PATRICIA LYNN OPRESKO

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Role for the Werner syndrome protein in the promotion of tumor cell growth
    Patricia L Opresko
    University of Pittsburgh, Department of Environmental and Occupational Health, Pittsburgh, PA, USA
    Mech Ageing Dev 128:423-36. 2007
  2. ncbi Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases
    Patricia L Opresko
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Bridgeside Pt, Pittsburgh, PA 15219, United States
    Mech Ageing Dev 129:79-90. 2008
  3. ncbi The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation
    Patricia L Opresko
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 4:e4825. 2009
  4. ncbi Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition Study
    Jason L Sanders
    Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 24:1531-6. 2009
  5. ncbi Replication protein A stimulates the Werner syndrome protein branch migration activity
    Gregory Sowd
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 284:34682-91. 2009
  6. ncbi The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage
    Fu Jun Liu
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15219, USA
    Toxicol Sci 110:307-18. 2009
  7. ncbi Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase
    Gregory Sowd
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15219, USA
    Nucleic Acids Res 36:4242-56. 2008
  8. ncbi Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase
    Gerald J Nora
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15219, USA
    Nucleic Acids Res 38:3984-98. 2010

Research Grants

  1. Mechanisms of Telomeric DNA Loss and Repair
    PATRICIA LYNN OPRESKO; Fiscal Year: 2010
  2. Mechanisms of Telomeric DNA Loss and Repair
    Patricia Opresko; Fiscal Year: 2009

Collaborators

Detail Information

Publications8

  1. ncbi Role for the Werner syndrome protein in the promotion of tumor cell growth
    Patricia L Opresko
    University of Pittsburgh, Department of Environmental and Occupational Health, Pittsburgh, PA, USA
    Mech Ageing Dev 128:423-36. 2007
    ..These findings suggest a possible therapeutic role for WRN as an anti-cancer target, and highlight the importance of WRN protein status for tumorigenesis and clinical treatments of patients...
  2. ncbi Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases
    Patricia L Opresko
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Bridgeside Pt, Pittsburgh, PA 15219, United States
    Mech Ageing Dev 129:79-90. 2008
    ..Genetic, cellular and biochemical evidence support roles for WRN in proper replication and repair of telomeric DNA, and indicate that telomere dysfunction contributes to the WS disease pathology...
  3. ncbi The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation
    Patricia L Opresko
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 4:e4825. 2009
    ..These findings led us to propose a novel model for WRN D-loop disruption. Our biochemical results offer an explanation for the cellular studies that indicate both WRN activities function in processing HR intermediates...
  4. ncbi Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition Study
    Jason L Sanders
    Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 24:1531-6. 2009
    ..TL is not associated with BMD, osteoporosis, or fracture in older men or women in this sample...
  5. ncbi Replication protein A stimulates the Werner syndrome protein branch migration activity
    Gregory Sowd
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 284:34682-91. 2009
    ..This is, to our knowledge, the first evidence that RPA can stimulate branch migration activity...
  6. ncbi The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage
    Fu Jun Liu
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15219, USA
    Toxicol Sci 110:307-18. 2009
    ....
  7. ncbi Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase
    Gregory Sowd
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15219, USA
    Nucleic Acids Res 36:4242-56. 2008
    ..Collectively, these data suggest POT1 promotes the apparent processivity of WRN helicase by maintaining partially unwound strands in a melted state, rather than preventing WRN dissociation from the substrate...
  8. ncbi Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase
    Gerald J Nora
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15219, USA
    Nucleic Acids Res 38:3984-98. 2010
    ..Our biochemical study provides a mechanistic basis for the cellular findings that TRF2 regulates WRN activity at telomeres...

Research Grants6

  1. Mechanisms of Telomeric DNA Loss and Repair
    PATRICIA LYNN OPRESKO; Fiscal Year: 2010
    ..Identifying mechanisms of telomere loss and cellular processes that preserve telomeric DNA is crucial for the design of intervention therapies that prevent or delay the onset of diseases associated with aging and cancer. ..
  2. Mechanisms of Telomeric DNA Loss and Repair
    Patricia Opresko; Fiscal Year: 2009
    ..Identifying mechanisms of telomere loss and cellular processes that preserve telomeric DNA is crucial for the design of intervention therapies that prevent or delay the onset of diseases associated with aging and cancer. ..