Research Topics
| J L OstremSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Clinical outcomes of PD patients having bilateral STN DBS using high-field interventional MR-imaging for lead placementJill L Ostrem
Department of Neurology, University of California, San Francisco, Surgical Movement Disorders, 1635 Divisadero Street, 5th Floor, Suites 520 530, San Francisco, CA 94115, USA Electronic address
Clin Neurol Neurosurg 115:708-12. 2013..Recently, an iMRI-guided technique for implanting DBS electrodes without MER was developed at our center. Here we report the clinical outcomes of PD patients undergoing STN DBS surgery using this surgical approach...- Subthalamic nucleus deep brain stimulation in primary cervical dystoniaJ L Ostrem
Department of Neurology, Surgical Movement Disorders, 1635 Divisadero Street, Fifth Floor, Suites 520 530, San Francisco, CA 94115, USA
Neurology 76:870-8. 2011.... - Treatment of dystonia with deep brain stimulationJill L Ostrem
Department of Neurology, University of California, San Francisco, California 94143, USA
Neurotherapeutics 5:320-30. 2008.... 
Pallidal deep brain stimulation in patients with cranial-cervical dystonia (Meige syndrome)Jill L Ostrem
Department of Neurology, University of California, San Francisco, California 94143, USA
Mov Disord 22:1885-91. 2007..Although GPi DBS was effective in these patients, the influence of GPi DBS on nondystonic body regions deserves further investigation...- Pedunculopontine nucleus deep brain stimulation in a patient with primary progressive freezing gait disorderJill L Ostrem
Department of Neurology, University of California San Francisco, Center for the Surgical Treatment of Movement Disorders, San Francisco, CA 94143, USA
Stereotact Funct Neurosurg 88:51-5. 2010..We report here on our experience with PPN DBS in treating a 76-year-old man with medication-refractory PPFG... 
Single unit "pauser" characteristics of the globus pallidus pars externa distinguish primary dystonia from secondary dystonia and Parkinson's diseaseSepehr Sani
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Exp Neurol 216:295-9. 2009..The differences may reflect increased phasic input from striatal D2 receptor positive cells in primary dystonia, and are consistent with a recent model proposing that GPe provides capacity scaling for cortical input...- The subthalamic nucleus in primary dystonia: single-unit discharge characteristicsLauren E Schrock
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
J Neurophysiol 102:3740-52. 2009.... - Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trialWilliam J Marks
Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Lancet Neurol 9:1164-72. 2010..We aimed to assess the safety and efficacy of AAV2-neurturin in a double-blind, phase 2 randomised trial... - Long-term benefit sustained after bilateral pallidal deep brain stimulation in patients with refractory tardive dystoniaEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Stereotact Funct Neurosurg 88:304-10. 2010..Tardive dystonia (TD) can be a highly disabling, permanent condition related to the use of dopamine-receptor-blocking medications. Our aim was to evaluate the long-term effect of bilateral pallidal deep brain stimulation (DBS) for TD... - Surgical repositioning of misplaced subthalamic electrodes in Parkinson's disease: location of effective and ineffective leadsR Mark Richardson
Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Stereotact Funct Neurosurg 87:297-303. 2009..These results are contrasted with findings in other studies demonstrating optimal lead placement in STN border zones or neighboring white-matter tracts... - Fluoroscopic, EMG-guided injection of botulinum toxin into the longus colli for the treatment of anterocollisGraham A Glass
Department of Neurology, UCSF Medical Center, San Francisco, CA 94143, USA
Parkinsonism Relat Disord 15:610-3. 2009..Deep cervical muscles such as the longus colli likely play an important role in neck flexion but are not routinely injected... - Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracyPhilip A Starr
Department of Neurosurgery, University of California, San Francisco, California 94143, USA
J Neurosurg 112:479-90. 2010.... - Interventional magnetic resonance guidance of deep brain stimulator implantation for Parkinson diseaseAlastair J Martin
Departments of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA
Top Magn Reson Imaging 19:213-21. 2009..Preliminary evaluation of clinical outcomes indicates comparable results to that achieved with conventional implantation methods, and the technique holds promise for substantially reducing operative durations... - Acute basilar artery occlusion: diffusion-perfusion MRI characterization of tissue salvage in patients receiving intra-arterial stroke therapiesJill L Ostrem
Department of Neurology, UCLA Medical Center, USA
Stroke 35:e30-4. 2004..Diffusion-perfusion MRI in patients with anterior circulation occlusions has demonstrated salvage of threatened tissue after thrombolytic therapy. Similar studies have not been reported with posterior circulation occlusions... - Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomesPhilip A Starr
Department of Neurosurgery, University of California, San Francisco, California 94143, USA
Neurosurg Focus 17:E4. 2004..Patients with juvenile-onset primary dystonia and those with the tardive form benefited greatly from this procedure, whereas benefits for most secondary dystonias and the adult-onset craniocervical form of this disorder were more modest... - Spontaneous pallidal neuronal activity in human dystonia: comparison with Parkinson's disease and normal macaquePhilip A Starr
Dept of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, 779 Moffitt, San Francisco, CA 94143, USA
J Neurophysiol 93:3165-76. 2005.... - Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imagingAlastair J Martin
Department of Radiology, University of California, San Francisco, California 94143, USA
Magn Reson Med 54:1107-14. 2005..0 +/- 0.8 mm (range = 0.1-1.9 mm). All procedures were considered technical successes and there were no intraoperative complications; however, one patient did develop a postoperative infection... - Microelectrode-guided implantation of deep brain stimulators into the globus pallidus internus for dystonia: techniques, electrode locations, and outcomesPhilip A Starr
Department of Neurosurgery, University of California, San Francisco 94143, USA
J Neurosurg 104:488-501. 2006.... - Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes' tremorDaniel A Lim
Department of Neurosurgery, University of California, San Francisco, CA 94143, USA
Stereotact Funct Neurosurg 85:144-9. 2007..Three recent case reports have suggested that simultaneous stimulation of multiple thalamic targets can result in sustained improvement in such cases... - Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patientsPhilip A Starr
Departments of Neurosurgery, University of California at San Francisco, California 94143, USA
J Neurosurg 106:999-1005. 2007..Two small case series have been described. Here, the authors report their technical approach, intraoperative physiological observations, and 1-year outcomes after hypothalamic DBS in four patients with medically intractable CHs... - Neuronal responses to passive movement in the globus pallidus internus in primary dystoniaEdward F Chang
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
J Neurophysiol 98:3696-707. 2007..There is an apparent preservation of GPi somatotopic organization in dystonia in comparison with prior studies of GPi somatotopic organization in non-human primates and humans with Parkinson's disease... - Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trialWilliam J Marks
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0138, USA
Lancet Neurol 7:400-8. 2008..The aim of this study was to assess the safety, tolerability, and potential efficacy of gene delivery of the neurotrophic factor neurturin... - Physiological identification of the human pedunculopontine nucleusS A Shimamoto
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
J Neurol Neurosurg Psychiatry 81:80-6. 2010..Despite the recent introduction of PPN deep brain stimulation (DBS) for the treatment of gait disorders, little is known about its physiology in humans... - Induction of bradykinesia with pallidal deep brain stimulation in patients with cranial-cervical dystoniaBrian D Berman
Department of Neurology, University of California, San Francisco, Calif, USA
Stereotact Funct Neurosurg 87:37-44. 2009..More recently, it has been applied as a treatment for focal and segmental dystonias. This patient population offers an opportunity to study the effects of alteration of pallidal outflow on previously normal limb function... - A child with progressive dystonia, dysarthria, and spasticityLauren E Schrock
Department of Neurology, University of California, San Francisco Department of Veterans Affairs Parkinson s Disease Research, Education, and Clinical Center PADRECC, San Francisco, CA, USA
Rev Neurol Dis 7:32-3; discussion 39-42. 2010..Diagnostic strategies focus on the use of neuroimaging and genetic testing to help establish the underlying diagnosis. Therapeutic options are also discussed...