Research Topics
Genomes and Genes
| MICHAEL A O'REILLYSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1MICHAEL A O'REILLY
Department of Pediatrics, The University of Rochester, Rochester, New York 14642, USA
Am J Pathol 181:441-51. 2012..People born prematurely may have defects in epithelial innate immunity that increase their risk for respiratory viral infections...
p53-independent induction of GADD45 and GADD153 in mouse lungs exposed to hyperoxiaM A O'Reilly
Division of Neonatology, Department of Pediatrics, and Department of Radiation Oncology, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
Am J Physiol Lung Cell Mol Physiol 278:L552-9. 2000..These studies are consistent with the hypothesis that hyperoxia-induced DNA fragmentation is associated with the expression of GADD genes that may participate in DNA repair and/or apoptosis...- Neonatal hyperoxia enhances the inflammatory response in adult mice infected with influenza A virusMICHAEL A O'REILLY
Department of Pediatrics, Box 850, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
Am J Respir Crit Care Med 177:1103-10. 2008..Because survivors of BPD also show increased risk for symptomatic respiratory infections, we investigated how neonatal hyperoxia affected the response of adult mice infected with influenza A virus infection... - Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung developmentMin Yee
Department of Pediatrics, Box 850, University of Rochester, School of Medicine and Dentistry, 601 Elmwood Ave, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 291:L1101-11. 2006..These data suggest that perinatal hyperoxia adversely affects alveolar development by disrupting the proper timing of type II cell proliferation and differentiation into type I cells... - p21(Cip1/WAF1/Sdi1) does not affect expression of base excision DNA repair enzymes during chronic oxidative stressMICHAEL A O'REILLY
Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Antioxid Redox Signal 7:719-25. 2005..This suggests that p21 may protect oxidized cells by affecting the activity of BER enzymes and/or through other mechanisms, such as apoptosis... - Redox activation of p21Cip1/WAF1/Sdi1: a multifunctional regulator of cell survival and deathMICHAEL A O'REILLY
Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Antioxid Redox Signal 7:108-18. 2005..The recent appreciation that p21 regulates cell survival and death implies that it is a master regulator of cell fate. This review discusses how p21 can affect the cellular response to oxidative stress... - The Cdk and PCNA domains on p21Cip1 both function to inhibit G1/S progression during hyperoxiaChristopher E Helt
Department of Enviromental Medicine, School of Medicine and Dentistry, The University of Rochester, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 286:L506-13. 2004..Because PCNA also participates in DNA repair, these results raise the possibility that p21 also affects repair of oxidized DNA... - Induced p21Cip1 in premature baboons with CLD: implications for alveolar hypoplasiaMICHAEL A O'REILLY
Dept of Pediatrics, Box 850, Univ of Rochester, 601 Elm wood Ave, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 285:L964-71. 2003..These data suggest that p21 may play a role in disorganized proliferation and alveolar hypoplasia seen in newborn chronic lung disease... - The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stressM A O'Reilly
Departments of Pediatrics Neonatology, School of Medicine and Dentistry, The University of Rochester, Rochester, New York, USA
Am J Respir Cell Mol Biol 24:703-10. 2001..Our findings have implications for patients suffering from the toxic effects of supplemental oxygen therapies... - Bcl-2 family gene expression during severe hyperoxia induced lung injuryM A O'Reilly
Department of Pediatrics, School of Medicine and Dentistry, Children s Hospital at Strong, University of Rochester, New York 14642, USA
Lab Invest 80:1845-54. 2000..These findings suggest that oxygen-induced lung injury does not depend on the relative expression of these Bcl-2 members... - DNA damage and cell cycle checkpoints in hyperoxic lung injury: braking to facilitate repairM A O'Reilly
Department of Pediatrics Neonatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
Am J Physiol Lung Cell Mol Physiol 281:L291-305. 2001..This review examines the effect of hyperoxia on DNA integrity, pulmonary cell proliferation, and cell cycle checkpoints activated by DNA damage... - Activation of the G2 cell cycle checkpoint enhances survival of epithelial cells exposed to hyperoxiaMICHAEL A O'REILLY
Department of Pediatrics, Box 850, School of Medicine and Dentistry, The University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 284:L368-75. 2003..These data indicate that hyperoxia rapidly inhibits proliferation after one cell cycle and that the G2 checkpoint is critical for limiting DNA damage and cell death... - Loss of Gadd45a does not modify the pulmonary response to oxidative stressJason M Roper
Departments of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 288:L663-71. 2005..We conclude that increased tolerance of airway and type II epithelial cells to hyperoxia is not attributed solely to expression of Gadd45a... - Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1)Rhonda J Staversky
Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
Am J Pathol 161:1383-93. 2002..This observation has important implications for therapeutic strategies designed to attenuate long-term chronic lung disease after oxidant injury... 
Murine mechanical ventilation stimulates alveolar epithelial cell proliferationPatricia Rose Chess
Departments of Pediatrics and Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA patricia
Exp Lung Res 36:331-41. 2010..Ventilation did not increase apoptosis in alveolar type II cells, as measured by TUNEL staining. Ventilation at low tidal volumes leads to a mild inflammatory response and alveolar epithelial cell proliferation...- p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growthPeter F Vitiello
Department of Environmental Medicine, Box 850, The University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
Am J Pathol 168:1838-47. 2006..Taken together, these data show that p21-mediated cytoprotection against hyperoxia involves regulation of Bcl-XL and is uncoupled from its ability to inhibit proliferation... - Epithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung developmentRhonda J Staversky
Department of Pediatrics, University of Rochester, NY 14642, USA
Am J Respir Cell Mol Biol 43:376-85. 2010.... - p21(Cip1) protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathwaysPeter F Vitiello
Department of Environmental Medicine, The University of Rochester, NY 14642, USA
Free Radic Biol Med 46:33-41. 2009..Taken together, these data show that p21 integrates the DNA damage response with ER stress signaling, which then regulates mitochondrial death pathways during chronic genotoxic stress... - Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damageChristopher E Helt
Department of Environmental Medicine, School of Medicine and Dentistry, The University of Rochester, Rochester, New York 14642, USA
J Biol Chem 280:1186-92. 2005..These data reveal activated ATM and ATR exhibit selective substrate specificity in response to different genotoxic agents... - Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxiaRichard L Auten
Neonatal Perinatal Research Institute, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Lung Cell Mol Physiol 290:L32-40. 2006..Reducing the 95% O2-induced impairment of epithelial proliferation at a critical window of lung development was associated with protection against DNA damage and preservation of apical T1alpha expression at P3... - PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax deathPeter F Vitiello
Department of Environmental Medicine, School of Medicine and Dentistry, The University of Rochester, Rochester NY 14642, USA
Free Radic Biol Med 44:367-74. 2008..Enhanced survival was associated with increased Bcl-X(L) to block Bax activated cell death during oxidative stress... - Lung development and the host response to influenza A virus are altered by different doses of neonatal oxygen in miceBradley W Buczynski
Department of Environmental Medicine, School of Medicine and Dentistry, The University of Rochester, 601 Elmwood Ave, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 302:L1078-87. 2012..Our findings suggest that measuring lung function alone may not be sufficient to identify individuals born prematurely who have increased risk for respiratory viral infection... - Neonatal hyperoxia causes pulmonary vascular disease and shortens life span in aging miceMin Yee
Department of Pediatrics, School of Medicine and Dentistry, The University of Rochester, Rochester, New York, USA
Am J Pathol 178:2601-10. 2011..People exposed to hyperoxia as neonates may be at increased risk for pulmonary hypertension... - Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activityMin Yee
Dept of Pediatrics, Univ of Rochester, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 297:L641-9. 2009..Furthermore, the disruptive effects of oxygen on epithelial development and lung mechanics are not equivalently dose dependent... - Increased epithelial cell proliferation in very premature baboons with chronic lung diseaseWilliam M Maniscalco
Division of Neonatology, Strong Children s Research Center, Department of Pediatrics, University of Rochester, Rochester, New York 14642, USA
Am J Physiol Lung Cell Mol Physiol 283:L991-L1001. 2002..These data show that the development of chronic lung disease is associated with major alterations in normal patterns of lung-cell proliferation... - Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumoniaGloria S Pryhuber
Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
J Immunol 181:1409-19. 2008..This study supports a key role of parenchymal cell TNFRs in lung injury induced by Pc and a potential protective effect of receptors on radiosensitive, bone marrow-derived cells... - Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expressionWilliam M Maniscalco
Division of Neonatology, Children s Research Center, Pulmonary Biology and Disease Program, University of Rochester School of Medicine, Rochester, NY 14642, USA
Pediatr Res 58:549-56. 2005..The findings suggest that oxidant DNA damage may be a mechanism of increased p53 in hyperoxic fetal lung... - The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNAJennifer S Gewandter
Department of Biochemistry and Biophysics, The University of Rochester, Rochester, NY, USA
Cell Cycle 10:2561-7. 2011.... - Activation of the aryl hydrocarbon receptor during different critical windows in pregnancy alters mammary epithelial cell proliferation and differentiationBetina J Lew
Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Toxicol Sci 111:151-62. 2009..These varying outcomes in mammary development due to exposure at different times in pregnancy suggest there are critical windows during which AhR activation impairs mammary epithelial cell proliferation and differentiation... - Hyperoxia augments ER-stress-induced cell death independent of BiP lossJennifer S Gewandter
Department of Biochemistry and Biophysics, The University of Rochester, Rochester, NY 14642, USA
Free Radic Biol Med 47:1742-52. 2009.... - Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cellsPatricia R Chess
Department of Pediatrics, University of Rochester, New York, USA
J Appl Physiol 99:1226-32. 2005.... - Bcl-X(L) is the primary mediator of p21 protection against hyperoxia-induced cell deathYu Chieh M Wu
Department of Biomedical Genetics, School of Medicine and Dentistry, The University of Rochester, Rochester, New York 14642, USA
Exp Lung Res 37:82-91. 2011..Altogether, these data suggest that Bcl-X(L) is the primary mediator by which p21 protects against hyperoxia-induced Bak/Bax-dependent cell death... - Acute tumor necrosis factor-alpha-induced liver injury in the absence of tumor necrosis factor receptor-associated factor 1 gene expressionGloria S Pryhuber
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Am J Pathol 166:1637-45. 2005..These studies suggest that TRAF1 provides negative feedback for TNF-alpha synthesis and limits TNFRI-mediated systemic effects of TNF-alpha originating in the lung... - Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in miceHongwei Yao
Lung Biology and Disease Program, Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 850, Rochester, NY 14642, USA
Am J Respir Cell Mol Biol 39:7-18. 2008..These data may have ramifications in CS-induced senescence in the pathogenesis of chronic obstructive pulmonary disease/emphysema... - Neonatal hyperoxia increases sensitivity of adult mice to bleomycin-induced lung fibrosisMin Yee
Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Am J Respir Cell Mol Biol 48:258-66. 2013.... - Macroarray analysis reveals a strain-induced oxidant response in pulmonary epithelial cellsPatricia R Chess
Department of Pediatrics, University of Rochester, Rochester, New York, USA
Exp Lung Res 30:739-53. 2004..Strain-induced oxidative stress was verified with the oxidant-sensitive dye dichlorodihydrofluorescein diacetate... - Memory CD8+ T cells are sufficient to alleviate impaired host resistance to influenza A virus infection caused by neonatal oxygen supplementationMatthew Giannandrea
Department of Environmental Medicine, The University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA
Clin Vaccine Immunol 19:1432-41. 2012..Our findings suggest that vaccines that generate robust T cell memory may be efficacious at reducing the increased sensitivity to respiratory viral infections in people born prematurely... - Carbonic anhydrase XII mRNA encodes a hydratase that is differentially expressed along the rabbit nephronGeorge J Schwartz
Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
Am J Physiol Renal Physiol 284:F399-410. 2003..Western blotting of expressed CA XII with two anti-rabbit CA IV peptide antibodies showed no cross-reactivity. Our findings indicate that CA XII may contribute to the membrane CA activity of proximal tubules and collecting ducts... - c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cellsKaiser M Bijli
Department of Pediatrics, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Am J Physiol Lung Cell Mol Physiol 292:L396-404. 2007..These data implicate an important role of c-Src in phosphorylating RelA/p65 to promote the transcriptional activity of NF-kappaB and thereby ICAM-1 expression in endothelial cells... - The role of hyperoxia in the pathogenesis of experimental BPDBradley W Buczynski
Department of Environmental Medicine, The University of Rochester, School of Medicine and Dentistry, Rochester, NY Electronic address
Semin Perinatol 37:69-78. 2013....
Research Grants
- Neonatal Oxygen and Susceptibility to Respiratory Viral InfectionsMICHAEL A contact O apos REILLY; Fiscal Year: 2010..End of Abstract) ..
- Cell Survival and Death in Oxidant Lung InjuryMICHAEL A O apos REILLY; Fiscal Year: 2010....
- Effect of Neonatal Hyperoxia on Alveolar Development and InfectionMICHAEL A O apos REILLY; Fiscal Year: 2010....
- Cell Survival and Death in Oxidant Lung InjuryMICHAEL O REILLY; Fiscal Year: 2007....
- DNA Repair and Replication in Oxidant Lung InjuryMICHAEL O REILLY; Fiscal Year: 2005..abstract_text> ..
- TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURYMICHAEL O REILLY; Fiscal Year: 2002..These studies are significant because understanding how ROS injure and kill pulmonary epithelial cells is critically important for improving clinical therapies that rely on supplemental oxygen. ..
- Effect of Neonatal Hyperoxia on Alveolar Development and InfectionMICHAEL A O apos REILLY; Fiscal Year: 2011....