D W Oslin

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Evidence-based treatment of geriatric substance abuse
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, 3535 Market Street Room 3002, Philadelphia, PA 19104, USA
    Psychiatr Clin North Am 28:897-911, ix. 2005
  2. ncbi request reprint The effects of naltrexone on alcohol and cocaine use in dually addicted patients
    D W Oslin
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Subst Abuse Treat 16:163-7. 1999
  3. ncbi request reprint A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1546-52. 2003
  4. ncbi request reprint Alcohol-related dementia: validation of diagnostic criteria
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 11:441-7. 2003
  5. ncbi request reprint Disease management for depression and at-risk drinking via telephone in an older population of veterans
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychosom Med 65:931-7. 2003
  6. ncbi request reprint Managing suicide risk in late life: access to firearms as a public health risk
    David W Oslin
    University of Pennsylvania, 3600 Chestnut Street, Room 790, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 12:30-6. 2004
  7. ncbi request reprint Treatment effects from UPBEAT: a randomized trial of care management for behavioral health problems in hospitalized elderly patients
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    J Geriatr Psychiatry Neurol 17:99-106. 2004
  8. ncbi request reprint Treatment outcomes for alcohol dependence among middle-aged and older adults
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Addict Behav 30:1431-6. 2005
  9. ncbi request reprint Late-life alcoholism: issues relevant to the geriatric psychiatrist
    David W Oslin
    Department of Psychiatry, Section on Geriatric Psychiatry, Center for the Study of Addictions, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 12:571-83. 2004
  10. pmc Treatment of late-life depression complicated by alcohol dependence
    David W Oslin
    University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 13:491-500. 2005

Detail Information

Publications76

  1. ncbi request reprint Evidence-based treatment of geriatric substance abuse
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, 3535 Market Street Room 3002, Philadelphia, PA 19104, USA
    Psychiatr Clin North Am 28:897-911, ix. 2005
  2. ncbi request reprint The effects of naltrexone on alcohol and cocaine use in dually addicted patients
    D W Oslin
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Subst Abuse Treat 16:163-7. 1999
    ..The results of this study provide a rationale for a double-blind placebo-controlled study of the efficacy of naltrexone in this difficult to treat but prevalent population...
  3. ncbi request reprint A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1546-52. 2003
    ..If replicated, these results would help to identify alcohol-dependent individuals who may be most likely to respond to treatment with naltrexone...
  4. ncbi request reprint Alcohol-related dementia: validation of diagnostic criteria
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 11:441-7. 2003
    ..The authors sought to validate the diagnostic criteria for alcohol-related dementia...
  5. ncbi request reprint Disease management for depression and at-risk drinking via telephone in an older population of veterans
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychosom Med 65:931-7. 2003
    ..The purpose of this study was to explore the efficacy in a primary care setting of a telephone-based disease management program for the acute management of depression and/or at-risk drinking...
  6. ncbi request reprint Managing suicide risk in late life: access to firearms as a public health risk
    David W Oslin
    University of Pennsylvania, 3600 Chestnut Street, Room 790, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 12:30-6. 2004
    ..The authors assessed the prevalence of gun availability for elderly patients to determine whether gun availability is related to the presence of suicidal or depressive symptoms...
  7. ncbi request reprint Treatment effects from UPBEAT: a randomized trial of care management for behavioral health problems in hospitalized elderly patients
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    J Geriatr Psychiatry Neurol 17:99-106. 2004
    ..Despite a theoretical and practically sound intervention, participation was low and treatment outcomes, while generally good, appeared unaffected by the addition of the program...
  8. ncbi request reprint Treatment outcomes for alcohol dependence among middle-aged and older adults
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
    Addict Behav 30:1431-6. 2005
    ..The purpose of this study was to examine differences in the clinical presentation and treatment outcomes of older adults with a diagnosis of alcohol dependence compared to middle-aged adults...
  9. ncbi request reprint Late-life alcoholism: issues relevant to the geriatric psychiatrist
    David W Oslin
    Department of Psychiatry, Section on Geriatric Psychiatry, Center for the Study of Addictions, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 12:571-83. 2004
    ..This article discusses the state of research in this area and reviews clinically-relevant concepts related to identifying, assessing, and treating older adults with alcohol-related disability...
  10. pmc Treatment of late-life depression complicated by alcohol dependence
    David W Oslin
    University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 13:491-500. 2005
    ..The aim of this study was to test the efficacy of naltrexone combined with sertraline for the treatment of older adults with major depression and alcohol dependence...
  11. pmc PRISM-E: comparison of integrated care and enhanced specialty referral in managing at-risk alcohol use
    David W Oslin
    Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Room 3002, Philadelphia, Pennsylvania 11104, USA
    Psychiatr Serv 57:954-8. 2006
    ....
  12. ncbi request reprint Heuristic comparison of sertraline with nortriptyline for the treatment of depression in frail elderly patients
    D W Oslin
    Section of Geriatric Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Am J Geriatr Psychiatry 8:141-9. 2000
    ..There were no differences in the tolerability of sertraline vs. nortriptyline. However, in this group of frail older adults, sertraline was not as effective as nortriptyline for the treatment of depression...
  13. pmc A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Alcohol Clin Exp Res 32:1299-308. 2008
    ....
  14. ncbi request reprint Alcoholism treatment adherence: older age predicts better adherence and drinking outcomes
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Am J Geriatr Psychiatry 10:740-7. 2002
    ..The authors compared therapy and medication adherence for treatment of alcohol dependence in older adults with adherence in younger adults...
  15. pmc Screening, assessment, and management of depression in VA primary care clinics. The Behavioral Health Laboratory
    David W Oslin
    Philadelphia VA Medical Center and VISN 4 Mental Illness Research, Education, and Clinical Center MIRECC, Philadelphia, PA, USA
    J Gen Intern Med 21:46-50. 2006
    ..The BHL was implemented to assist in the evaluation of patients who screened positively for depression at an annual clinical appointment or who were identified through routine care...
  16. ncbi request reprint Effects of alcohol consumption on the treatment of depression among elderly patients
    D W Oslin
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 8:215-20. 2000
    ..Moreover, there appeared to be an added benefit when even modest alcohol consumption was decreased among elderly patients suffering from depression...
  17. ncbi request reprint The disabling nature of comorbid depression among older DUI recipients
    D W Oslin
    Center for the Study of Addictions, University of Pennsylvania, Philadelphia 19104, USA
    Am J Addict 8:128-35. 1999
    ..These data support previous studies that suggest greater disability in patients with concurrent mental illnesses...
  18. ncbi request reprint Association between medical comorbidity and treatment outcomes in late-life depression
    David W Oslin
    Section of Geriatric Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Geriatr Soc 50:823-8. 2002
    ..The objectives of this study were to examine the relationship between specific medical illnesses and the outcomes of treatment for late-life depression...
  19. ncbi request reprint Family problems among recently returned military veterans referred for a mental health evaluation
    Steven L Sayers
    VISN 4 MIRECC 116, Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    J Clin Psychiatry 70:163-70. 2009
    ..Existing evidence suggests that military veterans with mental health disorders have poorer family functioning, although little research has focused on this topic...
  20. ncbi request reprint Improving access to geriatric mental health services: a randomized trial comparing treatment engagement with integrated versus enhanced referral care for depression, anxiety, and at-risk alcohol use
    Stephen J Bartels
    Department of Psychiatry, Dartmouth Medical School, Lebanon, NH, USA
    Am J Psychiatry 161:1455-62. 2004
    ..The authors sought to determine whether integrated mental health services or enhanced referral to specialty mental health clinics results in greater engagement in mental health/substance abuse services by older primary care patients...
  21. ncbi request reprint Drug treatment of depression in frail elderly nursing home residents
    J E Streim
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    Am J Geriatr Psychiatry 8:150-9. 2000
    ....
  22. ncbi request reprint PRISM-E: comparison of integrated care and enhanced specialty referral models in depression outcomes
    Dean D Krahn
    Department of Psychiatry, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Psychiatr Serv 57:946-53. 2006
    ..This study, entitled Primary Care Research in Substance Abuse and Mental Health for the Elderly, examined six-month outcomes for older primary care patients with depression who received different models of treatment...
  23. pmc The therapeutic alliance in medical-based interventions impacts outcome in treating alcohol dependence
    W D Dundon
    Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Drug Alcohol Depend 95:230-6. 2008
    ..The absence of other effects underscores the need for further research...
  24. pmc Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study
    George S Alexopoulos
    Department of Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Rd, White Plains, NY 10605, USA
    Am J Psychiatry 166:882-90. 2009
    ..This is the first report of outcomes over a 2-year period...
  25. ncbi request reprint Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
  26. ncbi request reprint A genetic association study of the mu opioid receptor and severe opioid dependence
    James J Crowley
    Department of Pharmacology, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Psychiatr Genet 13:169-73. 2003
    ..A recent report (Hoehe et al., 2000) found a significant association between a specific combination of OPRM1 single nucleotide polymorphisms (SNPs) and substance dependence...
  27. ncbi request reprint Gambling among older, primary-care patients: an important public health concern
    Suzi Levens
    Department of Psychiatry, Univ of Pennsylvania, 3600 Chestnut St, Room 790, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 13:69-76. 2005
    ..Authors assessed the prevalence rate of gambling in a sample of elderly patients (over age 65) and evaluated the sociodemographic characteristics, health, cognitive status, and psychiatric comorbidities of elderly gamblers...
  28. pmc Case-control association analysis of polymorphisms in the δ-opioid receptor, OPRD1, with cocaine and opioid addicted populations
    R C Crist
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 127:122-8. 2013
    ..The MOR, however, interacts with and is regulated by many known MOR interacting proteins (MORIPs), including the δ-opioid receptor (DOR)...
  29. ncbi request reprint Predicting treatment response to naltrexone: the influence of craving and family history
    J R Monterosso
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, Philadelphia, Philadelphia Veteran Affairs Medical Center, USA
    Am J Addict 10:258-68. 2001
    ..05). In both cases, the interaction was in the predicted direction. These data suggest that patients with high levels of alcohol craving or a strong family history of alcoholism are more likely to benefit from naltrexone treatment...
  30. ncbi request reprint Probing the safety of medications in the frail elderly: evidence from a randomized clinical trial of sertraline and venlafaxine in depressed nursing home residents
    David W Oslin
    Section of Geriatric Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    J Clin Psychiatry 64:875-82. 2003
    ..The purpose of this study was to examine the efficacy and tolerability of venlafaxine and sertraline for the treatment of depression among nursing home residents...
  31. pmc Psychological well-being among individuals aging with HIV: the value of social relationships
    Shahrzad Mavandadi
    Mental Illness Research, Education, and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 51:91-8. 2009
    ..Utilizing a heterogenous sample of adults diagnosed with HIV infection, the current study sought to explore associations among age, various dimensions of social support, and psychological and functional well-being...
  32. ncbi request reprint Pharmacologic treatment of depression in nursing home residents: a mental health services perspective
    Catherine J Datto
    Department of Psychiatry, University of Pennsylvania, and the Philadelphia VA Medical Center, 19104, USA
    J Geriatr Psychiatry Neurol 15:141-6. 2002
    ..Developing models to ensure quality of care will require focused mental health services research...
  33. ncbi request reprint The pilot study of a telephone disease management program for depression
    Catherine J Datto
    University of Pennsylvania, Philadelphia, PA, USA
    Gen Hosp Psychiatry 25:169-77. 2003
    ..The effect on patient outcome is at least partially explained by the effect of TDM on clinician adherence to depression treatment algorithms...
  34. ncbi request reprint Importance of subsyndromal symptoms of depression in elderly patients
    Mohit P Chopra
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Am J Geriatr Psychiatry 13:597-606. 2005
    ..The current study examined the cross-sectional and longitudinal significance of SSD in geriatric subjects both with and without a past history of major depression...
  35. doi request reprint Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction
    T K Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, 125 South 31st Street, Philadelphia, PA 19104, USA
    Genes Brain Behav 11:415-23. 2012
    ..These data show that polymorphisms in PDYN are associated with opioid addiction in EAs and provide further evidence that these risk variants may be more relevant in females...
  36. pmc Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurosci Lett 440:280-3. 2008
    ....
  37. ncbi request reprint The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6178, USA
    J Clin Psychopharmacol 26:610-25. 2006
    ..Clinical trial results in this article are evaluated by the type of outcome measure used to determine naltrexone's treatment advantage, that is, measures related to reducing heavy drinking versus those related to increasing abstinence...
  38. pmc Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900, Chestnut Street, Philadelphia, PA 19104, USA
    Addict Behav 34:581-6. 2009
    ..This trial compared the efficacy of acamprosate, started at the beginning of detoxification, to acamprosate started at the completion of detoxification, in the treatment of alcohol dependence...
  39. pmc Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 453:199-203. 2009
    ..However, additional studies using larger sample sizes, comprehensive SNP coverage, and clinically homogenous populations are necessary before confidently excluding CDNF as a significant genetic risk factor for cocaine dependence...
  40. doi request reprint Daily ratings measures of alcohol craving during an inpatient stay define subtypes of alcohol addiction that predict subsequent risk for resumption of drinking
    David W Oslin
    University of Pennsylvania, School of Medicine, Department of Psychiatry, Treatment Research Center, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 103:131-6. 2009
    ....
  41. pmc Combined effects of alcohol and hepatitis C: a secondary analysis of alcohol use biomarkers and high-risk behaviors from two medication trials for alcohol dependence
    Jennifer G Plebani
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States address
    Addict Behav 35:123-8. 2010
    ..In addition, the relationship between Hepatitis C virus (HCV) infection and behavioral risk factors for HCV infection in these clinical populations were examined...
  42. doi request reprint Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 473:87-91. 2010
    ..However, additional studies using larger sample sizes and clinically homogenous populations are necessary before confidently excluding these variants as contributing genetic risk factors for CD...
  43. pmc A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence
    Helen M Pettinati
    Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Psychiatry 167:668-75. 2010
    ....
  44. ncbi request reprint When late-life depression improves: what do older patients say about their treatment?
    Frances K Barg
    Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA, USA
    Am J Geriatr Psychiatry 18:596-605. 2010
    ....
  45. doi request reprint The Behavioral Health Laboratory: building a stronger foundation for the patient-centered medical home
    James Tew
    Mental Illness Research, Education and Clinical Center, Pittsburgh VA Medical Center, Pittsburgh, PA, USA
    Fam Syst Health 28:130-45. 2010
    ..Just as importantly, the authors review how this standardized platform for delivering integrated mental health services provides the flexibility to incorporate novel interventions for a changing population...
  46. pmc A randomized trial of extended telephone-based continuing care for alcohol dependence: within-treatment substance use outcomes
    James R McKay
    Department of Psychiatry, University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Consult Clin Psychol 78:912-23. 2010
    ....
  47. doi request reprint Missed opportunities: fewer service referrals after positive alcohol misuse screens in VA primary care
    Donovan T Maust
    Department of Psychiatry, University of Pennsylvania, 3535 Market St, Philadelphia, PA 19104, USA
    Psychiatr Serv 62:310-2. 2011
    ..The primary purpose of this study was to compare referral to additional clinical services after primary care clinicians screened for and found a positive screen for alcohol misuse, depression, or posttraumatic stress disorder (PTSD)...
  48. pmc Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratories, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:3078-84. 2008
    ..Additional studies are required to elucidate the role of COMT in the pathophysiology of substance use disorders...
  49. pmc Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Department of Psychiatry, Center for the Study of Addictions, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 34:378-90. 2008
    ..Thus, 150 mg/day naltrexone added to a psychosocial treatment resulted in reductions in cocaine and alcohol use and drug severity in men, compared to higher rates of cocaine and alcohol use and drug severity in women...
  50. pmc A double-blind, placebo-controlled pilot trial of quetiapine for the treatment of Type A and Type B alcoholism
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 27:344-51. 2007
    ..Quetiapine is an atypical antipsychotic with a favorable side effect profile, and may be a promising medication for the treatment of alcohol dependence, particularly Type B alcoholism...
  51. ncbi request reprint Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 56:703-13. 2004
  52. ncbi request reprint Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Psychiatr Res 39:475-9. 2005
    ..The results of this study suggest that polymorphisms in the CRHR 1 gene are not major risk factors for the development of alcohol dependence in persons of European ancestry...
  53. ncbi request reprint Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, PA 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 139:106-8. 2005
    ....
  54. ncbi request reprint Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, 19104, USA
    Psychiatr Genet 15:277-83. 2005
    ..The purpose of this study is to determine whether single-nucleotide polymorphisms in the Homer1 and Homer2 genes associate with the cocaine-dependent phenotype in an African American population...
  55. ncbi request reprint A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
    ..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls...
  56. pmc Older patients' aversion to antidepressants. A qualitative study
    Jane L Givens
    Division of General Internal Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Gen Intern Med 21:146-51. 2006
    ..Depression is common among older patients yet is often inadequately treated. Patient beliefs about antidepressants are known to affect treatment initiation and adherence, but are often not expressed in clinical settings...
  57. ncbi request reprint Carbohydrate-deficient transferrin levels reflect heavy drinking in alcohol-dependent women seeking treatment
    Margaret R Rukstalis
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, and Philadelphia Medical Center for Veteran Affairs, Philadelphia Pennsylvania 19104, USA
    Alcohol Clin Exp Res 26:1539-44. 2002
    ..The study also examined the extent that E2 levels mediated the relationship between CDT levels and heavy drinking in the alcohol-dependent women...
  58. ncbi request reprint Family involvement in the care of healthy medical outpatients
    Steven L Sayers
    VISN 4 Mental Illness, Research, Education, and Clinical Center and the Philadelphia Veterans Affairs Medical Center, PA 19104, USA
    Fam Pract 23:317-24. 2006
    ..Although the involvement of patients' family members in office visits has been examined extensively, less is known about the involvement of family members in supporting patients' medical care outside of office visits...
  59. ncbi request reprint Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence
    Rachel J Smith
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005
    ..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1...
  60. ncbi request reprint Effect of increasing the dose and duration of sertraline trial in the treatment of depressed nursing home residents
    Daniel Weintraub
    Section of Geriatric Psychiatry, University of Pennsylvania, and Philadelphia VA Medical Center, USA
    J Geriatr Psychiatry Neurol 16:109-11. 2003
    ..Our findings suggest that an extended trial or high dosages of sertraline may benefit some depressed elderly patients with persistent depression after acute treatment...
  61. ncbi request reprint Effect of depression treatment on depressive symptoms in older adulthood: the moderating role of pain
    Shahrzad Mavandadi
    Section of Geriatric Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Geriatr Soc 55:202-11. 2007
    ..To investigate whether pain severity and interference with normal work activities moderate the effects of depression treatment on changes in depressive symptoms over time in older adults in primary care...
  62. ncbi request reprint No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence
    Andrew E Weller
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychiatr Genet 16:193-6. 2006
    ..The aim of this study is to investigate whether polymorphisms in the human Par-4 gene contribute to the etiology of cocaine dependence...
  63. ncbi request reprint The association between chronic pain and prescription drug abuse in Veterans
    William C Becker
    Philadelphia VAMC, 3900 Woodland Avenue, Philadelphia, PA 19104, USA
    Pain Med 10:531-6. 2009
    ..We sought to investigate the association between chronic pain and self-reported prescription drug abuse in a large cohort of patients referred from primary care for a behavioral health assessment...
  64. ncbi request reprint Targeting treatments for alcohol dependence: the pharmacogenetics of naltrexone
    David W Oslin
    University of Pennsylvania, Geriartric and Addiction Psychiatry, Philadelphia, PA 19104, USA
    Addict Biol 11:397-403. 2006
    ..This article reviews the biological correlates and outlines a scientific agenda for better understanding the role of opioid neurotransmission in the etiology, maintenance and treatment of alcohol dependence...
  65. ncbi request reprint Predictors of sleep disturbances in Operation Iraqi Freedom/Operation Enduring Freedom veterans reporting a trauma
    Les A Gellis
    Philadelphia Veterans Medical Center, MIRECC 116, 2nd Floor, University and Woodland Avenues, Philadelphia, PA 19104, USA
    Mil Med 175:567-73. 2010
    ..80, p = 0.007), and greater nonsleep depression increased the likelihood of severe DIMS (OR = 1.20, p = 0.008). Thus, factors aside from PTSD severity are related to sleep disturbance in OIF/OEF veterans reporting a trauma...
  66. pmc A randomized controlled trial of a close monitoring program for minor depression and distress
    Jennifer T Ross
    Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Gen Intern Med 23:1379-85. 2008
    ..Minor depression is almost twice as common in primary care (PC) as major depression. Despite the high prevalence, few evidence-based algorithms exist for managing patients with minor depression or patients presenting solely with distress...
  67. pmc Alcohol consumption among older adults in primary care
    JoAnn E Kirchner
    VA South Central Mental Illness Research Education and Clinic Center, Little Rock, AR, USA
    J Gen Intern Med 22:92-7. 2007
    ..Alcohol misuse is a growing public health concern for older adults, particularly among primary care patients...
  68. ncbi request reprint Association of functional opioid receptor genotypes with alcohol dependence in Koreans
    Sung Gon Kim
    Department of Psychiatry, Pusan National University, Pusan, Korea
    Alcohol Clin Exp Res 28:986-90. 2004
    ..This study compared Koreans with one or two copies of the A118G polymorphism seeking treatment for alcohol dependence with a group of non-alcohol-dependent controls...
  69. ncbi request reprint Design and sample characteristics of the PRISM-E multisite randomized trial to improve behavioral health care for the elderly
    Sue E Levkoff
    Brigham and Women s Hospital, Harvard Medical School, USA
    J Aging Health 16:3-27. 2004
    ..To describe the design of the Primary Care Research in Substance Abuse and Mental Health for Elderly (PRISM-E) study and baseline characteristics of the randomized primary care patients with mental health problems and at-risk alcohol use...
  70. ncbi request reprint Methodological challenges in constructing effective treatment sequences for chronic psychiatric disorders
    Susan A Murphy
    Institute for Social Research, University of Michigan, Ann Arbor, MI 48106 1248, USA
    Neuropsychopharmacology 32:257-62. 2007
    ..Promising designs and methods are surveyed with a focus on those areas most immediately useful for informing clinical decision making...
  71. ncbi request reprint Longitudinal course of substance treatment benefits in older male veteran at-risk drinkers
    Faika Zanjani
    Graduate Center for Gerontology, University of Kentucky, Lexington, KY 41094, USA
    J Gerontol A Biol Sci Med Sci 63:98-106. 2008
    ....
  72. ncbi request reprint Assessment of late life depression
    George S Alexopoulos
    Weil Medical College, Cornell University GSA, White Plains, New York 10605, USA
    Biol Psychiatry 52:164-74. 2002
    ..Care managers working together with primary care physicians can improve the recognition and treatment of depressed elderly patients by obtaining the training in using validated instruments and treatment algorithms...
  73. ncbi request reprint Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ..To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research...
  74. ncbi request reprint Treatment-related decisional capacity
    Mohit P Chopra
    Am J Geriatr Psychiatry 11:257-8; author reply 258-9. 2003
  75. ncbi request reprint Psychiatrists and primary caring: what are our boundaries of responsibility?
    Lisa B Dixon
    Psychiatr Serv 58:600-2. 2007
    ..Characteristics of the setting, practitioner, and patient that affect how such responsibilities are fulfilled are also discussed...

Research Grants12

  1. TREATMENT OF LATE LIFE DEPRESSION COMPLICATED BY ALCOHOL
    David Oslin; Fiscal Year: 2003
    ..Finally, proposed plans for this MCSDA are well coordinated with the research activities of the Section of Geriatric Psychiatry and the Center for Studies on Addiction. ..
  2. Pharmacogenetic Response to Naltrexone for Alcohol Dependence
    David Oslin; Fiscal Year: 2009
    ....
  3. Non-response to NTX next steps in managing alcoholism
    David Oslin; Fiscal Year: 2007
    ..abstract_text> ..
  4. Non-response to NTX next steps in managing alcoholism
    David Oslin; Fiscal Year: 2006
    ..abstract_text> ..
  5. Non-response to NTX next steps in managing alcoholism
    David Oslin; Fiscal Year: 2006
    ..abstract_text> ..
  6. Pharmacogenetic Response to Naltrexone for Alcohol Dependence
    David W Oslin; Fiscal Year: 2010
    ....