PATRICIA LYNN OPRESKO

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase
    Gregory Sowd
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15219, USA
    Nucleic Acids Res 36:4242-56. 2008
  2. pmc Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase
    Gerald J Nora
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15219, USA
    Nucleic Acids Res 38:3984-98. 2010
  3. pmc DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation
    Justin D Lormand
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, 100 Technology Drive, Pittsburgh, PA 15219, USA, Department of Physics, North Carolina State University, 2401 Stinson Drive, Raleigh, NC, 27695, USA, Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA and Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 41:10323-33. 2013
  4. pmc The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress
    Fu Jun Liu
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e11152. 2010
  5. ncbi request reprint Role for the Werner syndrome protein in the promotion of tumor cell growth
    Patricia L Opresko
    University of Pittsburgh, Department of Environmental and Occupational Health, Pittsburgh, PA, USA
    Mech Ageing Dev 128:423-36. 2007
  6. pmc The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation
    Patricia L Opresko
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 4:e4825. 2009
  7. ncbi request reprint Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases
    Patricia L Opresko
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Bridgeside Pt, Pittsburgh, PA 15219, United States
    Mech Ageing Dev 129:79-90. 2008
  8. pmc Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition Study
    Jason L Sanders
    Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 24:1531-6. 2009
  9. pmc Replication protein A stimulates the Werner syndrome protein branch migration activity
    Gregory Sowd
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 284:34682-91. 2009
  10. pmc The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage
    Fu Jun Liu
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15219, USA
    Toxicol Sci 110:307-18. 2009

Research Grants

  1. Mechanisms of Telomeric DNA Loss and Repair
    Patricia Opresko; Fiscal Year: 2006
  2. Mechanisms of Telomeric DNA Loss and Repair
    Patricia Opresko; Fiscal Year: 2007
  3. Mechanisms of Telomeric DNA Loss and Repair
    Patricia Opresko; Fiscal Year: 2009
  4. Mechanisms of Telomeric DNA Loss and Repair
    PATRICIA LYNN OPRESKO; Fiscal Year: 2010
  5. Mechanisms of Telomeric DNA Loss and Repair
    Patricia Opresko; Fiscal Year: 2009

Collaborators

Detail Information

Publications10

  1. pmc Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase
    Gregory Sowd
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15219, USA
    Nucleic Acids Res 36:4242-56. 2008
    ..Collectively, these data suggest POT1 promotes the apparent processivity of WRN helicase by maintaining partially unwound strands in a melted state, rather than preventing WRN dissociation from the substrate...
  2. pmc Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase
    Gerald J Nora
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15219, USA
    Nucleic Acids Res 38:3984-98. 2010
    ..Our biochemical study provides a mechanistic basis for the cellular findings that TRF2 regulates WRN activity at telomeres...
  3. pmc DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation
    Justin D Lormand
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, 100 Technology Drive, Pittsburgh, PA 15219, USA, Department of Physics, North Carolina State University, 2401 Stinson Drive, Raleigh, NC, 27695, USA, Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA and Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 41:10323-33. 2013
    ..Our data indicate that G4 formation is not required for polymerase stalling on telomeric lagging strands and suggest that an alternative mechanism, in addition to stable G4s, contributes to replication stalling at telomeres. ..
  4. pmc The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress
    Fu Jun Liu
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e11152. 2010
    ..Our studies indicate that environmentally induced replication stress leads to telomere loss and aberrations that are suppressed by telomerase-mediated telomere elongation or WRN functions in replication fork restoration...
  5. ncbi request reprint Role for the Werner syndrome protein in the promotion of tumor cell growth
    Patricia L Opresko
    University of Pittsburgh, Department of Environmental and Occupational Health, Pittsburgh, PA, USA
    Mech Ageing Dev 128:423-36. 2007
    ..These findings suggest a possible therapeutic role for WRN as an anti-cancer target, and highlight the importance of WRN protein status for tumorigenesis and clinical treatments of patients...
  6. pmc The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation
    Patricia L Opresko
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 4:e4825. 2009
    ..These findings led us to propose a novel model for WRN D-loop disruption. Our biochemical results offer an explanation for the cellular studies that indicate both WRN activities function in processing HR intermediates...
  7. ncbi request reprint Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases
    Patricia L Opresko
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Bridgeside Pt, Pittsburgh, PA 15219, United States
    Mech Ageing Dev 129:79-90. 2008
    ..Genetic, cellular and biochemical evidence support roles for WRN in proper replication and repair of telomeric DNA, and indicate that telomere dysfunction contributes to the WS disease pathology...
  8. pmc Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition Study
    Jason L Sanders
    Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 24:1531-6. 2009
    ..TL is not associated with BMD, osteoporosis, or fracture in older men or women in this sample...
  9. pmc Replication protein A stimulates the Werner syndrome protein branch migration activity
    Gregory Sowd
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 284:34682-91. 2009
    ..This is, to our knowledge, the first evidence that RPA can stimulate branch migration activity...
  10. pmc The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage
    Fu Jun Liu
    Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15219, USA
    Toxicol Sci 110:307-18. 2009
    ....

Research Grants6

  1. Mechanisms of Telomeric DNA Loss and Repair
    Patricia Opresko; Fiscal Year: 2006
    ..Identifying mechanisms of telomere loss and cellular processes that preserve telomeric DNA is crucial for the design of intervention therapies that prevent or delay the onset of diseases associated with aging and cancer. ..
  2. Mechanisms of Telomeric DNA Loss and Repair
    Patricia Opresko; Fiscal Year: 2007
    ..Identifying mechanisms of telomere loss and cellular processes that preserve telomeric DNA is crucial for the design of intervention therapies that prevent or delay the onset of diseases associated with aging and cancer. ..
  3. Mechanisms of Telomeric DNA Loss and Repair
    Patricia Opresko; Fiscal Year: 2009
    ..Identifying mechanisms of telomere loss and cellular processes that preserve telomeric DNA is crucial for the design of intervention therapies that prevent or delay the onset of diseases associated with aging and cancer. ..
  4. Mechanisms of Telomeric DNA Loss and Repair
    PATRICIA LYNN OPRESKO; Fiscal Year: 2010
    ..Identifying mechanisms of telomere loss and cellular processes that preserve telomeric DNA is crucial for the design of intervention therapies that prevent or delay the onset of diseases associated with aging and cancer. ..
  5. Mechanisms of Telomeric DNA Loss and Repair
    Patricia Opresko; Fiscal Year: 2009
    ..Identifying mechanisms of telomere loss and cellular processes that preserve telomeric DNA is crucial for the design of intervention therapies that prevent or delay the onset of diseases associated with aging and cancer. ..