Jennifer L Orthmann-Murphy

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Loss-of-function GJA12/Connexin47 mutations cause Pelizaeus-Merzbacher-like disease
    Jennifer L Orthmann-Murphy
    Department of Neurology, University of Pennsylvania School of Medicine, Room 464 Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA 19104 6077, USA
    Mol Cell Neurosci 34:629-41. 2007
  2. ncbi Two distinct heterotypic channels mediate gap junction coupling between astrocyte and oligodendrocyte connexins
    Jennifer L Orthmann-Murphy
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6077, USA
    J Neurosci 27:13949-57. 2007
  3. ncbi Gap junctions couple astrocytes and oligodendrocytes
    Jennifer L Orthmann-Murphy
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Mol Neurosci 35:101-16. 2008
  4. ncbi Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations
    Jennifer L Orthmann-Murphy
    Department of Neurology, University of Pennsylvania School of Medicine, Room 464 Stemmler Hall, Philadelphia, PA 19104 6077, USA
    Brain 132:426-38. 2009

Research Grants

  1. How do Cx32 and Cx47 mutants cause CNS demyelination?
    JENNIFER ORTHMAN; Fiscal Year: 2007

Collaborators

Detail Information

Publications4

  1. ncbi Loss-of-function GJA12/Connexin47 mutations cause Pelizaeus-Merzbacher-like disease
    Jennifer L Orthmann-Murphy
    Department of Neurology, University of Pennsylvania School of Medicine, Room 464 Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA 19104 6077, USA
    Mol Cell Neurosci 34:629-41. 2007
    ..Thus, the Cx47 mutants associated with PMLD likely disrupt the gap junction coupling between astrocytes and oligodendrocytes...
  2. ncbi Two distinct heterotypic channels mediate gap junction coupling between astrocyte and oligodendrocyte connexins
    Jennifer L Orthmann-Murphy
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6077, USA
    J Neurosci 27:13949-57. 2007
    ..Finally, Cx47 mutants that cause Pelizaeus-Merzbacher-like disease do not efficiently form functional channels with Cx43, indicating that disrupted Cx47/Cx43 channels cause this disease...
  3. ncbi Gap junctions couple astrocytes and oligodendrocytes
    Jennifer L Orthmann-Murphy
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Mol Neurosci 35:101-16. 2008
    ..Mutations of these connexin genes demonstrate that the proper functioning of myelin and oligodendrocytes requires the expression of these connexins. The physiological function of O/A and A/A junctions, however, remains to be illuminated...
  4. ncbi Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations
    Jennifer L Orthmann-Murphy
    Department of Neurology, University of Pennsylvania School of Medicine, Room 464 Stemmler Hall, Philadelphia, PA 19104 6077, USA
    Brain 132:426-38. 2009
    ..Thus, GJA12/GJC2 mutations can result in a milder phenotype than previously appreciated, but whether I33M retains a function of Cx47 not directly related to forming functional gap junction channels is not known...

Research Grants1

  1. How do Cx32 and Cx47 mutants cause CNS demyelination?
    JENNIFER ORTHMAN; Fiscal Year: 2007
    ..This work should elucidate the molecular composition of gap junction channels that couple astrocytes and oligodendrocytes. ..