are in advanced stages of clinical development for potential use in patients with coronary artery disease...
  43. ncbi request reprint The Ultegra rapid platelet-function assay: comparison to standard platelet function assays in patients undergoing percutaneous coronary intervention with abciximab therapy
    Guy L Wheeler
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Am Heart J 143:602-11. 2002
    ..Furthermore, a diminished degree of platelet inhibition is an independent predictor of adverse cardiac events, highlighting the need for accurate and precise monitoring of platelet function...
  44. ncbi request reprint Clopidogrel linking evaluation of platelet response variability to mechanism of action
    Andrew L Frelinger
    J Am Coll Cardiol 46:646-7. 2005
  45. pmc Aspirin resistance and its implications in clinical practice
    John Eikelboom
    McMaster University, Hamilton, Ontario, Canada
    MedGenMed 7:76. 2005
    ....
  46. ncbi request reprint Antiplatelet therapy in children
    Sara J Israels
    Department of Pediatrics and Child Health, and the Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0V9
    Thromb Res 118:75-83. 2006
    ..Additional studies will be required to evaluate the relative benefits of aspirin and anticoagulants in these settings. A role for newer antiplatelet drugs in the management of pediatric arterial thrombosis is as yet unexplored...
  47. ncbi request reprint Measuring antiplatelet drug effects in the laboratory
    Paul Harrison
    Oxford Haemophilia Centre and Thrombosis Unit, Churchill Hospital, Oxford, United Kingdom
    Thromb Res 120:323-36. 2007
    ..A clinically meaningful definition of "resistance" to antiplatelet drugs needs to be developed, based on data linking drug-dependent laboratory tests to clinical outcomes in patients...
  48. ncbi request reprint An additional mechanism of action of abciximab: dispersal of newly formed platelet aggregates
    Stanley J Marciniak
    Centocor, Malvern, PA 19355, USA
    Thromb Haemost 87:1020-5. 2002
    ..The ability of abciximab to prevent fibrinogen binding to activated platelets indicates it may also promote dissolution of platelet-rich thrombi. The present study examined the capacity of abciximab to reverse platelet aggregation in vitro...