E M Ostertag

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Biology of mammalian L1 retrotransposons
    E M Ostertag
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Genet 35:501-38. 2001
  2. pmc Mutagenesis in rodents using the L1 retrotransposon
    Eric M Ostertag
    University of Pennsylvania School of Medicine, Department of Genetics, Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Genome Biol 8:S16. 2007
  3. ncbi request reprint Rapid amplification of a retrotransposon subfamily is evolving the mouse genome
    R J DeBerardinis
    Department of Genetics, University of Pennsylvania, Philadelphia 19104, USA
    Nat Genet 20:288-90. 1998
  4. ncbi request reprint A potential role for the nucleolus in L1 retrotransposition
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Hum Mol Genet 13:1041-8. 2004
  5. pmc A novel active L1 retrotransposon subfamily in the mouse
    J L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genome Res 11:1677-85. 2001
  6. pmc Twin priming: a proposed mechanism for the creation of inversions in L1 retrotransposition
    E M Ostertag
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genome Res 11:2059-65. 2001
  7. ncbi request reprint A mouse model of human L1 retrotransposition
    Eric M Ostertag
    Department of Genetics and University of Pennsylvania School of Medicine, 475 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 32:655-60. 2002
  8. ncbi request reprint Current topics in genome evolution: molecular mechanisms of new gene formation
    D V Babushok
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Cell Mol Life Sci 64:542-54. 2007
  9. pmc An actively retrotransposing, novel subfamily of mouse L1 elements
    T P Naas
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    EMBO J 17:590-7. 1998
  10. pmc L1 integration in a transgenic mouse model
    Daria V Babushok
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genome Res 16:240-50. 2006

Research Grants

Collaborators

  • HAIG KAZAZIAN
  • J L Goodier
  • S L Martin
  • Norihiro Okada
  • Daria V Babushok
  • Hiroki Kano
  • D V Babushok
  • R J DeBerardinis
  • Melissa R Vetter
  • Irene Godoy
  • George L Gerton
  • Christine Courtney
  • Charles S Abrams
  • Yanfeng Wang
  • Prabhat K Mandal
  • Kazuhiko Ohshima
  • Xinsheng Chen
  • Janice M Choi
  • Christine E Courtney
  • T P Naas
  • M F Seldin
  • Y Hayashizaki
  • J V Moran
  • S F Kingsmore

Detail Information

Publications14

  1. ncbi request reprint Biology of mammalian L1 retrotransposons
    E M Ostertag
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Genet 35:501-38. 2001
    ..L1 elements have proven useful as phylogenetic markers and may find other practical applications in gene discovery following insertional mutagenesis in mice and in the delivery of therapeutic genes...
  2. pmc Mutagenesis in rodents using the L1 retrotransposon
    Eric M Ostertag
    University of Pennsylvania School of Medicine, Department of Genetics, Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Genome Biol 8:S16. 2007
    ..Here we outline the advantages of using modified L1 retrotransposons for performing random mutagenesis in rodents and discuss several potential applications...
  3. ncbi request reprint Rapid amplification of a retrotransposon subfamily is evolving the mouse genome
    R J DeBerardinis
    Department of Genetics, University of Pennsylvania, Philadelphia 19104, USA
    Nat Genet 20:288-90. 1998
    ..Our data show that mice and humans differ considerably in the number of active L1s, and probably differ in the contribution of retrotransposition to ongoing sequence evolution...
  4. ncbi request reprint A potential role for the nucleolus in L1 retrotransposition
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Hum Mol Genet 13:1041-8. 2004
    ..These findings help explain the presence of chimeras between L1s and small RNA gene sequences recently discovered in the human genome...
  5. pmc A novel active L1 retrotransposon subfamily in the mouse
    J L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genome Res 11:1677-85. 2001
    ..This number is in great excess to the number of L1 elements thought to be active in the human genome...
  6. pmc Twin priming: a proposed mechanism for the creation of inversions in L1 retrotransposition
    E M Ostertag
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genome Res 11:2059-65. 2001
    ..The overhangs then serve as primers for reverse transcription. The data further indicate that a process identical to microhomology-driven single-strand annealing resolves L1 inversion intermediates...
  7. ncbi request reprint A mouse model of human L1 retrotransposition
    Eric M Ostertag
    Department of Genetics and University of Pennsylvania School of Medicine, 475 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 32:655-60. 2002
    ..In addition to providing a valuable in vivo model of retrotransposition in mammals, these mice are an important step in the development of a new random mutagenesis system...
  8. ncbi request reprint Current topics in genome evolution: molecular mechanisms of new gene formation
    D V Babushok
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Cell Mol Life Sci 64:542-54. 2007
    ....
  9. pmc An actively retrotransposing, novel subfamily of mouse L1 elements
    T P Naas
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    EMBO J 17:590-7. 1998
    ..Together, our data indicate that the TF subfamily of L1s contains a major class of mobile elements that is expanding in the mouse genome...
  10. pmc L1 integration in a transgenic mouse model
    Daria V Babushok
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genome Res 16:240-50. 2006
    ..We propose a unified model of L1 integration that explains all of the characteristic features of L1 retrotransposition, such as 5' truncations, inversions, extra nucleotide additions, and 5' boundary and inversion point microhomologies...
  11. pmc A novel testis ubiquitin-binding protein gene arose by exon shuffling in hominoids
    Daria V Babushok
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genome Res 17:1129-38. 2007
    ..PIPSL is a tightly regulated, testis-specific novel ubiquitin-binding protein formed by an unusual exon-shuffling mechanism in hominoid primates and represents a key example of rapid evolution of a testis-specific gene...
  12. pmc SVA elements are nonautonomous retrotransposons that cause disease in humans
    Eric M Ostertag
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, USA
    Am J Hum Genet 73:1444-51. 2003
    ..SVA elements, like Alus and L1s, occasionally insert into genes and cause disease. Furthermore, SVA elements are probably mobilized in trans by active L1 elements...
  13. pmc L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism
    Hiroki Kano
    Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 23:1303-12. 2009
    ..Thus, L1 creates somatic mosaicism during mammalian development, suggesting a role for L1 in carcinogenesis and other disease...
  14. ncbi request reprint Genetics: LINEs in mind
    Eric M Ostertag
    Nature 435:890-1. 2005

Research Grants1

  1. L1 retrotransposon-based mutagenesis for rat models of human diseases
    Eric Ostertag; Fiscal Year: 2007
    ..Transposagen's MutaRat Animal Models will contribute to human health by providing new vertebrate models of disease for studying pathogenesis and for discovery and development of pharmaceutical compounds. ..