G A Ordway
Affiliation: University of Mississippi Medical Center
- Pathophysiology of the locus coeruleus in suicideG A Ordway
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA
Ann N Y Acad Sci 836:233-52. 1997..It is hypothesized that persons who commit suicide have experienced chronic activation of the LC, resulting in depletion of synaptic norepinephrine and compensatory changes in concentrations of noradrenergic proteins...
- Reduced levels of norepinephrine transporters in the locus coeruleus in major depressionV Klimek
Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
J Neurosci 17:8451-8. 1997....
- Quantitative distribution of monoamine oxidase A in brainstem monoamine nuclei is normal in major depressionG A Ordway
Department of Psychiatry, University of Mississippi Medical Center, Jackson, MS, USA
Brain Res 847:71-9. 1999..These findings demonstrate that the pathophysiology of major depression is not likely to involve abnormalities in MAO-A...
- Effects of long-term cigarette smoking on the human locus coeruleusV Klimek
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216-4505, USA
Arch Gen Psychiatry 58:821-7. 2001..If the present observations reflect long-term effects of smoking on premortem noradrenergic biochemistry, smoking-induced changes in LC biochemistry may strengthen the smoking habit among subjects with major depression...
- Role of the dopamine transporter and the sodium channel in the cocaine-like discriminative stimulus effects of local anesthetics in ratsK M Wilcox
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, USA
Psychopharmacology (Berl) 157:260-8. 2001..Sodium channels seem to have a direct influence on discriminative effects at low cocaine doses, whereas they have an indirect influence on discriminative effects at high cocaine doses by decreasing response rates...
- Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanismsW L Woolverton
Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216, USA
J Pharmacol Exp Ther 303:211-7. 2002..These results suggest that (+)-CPCA is a weaker positive reinforcer than cocaine because it has a slower onset of action over the first few minutes after i.v. injection...