Emilio Ortiz-Riaño

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Viruses 4:2137-61. 2012
  2. pmc The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Virol 85:13038-48. 2011
  3. pmc Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:3307-17. 2012
  4. pmc Arenavirus nucleoproteins prevent activation of nuclear factor kappa B
    W W Shanaka I Rodrigo
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:8185-97. 2012
  5. pmc Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 88:878-89. 2014
  6. pmc Arenavirus reverse genetics for vaccine development
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Gen Virol 94:1175-88. 2013

Collaborators

Detail Information

Publications6

  1. pmc D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Viruses 4:2137-61. 2012
    ..Additionally, we also document the dominant negative effect of D471G mutation on viral infection, suggesting that NP self-association is an excellent target for the development of new antivirals against arenaviruses...
  2. pmc The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Virol 85:13038-48. 2011
    ..In addition, this NP-Z interaction represents a potential target for the development of antiviral drugs to combat human-pathogenic arenaviruses...
  3. pmc Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:3307-17. 2012
    ....
  4. pmc Arenavirus nucleoproteins prevent activation of nuclear factor kappa B
    W W Shanaka I Rodrigo
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 86:8185-97. 2012
    ..Altogether, our findings demonstrate that arenavirus infection inhibits NF-κB-dependent innate immune and inflammatory responses, possibly playing a key role in the pathogenesis and virulence of arenavirus...
  5. pmc Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA
    J Virol 88:878-89. 2014
    ..We document an additive antiarenavirus effect of A3 and ribavirin, supporting the potential combination therapy of ribavirin and pyrimidine biosynthesis inhibitors for the treatment of arenavirus infections. ..
  6. pmc Arenavirus reverse genetics for vaccine development
    Emilio Ortiz-Riaño
    Department of Microbiology and Immunology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Gen Virol 94:1175-88. 2013
    ..Moreover, we show the feasibility of using these novel strategies for efficient rescue of recombinant tri-segmented both LCMV and Candid#1...