Research Topics
| Mark OppSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Detail Information
Publications
Rat strain differences suggest a role for corticotropin-releasing hormone in modulating sleepM R Opp
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555, USA
Physiol Behav 63:67-74. 1997..These data provide support for the hypothesis that CRH may be a modulator of waking and sleep...
Sleep and psychoneuroimmunologyMark R Opp
Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 0615, USA
Immunol Allergy Clin North Am 29:295-307. 2009..Sleep is one of the behaviors altered in response to immune challenge. The role of cytokines as mediators of responses to infectious challenge and regulators and modulators of sleep is the focus of this article...
Sleeping to fuel the immune system: mammalian sleep and resistance to parasitesMark R Opp
Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA
BMC Evol Biol 9:8. 2009....- Sleep and psychoneuroimmunologyMark R Opp
Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 0615, USA
Neurol Clin 24:493-506. 2006.... - Cytokines and sleepMark R Opp
Department of Anesthesiology, University of Michigan, 7422 Medical Sciences Bldg I, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0615, USA
Sleep Med Rev 9:355-64. 2005..Whether the changes in sleep that occur during infection are beneficial and aid in recovery remains to be determined... - Rat strains that differ in corticotropin-releasing hormone production exhibit different sleep-wake responses to interleukin 1M R Opp
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Tex, USA
Neuroendocrinology 73:272-84. 2001..These observations support the hypothesis that CRH is both a modulator of responses to IL-1 and is involved in the regulation of waking... - Cytokines and sleep: the first hundred yearsMark R Opp
Departments of Anesthesiology and Molecular and Integrative, Physiology and the Neuroscience Graduate Program, Ann Arbor, MI 48109-0615, USA
Brain Behav Immun 18:295-7. 2004 - Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient miceM D Olivadoti
Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA
Neuroscience 153:338-48. 2008..muIL-1beta induced fever in C57Bl/6J mice but not in IL-6 KO mice. Collectively, these data demonstrate IL-6 is necessary for IL-1 to induce fever, but IL-6 is not necessary for IL-1 to alter NREM sleep... - Somnogenic and pyrogenic effects of interleukin-1beta and lipopolysaccharide in intact and vagotomized ratsM R Opp
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555, USA
Life Sci 62:923-36. 1998.... - Beta (CC)-chemokines as modulators of sleep: implications for HIV-induced alterations in arousal stateD Hogan
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston TX, USA
J Neuroimmunol 119:317-26. 2001..mRNA for the chemokine receptor CCR3 was detectable under basal conditions in multiple brain regions. These data suggest some CC chemokines may also be involved in processes by which HIV alters sleep... - Sleep as a behavioral model of neuro-immune interactionsM R Opp
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0431, USA
Acta Neurobiol Exp (Wars) 59:45-53. 1999..Since regulation of behavior is the function of the central nervous system, infection-induced alterations in behavior provide a unique model for the study of neuro-immune interactions... - Factors altering the sleep of burned childrenM Rose
Shriners Burns Hospital, Galveston, TX 77555 0803, USA
Sleep 24:45-51. 2001..The experiments to test such hypotheses remain to be conducted, yet the results of such experiments may provide the basis for beginning to answer the question of whether or not sleep aids in recovery from injury... - Murine gammaherpesvirus 68: a model for the study of Epstein-Barr virus infections and related diseasesMelissa Olivadoti
Neuroscience Graduate Program, University of Michigan, Ann Arbor, USA
Comp Med 57:44-50. 2007..These features make MuGHV a valuable experimental model for studying the pathophysiology of a GHV in a natural host... - Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1Francesca Baracchi
Department of Anesthesiology, University of Michigan, 7422 Medical Sciences Building I, 1150 W Medical Center Drive, Ann Arbor, MI 48109 5615, USA
Brain Behav Immun 22:982-93. 2008..These results provide additional evidence that the IL-1 beta and TNFalpha cytokine systems play a role in sleep regulation and in the alterations in sleep that follow prolonged wakefulness... - Modeling sepsis in the laboratory: merging sound science with animal well-beingJean A Nemzek
Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI, USA
Comp Med 58:120-8. 2008..A balance between the needs of sepsis research and animal welfare can only be achieved through knowledge of the strengths and weaknesses of and alternatives to in vivo sepsis models... - Role of corticotropin-releasing hormone in stressor-induced alterations of sleep in ratFang-Chia Chang
Neuroscience Laboratory, Department of Neurology, China Medical College Hospital, Taichung 404, Taiwan
Am J Physiol Regul Integr Comp Physiol 283:R400-7. 2002.... - Neural-immune interactions in the regulation of sleepMark R Opp
Department of Anesthesiology, University of Michigan School of Medicine, Ann Arbor 48109 0615, USA
Front Biosci 8:d768-79. 2003.... - Effects of serotonergic activation by 5-hydroxytryptophan on sleep and body temperature of C57BL/6J and interleukin-6-deficient mice are dose and time relatedJonathan D Morrow
Department of Psychiatry, University of Michigan, Ann Arbor, USA
Sleep 31:21-33. 2008..The objectives of this study were to (1) determine effects of serotonergic activation on sleep of mice and (2) elucidate a potential role for the cytokine interleukin-6 as a sleep factor mediating serotonergic effects on sleep... - Role of interleukin-6 in a glucan-induced model of granulomatous vasculitisShannon D McClintock
Department of Pathology, University of Michigan Medical School, 7520 MSRB I, 1301 Catherine Rd, Ann Arbor, MI 48109, USA
Exp Mol Pathol 82:203-9. 2007..These studies suggest that IL-6, while possibly involved in early neutrophil accumulation in this model does not appear critical to the development of the TH-2 mediated granulomatous vasculitis... - Interleukin-6 alters sleep of ratsDale Hogan
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX, USA
J Neuroimmunol 137:59-66. 2003..The interpretation of these data is consistent with those of previous studies demonstrating correlations between increased IL-6 and excessive daytime sleepiness during some pathophysiological conditions... - Inhibition of caspase-1 in rat brain reduces spontaneous nonrapid eye movement sleep and nonrapid eye movement sleep enhancement induced by lipopolysaccharideLuca Imeri
Institute of Human Physiology II, University of Milan Medical School, Milan, Italy
Am J Physiol Regul Integr Comp Physiol 291:R197-204. 2006..These results, in agreement with previous evidence, support the involvement of brain IL-1beta in physiological promotion of NREM sleep and in mediating NREM sleep enhancement induced by peripheral immune challenge... - Cytokines and normal sleepFotis Kapsimalis
Department of Pulmonology, Sleep Laboratory, Henry Dunant Hospital, Athens, Greece
Curr Opin Pulm Med 11:481-4. 2005..The somatotropic hormonal system and hypothalamic-pituitary-adrenal axis mediate, in part, the effects of cytokines on sleep... - Antagonism of corticotropin-releasing hormone alters serotonergic-induced changes in brain temperature, but not sleep, of ratsLuca Imeri
Institute of Human Physiology II, University of Milan Medical School, Milan, Italy
Am J Physiol Regul Integr Comp Physiol 289:R1116-23. 2005.... - Sleep-wake behavior and responses of interleukin-6-deficient mice to sleep deprivationJonathan D Morrow
Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109 0615, USA
Brain Behav Immun 19:28-39. 2005..That mice lacking IL-6 spend more time in REMS suggests that interactions between IL-6 and REMS regulatory mechanisms may differ from those of IL-1 and/or TNF... - Interleukin-1beta modulates state-dependent discharge activity of preoptic area and basal forebrain neurons: role in sleep regulationMd Noor Alam
Veteran Affairs Greater Los Angeles Health Care System, 16111 Plummer Street, North Hills, CA 91343, USA
Eur J Neurosci 20:207-16. 2004..These results suggest that the sleep-promoting effects of IL-1 may be mediated, in part, via the suppression of wake-related neurons and the activation of a subpopulation of sleep-related neurons in the POA/BF... - Sleep, but not febrile responses of Fisher 344 rats to immune challenge are affected by agingLuca Imeri
Institute of Human Physiology II, University of Milan Medical School, Milan, Italy
Brain Behav Immun 18:399-404. 2004.... - A corticotropin-releasing hormone antisense oligodeoxynucleotide reduces spontaneous waking in the ratFang-Chia Chang
Neuroscience Laboratory, Department of Neurology, China Medical College Hospital, Taichung 404, Taiwan
Regul Pept 117:43-52. 2004..These findings provide additional support for the hypothesis that CRH is involved in the regulation/modulation of wakefulness... - Diurnal variation of lipopolysaccharide-induced alterations in sleep and body temperature of interleukin-6-deficient miceJonathan D Morrow
Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109 0615, USA
Brain Behav Immun 19:40-51. 2005..These results indicate that IL-6 mediates some of the effects of LPS on NREMS and body temperature of mice, and that the magnitude and duration of these effects differ as a function of the time at which the challenge is given...
Research Grants
- Cytokine and neurotransmitter interactions in sleep regulationMark Opp; Fiscal Year: 2009..Once we understand how (by what means) sleep is altered during infection, we will be able to study why sleep is altered during infection, i.e., does altered sleep facilitate recovery? ..
- Sleep, Cytokines and InfectionMark Opp; Fiscal Year: 2007..Successful completion of the proposed studies will provide information critical to understanding how infection impacts CNS function, as evidenced by alterations in sleep. ..
- Cytokine neurotransmitter interactions and sleepMark Opp; Fiscal Year: 2005..As such, although our focus remains firmly on sleep, the integrated experimental approach we propose will result in information relevant to several fields of basic and clinical neuroscience. ..