Research Topics
| J OshimaSummaryAffiliation: University of Washington Country: USA Publications
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Detail Information
Publications
Comparative aspects of the Werner syndrome geneJ Oshima
Department of Pathology, University of Washington, Seattle 98195, USA
In Vivo 14:165-72. 2000..This review focuses on the comparative aspects of WRN, including differential gene action within humans and the potential differences between species, particularly the mouse and human...- Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosisE Castro
Department of Pathology, University of Washington, Seattle, USA
Am J Med Genet 95:374-80. 2000..These data support the hypothesis that WRN may mediate not only WS, but may also modulate more common age-related disorders and, perhaps, a basic aging process... 
Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein AJ C Shen
Department of Pathology, University of Washington, Box 357705, Seattle, WA 98195 7705, USA
Nucleic Acids Res 26:2879-85. 1998..A deficit in the interaction of WRN with hRPA may be associated with deletion mutations that occur at elevated frequency in Werner syndrome cells...- WRN mutations in Werner syndromeM J Moser
Department of Pathology, University of Washington, Seattle 98195 7705, USA
Hum Mutat 13:271-9. 1999.... - Structure and function of the human Werner syndrome gene promoter: evidence for transcriptional modulationL Wang
Department of Genetics and Department of Pathology, University of Washington, Seattle, WA 98195, USA
Nucleic Acids Res 26:3480-5. 1998..The reduction of activity was not seen in three other promoters tested, including one TATA-less promoter and one TATA-containing promoter. This is consistent with the presence of a positive regulatory mechanism of WRN expression... - The Werner syndrome protein is a DNA helicaseM D Gray
Department of Pathology, University of Washington, Seattle 98195 7705, USA
Nat Genet 17:100-3. 1997..Here we report that the WS protein does indeed catalyze DNA unwinding... - Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenariansE Castro
Department of Pathology, University of Washington, Seattle 98195, USA
Am J Med Genet 82:399-403. 1999..Thus, unlike the APOE polymorphism, there is no evidence of an association of this WRN polymorphism with longevity... - The Werner syndrome protein: an updateJ Oshima
Department of Pathology, Box 357470, HSB K 543 University of Washington, 1959 NE Pacific Ave, Seattle, WA 98195 7470, USA
Bioessays 22:894-901. 2000..However, the precise molecular mechanisms by which mutations in WRN cause the WS phenotype remain unknown. Recent progress in the understanding of the WRN protein and its implication in the normal aging process are discussed... - Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease geneE Levy-Lahad
Division of Medical Genetics, University of Washington, Seattle, Washington, 98195, USA
Genomics 34:198-204. 1996..This expression pattern is intriguing since in Alzheimer disease, pathology and degeneration are observed only in the central nervous system... - Effect of Ku86 and DNA-PKcs deficiency on non-homologous end-joining and homologous recombination using a transient transfection assayM B Secretan
Department of Pathology, UCLA School of Medicine and Public Health, Los Angeles, CA, USA
Mutat Res 554:351-64. 2004..On the other hand, the DNA-PKcs deficient cell lines showed efficient double-strand break repair by both mechanisms... - A Novel LMNA Mutation Causes Altered Nuclear Morphology and Symptoms of Familial Partial Lipodystrophy (Dunnigan Variety) with Progeroid FeaturesB Saha
Department of Pathology, University of Washington, Seattle, Wash, USA
Mol Syndromol 1:127-132. 2010..Our findings indicate that FPLD2 should be considered in the differential diagnosis of the Werner syndrome... - Evidence against DNA polymerase beta as a candidate gene for Werner syndromeM Chang
Department of Pathology, University of Washington, Seattle 98195
Hum Genet 93:507-12. 1994..2 and thus beyond the region of peak LOD scores for WS... - Characterization of the human and mouse WRN 3'-->5' exonucleaseS Huang
Life Sciences Division, Mailstop 84 144, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
Nucleic Acids Res 28:2396-405. 2000..Finally, we show that hWRN forms a trimer and interacts with the proliferating cell nuclear antigen in vitro. These findings provide new data on the biochemical activities of WRN that may help elucidate its role(s) in DNA metabolism... - Werner protein recruits DNA polymerase delta to the nucleolusA M Szekely
Boyer Center for Molecular Medicine and Department of Genetics, Yale University School of Medicine, New Haven CT, 06510, USA
Proc Natl Acad Sci U S A 97:11365-70. 2000..These results suggest that one of the functions of WRN protein is to directly modify DNA replication via its interaction with p50 and abet dynamic relocalization of the DNA polymerase delta complexes within the nucleus... - Positional cloning of the Werner's syndrome geneC E Yu
Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Division, WA 98108, USA
Science 272:258-62. 1996..The other two mutations are nonsense mutations. The identification of a mutated putative helicase as the gene product of the WS gene suggests that defective DNA metabolism is involved in the complex process of aging in WS patients... - WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblastsF M Hisama
Boyer Center for Molecular Medicine, Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Cancer Res 60:2372-6. 2000..Curiously, the sensitivity can be reversed equally well by transfecting a telomerase gene (TERT) into the cells. These data indicate the possibility of an interdependent function of these two genes... - Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese populationL Ye
Department of Geriatric Medicine, Osaka University Medical School, Japan
Am J Med Genet 68:494-8. 1997..However, given the caveats implicit in genetic association studies, it is imperative that the present results be replicated in independent populations... - Analysis of microsatellite instability and hypermutation of immunoglobulin variable genes in Werner syndromeK Rosner
Laboratory of Molecular Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Mech Ageing Dev 122:1121-33. 2001..The frequency and pattern of mutation was similar to that from normal individuals, suggesting that the Werner protein is not involved in generating hypermutation... - Atypical progeroid syndrome: an unknown helicase gene defect?M W G Ruijs
Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
Am J Med Genet A 116:295-9. 2003..Therefore, this patient probably represents a provisionally unique syndrome, perhaps due to a mutation in a related (helicase) gene... - Topical PDGF-BB results in limited healing in a patient with Werner's syndrome and chronic leg ulcersU Wollina
Department of Dermatology, Academic Teaching Hospital Dresden Friedrichstadt, Dresden, Germany
J Wound Care 13:415-6. 2004..Treatment of one such patient with painful chronic leg ulcers included topical application of PDGF-BB. Granulation increased slightly, enabling full-thickness skin grafting to take place...