M B Orringer

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Eliminating the cervical esophagogastric anastomotic leak with a side-to-side stapled anastomosis
    M B Orringer
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Thorac Cardiovasc Surg 119:277-88. 2000
  2. ncbi request reprint Transhiatal esophagectomy for distal and cardia cancers: implications of a positive gastric margin
    Paul D DiMusto
    Section of Thoracic Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 83:1993-8; discussion 1998-9. 2007
  3. doi request reprint Herbert sloan, MD, october 10, 1914 - may 17, 2013
    Mark B Orringer
    Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor, Michigan Electronic address
    Ann Thorac Surg 97:1116-9. 2014
  4. doi request reprint Richard Anderson: cardiothoracic surgeon personified
    Mark B Orringer
    Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 88:1729-31. 2009
  5. ncbi request reprint Unity and participation: embracing counterintuitive survival skills
    Mark B Orringer
    University of Michigan Medical Center, Ann Arbor 48109, USA
    Ann Thorac Surg 74:3-12. 2002
  6. pmc Two thousand transhiatal esophagectomies: changing trends, lessons learned
    Mark B Orringer
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Ann Surg 246:363-72; discussion 372-4. 2007
  7. ncbi request reprint Transhiatal esophagectomy for treatment of benign and malignant esophageal disease
    M B Orringer
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical Center, 2120 Taubman Health Care Center, 1500 E Medical Center Drive, Box 0344, Ann Arbor, Michigan 48109, USA
    World J Surg 25:196-203. 2001
  8. doi request reprint Analysis of cervical esophagogastric anastomotic leaks after transhiatal esophagectomy: risk factors, presentation, and detection
    David T Cooke
    Section of Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 88:177-84; discussion 184-5. 2009
  9. pmc Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas
    W J Rachwal
    Department of Surgery, University of Michigan Medical School, Ann Arbor 48109, USA
    Br J Cancer 72:56-64. 1995
  10. ncbi request reprint Adjuvant treatment using transfer factor for bronchogenic carcinoma: long-term follow-up
    R I Whyte
    Section of Thoracic Surgery, University of Michigan, Ann Arbor
    Ann Thorac Surg 53:391-6. 1992

Detail Information

Publications77

  1. ncbi request reprint Eliminating the cervical esophagogastric anastomotic leak with a side-to-side stapled anastomosis
    M B Orringer
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Thorac Cardiovasc Surg 119:277-88. 2000
    ..Nearly 50% of cervical anastomotic leaks result in an anastomotic stricture, and the subsequent need for chronic dilatations negates the merits of an operation intended to restore comfortable swallowing...
  2. ncbi request reprint Transhiatal esophagectomy for distal and cardia cancers: implications of a positive gastric margin
    Paul D DiMusto
    Section of Thoracic Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 83:1993-8; discussion 1998-9. 2007
    ..This study was undertaken to determine the incidence of a positive gastric margin in these patients and the impact of adjuvant treatment...
  3. doi request reprint Herbert sloan, MD, october 10, 1914 - may 17, 2013
    Mark B Orringer
    Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor, Michigan Electronic address
    Ann Thorac Surg 97:1116-9. 2014
    ..He left a legacy of thoracic surgery resident education as head of the Section of Thoracic Surgery at the University of Michigan. ..
  4. doi request reprint Richard Anderson: cardiothoracic surgeon personified
    Mark B Orringer
    Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 88:1729-31. 2009
    ..Richard Anderson will be remembered for his strength of character and his enormous selfless contributions of time and energy to our specialty...
  5. ncbi request reprint Unity and participation: embracing counterintuitive survival skills
    Mark B Orringer
    University of Michigan Medical Center, Ann Arbor 48109, USA
    Ann Thorac Surg 74:3-12. 2002
  6. pmc Two thousand transhiatal esophagectomies: changing trends, lessons learned
    Mark B Orringer
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Ann Surg 246:363-72; discussion 372-4. 2007
    ..The objective of this study was to review the authors' 30-year experience with THE and changing trends in its use...
  7. ncbi request reprint Transhiatal esophagectomy for treatment of benign and malignant esophageal disease
    M B Orringer
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical Center, 2120 Taubman Health Care Center, 1500 E Medical Center Drive, Box 0344, Ann Arbor, Michigan 48109, USA
    World J Surg 25:196-203. 2001
    ..We concluded that THE can be achieved in most patients requiring esophageal resection for benign and malignant disease and with greater safety and less morbidity than the traditional transthoracic approaches...
  8. doi request reprint Analysis of cervical esophagogastric anastomotic leaks after transhiatal esophagectomy: risk factors, presentation, and detection
    David T Cooke
    Section of Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 88:177-84; discussion 184-5. 2009
    ..Factors for developing cervical esophagogastric anastomosis leaks (CEGAL), their presentation, and the value of a routine postoperative screening barium swallow in detecting CEGALs and other complications were analyzed...
  9. pmc Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas
    W J Rachwal
    Department of Surgery, University of Michigan Medical School, Ann Arbor 48109, USA
    Br J Cancer 72:56-64. 1995
    ..The growth stimulus that ligand-activated erbB-2 and EGFR provides to lung adenocarcinoma cells may establish a background of continued cell proliferation over which other critical transforming events may occur...
  10. ncbi request reprint Adjuvant treatment using transfer factor for bronchogenic carcinoma: long-term follow-up
    R I Whyte
    Section of Thoracic Surgery, University of Michigan, Ann Arbor
    Ann Thorac Surg 53:391-6. 1992
    ....
  11. ncbi request reprint Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma
    S G Urba
    University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Clin Oncol 19:305-13. 2001
    ..We designed a randomized trial to compare survival for patients treated with this preoperative chemoradiation regimen versus surgery alone...
  12. pmc Differential expression of Hsp27 in normal oesophagus, Barrett's metaplasia and oesophageal adenocarcinomas
    O S Soldes
    Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109, USA
    Br J Cancer 79:595-603. 1999
    ....
  13. doi request reprint Comparative survival in patients with postresection recurrent versus newly diagnosed non-small-cell lung cancer treated with radiotherapy
    Xu Wei Cai
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 76:1100-5. 2010
    ..To compare the survival of postresection recurrent vs. newly diagnosed non-small-cell lung cancer (NSCLC) patients treated with radiotherapy or chemoradiotherapy...
  14. ncbi request reprint The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas
    Lin Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 62:5273-9. 2002
    ..Amplification of HNF3alpha in esophageal and lung tumors may suggest a potential oncogenic role for this gene in tumorigenesis...
  15. ncbi request reprint Challenges in reversing esophageal discontinuity operations
    Christina Barkley
    University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 76:989-94; discussion 995. 2003
    ..After catastrophic esophageal or gastric disruption results in esophageal discontinuity, operations to restore swallowing are surgical challenges...
  16. ncbi request reprint Epidural abscess: a delayed complication of esophageal stenting for benign stricture
    N M Boulis
    Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109, USA
    Ann Thorac Surg 68:568-70. 1999
    ..The increasing application of endoscopic stenting for benign esophageal strictures provides greater opportunity for this type of delayed complication...
  17. ncbi request reprint Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Pathol 202:321-9. 2004
    ..Analysis of the tumour proliferation status using Ki-67 suggests that down-regulated expression of SBP1 may reflect increased cell proliferation and decreased differentiation in lung adenocarcinomas...
  18. ncbi request reprint Surgical patient outcomes after the increased use of bilateral lung transplantation
    Andrew C Chang
    Section of Thoracic Surgery, University of Michigan Health System, Ann Arbor, Mich 48109, USA
    J Thorac Cardiovasc Surg 133:532-40. 2007
    ..Comparative results for single and sequential double lung transplantation performed at a single center are evaluated to determine whether such a policy improves patient outcome...
  19. ncbi request reprint Awake tracheobronchial dilation without the use of rigid bronchoscopy
    Andrew C Chang
    Section of Thoracic Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 82:e43-5. 2006
    ..This method may be less traumatic than rigid bronchoscopy and can be accomplished on an outpatient basis without the use of general anesthesia...
  20. ncbi request reprint Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma
    Lin Lin
    Department of Surgery Thoracic Section, University of Michigan Medical School, B560 MSRB2, Box 0686, Ann Arbor, MI 48109, USA
    Genes Chromosomes Cancer 45:319-31. 2006
    ..Thus, the fine dissection of a 2-Mb amplified DNA segment in 3q26.3-q27 in EA revealed multiple genetic alterations that had occurred sequentially and/or concurrently during EA development...
  21. ncbi request reprint National trends in outcomes for esophageal resection
    Justin B Dimick
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Ann Thorac Surg 79:212-6; discussion 217-8. 2005
    ..The objective of the current study was to determine trends in short-term outcomes after esophageal resection in a representative sample of United States (US) hospitals...
  22. ncbi request reprint Reversing esophageal discontinuity
    Mark B Orringer
    Section of General Thoracic Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Semin Thorac Cardiovasc Surg 19:47-55. 2007
    ..The nuances of reestablishing alimentary continuity in this disparate patient population are the focus of this article...
  23. ncbi request reprint Management of the cervical esophagogastric anastomotic stricture
    Andrew C Chang
    Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Semin Thorac Cardiovasc Surg 19:66-71. 2007
    ..We describe the clinical practice at a single center with extensive experience in esophageal surgery for management of this complication...
  24. ncbi request reprint Clinical problem-solving. The Drenched Doctor - a 55-year-old male physician was seen in August because of a 1-week history of fever and night sweats
    Daniel R Kaul
    Division of Infectious Diseases, University of Michigan Medical School, USA
    N Engl J Med 356:1871-6. 2007
  25. doi request reprint Outcomes after transhiatal and transthoracic esophagectomy for cancer
    Andrew C Chang
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Ann Thorac Surg 85:424-9. 2008
    ..This study was performed to determine outcomes after transhiatal and transthoracic esophagectomy for patients undergoing resection nationwide...
  26. doi request reprint Esophageal mythology
    Mark B Orringer
    Section of General Thoracic Surgery, Department of Surgery University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Am Coll Surg 207:151-63. 2008
  27. doi request reprint AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma
    Daniel L Albertus
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Thorac Oncol 3:1236-44. 2008
    ..Analysis of serum autoantibodies to tumor antigens combined with gene expression profiling of primary tumors may provide insight into the mechanisms underlying lung carcinogenesis and identify new AD biomarkers...
  28. pmc Proteomic analysis of cytokeratin isoforms uncovers association with survival in lung adenocarcinoma
    Tarek G Gharib
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Neoplasia 4:440-8. 2002
    ..Therefore, specific isoforms of individual CK may have utility as diagnostic or predictive markers in lung adenocarcinomas...
  29. pmc Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity
    Amy L Silvers
    Section of Thoracic Surgery, Department of Surgery and Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2009-21. 2010
    ....
  30. pmc Outcomes after esophagectomy in patients with prior antireflux or hiatal hernia surgery
    Andrew C Chang
    Section of Thoracic Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 89:1015-21; discussion 1022-3. 2010
    ..The purpose of this study was to evaluate the impact of previous gastroesophageal operations on outcomes after esophagectomy for recurrent GERD or hiatus hernia...
  31. ncbi request reprint Concurrent cisplatin, paclitaxel, and radiotherapy as preoperative treatment for patients with locoregional esophageal carcinoma
    Susan G Urba
    Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Cancer 98:2177-83. 2003
    ..A Phase II trial was conducted at the University of Michigan to determine the efficacy of a preoperative regimen of concurrent cisplatin, paclitaxel, and radiation for patients with locoregional esophageal carcinoma...
  32. ncbi request reprint Gene-expression profiles predict survival of patients with lung adenocarcinoma
    David G Beer
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Nat Med 8:816-24. 2002
    ..The identification of a set of genes that predict survival in early-stage lung adenocarcinoma allows delineation of a high-risk group that may benefit from adjuvant therapy...
  33. ncbi request reprint Amplification and overexpression of the dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) gene in esophageal and lung adenocarcinomas
    Charles T Miller
    Department of Surgery, Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 63:4136-43. 2003
    ..DYRK2 mRNA overexpression occurs more frequently than gene amplification in both esophageal and lung adenocarcinomas. This is the first report of amplification and overexpression of DYRK2 in any tumor type...
  34. ncbi request reprint Geographical distribution and racial disparity in esophageal cancer
    Allan Pickens
    University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 76:S1367-9. 2003
  35. ncbi request reprint Proteomic analysis of eIF-5A in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, MI 48109 086, USA
    Proteomics 3:496-504. 2003
    ..Moreover, the investigation on agents that inhibit eIF-5A function is encouraged...
  36. ncbi request reprint RANTES expression is a predictor of survival in stage I lung adenocarcinoma
    Christopher J Moran
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 8:3803-12. 2002
    ..The purpose of this study was to identify differences in global gene expression profiles between stage I NSCLC tumors with ALR (ALR+) and those without ALR (ALR-)...
  37. ncbi request reprint Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors
    Guoan Chen
    Section of General Thoracic Surgery, Departments of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 8:2298-305. 2002
    ..The goal of this study was to identify potential protein markers in lung adenocarcinomas...
  38. doi request reprint Refractory cervical esophagogastric anastomotic strictures: management and outcomes
    Samantha J Davis
    University of Michigan Medical School, Section of Thoracic Surgery, Ann Arbor, MI 48109 5344, USA
    J Thorac Cardiovasc Surg 141:444-8. 2011
    ..This study was undertaken to determine the outcomes of this treatment...
  39. ncbi request reprint Detection of erbB-2 amplifications in tumors and sera from esophageal carcinoma patients
    P W Chiang
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor 48109 0650, USA
    Clin Cancer Res 5:1381-6. 1999
    ..The capability of TaqMan PCR to detect abnormalities in serum of esophageal cancer patients creates an opportunity to diagnose esophageal cancer and to monitor the outcome of treatment with a blood test...
  40. ncbi request reprint A minimal critical region of the 8p22-23 amplicon in esophageal adenocarcinomas defined using sequence tagged site-amplification mapping and quantitative polymerase chain reaction includes the GATA-4 gene
    L Lin
    Department of Surgery, University of Michigan Medical School, Ann Arbor 48109, USA
    Cancer Res 60:1341-7. 2000
    ..The relatively high frequency of the 8p22-23 amplification in esophageal (13.6%) and gastric cardia (12.5%) adenocarcinomas may indicate a specificity of this amplicon for tumors of gastroesophageal origin...
  41. ncbi request reprint Discordant protein and mRNA expression in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 1:304-13. 2002
    ..Using a quantitative analysis of mRNA and protein expression within the same lung adenocarcinomas, we showed that only a subset of the proteins exhibited a significant correlation with mRNA abundance...
  42. ncbi request reprint Surgical treatment of epiphrenic diverticula: a 30-year experience
    Thomas K Varghese
    Section of Thoracic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0344, USA
    Ann Thorac Surg 84:1801-9; discussion 1801-9. 2007
    ..Our experience with a traditional thoracic approach was reviewed to provide benchmark data against which newer surgical techniques can be measured...
  43. pmc Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma
    Christopher W Seder
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 11:388-96. 2009
    ..The expression, mechanisms of regulation, and functional impact of INHBA (activin A) in lung adenocarcinoma (AD) have not been fully elucidated...
  44. doi request reprint A histologically defined subset of high-grade dysplasia in Barrett mucosa is predictive of associated carcinoma
    Weijian Zhu
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Am J Clin Pathol 132:94-100. 2009
    ..Our findings highlight the evolution of diagnostic criteria for Barrett dysplasia...
  45. ncbi request reprint Delayed pericardial tamponade following transthoracic hiatal hernia repair
    Madhusudan Rao Puchakayala
    Department of Anesthesiology and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    J Cardiothorac Vasc Anesth 20:245-6. 2006
  46. pmc Protein profiles associated with survival in lung adenocarcinoma
    Guoan Chen
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:13537-42. 2003
    ..These studies identify new prognostic biomarkers and indicate that protein expression profiles can predict the outcome of patients with early-stage lung cancer...
  47. pmc L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma
    Jules Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 6:74-84. 2004
    ..LAT-1 expression is also retained in cell lines grown in nude mice providing a model to evaluate melphalan as a chemotherapeutic agent against esophageal adenocarcinomas expressing LAT-1...
  48. pmc Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas
    Guoan Chen
    Departments of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 102:12507-12. 2005
    ....
  49. ncbi request reprint Genomic and proteomic analyses of vascular endothelial growth factor and insulin-like growth factor-binding protein 3 in lung adenocarcinomas
    Tarek G Gharib
    Department of Surgery, University of Michigan, Ann Arbor 48109, USA
    Clin Lung Cancer 5:307-12. 2004
    ..Among other highly correlated genes, several, including bradykinin receptor B2, suggest additional cellular processes that were not previously known to be associated with VEGF expression in lung adenocarcinoma...
  50. ncbi request reprint Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia
    Charles T Miller
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 9:4819-25. 2003
    ..The relationship of gene amplification to clinical-pathological variables and its potential usefulness as a marker for early cancer detection were also examined...
  51. ncbi request reprint Content of thoracic residency training and its relevance to the practice of medicine
    D A DaRosa
    Department of Surgery, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Ann Thorac Surg 69:1321-6. 2000
    ..The Thoracic Surgery Directors Association (TSDA) curriculum book provides learning objectives for a thoracic surgery residency. Our purpose was to evaluate the relevance of these objectives through feedback from recent graduates...
  52. ncbi request reprint Esophagectomy for achalasia: patient selection and clinical experience
    E J Devaney
    Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109, USA
    Ann Thorac Surg 72:854-8. 2001
    ....
  53. pmc A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma
    S J Hughes
    Department of Surgery, Section of Thoracic Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 95:12410-5. 1998
    ..The finding of an amplicon at 8p22-23 resulting in CTSB gene amplification and overexpression supports an important role for CTSB in esophageal adenocarcinoma and possibly in other tumors...
  54. ncbi request reprint Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma
    C T Miller
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Oncogene 25:409-18. 2006
    ..The data indicate that upregulation of the MET pathway may contribute to the poor outcome of EA patients and that therapeutic agents targeting this pathway may help improve patient survival...
  55. ncbi request reprint Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants
    Jules Lin
    Department of Surgery, Section of General Thoracic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 10:5708-16. 2004
    ..In this study, expression of MAGE family A members was evaluated during the development of esophageal adenocarcinoma (EA) as potential targets for immunotherapy...
  56. doi request reprint INHBA overexpression promotes cell proliferation and may be epigenetically regulated in esophageal adenocarcinoma
    Christopher W Seder
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Thorac Oncol 4:455-62. 2009
    ..The expression, mechanisms of regulation, and functional impact of activin (INHBA) in esophageal adenocarcinoma (EAC) have not been fully defined...
  57. ncbi request reprint Transhiatal esophagectomy in the profoundly obese: implications and experience
    Christopher N Scipione
    Department of Surgery, Section of Thoracic Surgery, The University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Ann Thorac Surg 84:376-82; discussion 383. 2007
    ....
  58. ncbi request reprint A 25-year experience with open primary transthoracic repair of paraesophageal hiatal hernia
    Himanshu J Patel
    Section of Thoracic Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA
    J Thorac Cardiovasc Surg 127:843-9. 2004
    ..Our experience with a traditional transthoracic approach was reviewed to provide "benchmark" data against which newer surgical techniques can be measured...
  59. ncbi request reprint Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis
    Eric S White
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Clin Cancer Res 9:853-60. 2003
    ..The purpose of this study was to determine whether expression of migration inhibitory factor (MIF) is increased in non-small cell lung cancer, and whether it correlates with angiogenesis and/or prognosis...
  60. ncbi request reprint Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 2:107-16. 2003
    ....
  61. pmc E-cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus
    P F Bongiorno
    Department of Surgery, University of Michigan Medical School, Ann Arbor 48109
    Br J Cancer 71:166-72. 1995
    ....
  62. ncbi request reprint Diagnostic thoracoscopic lung biopsy: an outpatient experience
    Andrew C Chang
    Section of Thoracic Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0344, USA
    Ann Thorac Surg 74:1942-6; discussion 1946-7. 2002
    ..Both procedures traditionally have required hospital admission. We report a series of patients undergoing outpatient thoracoscopic lung biopsy to demonstrate the safety and efficacy of this practice...
  63. ncbi request reprint Tension chylothorax
    John B Ammori
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Ann Thorac Surg 82:729-30. 2006
    ..Early recognition and treatment of this entity are essential for optimal patient outcome. Herein we present two cases of postoperative tension chylothorax followed by a review of the diagnostic work-up and therapy for this complication...
  64. pmc Diversity of the angiogenic phenotype in non-small cell lung cancer
    Marc R McClelland
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Am J Respir Cell Mol Biol 36:343-50. 2007
    ..We conclude that lung cancer tumors evolve a unique and dominant angiogenic phenotype. Once an angiogenic pathway is activated, it may allow for tumor growth to proceed in the absence of a selection pressure to activate a second pathway...
  65. ncbi request reprint Autoantibody profiles reveal ubiquilin 1 as a humoral immune response target in lung adenocarcinoma
    Guoan Chen
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 67:3461-7. 2007
    ..These studies indicate that autoantibody profiles, as well as individual candidates, may be useful for the noninvasive detection of lung adenocarcinoma...
  66. ncbi request reprint Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas
    Charles T Miller
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Oncogene 22:7950-7. 2003
    ..05). This study provides the first quantitative analysis of discrete CRKI and CRKII protein isoforms in human lung tumors and provides evidence that the C-CRK proto-oncogene may foment a more aggressive phenotype in lung cancers...
  67. pmc Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma
    Jules Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 8:1062-71. 2006
    ..02). EA-derived cells expressing UBE2C are sensitive to treatment with MG-262 and to silencing of UBE2C, suggesting that patients with EAs overexpressing UBE2C may benefit from agents targeting this ubiquitin-conjugating enzyme...
  68. pmc Cytochromes P450 are expressed in proliferating cells in Barrett's metaplasia
    S J Hughes
    Department of Surgery, University of Michigan Medical School, Ann Arbor, USA
    Neoplasia 1:145-53. 1999
    ..These data suggest that the potential ability of cells in Barrett's esophagus to both activate carcinogens and proliferate may be important risk factors affecting carcinogenesis in this metaplastic tissue...
  69. pmc Characterizing the cancer genome in lung adenocarcinoma
    Barbara A Weir
    Department of Medical Oncology and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 450:893-8. 2007
    ..More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered...
  70. ncbi request reprint Specialty training and mortality after esophageal cancer resection
    Justin B Dimick
    VA Outcomes Group, Department of Veterans Affairs Medical Center, White River Junction, Vermont 05009, USA
    Ann Thorac Surg 80:282-6. 2005
    ..Surgeons with advanced training have lower mortality rates with some surgical procedures. The objective of the current study was to investigate the impact of thoracic surgery training on mortality rates of esophageal cancer resection...
  71. ncbi request reprint Esophageal Cancer Clinical Practice Guidelines
    Jaffer Ajani
    J Natl Compr Canc Netw 4:328-47. 2006
  72. pmc Somatic mutations affect key pathways in lung adenocarcinoma
    Li Ding
    The Genome Center at Washington University, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Nature 455:1069-75. 2008
    ..Our findings shed further light on several important signalling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment...
  73. doi request reprint Broadcast of surgical procedures as a teaching instrument in cardiothoracic surgery
    Robert M Sade
    American Association for Thoracic Surgery, Beverly, Massachusetts, USA
    Ann Thorac Surg 86:357-61. 2008
  74. ncbi request reprint Hard to swallow
    Madhusudan Grover
    Department of Internal Medicine, Michigan State University, East Lansing, Mich 48842, USA
    Am J Med 120:1023-5. 2007
  75. ncbi request reprint Development of a CD-ROM Internet Hybrid: a new thoracic surgery curriculum
    Jeffrey P Gold
    Department of Cardiovascular and Thoracic Surgery, The Albert Einstein College of Medicine Montefiore Medical Center, Bronx, New York 10467, USA
    Ann Thorac Surg 74:1741-6; discussion 1746. 2002
    ....
  76. ncbi request reprint Evaluation of web-based learning tools: lessons learned from the thoracic surgery directors association curriculum project three-year experience
    Jeffrey P Gold
    Department of Cardiothoracic Surgery, The Albert Einstein College of Medicine, New York, New York, USA
    Ann Thorac Surg 80:802-9; discussion 809-10. 2005
    ..Curriculum content was provided as a randomized prospective trial one year prior to matriculation to residents matching into a TS program from 2001 to 2004...
  77. ncbi request reprint Gastric Cancer Clinical Practice Guidelines
    Jaffer Ajani
    J Natl Compr Canc Netw 4:350-66. 2006