Jorge E Osorio

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Characterization of West Nile viruses isolated from captive American Flamingoes (Phoenicopterus ruber) in Medellin, Colombia
    Jorge E Osorio
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Am J Trop Med Hyg 87:565-72. 2012
  2. doi request reprint Development of DENVax: a chimeric dengue-2 PDK-53-based tetravalent vaccine for protection against dengue fever
    Jorge E Osorio
    Inviragen, Inc, Fort Collins, CO 80525, USA
    Vaccine 29:7251-60. 2011
  3. pmc Efficacy of a tetravalent chimeric dengue vaccine (DENVax) in Cynomolgus macaques
    Jorge E Osorio
    Inviragen, Inc, Madison, WI 53706, USA
    Am J Trop Med Hyg 84:978-87. 2011
  4. pmc Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging
    Jorge E Osorio
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
    PLoS ONE 4:e6592. 2009
  5. doi request reprint Consumption of baits containing raccoon pox-based plague vaccines protects black-tailed prairie dogs (Cynomys ludovicianus)
    Tonie E Rocke
    USGS National Wildlife Health Center, Madison, Wisconsin 53711, USA
    Vector Borne Zoonotic Dis 10:53-8. 2010
  6. pmc Efficacy and safety of a modified vaccinia Ankara (MVA) vectored plague vaccine in mice
    Joseph N Brewoo
    Inviragen, Inc, Madison, WI 53719, USA
    Vaccine 28:5891-9. 2010
  7. ncbi request reprint Hepatitis-B surface antigen (HBsAg) powder formulation: process and stability assessment
    Yuh Fun Maa
    PowderJect Vaccines, Inc, 8551 Research Way Boulevard, Middleton, WI 53562, USA
    Curr Drug Deliv 4:57-67. 2007
  8. pmc Cross-protective immunity against o'nyong-nyong virus afforded by a novel recombinant chikungunya vaccine
    Charalambos D Partidos
    Inviragen, Inc, Madison, 6502 Odana Rd, Madison, WI 53719, USA
    Vaccine 30:4638-43. 2012
  9. doi request reprint Immunogenicity and efficacy of chimeric dengue vaccine (DENVax) formulations in interferon-deficient AG129 mice
    Joseph N Brewoo
    Inviragen, Inc, Madison, WI, United States
    Vaccine 30:1513-20. 2012
  10. pmc Deciphering the protective role of adaptive immunity to CHIKV/IRES a novel candidate vaccine against Chikungunya in the A129 mouse model
    Haiyan Chu
    Inviragen, Inc, Madison, WI 53719, USA
    Vaccine 31:3353-60. 2013

Collaborators

Detail Information

Publications27

  1. pmc Characterization of West Nile viruses isolated from captive American Flamingoes (Phoenicopterus ruber) in Medellin, Colombia
    Jorge E Osorio
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Am J Trop Med Hyg 87:565-72. 2012
    ..When compared with attenuated strains isolated from Texas, COL isolates differed in their plaque size and temperature sensitivity phenotype. The COL viruses were pathogenic in embryonated chicken eggs and Balb/c mice...
  2. doi request reprint Development of DENVax: a chimeric dengue-2 PDK-53-based tetravalent vaccine for protection against dengue fever
    Jorge E Osorio
    Inviragen, Inc, Fort Collins, CO 80525, USA
    Vaccine 29:7251-60. 2011
    ..Based on the safety, immunogenicity and efficacy in preclinical studies, Phase 1 clinical testing of DENVax has been initiated...
  3. pmc Efficacy of a tetravalent chimeric dengue vaccine (DENVax) in Cynomolgus macaques
    Jorge E Osorio
    Inviragen, Inc, Madison, WI 53706, USA
    Am J Trop Med Hyg 84:978-87. 2011
    ..In contrast, all control animals developed high levels of viremia for multiple days after challenge with DENV 1-4. This study highlights the immunogenicity and efficacy of the tetravalent DENVax formulations in nonhuman primates...
  4. pmc Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging
    Jorge E Osorio
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
    PLoS ONE 4:e6592. 2009
    ..These studies demonstrate the suitability of a mouse model and biophotonic imaging to compare the disease progression and tissue tropism of MPX viruses...
  5. doi request reprint Consumption of baits containing raccoon pox-based plague vaccines protects black-tailed prairie dogs (Cynomys ludovicianus)
    Tonie E Rocke
    USGS National Wildlife Health Center, Madison, Wisconsin 53711, USA
    Vector Borne Zoonotic Dis 10:53-8. 2010
    ....
  6. pmc Efficacy and safety of a modified vaccinia Ankara (MVA) vectored plague vaccine in mice
    Joseph N Brewoo
    Inviragen, Inc, Madison, WI 53719, USA
    Vaccine 28:5891-9. 2010
    ..Based on their safety and efficacy in mice, these MVA/Y. pestis recombinants are candidates for further development as biodefense and public health vaccines...
  7. ncbi request reprint Hepatitis-B surface antigen (HBsAg) powder formulation: process and stability assessment
    Yuh Fun Maa
    PowderJect Vaccines, Inc, 8551 Research Way Boulevard, Middleton, WI 53562, USA
    Curr Drug Deliv 4:57-67. 2007
    ..Further, a systematic formulation development strategy allowed the development and optimization of an HBsAg dry powder formulation, demonstrating excellent long-term physical, biochemical, and immunological stability...
  8. pmc Cross-protective immunity against o'nyong-nyong virus afforded by a novel recombinant chikungunya vaccine
    Charalambos D Partidos
    Inviragen, Inc, Madison, 6502 Odana Rd, Madison, WI 53719, USA
    Vaccine 30:4638-43. 2012
    ..These findings highlight the potential of the CHIKV/IRES vaccine to protect humans against not only CHIKV but also against ONNV-induced disease...
  9. doi request reprint Immunogenicity and efficacy of chimeric dengue vaccine (DENVax) formulations in interferon-deficient AG129 mice
    Joseph N Brewoo
    Inviragen, Inc, Madison, WI, United States
    Vaccine 30:1513-20. 2012
    ....
  10. pmc Deciphering the protective role of adaptive immunity to CHIKV/IRES a novel candidate vaccine against Chikungunya in the A129 mouse model
    Haiyan Chu
    Inviragen, Inc, Madison, WI 53719, USA
    Vaccine 31:3353-60. 2013
    ..Overall, our findings demonstrate the immunogenic potential of the CHIKV/IRES vaccine and highlight the important role that neutralizing antibodies play in protection against an acute CHIKV infection. ..
  11. ncbi request reprint Limited infection upon human exposure to a recombinant raccoon pox vaccine vector
    Tonie E Rocke
    USGS National Wildlife Health Center, 6006 Schroeder Road, Madison, WI 53711, USA
    Vaccine 22:2757-60. 2004
    ..Raccoon poxvirus was cultured from the lesion, and the patient developed antibody to plague antigen (F1) and RCN. This is the first documented case of human exposure to RCN...
  12. doi request reprint Cross-protective immunity against multiple influenza virus subtypes by a novel modified vaccinia Ankara (MVA) vectored vaccine in mice
    Joseph N Brewoo
    Inviragen, Inc, 6502 Odana Rd, Madison, WI 53719, USA
    Vaccine 31:1848-55. 2013
    ..Our findings highlight MVA as suitable vector to express multiple influenza antigens that could afford broad cross-protective immunity against multiple subtypes of influenza virus...
  13. ncbi request reprint Immunization of black-tailed prairie dog against plague through consumption of vaccine-laden baits
    Tonie E Rocke
    US Geological Survey, National Wildlife Health Center, Madison, Wisconsin 53711, USA
    J Wildl Dis 44:930-7. 2008
    ..These results show that oral immunization of prairie dogs against plague provides some protection against challenge at dosages that simulate simultaneous delivery of the plague bacterium by numerous (3-10) flea bites...
  14. pmc Genetic and phenotypic characterization of manufacturing seeds for a tetravalent dengue vaccine (DENVax)
    Claire Y H Huang
    Arboviral Diseases Branch, Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    PLoS Negl Trop Dis 7:e2243. 2013
    ..These viruses, containing the pre-membrane (prM) and envelope (E) genes of dengue serotypes 1-4 in the replicative background of the attenuated dengue-2 PDK-53 vaccine virus candidate, were manufactured under cGMP...
  15. pmc Potential effect of prior raccoonpox virus infection in raccoons on vaccinia-based rabies immunization
    J Jeffrey Root
    United States Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, CO 80521, USA
    BMC Immunol 9:57. 2008
    ..The effect of naturally occurring antibodies to orthopoxviruses on successful V-RG vaccination in raccoons is the focus of this study...
  16. ncbi request reprint Raccoon poxvirus as a mucosal vaccine vector for domestic cats
    Jorge E Osorio
    Heska Corporation, Fort Collins, CO 80525, USA
    J Drug Target 11:463-70. 2003
    ..These results suggest that recombinant RCN vaccines undergo limited replication after intranasal administration in cats that is sufficient to elicit strong, long-lasting systemic antibody responses...
  17. doi request reprint Sylvatic plague vaccine: a new tool for conservation of threatened and endangered species?
    Rachel C Abbott
    US Geological Survey, National Wildlife Health Center, Madison, WI 53711, USA
    Ecohealth 9:243-50. 2012
    ..Control of plague in prairie dogs, and potentially other rodents, would significantly advance prairie dog conservation and black-footed ferret recovery...
  18. ncbi request reprint Characterization of recombinant raccoonpox vaccine vectors in chickens
    Shi Hsia Hwa
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Avian Dis 54:1157-65. 2010
    ..These studies demonstrate the potential of RCN as a vaccine vector for avian influenza and other poultry pathogens...
  19. doi request reprint Dengue virus-specific CD4+ and CD8+ T lymphocytes target NS1, NS3 and NS5 in infected Indian rhesus macaques
    Katherine M Mladinich
    Microbiology Doctoral Training Program, University of Wisconsin Madison, 1326 Microbial Sciences, 1550 Linden Drive, Madison, WI 53706, USA
    Immunogenetics 64:111-21. 2012
    ....
  20. ncbi request reprint Recombinant raccoon pox vaccine protects mice against lethal plague
    Jorge E Osorio
    Heska Corporation, 1613 Prospect Parkway, Ft Collins, CO 80525, USA
    Vaccine 21:1232-8. 2003
    ..These molecular tools provide a new approach for improving the efficacy of vaccines. In addition, these novel recombinant vaccines could have human, veterinary, and wildlife applications in the prevention of plague...
  21. ncbi request reprint Evaluation of monkeypox virus infection of black-tailed prairie dogs (cynomys ludovicianus) using in vivo bioluminescent imaging
    Elizabeth A Falendysz
    1 US Geological Survey National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711, USA
    J Wildl Dis 50:524-36. 2014
    ....
  22. pmc Adaptation of enterovirus 71 to adult interferon deficient mice
    Elizabeth A Caine
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 8:e59501. 2013
    ....
  23. doi request reprint Effects of route and coadministration of recombinant raccoon poxviruses on immune responses and protection against highly pathogenic avian influenza in mice
    Brock Kingstad-Bakke
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Vaccine 30:6402-8. 2012
    ..However, protection was reduced when the different RCN constructs were pre-mixed, perhaps due to reduced expression of antigen...
  24. pmc Probing the attenuation and protective efficacy of a candidate chikungunya virus vaccine in mice with compromised interferon (IFN) signaling
    Charalambos D Partidos
    Inviragen, Inc, Madison, 6502 Odana Rd, Madison, WI 53719, United States
    Vaccine 29:3067-73. 2011
    ....
  25. ncbi request reprint Powder and particle-mediated approaches for delivery of DNA and protein vaccines into the epidermis
    Hansi J Dean
    PowderJect Vaccines Inc, 585 Science Drive, Madison, WI 53711, USA
    Comp Immunol Microbiol Infect Dis 26:373-88. 2003
    ..Recent studies demonstrate that epidermal vaccine delivery induces humoral, cellular, and protective immune responses against infectious diseases in both laboratory animals and man...
  26. ncbi request reprint Optimization of an alum-adsorbed vaccine powder formulation for epidermal powder immunization
    Yuh Fun Maa
    PowderJect Vaccines, Inc, Madison, Wisconsin 53711, USA
    Pharm Res 20:969-77. 2003
    ..To develop stable and effective aluminum salt (alum)-adsorbed vaccine powder formulations for epidermal powder immunization (EPI) via a spray freeze-drying (SFD) process...
  27. ncbi request reprint Immune responses to hepatitis B surface antigen following epidermal powder immunization
    Jorge E Osorio
    PowderJect Vaccines Inc, Madison, Wisconsin, USA
    Immunol Cell Biol 81:52-8. 2003
    ..These results show that epidermal powder immunization is a safe and effective method to deliver hepatitis B surface antigen and the addition of new adjuvants, such as CpG DNA, may further enhance the efficacy of this vaccine...