Jon Oscherwitz

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Low-dose intraperitoneal Freund's adjuvant: toxicity and immunogenicity in mice using an immunogen targeting amyloid-beta peptide
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Vaccine 24:3018-25. 2006
  2. pmc Synthetic peptide vaccine targeting a cryptic neutralizing epitope in domain 2 of Bacillus anthracis protective antigen
    Jon Oscherwitz
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, 48105, USA
    Infect Immun 77:3380-8. 2009
  3. doi request reprint Anthrax vaccine recipients lack antibody against the loop neutralizing determinant: A protective neutralizing epitope from Bacillus anthracis protective antigen
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA Veterans Administration Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA Electronic address
    Vaccine 33:2342-6. 2015
  4. doi request reprint Epitope-focused peptide immunogens in human use adjuvants protect rabbits from experimental inhalation anthrax
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA Veterans Administration Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA Electronic address
    Vaccine 33:430-6. 2015
  5. doi request reprint In vivo mapping of a protective linear neutralizing epitope at the N-terminus of alpha hemolysin from Staphylococcus aureus
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA VA Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA Electronic address
    Mol Immunol 60:62-71. 2014
  6. pmc Recombinant vaccine displaying the loop-neutralizing determinant from protective antigen completely protects rabbits from experimental inhalation anthrax
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Clin Vaccine Immunol 20:341-9. 2013
  7. doi request reprint A synthetic peptide vaccine directed against the 2ß2-2ß3 loop of domain 2 of protective antigen protects rabbits from inhalation anthrax
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Immunol 185:3661-8. 2010
  8. pmc A heterologous helper T-cell epitope enhances the immunogenicity of a multiple-antigenic-peptide vaccine targeting the cryptic loop-neutralizing determinant of Bacillus anthracis protective antigen
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Infect Immun 77:5509-18. 2009
  9. ncbi request reprint A V3 loop haptenic peptide sequence, when tandemly repeated, enhances immunogenicity by facilitating helper T-cell responses to a covalently linked carrier protein
    J Oscherwitz
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, 48105, USA
    Vaccine 17:2392-9. 1999
  10. pmc Staphylococcus δ-toxin induces allergic skin disease by activating mast cells
    Yuumi Nakamura
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 503:397-401. 2013

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Low-dose intraperitoneal Freund's adjuvant: toxicity and immunogenicity in mice using an immunogen targeting amyloid-beta peptide
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Vaccine 24:3018-25. 2006
    ..p., the accompanying toxicity remains significant, and thus alternative adjuvants and/or routes should be considered...
  2. pmc Synthetic peptide vaccine targeting a cryptic neutralizing epitope in domain 2 of Bacillus anthracis protective antigen
    Jon Oscherwitz
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, 48105, USA
    Infect Immun 77:3380-8. 2009
    ..These results highlight the potential importance of this immunologically cryptic neutralizing epitope from PA as a target for alternative and adjunctive vaccines for anthrax...
  3. doi request reprint Anthrax vaccine recipients lack antibody against the loop neutralizing determinant: A protective neutralizing epitope from Bacillus anthracis protective antigen
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA Veterans Administration Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA Electronic address
    Vaccine 33:2342-6. 2015
    ..Interestingly, data suggests that this epitope is relatively immunosilent in rabbits and non-human primates immunized with full length PA...
  4. doi request reprint Epitope-focused peptide immunogens in human use adjuvants protect rabbits from experimental inhalation anthrax
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA Veterans Administration Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA Electronic address
    Vaccine 33:430-6. 2015
    ..anthracis Ames strain. However, demonstration of efficacy using human-use adjuvants is required before proceeding with further development of an LND vaccine for testing in non-human primates and humans...
  5. doi request reprint In vivo mapping of a protective linear neutralizing epitope at the N-terminus of alpha hemolysin from Staphylococcus aureus
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA VA Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA Electronic address
    Mol Immunol 60:62-71. 2014
    ..aureus...
  6. pmc Recombinant vaccine displaying the loop-neutralizing determinant from protective antigen completely protects rabbits from experimental inhalation anthrax
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Clin Vaccine Immunol 20:341-9. 2013
    ..We conclude that Rec-LND may represent a prototype anthrax vaccine for use alone or potentially combined with PA-containing vaccines...
  7. doi request reprint A synthetic peptide vaccine directed against the 2ß2-2ß3 loop of domain 2 of protective antigen protects rabbits from inhalation anthrax
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Immunol 185:3661-8. 2010
    ..We conclude that a synthetic peptide vaccine targeting the LND would be a potentially efficacious vaccine for anthrax...
  8. pmc A heterologous helper T-cell epitope enhances the immunogenicity of a multiple-antigenic-peptide vaccine targeting the cryptic loop-neutralizing determinant of Bacillus anthracis protective antigen
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    Infect Immun 77:5509-18. 2009
    ..P30-containing MAP304 represents a promising LND-specific vaccine for anthrax...
  9. ncbi request reprint A V3 loop haptenic peptide sequence, when tandemly repeated, enhances immunogenicity by facilitating helper T-cell responses to a covalently linked carrier protein
    J Oscherwitz
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, 48105, USA
    Vaccine 17:2392-9. 1999
    ....
  10. pmc Staphylococcus δ-toxin induces allergic skin disease by activating mast cells
    Yuumi Nakamura
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nature 503:397-401. 2013
    ..These studies identify δ-toxin as a potent inducer of mast cell degranulation and suggest a mechanistic link between S. aureus colonization and allergic skin disease. ..
  11. doi request reprint A CD20 tandem-epitope immunogen elicits antibody in mice that binds murine cell surface CD20 and depletes splenic B cells in vivo
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Mol Immunol 47:1484-91. 2010
    ..The tandem-epitope immunogen represents a promising tool for eliciting and studying active autoimmunity to CD20, as a basis for potential development of new immunotherapeutics for cancer and autoimmune diseases...
  12. pmc Identification and validation of a linear protective neutralizing epitope in the β-pore domain of alpha toxin
    Jon Oscherwitz
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, 48105, United States of America VA Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, Michigan, 48105, United States of America
    PLoS ONE 10:e0116882. 2015
    ..aureus USA300 skin infection. The delineation of this linear neutralizing determinant in alpha toxin could facilitate the development of an epitope-focused vaccine against S. aureus. ..