Mark J Osborn

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of α-L-iduronidase in mice with mucopolysaccharidosis type I
    Mark J Osborn
    Department of Pediatrics, Division of Bone Marrow Transplant, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Mol Ther 19:450-60. 2011
  2. doi request reprint Synthetic zinc finger nuclease design and rapid assembly
    Mark J Osborn
    University of Minnesota Masonic Cancer Center and Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics, Minneapolis, MN 55455, USA
    Hum Gene Ther 22:1155-65. 2011
  3. pmc Targeting of the CNS in MPS-IH using a nonviral transferrin-alpha-L-iduronidase fusion gene product
    Mark J Osborn
    University of Minnesota Cancer Center, Minneapolis, Minnesota, USA
    Mol Ther 16:1459-66. 2008
  4. doi request reprint Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa
    Jakub Tolar
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Invest Dermatol 131:848-56. 2011
  5. pmc Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome)
    Jakub Tolar
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of MN, Minneapolis, MN, USA
    Blood 117:839-47. 2011
  6. ncbi request reprint A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system
    Mark J Osborn
    Pediatrics, Hematology Oncology, Blood and Marrow Transplant Program, Institute of Human Genetics, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Ther 12:569-74. 2005
  7. ncbi request reprint Sarcoma derived from cultured mesenchymal stem cells
    Jakub Tolar
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant and Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Stem Cells 25:371-9. 2007
  8. pmc Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation
    Ryan M Kelly
    Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 115:1088-97. 2010
  9. ncbi request reprint Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis
    Mark J Osborn
    Department of Laboratory Medicine and Pathology, Division of Medical Technology, University of Minnesota, BSBE 6 118, 312 Church Street SE, Minneapolis, MN 55455, USA
    Blood 103:843-51. 2004
  10. pmc TALEN-based gene correction for epidermolysis bullosa
    Mark J Osborn
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Mol Ther 21:1151-9. 2013

Detail Information

Publications11

  1. pmc Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of α-L-iduronidase in mice with mucopolysaccharidosis type I
    Mark J Osborn
    Department of Pediatrics, Division of Bone Marrow Transplant, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Mol Ther 19:450-60. 2011
    ..MC gene delivery combined with costimulatory pathway blockade maximizes safety, efficacy, and sustained gene expression and is a new approach in the treatment of lysosomal storage disease...
  2. doi request reprint Synthetic zinc finger nuclease design and rapid assembly
    Mark J Osborn
    University of Minnesota Masonic Cancer Center and Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Pediatrics, Minneapolis, MN 55455, USA
    Hum Gene Ther 22:1155-65. 2011
    ..This method, termed CoDA-syn (context-dependent assembly-synthetic), should facilitate a more widespread use of ZFNs in the research community...
  3. pmc Targeting of the CNS in MPS-IH using a nonviral transferrin-alpha-L-iduronidase fusion gene product
    Mark J Osborn
    University of Minnesota Cancer Center, Minneapolis, Minnesota, USA
    Mol Ther 16:1459-66. 2008
    ..Short-term treatment resulted in a decrease in GAGs in the cerebellum of mucopolysaccharidosis type I (MPS I) mice. This approach, therefore, represents a potential strategy for the delivery of therapeutic enzyme to the CNS...
  4. doi request reprint Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa
    Jakub Tolar
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Invest Dermatol 131:848-56. 2011
    ..These data identify the potential of RDEB iPS cells to generate autologous hematopoietic grafts and skin cells with the inherent capacity to treat skin and mucosal erosions that typify this genodermatosis...
  5. pmc Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome)
    Jakub Tolar
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of MN, Minneapolis, MN, USA
    Blood 117:839-47. 2011
    ....
  6. ncbi request reprint A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system
    Mark J Osborn
    Pediatrics, Hematology Oncology, Blood and Marrow Transplant Program, Institute of Human Genetics, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Ther 12:569-74. 2005
    ....
  7. ncbi request reprint Sarcoma derived from cultured mesenchymal stem cells
    Jakub Tolar
    Department of Pediatrics, Division of Hematology Oncology, Blood and Marrow Transplant and Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Stem Cells 25:371-9. 2007
    ..More importantly, our study indicates that sarcoma can evolve from MSC cultures...
  8. pmc Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation
    Ryan M Kelly
    Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 115:1088-97. 2010
    ..Thus, transient p53 inhibition combined with KGF represents a novel and potentially translatable approach to promote rapid and durable thymic and peripheral T-cell recovery after BMT...
  9. ncbi request reprint Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis
    Mark J Osborn
    Department of Laboratory Medicine and Pathology, Division of Medical Technology, University of Minnesota, BSBE 6 118, 312 Church Street SE, Minneapolis, MN 55455, USA
    Blood 103:843-51. 2004
    ..The arrest in lymphopoiesis and the expansion of myeloid progenitor cells in TSLP transgenic mice suggest that TSLP has negative and positive regulatory effects on lymphoid and myeloid development, respectively...
  10. pmc TALEN-based gene correction for epidermolysis bullosa
    Mark J Osborn
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Mol Ther 21:1151-9. 2013
    ....
  11. pmc Bone marrow transplantation for recessive dystrophic epidermolysis bullosa
    John E Wagner
    Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    N Engl J Med 363:629-39. 2010
    ....