Mark Opp

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Rat strain differences suggest a role for corticotropin-releasing hormone in modulating sleep
    M R Opp
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555, USA
    Physiol Behav 63:67-74. 1997
  2. doi request reprint Sleep and psychoneuroimmunology
    Mark R Opp
    Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 0615, USA
    Immunol Allergy Clin North Am 29:295-307. 2009
  3. pmc Sleeping to fuel the immune system: mammalian sleep and resistance to parasites
    Mark R Opp
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA
    BMC Evol Biol 9:8. 2009
  4. ncbi request reprint Sleep and psychoneuroimmunology
    Mark R Opp
    Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 0615, USA
    Neurol Clin 24:493-506. 2006
  5. ncbi request reprint Cytokines and sleep
    Mark R Opp
    Department of Anesthesiology, University of Michigan, 7422 Medical Sciences Bldg I, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0615, USA
    Sleep Med Rev 9:355-64. 2005
  6. ncbi request reprint Rat strains that differ in corticotropin-releasing hormone production exhibit different sleep-wake responses to interleukin 1
    M R Opp
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Tex, USA
    Neuroendocrinology 73:272-84. 2001
  7. ncbi request reprint Cytokines and sleep: the first hundred years
    Mark R Opp
    Departments of Anesthesiology and Molecular and Integrative, Physiology and the Neuroscience Graduate Program, Ann Arbor, MI 48109 0615, USA
    Brain Behav Immun 18:295-7. 2004
  8. pmc Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice
    M D Olivadoti
    Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA
    Neuroscience 153:338-48. 2008
  9. ncbi request reprint Somnogenic and pyrogenic effects of interleukin-1beta and lipopolysaccharide in intact and vagotomized rats
    M R Opp
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555, USA
    Life Sci 62:923-36. 1998
  10. ncbi request reprint Beta (CC)-chemokines as modulators of sleep: implications for HIV-induced alterations in arousal state
    D Hogan
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston TX, USA
    J Neuroimmunol 119:317-26. 2001

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Rat strain differences suggest a role for corticotropin-releasing hormone in modulating sleep
    M R Opp
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555, USA
    Physiol Behav 63:67-74. 1997
    ..These data provide support for the hypothesis that CRH may be a modulator of waking and sleep...
  2. doi request reprint Sleep and psychoneuroimmunology
    Mark R Opp
    Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 0615, USA
    Immunol Allergy Clin North Am 29:295-307. 2009
    ..Sleep is one of the behaviors altered in response to immune challenge. The role of cytokines as mediators of responses to infectious challenge and regulators and modulators of sleep is the focus of this article...
  3. pmc Sleeping to fuel the immune system: mammalian sleep and resistance to parasites
    Mark R Opp
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA
    BMC Evol Biol 9:8. 2009
    ....
  4. ncbi request reprint Sleep and psychoneuroimmunology
    Mark R Opp
    Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 0615, USA
    Neurol Clin 24:493-506. 2006
    ....
  5. ncbi request reprint Cytokines and sleep
    Mark R Opp
    Department of Anesthesiology, University of Michigan, 7422 Medical Sciences Bldg I, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0615, USA
    Sleep Med Rev 9:355-64. 2005
    ..Whether the changes in sleep that occur during infection are beneficial and aid in recovery remains to be determined...
  6. ncbi request reprint Rat strains that differ in corticotropin-releasing hormone production exhibit different sleep-wake responses to interleukin 1
    M R Opp
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Tex, USA
    Neuroendocrinology 73:272-84. 2001
    ..These observations support the hypothesis that CRH is both a modulator of responses to IL-1 and is involved in the regulation of waking...
  7. ncbi request reprint Cytokines and sleep: the first hundred years
    Mark R Opp
    Departments of Anesthesiology and Molecular and Integrative, Physiology and the Neuroscience Graduate Program, Ann Arbor, MI 48109 0615, USA
    Brain Behav Immun 18:295-7. 2004
  8. pmc Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice
    M D Olivadoti
    Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA
    Neuroscience 153:338-48. 2008
    ..muIL-1beta induced fever in C57Bl/6J mice but not in IL-6 KO mice. Collectively, these data demonstrate IL-6 is necessary for IL-1 to induce fever, but IL-6 is not necessary for IL-1 to alter NREM sleep...
  9. ncbi request reprint Somnogenic and pyrogenic effects of interleukin-1beta and lipopolysaccharide in intact and vagotomized rats
    M R Opp
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555, USA
    Life Sci 62:923-36. 1998
    ....
  10. ncbi request reprint Beta (CC)-chemokines as modulators of sleep: implications for HIV-induced alterations in arousal state
    D Hogan
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston TX, USA
    J Neuroimmunol 119:317-26. 2001
    ..mRNA for the chemokine receptor CCR3 was detectable under basal conditions in multiple brain regions. These data suggest some CC chemokines may also be involved in processes by which HIV alters sleep...
  11. ncbi request reprint Sleep as a behavioral model of neuro-immune interactions
    M R Opp
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0431, USA
    Acta Neurobiol Exp (Wars) 59:45-53. 1999
    ..Since regulation of behavior is the function of the central nervous system, infection-induced alterations in behavior provide a unique model for the study of neuro-immune interactions...
  12. ncbi request reprint Factors altering the sleep of burned children
    M Rose
    Shriners Burns Hospital, Galveston, TX 77555 0803, USA
    Sleep 24:45-51. 2001
    ..The experiments to test such hypotheses remain to be conducted, yet the results of such experiments may provide the basis for beginning to answer the question of whether or not sleep aids in recovery from injury...
  13. ncbi request reprint Murine gammaherpesvirus 68: a model for the study of Epstein-Barr virus infections and related diseases
    Melissa Olivadoti
    Neuroscience Graduate Program, University of Michigan, Ann Arbor, USA
    Comp Med 57:44-50. 2007
    ..These features make MuGHV a valuable experimental model for studying the pathophysiology of a GHV in a natural host...
  14. doi request reprint Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1
    Francesca Baracchi
    Department of Anesthesiology, University of Michigan, 7422 Medical Sciences Building I, 1150 W Medical Center Drive, Ann Arbor, MI 48109 5615, USA
    Brain Behav Immun 22:982-93. 2008
    ..These results provide additional evidence that the IL-1 beta and TNFalpha cytokine systems play a role in sleep regulation and in the alterations in sleep that follow prolonged wakefulness...
  15. pmc Modeling sepsis in the laboratory: merging sound science with animal well-being
    Jean A Nemzek
    Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI, USA
    Comp Med 58:120-8. 2008
    ..A balance between the needs of sepsis research and animal welfare can only be achieved through knowledge of the strengths and weaknesses of and alternatives to in vivo sepsis models...
  16. ncbi request reprint Role of corticotropin-releasing hormone in stressor-induced alterations of sleep in rat
    Fang Chia Chang
    Neuroscience Laboratory, Department of Neurology, China Medical College Hospital, Taichung 404, Taiwan
    Am J Physiol Regul Integr Comp Physiol 283:R400-7. 2002
    ....
  17. ncbi request reprint Neural-immune interactions in the regulation of sleep
    Mark R Opp
    Department of Anesthesiology, University of Michigan School of Medicine, Ann Arbor 48109 0615, USA
    Front Biosci 8:d768-79. 2003
    ....
  18. pmc Effects of serotonergic activation by 5-hydroxytryptophan on sleep and body temperature of C57BL/6J and interleukin-6-deficient mice are dose and time related
    Jonathan D Morrow
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Sleep 31:21-33. 2008
    ..The objectives of this study were to (1) determine effects of serotonergic activation on sleep of mice and (2) elucidate a potential role for the cytokine interleukin-6 as a sleep factor mediating serotonergic effects on sleep...
  19. ncbi request reprint Role of interleukin-6 in a glucan-induced model of granulomatous vasculitis
    Shannon D McClintock
    Department of Pathology, University of Michigan Medical School, 7520 MSRB I, 1301 Catherine Rd, Ann Arbor, MI 48109, USA
    Exp Mol Pathol 82:203-9. 2007
    ..These studies suggest that IL-6, while possibly involved in early neutrophil accumulation in this model does not appear critical to the development of the TH-2 mediated granulomatous vasculitis...
  20. ncbi request reprint Interleukin-6 alters sleep of rats
    Dale Hogan
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX, USA
    J Neuroimmunol 137:59-66. 2003
    ..The interpretation of these data is consistent with those of previous studies demonstrating correlations between increased IL-6 and excessive daytime sleepiness during some pathophysiological conditions...
  21. ncbi request reprint Inhibition of caspase-1 in rat brain reduces spontaneous nonrapid eye movement sleep and nonrapid eye movement sleep enhancement induced by lipopolysaccharide
    Luca Imeri
    Institute of Human Physiology II, University of Milan Medical School, Milan, Italy
    Am J Physiol Regul Integr Comp Physiol 291:R197-204. 2006
    ..These results, in agreement with previous evidence, support the involvement of brain IL-1beta in physiological promotion of NREM sleep and in mediating NREM sleep enhancement induced by peripheral immune challenge...
  22. ncbi request reprint Cytokines and normal sleep
    Fotis Kapsimalis
    Department of Pulmonology, Sleep Laboratory, Henry Dunant Hospital, Athens, Greece
    Curr Opin Pulm Med 11:481-4. 2005
    ..This short review highlights selected findings that have advanced our understanding of the relation between cytokines and sleep...
  23. ncbi request reprint Antagonism of corticotropin-releasing hormone alters serotonergic-induced changes in brain temperature, but not sleep, of rats
    Luca Imeri
    Institute of Human Physiology II, University of Milan Medical School, Milan, Italy
    Am J Physiol Regul Integr Comp Physiol 289:R1116-23. 2005
    ....
  24. ncbi request reprint Sleep-wake behavior and responses of interleukin-6-deficient mice to sleep deprivation
    Jonathan D Morrow
    Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109 0615, USA
    Brain Behav Immun 19:28-39. 2005
    ..That mice lacking IL-6 spend more time in REMS suggests that interactions between IL-6 and REMS regulatory mechanisms may differ from those of IL-1 and/or TNF...
  25. ncbi request reprint Interleukin-1beta modulates state-dependent discharge activity of preoptic area and basal forebrain neurons: role in sleep regulation
    Md Noor Alam
    Veteran Affairs Greater Los Angeles Health Care System, 16111 Plummer Street, North Hills, CA 91343, USA
    Eur J Neurosci 20:207-16. 2004
    ..These results suggest that the sleep-promoting effects of IL-1 may be mediated, in part, via the suppression of wake-related neurons and the activation of a subpopulation of sleep-related neurons in the POA/BF...
  26. ncbi request reprint Sleep, but not febrile responses of Fisher 344 rats to immune challenge are affected by aging
    Luca Imeri
    Institute of Human Physiology II, University of Milan Medical School, Milan, Italy
    Brain Behav Immun 18:399-404. 2004
    ....
  27. ncbi request reprint A corticotropin-releasing hormone antisense oligodeoxynucleotide reduces spontaneous waking in the rat
    Fang Chia Chang
    Neuroscience Laboratory, Department of Neurology, China Medical College Hospital, Taichung 404, Taiwan
    Regul Pept 117:43-52. 2004
    ..These findings provide additional support for the hypothesis that CRH is involved in the regulation/modulation of wakefulness...
  28. ncbi request reprint Diurnal variation of lipopolysaccharide-induced alterations in sleep and body temperature of interleukin-6-deficient mice
    Jonathan D Morrow
    Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109 0615, USA
    Brain Behav Immun 19:40-51. 2005
    ..These results indicate that IL-6 mediates some of the effects of LPS on NREMS and body temperature of mice, and that the magnitude and duration of these effects differ as a function of the time at which the challenge is given...

Research Grants11

  1. Cytokine and neurotransmitter interactions in sleep regulation
    Mark Opp; Fiscal Year: 2009
    ..Once we understand how (by what means) sleep is altered during infection, we will be able to study why sleep is altered during infection, i.e., does altered sleep facilitate recovery? ..
  2. Sleep, Cytokines and Infection
    Mark Opp; Fiscal Year: 2007
    ..Successful completion of the proposed studies will provide information critical to understanding how infection impacts CNS function, as evidenced by alterations in sleep. ..
  3. Cytokine neurotransmitter interactions and sleep
    Mark Opp; Fiscal Year: 2005
    ..As such, although our focus remains firmly on sleep, the integrated experimental approach we propose will result in information relevant to several fields of basic and clinical neuroscience. ..