Emilio Ortiz-Riaño

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Viruses 4:2137-61. 2012
  2. pmc The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Virol 85:13038-48. 2011
  3. pmc Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:3307-17. 2012
  4. pmc Arenavirus nucleoproteins prevent activation of nuclear factor kappa B
    W W Shanaka I Rodrigo
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:8185-97. 2012
  5. pmc Arenavirus reverse genetics for vaccine development
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Gen Virol 94:1175-88. 2013

Collaborators

Detail Information

Publications5

  1. pmc D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Viruses 4:2137-61. 2012
    ..Additionally, we also document the dominant negative effect of D471G mutation on viral infection, suggesting that NP self-association is an excellent target for the development of new antivirals against arenaviruses...
  2. pmc The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Virol 85:13038-48. 2011
    ..In addition, this NP-Z interaction represents a potential target for the development of antiviral drugs to combat human-pathogenic arenaviruses...
  3. pmc Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:3307-17. 2012
    ....
  4. pmc Arenavirus nucleoproteins prevent activation of nuclear factor kappa B
    W W Shanaka I Rodrigo
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:8185-97. 2012
    ..Altogether, our findings demonstrate that arenavirus infection inhibits NF-κB-dependent innate immune and inflammatory responses, possibly playing a key role in the pathogenesis and virulence of arenavirus...
  5. pmc Arenavirus reverse genetics for vaccine development
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Gen Virol 94:1175-88. 2013
    ..Moreover, we show the feasibility of using these novel strategies for efficient rescue of recombinant tri-segmented both LCMV and Candid#1...