M Oshiro

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
    P K Epling-Burnette
    Hematologic Malignancy Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC, Room 2068 f and g, Tampa, Florida 33612, USA
    J Clin Invest 107:351-62. 2001
  2. ncbi Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils
    P K Epling-Burnette
    Malignant Hematology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cell Immunol 217:1-11. 2002
  3. ncbi Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes
    Pearlie Kay Epling-Burnette
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, and James A Haley Veterans Administration Hospital, Tampa, FL 33612, USA
    Blood 103:3431-9. 2004
  4. ncbi ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL)
    Pearlie K Epling-Burnette
    Hematologic Malignancies, Programs from the Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Oncogene 23:9220-9. 2004

Research Grants

  1. TARGETED DRUG THERAPY FOR LGL LEUKEMIA
    Pearlie K Epling Burnette; Fiscal Year: 2007

Collaborators

  • Julie Y Djeu
  • J Turkson
  • Y Li
  • Pearlie K Epling Burnette
  • P K Epling-Burnette
  • Thomas P Loughran
  • Sheng Wei
  • Fanqi Bai
  • Pearlie K Epling-Burnette
  • Pratima Chaurasia
  • Pearlie Kay Epling-Burnette
  • Jeffrey S Painter
  • Said Sebti
  • Andrew Hamilton
  • Nancy Olashaw
  • Richard Jove
  • Roy Garcia
  • Sajid Ismail
  • H F Yang-Yen
  • R Kothapalli
  • J H Liu
  • R Catlett-Falcone
  • T P Loughran
  • J Karras
  • J M Wang
  • R Jove

Detail Information

Publications4

  1. ncbi Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
    P K Epling-Burnette
    Hematologic Malignancy Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC, Room 2068 f and g, Tampa, Florida 33612, USA
    J Clin Invest 107:351-62. 2001
    ..We conclude that STAT3 activation contributed to accumulation of the leukemic LGL clones. These findings suggest that investigation should focus on novel strategies targeting STAT3 in the treatment of LGL leukemia...
  2. ncbi Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils
    P K Epling-Burnette
    Malignant Hematology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cell Immunol 217:1-11. 2002
    ..These findings provide new insights to a mechanism by which PMN, a terminally differentiated cell, may regulate gene transcription by alternative proteolytic processing...
  3. ncbi Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes
    Pearlie Kay Epling-Burnette
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, and James A Haley Veterans Administration Hospital, Tampa, FL 33612, USA
    Blood 103:3431-9. 2004
    ..These results demonstrate that patients with NK-LDGL have an increased activating-to-inhibitory KIR ratio. This altered ratio might induce inappropriate lysis or cytokine production and impact the disease pathogenesis...
  4. ncbi ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL)
    Pearlie K Epling-Burnette
    Hematologic Malignancies, Programs from the Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Oncogene 23:9220-9. 2004
    ..These findings suggest that strategies to inhibit this signaling pathway may be useful for the treatment of the NK type of LDGL...

Research Grants1

  1. TARGETED DRUG THERAPY FOR LGL LEUKEMIA
    Pearlie K Epling Burnette; Fiscal Year: 2007
    ..Results of these studies should identify important molecular targets for drug development in bone marrow failure syndromes. ..