Randall C O'Reilly

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. pmc Midazolam, hippocampal function, and transitive inference: Reply to Greene
    Michael J Frank
    Dept of Psychology and Program in Neuroscience, University of Arizona, Tucson, USA
    Behav Brain Funct 4:5. 2008
  2. ncbi request reprint PVLV: the primary value and learned value Pavlovian learning algorithm
    Randall C O'Reilly
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    Behav Neurosci 121:31-49. 2007
  3. ncbi request reprint Biologically based computational models of high-level cognition
    Randall C O'Reilly
    Department of Psychology, University of Colorado Boulder, Boulder, CO 80309, USA
    Science 314:91-4. 2006
  4. ncbi request reprint Making working memory work: a computational model of learning in the prefrontal cortex and basal ganglia
    Randall C O'Reilly
    Department of Psychology, University of Colorado Boulder, Boulder, CO 80309, USA
    Neural Comput 18:283-328. 2006
  5. ncbi request reprint Prefrontal cortex and dynamic categorization tasks: representational organization and neuromodulatory control
    Randall C O'Reilly
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    Cereb Cortex 12:246-57. 2002
  6. ncbi request reprint Conjunctive representations in learning and memory: principles of cortical and hippocampal function
    R C O'Reilly
    Department of Psychology, University of Colorado at Boulder, 345 UCB, Boulder, Colorado 80309, USA
    Psychol Rev 108:311-45. 2001
  7. ncbi request reprint Computational principles of learning in the neocortex and hippocampus
    R C O'Reilly
    Department of Psychology, University of Colorado at Boulder, 80309, USA
    Hippocampus 10:389-97. 2000
  8. ncbi request reprint Postconditioning isolation disrupts contextual conditioning: an experimental analysis
    J W Rudy
    Department of Psychology, University of Colorado, Boulder 80309 0345, USA
    Behav Neurosci 110:238-46. 1996
  9. doi request reprint The role of the dorsal striatum and dorsal hippocampus in probabilistic and deterministic odor discrimination tasks
    Hisham E Atallah
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80302, USA
    Learn Mem 15:294-8. 2008
  10. ncbi request reprint A comparison of contextual and generalized auditory-cue fear conditioning: evidence for similar memory processes
    J W Rudy
    Department of Psychology, University of Colorado at Boulder
    Behav Neurosci 110:1299-308. 1996

Research Grants

  1. Toward a Unified Model of Cognitive Control
    RANDALL O REILLY; Fiscal Year: 2007

Detail Information

Publications40

  1. pmc Midazolam, hippocampal function, and transitive inference: Reply to Greene
    Michael J Frank
    Dept of Psychology and Program in Neuroscience, University of Arizona, Tucson, USA
    Behav Brain Funct 4:5. 2008
    ..Here we stand by our original hypothesis, which remains the most parsimonious account of the data, and is grounded by multiple lines of evidence...
  2. ncbi request reprint PVLV: the primary value and learned value Pavlovian learning algorithm
    Randall C O'Reilly
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    Behav Neurosci 121:31-49. 2007
    ..Overall, the model provides a biologically plausible framework for understanding the neural basis of reward learning...
  3. ncbi request reprint Biologically based computational models of high-level cognition
    Randall C O'Reilly
    Department of Psychology, University of Colorado Boulder, Boulder, CO 80309, USA
    Science 314:91-4. 2006
    ..These mechanisms are fundamental to digital computers and may be critical for the distinctive aspects of human intelligence...
  4. ncbi request reprint Making working memory work: a computational model of learning in the prefrontal cortex and basal ganglia
    Randall C O'Reilly
    Department of Psychology, University of Colorado Boulder, Boulder, CO 80309, USA
    Neural Comput 18:283-328. 2006
    ..The model's performance compares favorably with standard backpropagation-based temporal learning mechanisms on the challenging 1-2-AX working memory task and other benchmark working memory tasks...
  5. ncbi request reprint Prefrontal cortex and dynamic categorization tasks: representational organization and neuromodulatory control
    Randall C O'Reilly
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    Cereb Cortex 12:246-57. 2002
    ..with orbital versus dorsolateral lesions supports the validity of these principles, many of which have also been useful in accounting for other frontal phenomena...
  6. ncbi request reprint Conjunctive representations in learning and memory: principles of cortical and hippocampal function
    R C O'Reilly
    Department of Psychology, University of Colorado at Boulder, 345 UCB, Boulder, Colorado 80309, USA
    Psychol Rev 108:311-45. 2001
    ..The authors implement this framework in a computational neural network model and show that it can account for a wide range of data in animal learning...
  7. ncbi request reprint Computational principles of learning in the neocortex and hippocampus
    R C O'Reilly
    Department of Psychology, University of Colorado at Boulder, 80309, USA
    Hippocampus 10:389-97. 2000
    ..We summarize the results of applying these principles to a wide range of phenomena in conditioning, habituation, contextual learning, recognition memory, recall, and retrograde amnesia, and we point to directions of current development...
  8. ncbi request reprint Postconditioning isolation disrupts contextual conditioning: an experimental analysis
    J W Rudy
    Department of Psychology, University of Colorado, Boulder 80309 0345, USA
    Behav Neurosci 110:238-46. 1996
    ..These results support the consolidation hypothesis and the view that contextual- and auditory-cue fear conditioning depend on different processes...
  9. doi request reprint The role of the dorsal striatum and dorsal hippocampus in probabilistic and deterministic odor discrimination tasks
    Hisham E Atallah
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80302, USA
    Learn Mem 15:294-8. 2008
    ..These results suggest that the trial-specific information captured by the hippocampal system can be incompatible with the across-trial integration of trial outcomes captured by the cortico-striatal system...
  10. ncbi request reprint A comparison of contextual and generalized auditory-cue fear conditioning: evidence for similar memory processes
    J W Rudy
    Department of Psychology, University of Colorado at Boulder
    Behav Neurosci 110:1299-308. 1996
    ..At a neural systems level, they may influence processing carried out in the thalamo-corticoamygdaloid auditory pathway...
  11. ncbi request reprint Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation
    C R Pugh
    Department of Psychology, University of Colorado at Boulder, 80309 0345, USA
    Behav Brain Res 106:109-18. 1999
    ..These findings also add to the generality of the idea that stressors induce IL-1beta activity in the brain and that IL-1beta may play physiological roles in the uninjured brain...
  12. doi request reprint Expectancy, ambiguity, and behavioral flexibility: separable and complementary roles of the orbital frontal cortex and amygdala in processing reward expectancies
    Wolfgang M Pauli
    Department of Psychology, University of Colorado at Boulder, 345 UCB, Boulder, CO 80309, USA
    J Cogn Neurosci 24:351-66. 2012
    ..Furthermore, at the beginning of reversal, the OFC is critical for supporting responses that are no longer inappropriate. This result is inconsistent with an exclusive inhibitory account of OFC function...
  13. pmc Computational models of cognitive control
    Randall C O'Reilly
    Department of Psychology and Neuroscience, University of Colorado Boulder, 345 UCB, Boulder, CO 80309, USA
    Curr Opin Neurobiol 20:257-61. 2010
    ..Models in these and other areas are advancing the field further forward...
  14. ncbi request reprint By carrot or by stick: cognitive reinforcement learning in parkinsonism
    Michael J Frank
    Department of Psychology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309 0345, USA
    Science 306:1940-3. 2004
    ....
  15. pmc Neural mechanisms of acquired phasic dopamine responses in learning
    Thomas E Hazy
    Department of Psychology and Neuroscience, University of Colorado Boulder, 345 UCB, Boulder, CO 80309, United States
    Neurosci Biobehav Rev 34:701-20. 2010
    ....
  16. pmc Neural inhibition enables selection during language processing
    Hannah R Snyder
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 107:16483-8. 2010
    ..Neural inhibition is key to choosing our words...
  17. ncbi request reprint A comparison of kainic acid plus colchicine and ibotenic acid-induced hippocampal formation damage on four configural tasks in rats
    M C Alvarado
    Department of Psychology, University of Colorado, Boulder 80309, USA
    Behav Neurosci 109:1052-62. 1995
    ..C. Holland) but were impaired on negative patterning, transverse patterning, and place learning. In contrast, rats with K-C lesions were impaired on all 4 tasks. The implications of these results for theories of HF function are discussed...
  18. doi request reprint Inhibiting PKMĪ¶ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior
    Wolfgang M Pauli
    Department of Neuroscience and Psychology, University of Colorado at Boulder, Boulder, Colorado 80309, USA
    Learn Mem 19:307-14. 2012
    ..These results support the hypothesis that the DMS stores information needed to support actions and the DLS stores information needed to support habits...
  19. pmc A unified framework for inhibitory control
    Yuko Munakata
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80309 0345, USA
    Trends Cogn Sci 15:453-9. 2011
    ..These distinctions are crucial for understanding the mechanisms of inhibition and how they can be impaired or improved...
  20. pmc Developing PFC representations using reinforcement learning
    Jeremy R Reynolds
    Department of Psychology, University of Denver, 2155 S Race St, Denver, CO 80208, USA
    Cognition 113:281-92. 2009
    ..These findings are consistent with the idea that there is a functional hierarchy in PFC, as captured in our earlier computational models of PFC function and a growing body of empirical data...
  21. ncbi request reprint Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration
    Ruth M Barrientos
    Department of Psychology and the Center for Neuroscience, University of Colorado, CB345, Boulder, CO 80309, USA
    Behav Brain Res 134:299-306. 2002
    ....
  22. ncbi request reprint Modeling hippocampal and neocortical contributions to recognition memory: a complementary-learning-systems approach
    Kenneth A Norman
    University of Colorado at Boulder, Department of Psychology, Boulder, CO, USA
    Psychol Rev 110:611-46. 2003
    ..They also use the model to address the stochastic relationship between recall and familiarity and the effects of partial versus complete hippocampal lesions on recognition...
  23. pmc Attentional control of associative learning--a possible role of the central cholinergic system
    Wolfgang M Pauli
    Department of Psychology, Muenzinger Psychology Building, University of Colorado Boulder, 345 UCB, Boulder, CO 80309 0345, USA
    Brain Res 1202:43-53. 2008
    ..These effects result in increased attentional contrast in our model. This model thus represents an initial attempt to link human attentional learning data with underlying neural substrates...
  24. ncbi request reprint Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments
    C R Pugh
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    Brain Res 861:8-15. 2000
    ..Finally, heat denaturation of the tertiary structure of gp120 abolished its effects on fear conditioning, suggesting that gp120 impairs contextual fear conditioning by binding to its receptors on glia...
  25. ncbi request reprint Isolation reduces contextual but not auditory-cue fear conditioning: a role for endogenous opioids
    J W Rudy
    Department of Psychology, University of Colorado at Boulder, 80309, USA
    Behav Neurosci 113:316-23. 1999
    ..These results imply that opioids released in the periphery play an important role in producing the isolation effect and that they do so by disrupting the postconditioning memory consolidation processes...
  26. ncbi request reprint The immune system and memory consolidation: a role for the cytokine IL-1beta
    C Rachal Pugh
    University of Colorado at Boulder, Department of Psychology, Campus Box 345, Boulder, CO 80310, USA
    Neurosci Biobehav Rev 25:29-41. 2001
    ....
  27. ncbi request reprint Conjunctive representations, the hippocampus, and contextual fear conditioning
    J W Rudy
    Department of Psychology, CB345, University of Colorado, Boulder, CO 80309, USA
    Cogn Affect Behav Neurosci 1:66-82. 2001
    ..Moreover, this result is predicted by our computational model of cortical and hippocampal function. We suggest that pattern completion demonstrated in animals and by our model provides a mechanistic bridge to human declarative memory...
  28. ncbi request reprint Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist
    R M Barrientos
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309, USA
    Neuroscience 121:847-53. 2003
    ..These data suggest that hippocampal-dependent memory impairments induced by elevated levels of brain IL-1beta may occur via an IL-1beta-induced downregulation in hippocampal BDNF...
  29. pmc Strategic cognitive sequencing: a computational cognitive neuroscience approach
    Seth A Herd
    Department of Psychology, University of Colorado Boulder, Boulder, CO 80309, USA
    Comput Intell Neurosci 2013:149329. 2013
    ..We discuss how these processes could work together to produce strategic cognitive sequencing and discuss future directions in this area. ..
  30. pmc Anorexia nervosa and obesity are associated with opposite brain reward response
    Guido K W Frank
    Department of Psychiatry, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA
    Neuropsychopharmacology 37:2031-46. 2012
    ..The mechanism for this association is uncertain, but these brain reward response patterns could be biomarkers for the respective weight state...
  31. ncbi request reprint When logic fails: implicit transitive inference in humans
    Michael J Frank
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    Mem Cognit 33:742-50. 2005
    ..In this account, choice performance is based on differential associative strengths across the stimulus items that develop over training, despite equal overt reinforcement...
  32. ncbi request reprint Separate neural substrates for skill learning and performance in the ventral and dorsal striatum
    Hisham E Atallah
    Department of Psychology and Center for Neuroscience, University of Colorado Boulder, 345 UCB, Boulder, Colorado 80309, USA
    Nat Neurosci 10:126-31. 2007
    ..Our results also imply that the successful performance of a skill can ultimately result in its establishment as a habit outside the basal ganglia...
  33. pmc The What and How of prefrontal cortical organization
    Randall C O'Reilly
    Department of Psychology and Neuroscience, University of Colorado Boulder, 345 UCB, Boulder, CO 80309, USA
    Trends Neurosci 33:355-61. 2010
    ..This distinction has implications for the rostro-caudal and medial-lateral axes of organization as well. The resulting large-scale functional map of PFC could prove useful in integrating diverse data, and in generating novel predictions...
  34. ncbi request reprint Understanding contextual fear conditioning: insights from a two-process model
    J W Rudy
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    Neurosci Biobehav Rev 28:675-85. 2004
    ....
  35. ncbi request reprint Time of conditioning selectively influences contextual fear conditioning: further support for a multiple-memory systems view of fear conditioning
    J W Rudy
    Department of Psychology, University of Colorado, Boulder 80309, USA
    J Exp Psychol Anim Behav Process 24:316-24. 1998
    ..They also support the view that contextual and auditory-cue fear conditioning depend on different processes. These results are discussed in relation to the concept of memory storage modulators...
  36. ncbi request reprint Contextual fear conditioning, conjunctive representations, pattern completion, and the hippocampus
    J W Rudy
    Department of Psychology, University of Colorado, Boulder 80309, USA
    Behav Neurosci 113:867-80. 1999
    ....
  37. doi request reprint Assembling old tricks for new tasks: a neural model of instructional learning and control
    Tsung Ren Huang
    University of Colorado, Boulder
    J Cogn Neurosci 25:843-51. 2013
    ..The interactions between the two model learning pathways explain how instructions can override habits and how automaticity can be achieved through motor consolidation...
  38. ncbi request reprint Hippocampal formation supports conditioning to memory of a context
    Jerry W Rudy
    Department of Psychology, University of Colorado, Boulder 80309, USA
    Behav Neurosci 116:530-8. 2002
    ..These results support the hypothesis that the hippocampal formation supports contextual fear conditioning by storing a conjunctive representation of context...
  39. pmc Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus
    A M Hein
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309, USA
    Neuroscience 150:754-63. 2007
    ....
  40. ncbi request reprint Serial visual search from a parallel model
    Seth A Herd
    Department of Psychology, University of Colorado Boulder, 345 UCB, Boulder, CO 80309, USA
    Vision Res 45:2987-92. 2005
    ..Furthermore, in our model the most efficient mode of processing varied with the type of search. If the nature of visual search varies with task demands, seemingly contradictory findings can be reconciled...

Research Grants5

  1. Toward a Unified Model of Cognitive Control
    RANDALL O REILLY; Fiscal Year: 2007
    ..Demonstrating this principle in an explicit computational model will have important implications for understanding human intelligence, education, and development. ..