John Oram

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint ATP-binding cassette transporter A1 mediates cellular secretion of alpha-tocopherol
    J F Oram
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Biol Chem 276:39898-902. 2001
  2. ncbi request reprint Molecular basis of cholesterol homeostasis: lessons from Tangier disease and ABCA1
    John F Oram
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    Trends Mol Med 8:168-73. 2002
  3. ncbi request reprint The cholesterol mobilizing transporter ABCA1 as a new therapeutic target for cardiovascular disease
    John F Oram
    Department of Medicine, University of Washington, Seattle, WA 98195 6426, USA
    Trends Cardiovasc Med 12:170-5. 2002
  4. ncbi request reprint ATP-binding cassette transporter A1 and cholesterol trafficking
    John F Oram
    Department of Medicine, University of Washington, Seattle 98195 6426, USA
    Curr Opin Lipidol 13:373-81. 2002
  5. ncbi request reprint HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol
    John F Oram
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 23:720-7. 2003
  6. pmc An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux
    John F Oram
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Box 356426, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 283:11541-9. 2008
  7. ncbi request reprint Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells
    John F Oram
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 278:52379-85. 2003
  8. ncbi request reprint ATP-Binding cassette cholesterol transporters and cardiovascular disease
    John F Oram
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    Circ Res 99:1031-43. 2006
  9. ncbi request reprint When good cholesterol turns bad: the evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein
    John F Oram
    Department of Medicine, Box 356426, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195 6426, USA
    Curr Diab Rep 8:165-7. 2008
  10. ncbi request reprint ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease
    John F Oram
    Department of Medicine, University of Washington, Seattle, WA 98195 6426, USA
    Physiol Rev 85:1343-72. 2005

Collaborators

Detail Information

Publications51

  1. ncbi request reprint ATP-binding cassette transporter A1 mediates cellular secretion of alpha-tocopherol
    J F Oram
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Biol Chem 276:39898-902. 2001
    ..These studies provide evidence that ABCA1 mediates secretion of cellular alpha-TOH into the HDL metabolic pathway, a process that may facilitate vitamin transport between tissues and influence lipid oxidation...
  2. ncbi request reprint Molecular basis of cholesterol homeostasis: lessons from Tangier disease and ABCA1
    John F Oram
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    Trends Mol Med 8:168-73. 2002
    ..Because of its ability to deplete macrophages of cholesterol and to raise plasma HDL levels, ABCA1 has become a promising therapeutic target for preventing cardiovascular disease...
  3. ncbi request reprint The cholesterol mobilizing transporter ABCA1 as a new therapeutic target for cardiovascular disease
    John F Oram
    Department of Medicine, University of Washington, Seattle, WA 98195 6426, USA
    Trends Cardiovasc Med 12:170-5. 2002
    ..This makes ABCA1 a promising new therapeutic target for reducing cholesterol deposits in tissues, eliminating excess cholesterol from the body, and preventing cardiovascular disease...
  4. ncbi request reprint ATP-binding cassette transporter A1 and cholesterol trafficking
    John F Oram
    Department of Medicine, University of Washington, Seattle 98195 6426, USA
    Curr Opin Lipidol 13:373-81. 2002
    ..The present review summarizes the more recent of those studies and evaluates their implications for the role of ABCA1 in cholesterol transport, HDL metabolism, and atherogenesis...
  5. ncbi request reprint HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol
    John F Oram
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 23:720-7. 2003
    ..These findings implicate the apolipoprotein/ABCA1 pathway as an important therapeutic target for treating cardiovascular disease...
  6. pmc An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux
    John F Oram
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Box 356426, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 283:11541-9. 2008
    ..Direct interactions with ABCA1 and activation of signaling pathways likely involve other structural determinants of PLTP...
  7. ncbi request reprint Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells
    John F Oram
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 278:52379-85. 2003
    ..Thus, PLTP mimics apolipoproteins in removing cellular lipids by the ABCA1 pathway, except that PLTP acts more as an intermediary in the transfer of cellular lipids to lipoprotein particles...
  8. ncbi request reprint ATP-Binding cassette cholesterol transporters and cardiovascular disease
    John F Oram
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    Circ Res 99:1031-43. 2006
    ..Their beneficial effects on cholesterol homeostasis have made these transporters important new therapeutic targets for preventing and reversing CVD...
  9. ncbi request reprint When good cholesterol turns bad: the evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein
    John F Oram
    Department of Medicine, Box 356426, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195 6426, USA
    Curr Diab Rep 8:165-7. 2008
  10. ncbi request reprint ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease
    John F Oram
    Department of Medicine, University of Washington, Seattle, WA 98195 6426, USA
    Physiol Rev 85:1343-72. 2005
    ..The ABCA1 pathway has therefore become an important new therapeutic target for treating cardiovascular disease...
  11. doi request reprint The ins and outs of ABCA
    John F Oram
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 49:1150-1. 2008
  12. ncbi request reprint When good cholesterol turns bad: the evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein
    John F Oram
    Department of Medicine, Box 356426, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195 6426, USA
    Curr Atheroscler Rep 9:425-7. 2007
  13. ncbi request reprint ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins
    J F Oram
    Department of Medicine, University of Washington, Seattle 98195, USA
    Curr Opin Lipidol 11:253-60. 2000
    ..Thus, the ABCA1 pathway has become an important therapeutic target for mobilizing excess cholesterol from tissue macrophages and protecting against atherosclerosis...
  14. ncbi request reprint ABCA1. The gatekeeper for eliminating excess tissue cholesterol
    J F Oram
    Department of Medicine, Box 356426, 1959 NE Pacific Pl, University of Washington, Seattle, WA 98195 6426, USA
    J Lipid Res 42:1173-9. 2001
    ..Therefore, as the primary gatekeeper for eliminating tissue cholesterol, ABCA1 has a major impact on cellular and whole body cholesterol metabolism and is likely to play an important role in protecting against cardiovascular disease...
  15. ncbi request reprint Novel approaches to treating cardiovascular disease: lessons from Tangier disease
    J F Oram
    University of Washington, Department of Medicine, Seattle, Washington, WA 98195 6426, USA
    Expert Opin Investig Drugs 10:427-38. 2001
    ..By reducing plaque formation and rupture independently of the atherogenic factors involved, these drugs would be powerful agents for treating CVD...
  16. ncbi request reprint Tangier disease and ABCA1
    J F Oram
    University of Washington, Division of Metabolism, Endocrinology and Nutrition, Box 356426, Seattle, WA 98195 6426, USA
    Biochim Biophys Acta 1529:321-30. 2000
    ....
  17. ncbi request reprint ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages
    J F Oram
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 275:34508-11. 2000
    ..Thus, ABCA1 is likely to be the cAMP-inducible apolipoprotein receptor that promotes removal of cholesterol and phospholipids from macrophages...
  18. ncbi request reprint Sterol efflux mediated by endogenous macrophage ApoE expression is independent of ABCA1
    Z H Huang
    Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA
    Arterioscler Thromb Vasc Biol 21:2019-25. 2001
    ..The results of these studies indicate that the increment in sterol efflux mediated by the endogenous expression of apoE in macrophages does not depend on ABCA1 expression or activity...
  19. ncbi request reprint Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells
    B M Hokland
    Department of Medicine, University of Washington, Seattle 98195
    J Biol Chem 268:25343-9. 1993
    ..Thus, at least two distinct protein kinase signalling pathways modulate transport of intracellular sterols in cholesterol-loaded cells...
  20. ncbi request reprint Cellular localization and characterization of proteins that bind high density lipoprotein
    B Hokland
    Department of Medicine, University of Washington, Seattle 98195
    J Lipid Res 33:1335-42. 1992
    ..The cellular localization and physical properties of the 110 and 130 kDa proteins suggest that they may play a role in binding of HDL to the cell surface...
  21. ncbi request reprint Mapping of the gene for high-density lipoprotein binding protein (Hdlbp) to proximal mouse chromosome 1
    R C LeBoeuf
    Department of Medicine, University of Washington, Seattle 98195
    Genomics 23:296-8. 1994
  22. ncbi request reprint High density lipoprotein stimulates sterol translocation between intracellular and plasma membrane pools in human monocyte-derived macrophages
    M Aviram
    Department of Medicine, University of Washington, Seattle 98195
    J Lipid Res 30:65-76. 1989
    ..However, in nonloaded macrophages, HDL stimulates sterol movement from the plasma membrane into intracellular pools by a receptor-independent process...
  23. ncbi request reprint Myeloperoxidase and inflammatory proteins: pathways for generating dysfunctional high-density lipoprotein in humans
    Tomas Vaisar
    Department of Medicine, HSB BB512, Box 356426, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Curr Atheroscler Rep 9:417-24. 2007
    ..Thus, oxidative modifications to HDL and changes in its protein composition might be useful biomarkers-and perhaps mediators-of CVD...
  24. ncbi request reprint Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway
    Yutong Wang
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:35896-903. 2005
    ..These data provide evidence that intracellular unsaturated acyl-CoA derivatives destabilize ABCA1 by activating a PLD2 signaling pathway...
  25. ncbi request reprint Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I
    Baohai Shao
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:36386-96. 2005
    ..Thus, acrolein might contribute to atherogenesis by impairing cholesterol removal from the artery wall...
  26. ncbi request reprint Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1
    Chongren Tang
    Division of Metabolism, Endocrinology, and Nutrition, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA
    J Lipid Res 47:107-14. 2006
    ..These findings show that amphipathic helices coordinate the activity of ABCA1 by several distinct mechanisms that are likely to involve different cell surface binding sites...
  27. ncbi request reprint Myeloperoxidase: an inflammatory enzyme for generating dysfunctional high density lipoprotein
    Baohai Shao
    Department of Medicine, University of Washington, Seattle, 98195, USA
    Curr Opin Cardiol 21:322-8. 2006
    ..Anti-inflammatory and antioxidant properties also might contribute to HDL's ability to inhibit atherosclerosis...
  28. ncbi request reprint Pathways for oxidation of high-density lipoprotein in human cardiovascular disease
    Baohai Shao
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Curr Opin Mol Ther 8:198-205. 2006
    ..Collectively, these observations indicate that MPO oxidatively damages HDL in humans and suggest that oxidation of specific amino acid residues in apoA-I may contribute to atherogenesis by impairing cholesterol efflux from macrophages...
  29. ncbi request reprint ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL
    Ashley M Vaughan
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA 98195 6426, USA
    J Lipid Res 47:2433-43. 2006
    ..These results suggest that ABCG1 and ABCG4 act in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles...
  30. ncbi request reprint Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I
    Baohai Shao
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 281:9001-4. 2006
    ....
  31. ncbi request reprint Ethanol induces cholesterol efflux and up-regulates ATP-binding cassette cholesterol transporters in fetal astrocytes
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Biol Chem 282:18740-9. 2007
    ..Ethanol did not affect cholesterol synthesis and reduced the levels of intracellular cholesterol in rat astrocytes. Retinoic acid, which induces teratogenic effects similarly to ethanol, also caused up-regulation of ABCA1 and ABCG1...
  32. ncbi request reprint Acrolein modifies apolipoprotein A-I in the human artery wall
    Baohai Shao
    Division of Metabolism, Endocrinology and Nutrition, Box 356426, University of Washington, Seattle, WA 98195
    Ann N Y Acad Sci 1043:396-403. 2005
    ..Our observations suggest that acrolein may interfere with normal HDL cholesterol transport by modifying apoA-I. This structural damage might play a critical role in atherogenesis by impairing cholesterol removal from artery wall cells...
  33. ncbi request reprint ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins
    Ashley M Vaughan
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 280:30150-7. 2005
    ..These studies show that ABCG1 redistributes cholesterol to cell-surface domains where it becomes accessible for removal by HDL, consistent with a direct role of ABCG1 in cellular cholesterol transport...
  34. ncbi request reprint Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1
    Yutong Wang
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 277:5692-7. 2002
    ..These findings raise the possibility that an increased supply of unsaturated fatty acids in the artery wall promotes atherogenesis by impairing the ABCA1 cholesterol secretory pathway in macrophages...
  35. pmc Polarized cholesterol and phospholipid efflux in cultured gall-bladder epithelial cells: evidence for an ABCA1-mediated pathway
    Jin Lee
    Division of Gastroenterology, Box 356424, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Biochem J 364:475-84. 2002
    ..This efflux pathway is stimulated by cAMP and by LXRalpha/RXR ligands, and in the case of the cAMP pathway appears to involve a role for biliary apoA-I...
  36. ncbi request reprint ABCA1 redistributes membrane cholesterol independent of apolipoprotein interactions
    Ashley M Vaughan
    Department of Medicine, University of Washington, Seattle, WA 98195 6426, USA
    J Lipid Res 44:1373-80. 2003
    ..These studies show that ABCA1 redistributes cholesterol to cell-surface domains, where it becomes accessible for removal by apolipoproteins, consistent with a direct role of ABCA1 in cholesterol transport...
  37. ncbi request reprint Cultured gallbladder epithelial cells synthesize apolipoproteins A-I and E
    Jin Lee
    Division of Gastroenterology, University of Washington, Seattle, WA 98195, USA
    Am J Physiol Gastrointest Liver Physiol 285:G630-41. 2003
    ..Therefore, GBEC synthesize apoA-I and -E and efflux cholesterol using ABCA1- and non-ABCA1- mediated pathways. These processes may alter gallbladder biliary cholesterol concentrations and thereby influence gallstone formation...
  38. pmc Lipoprotein lipase and hepatic lipase: their relationship with HDL subspecies Lp(A-I) and Lp(A-I,A-II)
    Marian C Cheung
    Department of Medicine, University of Washington, Seattle, WA 98103, USA
    J Lipid Res 44:1552-8. 2003
    ..Furthermore, select correlations of LPL and/or HL with the apoA-I, cholesterol, and triglyceride of Lp(A-I) but not Lp(A-I,A-II) imply that the apoA-I and lipid of Lp(A-I) and Lp(A-I,A-II) are not fully equilibrated...
  39. ncbi request reprint Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol
    Chongren Tang
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 279:7622-8. 2004
    ..These results suggest that the interaction of apolipoproteins with ABCA1-expressing cells activates JAK2, which in turn activates a process that enhances apolipoprotein interactions with ABCA1 and lipid removal from cells...
  40. ncbi request reprint LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1
    Yutong Wang
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 45:972-80. 2004
    ..Thus, with cholesterol-loaded macrophages exposed to saturated fatty acids, activated LXR/RXR may counteract the enhanced ABCA1 transcription by reducing the ABCA1 protein content...
  41. ncbi request reprint Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1
    Pradeep Natarajan
    Lawrence Berkeley National Laboratory, Donner Laboratory MS1 224, University of California at Berkeley, California 94720, USA
    J Biol Chem 279:24044-52. 2004
    ..These results suggest that a specific structural element possessing a linear array of acidic residues spanning two apoA-I amphipathic alpha-helices is required to mediate cholesterol efflux and stabilize ABCA1...
  42. ncbi request reprint Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells
    Marisa Passarelli
    Department of Medicine, Box 356426, University of Washington, Seattle, WA 98195 6426, USA
    Diabetes 54:2198-205. 2005
    ....
  43. ncbi request reprint Thematic review series: The immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?
    Alan Chait
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 46:389-403. 2005
    ..In future studies, it will be important to determine whether these proteins play a causal role in atherogenesis...
  44. ncbi request reprint Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport
    Baohai Shao
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Biol Chem 280:5983-93. 2005
    ..This impaired biological activity of chlorinated apoA-I suggests that MPO-mediated oxidation of HDL might contribute to the link between inflammation and cardiovascular disease...
  45. ncbi request reprint Direct effects of long-chain non-esterified fatty acids on vascular cells and their relevance to macrovascular complications of diabetes
    John F Oram
    Department of Medicine, University of Washington School of Medicine, Seattle WA 98195 7470, USA
    Front Biosci 9:1240-53. 2004
    ..Certain NEFAs liberated from triglycerides may therefore play an important role in accelerating atherosclerosis caused by diabetes by directly affecting the key cell types involved in atherogenesis...
  46. ncbi request reprint IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride
    Anne K Berfield
    Univ of Washington School of Medicine and Department of Medicine, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Am J Physiol Renal Physiol 290:F138-47. 2006
    ..These observations are relevant to understanding vascular disease and progressive renal diseases that are accelerated by abnormalities in lipid metabolism...
  47. pmc The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport
    Constanze Bergt
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 101:13032-7. 2004
    ....
  48. ncbi request reprint Oxidized HDL: the paradox-idation of lipoproteins
    Constanze Bergt
    Arterioscler Thromb Vasc Biol 23:1488-90. 2003
  49. ncbi request reprint Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C delta pathway
    Yutong Wang
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 48:1062-8. 2007
    ..These data indicate that unsaturated fatty acids destabilize ABCA1 by activating a PKCdelta pathway that phosphorylates ABCA1 serines...
  50. ncbi request reprint Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species
    Subramaniam Pennathur
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 279:42977-83. 2004
    ..Thus, nitrated HDL might represent a previously unsuspected link between nitrosative stress, atherosclerosis, and inflammation...
  51. pmc Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL
    Tomas Vaisar
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Clin Invest 117:746-56. 2007
    ....

Research Grants13

  1. Modulation of ABCA1 Expression and Activity
    John Oram; Fiscal Year: 2007
    ..These studies will suggest possible sites of impairment of the ABCA1 pathway and uncover potential therapeutic targets for treating cardiovascular disease. ..
  2. Atherogenic Effects of Oxidized High Density Lipoproteins
    John Oram; Fiscal Year: 2006
    ....
  3. Atherogenic Effects of Tyrosine Oxidation in HDL
    John Oram; Fiscal Year: 2004
    ....
  4. CELLULAR DISORDERS IN FAMILIAL HDL DEFICIENCIES
    John Oram; Fiscal Year: 2003
    ..These studies will help design therapeutic approaches for correcting cellular disorders associated with low plasma HDL and increased risk for heart disease. ..
  5. Anti-inflammatory, cholesterol export, and cardioprotective functions of ABCA1
    John Oram; Fiscal Year: 2009
    ..This research will investigate the cell pathways involved in the cholesterol removal and anti-inflammatory actions of ABCA1 and determine if these pathways protect against heart disease in animals. ..