G M Ortiz
Affiliation: University of California
- Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjectsG M Ortiz
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141 9100, USA
Proc Natl Acad Sci U S A 98:13288-93. 2001..Despite increases in antiviral immunity, no control of VL was observed. Future studies of STI should proceed with caution...
- Residual viral replication during antiretroviral therapy boosts human immunodeficiency virus type 1-specific CD8+ T-cell responses in subjects treated early after infectionGabriel M Ortiz
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA
J Virol 76:411-5. 2002..HIV-1-specific CD8+ T cells can increase in number after HAART in subjects treated early after infection who have episodes of transient viremia...
- The relationship between T cell proliferative responses and plasma viremia during treatment of human immunodeficiency virus type 1 infection with combination antiretroviral therapyJ M Binley
The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
J Infect Dis 181:1249-63. 2000..Thus, CD4+ T cell responses can sometimes be regenerated if viral load is suppressed to allow some immune recovery and if antigenic stimulation is later provided...
- Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptionsBecky Schweighardt
Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, USA
AIDS 16:2342-4. 2002..We concluded that the repeated abrupt termination and resumption of certain antiretroviral drug regimens during STI therapy may lead to the development of drug resistance in chronically HIV-infected individuals...
- A cytostatic drug improves control of HIV-1 replication during structured treatment interruptions: a randomized studyFelipe Garcia
Infectious Diseases Unit, Clinic Institute of Infectious Diseases and Immunology, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
AIDS 17:43-51. 2003....
- Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease geneAnnika C Karlsson
Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
J Virol 77:6743-52. 2003..Our results indicate that both HIV type 1-specific CD8(+) T cells and antiretroviral drugs provide complex pressures on the same amino acid sequence of the HIV protease gene and, thus, can influence viral sequence evolution...
- Changes in CD4+ T-cell differentiation phenotype during structured treatment interruption in patients with chronic HIV-1 infectionThomas H Alexander
Duke University Medical Center, Durham, NC 27705, USA
J Acquir Immune Defic Syndr 34:475-81. 2003..These results suggest that interruptions should be avoided whenever possible in patients on HAART with high plasma HIV-1 RNA set-points...
- Relevance of HIV-1-specific CD4+ helper T-cell responses during structured treatment interruptions in patients with CD4+ T-cell nadir above 400/mm3Montserrat Plana
Clinic Institute of Infectious Diseases and Immunology, IDIBAPS, Hospital Clinic, Faculty of Medicine, University of Barcelona, Spain
J Acquir Immune Defic Syndr 36:791-9. 2004..To analyze the dynamics of both HIV-1-specific CD4 and CD8 T-cell responses during structured treatment interruptions (STIs) in chronically HIV-1-infected (CHI) patients and to correlate them with the viral set point achieved...