Sean B Ostlund

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Consolidation and reconsolidation of incentive learning in the amygdala
    Szu Han Wang
    University of California, Los Angeles, USA
    J Neurosci 25:830-5. 2005
  2. ncbi request reprint Still at the choice-point: action selection and initiation in instrumental conditioning
    Bernard W Balleine
    Department of Psychology, University of California, Los Angeles, CA, USA
    Ann N Y Acad Sci 1104:147-71. 2007
  3. ncbi request reprint The contribution of orbitofrontal cortex to action selection
    Sean B Ostlund
    Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095 14563, USA
    Ann N Y Acad Sci 1121:174-92. 2007
  4. pmc Dopamine receptor blockade attenuates the general incentive motivational effects of noncontingently delivered rewards and reward-paired cues without affecting their ability to bias action selection
    Sean B Ostlund
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90024, USA
    Neuropsychopharmacology 37:508-19. 2012
  5. pmc Decreased consumption of sweet fluids in μ opioid receptor knockout mice: a microstructural analysis of licking behavior
    Sean B Ostlund
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Psychopharmacology (Berl) 229:105-13. 2013
  6. pmc Relative response cost determines the sensitivity of instrumental reward seeking to dopamine receptor blockade
    Sean B Ostlund
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA
    Neuropsychopharmacology 37:2653-60. 2012
  7. doi request reprint Evidence of action sequence chunking in goal-directed instrumental conditioning and its dependence on the dorsomedial prefrontal cortex
    Sean B Ostlund
    Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA
    J Neurosci 29:8280-7. 2009
  8. pmc Differential involvement of the basolateral amygdala and mediodorsal thalamus in instrumental action selection
    Sean B Ostlund
    Department of Psychology and the Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095 1563, USA
    J Neurosci 28:4398-405. 2008
  9. pmc Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning
    Sean B Ostlund
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90024, USA
    J Neurosci 31:200-7. 2011
  10. ncbi request reprint Selective reinstatement of instrumental performance depends on the discriminative stimulus properties of the mediating outcome
    Sean B Ostlund
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Learn Behav 35:43-52. 2007

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Consolidation and reconsolidation of incentive learning in the amygdala
    Szu Han Wang
    University of California, Los Angeles, USA
    J Neurosci 25:830-5. 2005
    ....
  2. ncbi request reprint Still at the choice-point: action selection and initiation in instrumental conditioning
    Bernard W Balleine
    Department of Psychology, University of California, Los Angeles, CA, USA
    Ann N Y Acad Sci 1104:147-71. 2007
    ..We discuss a conceptual model that integrates these processes and its neural implementation...
  3. ncbi request reprint The contribution of orbitofrontal cortex to action selection
    Sean B Ostlund
    Department of Psychology, University of California at Los Angeles, Los Angeles, CA 90095 14563, USA
    Ann N Y Acad Sci 1121:174-92. 2007
    ..Rather than processing goal value, therefore, we hypothesize that the contribution of the OFC to goal-directed action is limited to encoding predictive stimulus-outcome relationships that can bias instrumental response selection...
  4. pmc Dopamine receptor blockade attenuates the general incentive motivational effects of noncontingently delivered rewards and reward-paired cues without affecting their ability to bias action selection
    Sean B Ostlund
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90024, USA
    Neuropsychopharmacology 37:508-19. 2012
    ..These findings indicate that dopamine mediates the general incentive motivational effects of noncontingent rewards and reward-paired cues but does not support their ability to bias action selection...
  5. pmc Decreased consumption of sweet fluids in μ opioid receptor knockout mice: a microstructural analysis of licking behavior
    Sean B Ostlund
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Psychopharmacology (Berl) 229:105-13. 2013
    ..Pharmacological studies implicate opioid transmission in the hedonic control of feeding, though these studies often rely on agents lacking specificity for particular opioid receptors...
  6. pmc Relative response cost determines the sensitivity of instrumental reward seeking to dopamine receptor blockade
    Sean B Ostlund
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA
    Neuropsychopharmacology 37:2653-60. 2012
    ..These findings suggest that response costs are evaluated in both absolute and relative terms and that dopamine has a role in overcoming both kinds of cost...
  7. doi request reprint Evidence of action sequence chunking in goal-directed instrumental conditioning and its dependence on the dorsomedial prefrontal cortex
    Sean B Ostlund
    Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA
    J Neurosci 29:8280-7. 2009
    ..These findings demonstrate that rats can use sequence-level representations, or action chunks, to organize their behavior in a goal-directed manner and indicate that the dmPFC plays a critical role in this process...
  8. pmc Differential involvement of the basolateral amygdala and mediodorsal thalamus in instrumental action selection
    Sean B Ostlund
    Department of Psychology and the Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095 1563, USA
    J Neurosci 28:4398-405. 2008
    ..These findings demonstrate that the BLA and MD make important yet distinct contributions to instrumental action selection...
  9. pmc Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning
    Sean B Ostlund
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90024, USA
    J Neurosci 31:200-7. 2011
    ..Together, the results indicate that tonic DA contributes to the control of instrumental performance by conveying information about the costs and benefits of responding to different striatal subregions...
  10. ncbi request reprint Selective reinstatement of instrumental performance depends on the discriminative stimulus properties of the mediating outcome
    Sean B Ostlund
    Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
    Learn Behav 35:43-52. 2007
    ..Together, these findings are consistent with the view that instrumental reinstatement depends on the discriminative stimulus properties of the reinstating outcome...
  11. ncbi request reprint Orbitofrontal cortex mediates outcome encoding in Pavlovian but not instrumental conditioning
    Sean B Ostlund
    Department of Psychology and the Brain Research Institute, University of California, Los Angeles, California 90095 1563, USA
    J Neurosci 27:4819-25. 2007
    ..In contrast, OFC-lesioned rats stopped responding to both stimuli, regardless of their predictive status. Together, these findings suggest that the OFC supports outcome encoding in pavlovian, but not instrumental conditioning...
  12. ncbi request reprint Lesions of medial prefrontal cortex disrupt the acquisition but not the expression of goal-directed learning
    Sean B Ostlund
    Department of Psychology, The Brain Research Institute, University of California, Los Angeles, California 90095 1563, USA
    J Neurosci 25:7763-70. 2005
    ..These results indicate that the mPFC is selectively involved in the acquisition, but not the permanent storage or expression, of action-outcome associations in instrumental conditioning...
  13. doi request reprint Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
    Yijun Cui
    1 Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA 2 Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA 3 Brain Research Institute, University of California, Los Angeles, Los Angeles, California, USA 4 David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Nat Neurosci 17:254-61. 2014
    ....
  14. pmc Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling
    Kate M Wassum
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California 90024, USA
    Learn Mem 18:475-83. 2011
    ....
  15. doi request reprint The orbitofrontal cortex, predicted value, and choice
    Bernard W Balleine
    Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Ann N Y Acad Sci 1239:43-50. 2011
    ..How these structures interact, however, is not yet fully understood and is an important question for future research...
  16. ncbi request reprint The role of the dorsomedial striatum in instrumental conditioning
    Henry H Yin
    Department of Psychology and Brain Research Institute, University of California, Los Angeles, Box 951563, Los Angeles, CA 90095 1563, USA
    Eur J Neurosci 22:513-23. 2005
    ..Taken together, these results suggest that the posterior region of the DMS is a crucial neural substrate for the acquisition and expression of action-outcome associations in instrumental conditioning...
  17. ncbi request reprint Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6
    Mary Kay Lobo
    Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095, USA
    Nat Neurosci 10:1395-7. 2007
    ..Thus, Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal...
  18. pmc Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats
    Kimberly H Leblanc
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e61355. 2013
    ....
  19. ncbi request reprint Sensitivity to instrumental contingency degradation is mediated by the entorhinal cortex and its efferents via the dorsal hippocampus
    Laura H Corbit
    Department of Psychology University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 22:10976-84. 2002
    ..The data from these tests suggest that the deficits observed previously after electrolytic hippocampal lesions were the result of damage to entorhinal efferents...
  20. pmc Phasic mesolimbic dopamine signaling precedes and predicts performance of a self-initiated action sequence task
    Kate M Wassum
    University of California Los Angeles, Department of Psychology, Los Angeles, CA 90095, USA
    Biol Psychiatry 71:846-54. 2012
    ..Fast dopamine signaling is hypothesized to mediate this form of learning by reporting errors in reward prediction. However, such a role for dopamine release in voluntarily initiated action sequences remains to be demonstrated...
  21. pmc Pavlovian-to-instrumental transfer in cocaine seeking rats
    Kimberly H Leblanc
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90024, USA
    Behav Neurosci 126:681-9. 2012
    ..This phenomenon may provide a useful new tool for modeling drug relapse, particularly as a method for targeting the response-invigorating effects of stimulus-drug learning...
  22. doi request reprint The integrative function of the basal ganglia in instrumental conditioning
    Bernard W Balleine
    Department of Psychology and the Brain Research Institute, University of California, Los Angeles, CA, United States
    Behav Brain Res 199:43-52. 2009
    ....
  23. pmc Phasic mesolimbic dopamine release tracks reward seeking during expression of pavlovian-to-instrumental transfer
    Kate M Wassum
    Department of Psychology, University of California, Los Angeles, CA 90095, USA
    Biol Psychiatry 73:747-55. 2013
    ..e., prediction error) and another in incentive motivation (i.e., the invigoration of reward seeking elicited by reward-paired cues). Here, we evaluate the latter...