Affiliation: University of Minnesota
Osborn J, Averina V, Fink G. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol. 2009;94:389-96 pubmed publisher
Osborn J, Fink G, Kuroki M. Neural mechanisms of angiotensin II-salt hypertension: implications for therapies targeting neural control of the splanchnic circulation. Curr Hypertens Rep. 2011;13:221-8 pubmed publisher
..The relevance of these findings to human hypertension and the future development of targeted sympatholytic therapies are discussed. ..
Foss J, Wainford R, Engeland W, Fink G, Osborn J. A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin. Am J Physiol Regul Integr Comp Physiol. 2015;308:R112-22 pubmed publisher
..Lastly, renal-CAP significantly attenuated the development of deoxycorticosterone acetate-salt hypertension. These results demonstrate that renal-CAP effectively causes selective ablation of afferent renal nerves in rats. ..
Osborn J, Hendel M, Collister J, Ariza Guzman P, Fink G. The role of the subfornical organ in angiotensin II-salt hypertension in the rat. Exp Physiol. 2012;97:80-8 pubmed publisher
..We conclude that, although the SFO is required for the complete expression of Ang II-salt hypertension in the rat, other brain sites are also involved. ..
Foss J, Fink G, Osborn J. Differential role of afferent and efferent renal nerves in the maintenance of early- and late-phase Dahl S hypertension. Am J Physiol Regul Integr Comp Physiol. 2016;310:R262-7 pubmed publisher
..These results suggest that, in the Dahl S rat, the antihypertensive effect of RDNX is not dependent on pretreatment arterial pressure, nor is it due to ablation of afferent renal nerves. ..
Asirvatham Jeyaraj N, Fiege J, Han R, Foss J, Banek C, Burbach B, et al
. Renal Denervation Normalizes Arterial Pressure With No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice. Hypertension. 2016;68:929-36 pubmed publisher
..These results indicate that although renal nerves play a role in obesity-induced hypertension, they do not contribute to impaired glucose metabolism or renal inflammation in this model. ..
Osborn J, Fink G. Region-specific changes in sympathetic nerve activity in angiotensin II-salt hypertension in the rat. Exp Physiol. 2010;95:61-8 pubmed publisher
Banek C, Knuepfer M, Foss J, Fiege J, Asirvatham Jeyaraj N, Van Helden D, et al
. Resting Afferent Renal Nerve Discharge and Renal Inflammation: Elucidating the Role of Afferent and Efferent Renal Nerves in Deoxycorticosterone Acetate Salt Hypertension. Hypertension. 2016;68:1415-1423 pubmed
..Also, resting afferent renal nerve activity is elevated in DOCA salt rats, which may highlight a crucial neural mechanism in the development and maintenance of hypertension. ..