S Oparil

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Managing the patient with hard-to-control hypertension
    S Oparil
    Division of Cardiovascular Disease, University of Alabama School of Medicine, Birmingham, USA
    Am Fam Physician 57:1007-14, 1019-20. 1998
  2. ncbi request reprint Ethnicity and blood pressure
    Suzanne Oparil
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Clin Hypertens (Greenwich) 7:357-64. 2005
  3. ncbi request reprint [Calcium antagonists in cardiovascular disease. Clinical evidence from morbidity and mortality trials]
    S Oparil
    Université d Alabama, Departement de Medecine, Biologie Vasculaire et Hypertension, Birmingham, USA
    Drugs 59:25-37. 2000
  4. ncbi request reprint Comparative efficacy of olmesartan, losartan, valsartan, and irbesartan in the control of essential hypertension
    S Oparil
    Division of Cardiovascular Disease, University of Alabama, Birmingham, AL 35294, USA
    J Clin Hypertens (Greenwich) 3:283-91, 318. 2001
  5. doi request reprint Results of an olmesartan medoxomil-based treatment regimen in hypertensive patients
    Suzanne Oparil
    Division of Cardiovascular Diseases, University of Alabama at Birmingham School of Medicine, AL, USA
    J Clin Hypertens (Greenwich) 10:911-21. 2008
  6. ncbi request reprint Efficacy of perindopril in the treatment of systemic hypertension
    S Oparil
    Vascular Biology and Hypertension Program of the Division of Cardiovascular Disease, University of Alabama School of Medicine, Birmingham, Alabama 35294, USA
    Am J Cardiol 88:3i-12i. 2001
  7. ncbi request reprint Treating multiple-risk hypertensive populations
    S Oparil
    Vascular Biology and Hypertension Program, University of Alabama Birmingham, 35294, USA
    Am J Hypertens 12:121S-129S. 1999
  8. ncbi request reprint Nontraditional cardiovascular risk factors
    S Oparil
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Am J Med Sci 317:193-207. 1999
  9. doi request reprint Angiotensin receptor blocker and dihydropyridine calcium channel blocker combinations: an emerging strategy in hypertension therapy
    Suzanne Oparil
    Vascular Biology and Hypertension Program, Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Postgrad Med 121:25-39. 2009
  10. ncbi request reprint Arthur C. Corcoran Memorial Lecture. Hormones and vasoprotection
    S Oparil
    Department of Medicine, University of Alabama at Birmingham, Vascular Biology and Hypertension Program, USA
    Hypertension 33:170-6. 1999

Research Grants

Collaborators

Detail Information

Publications135 found, 100 shown here

  1. ncbi request reprint Managing the patient with hard-to-control hypertension
    S Oparil
    Division of Cardiovascular Disease, University of Alabama School of Medicine, Birmingham, USA
    Am Fam Physician 57:1007-14, 1019-20. 1998
    ..In many patients, these factors must be dealt with before blood pressure can be controlled...
  2. ncbi request reprint Ethnicity and blood pressure
    Suzanne Oparil
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Clin Hypertens (Greenwich) 7:357-64. 2005
    ..This brief review will discuss recent findings that bear on the management of hypertension in these special patient groups...
  3. ncbi request reprint [Calcium antagonists in cardiovascular disease. Clinical evidence from morbidity and mortality trials]
    S Oparil
    Université d Alabama, Departement de Medecine, Biologie Vasculaire et Hypertension, Birmingham, USA
    Drugs 59:25-37. 2000
    ..To date, these trials in progress have provided no evidence to support these concerns...
  4. ncbi request reprint Comparative efficacy of olmesartan, losartan, valsartan, and irbesartan in the control of essential hypertension
    S Oparil
    Division of Cardiovascular Disease, University of Alabama, Birmingham, AL 35294, USA
    J Clin Hypertens (Greenwich) 3:283-91, 318. 2001
    ..3 mm Hg). All drugs were well tolerated. The authors conclude that olmesartan, at its starting dose, is more effective than the starting doses of the other ARBs tested in reducing cuff DBP in patients with essential hypertension...
  5. doi request reprint Results of an olmesartan medoxomil-based treatment regimen in hypertensive patients
    Suzanne Oparil
    Division of Cardiovascular Diseases, University of Alabama at Birmingham School of Medicine, AL, USA
    J Clin Hypertens (Greenwich) 10:911-21. 2008
    ..1% and 30.7% of OM- compared with placebo-treated patients, respectively (P<.0001). BP normalized (<120/80 mm Hg) in 44.8% of OM- vs 1.4% of placebo-treated patients with stage 1 hypertension (P<.0001)...
  6. ncbi request reprint Efficacy of perindopril in the treatment of systemic hypertension
    S Oparil
    Vascular Biology and Hypertension Program of the Division of Cardiovascular Disease, University of Alabama School of Medicine, Birmingham, Alabama 35294, USA
    Am J Cardiol 88:3i-12i. 2001
    ..Both of these effects are at least partly independent of its ability to lower BP. Perindopril is safe and well tolerated in patients with hypertension. Rates of adverse events and discontinuation because of such events are low...
  7. ncbi request reprint Treating multiple-risk hypertensive populations
    S Oparil
    Vascular Biology and Hypertension Program, University of Alabama Birmingham, 35294, USA
    Am J Hypertens 12:121S-129S. 1999
    ....
  8. ncbi request reprint Nontraditional cardiovascular risk factors
    S Oparil
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Am J Med Sci 317:193-207. 1999
    ..The strength of the associations of the newer risk factors with cardiovascular therapy are currently being tested. This review will briefly discuss evidence that these risk factors are related to cardiovascular disease...
  9. doi request reprint Angiotensin receptor blocker and dihydropyridine calcium channel blocker combinations: an emerging strategy in hypertension therapy
    Suzanne Oparil
    Vascular Biology and Hypertension Program, Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Postgrad Med 121:25-39. 2009
    ..This article discusses the rationale for using CCB/ARB combinations in patients with hypertension...
  10. ncbi request reprint Arthur C. Corcoran Memorial Lecture. Hormones and vasoprotection
    S Oparil
    Department of Medicine, University of Alabama at Birmingham, Vascular Biology and Hypertension Program, USA
    Hypertension 33:170-6. 1999
    ..These fundamental studies will establish more rational strategies for therapeutic intervention in vascular diseases, including the basis for future gene therapy...
  11. doi request reprint Hypertension in 2010: new challenges in blood pressure goals and assessment
    Suzanne Oparil
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, School of Medicine, University of Alabama at Birmingham, 703 19th Street South, Birmingham, AL 35294, USA
    Nat Rev Cardiol 8:73-5. 2011
    ..the impact of these findings on future hypertension guidelines remains to be assessed...
  12. ncbi request reprint Estrogen attenuates the adventitial contribution to neointima formation in injured rat carotid arteries
    S Oparil
    Cardiovasc Res 44:608-14. 1999
    ....
  13. ncbi request reprint Comparative antihypertensive efficacy of olmesartan: comparison with other angiotensin II receptor antagonists
    S Oparil
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Dept of Medicine, University of Alabama at Birmingham, 1034 Zeigler Research Building, Birmingham, AL 35294, USA
    J Hum Hypertens 16:S17-23. 2002
    ..Preliminary evidence suggests that olmesartan, an A II receptor blocker currently being evaluated for approval for clinical use, may provide antihypertensive efficacy that is superior to other members of the class...
  14. ncbi request reprint Role of angiotensin receptor blockers as monotherapy in reaching blood pressure goals
    Suzanne Oparil
    Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Am J Hypertens 18:287-94. 2005
    ..9%). Optimal ARB monotherapy can achieve recommended BP goals in a significant proportion of hypertensive patients. However, the majority of hypertensive patients will require combination therapy with two or more antihypertensive agents...
  15. doi request reprint Subgroup analyses of an efficacy and safety study of concomitant administration of amlodipine besylate and olmesartan medoxomil: evaluation by baseline hypertension stage and prior antihypertensive medication use
    Suzanne Oparil
    Department of Medicine, University of Alabama at Birmingham School of Medicine, 35294 0007, USA
    J Cardiovasc Pharmacol 54:427-36. 2009
    ..Subgroup categorization did not affect safety. After 8 weeks of treatment, the combination of amlodipine + OM is safe and efficacious, irrespective of baseline hypertension stage or prior antihypertensive medication use...
  16. ncbi request reprint Gender and blood pressure
    Suzanne Oparil
    Division of Cardiovascular Disease, Vascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Clin Hypertens (Greenwich) 7:300-9. 2005
    ..This brief review will discuss recent findings that bear on considerations of gender in the management of hypertension, particularly among older women...
  17. ncbi request reprint Are there meaningful differences in blood pressure control with current antihypertensive agents?
    Suzanne Oparil
    Vascular Biology and Hypertensive Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, 35294, USA
    Am J Hypertens 15:14S-21S. 2002
    ..Based on comparative antihypertensive efficacy, olmesartan, a new ARB, may represent a significant addition to this drug class...
  18. ncbi request reprint Women and hypertension: what did we learn from the Women's Health Initiative?
    Suzanne Oparil
    Center for Aging, the Vascular Biology and Hypertension Program of the Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Cardiol Rev 14:267-75. 2006
    ....
  19. ncbi request reprint Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial
    Suzanne Oparil
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2041, USA
    Lancet 370:221-9. 2007
    ..The aim of this study was to assess dual renin system intervention with the maximum recommended doses of aliskiren and valsartan, compared with each drug alone in patients with hypertension...
  20. ncbi request reprint Renin inhibitors in the management of hypertension
    Suzanne Oparil
    University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294 0007, USA
    J Clin Hypertens (Greenwich) 9:706-7. 2007
  21. pmc Long-term efficacy of a combination of amlodipine and olmesartan medoxomil ± hydrochlorothiazide in patients with hypertension stratified by age, race and diabetes status: a substudy of the COACH trial
    S Oparil
    Division of Cardiovascular Diseases, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294 0007, USA
    J Hum Hypertens 24:831-8. 2010
    ..3% of Blacks, 67.8% of non-Blacks, 26.9% of patients with diabetes and 72.9% of patients without diabetes. The combination of AML + OM ± HCTZ was efficacious, safe and well tolerated by these subgroups...
  22. doi request reprint Long-term effects of aldosterone blockade in resistant hypertension associated with chronic kidney disease
    R Pisoni
    Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Hum Hypertens 26:502-6. 2012
    ....
  23. ncbi request reprint Estrogen restores endothelial cell function in an experimental model of vascular injury
    C R White
    University of Alabama at Birmingham, Department of Medicine, Vascular Biology, and Hypertension Program, 35294 0007, USA
    Circulation 96:1624-30. 1997
    ..The goal of the present study was to determine whether estrogen restores endothelial cell function in balloon-injured rat carotid arteries...
  24. ncbi request reprint Estrogen-induced vasoprotection is estrogen receptor dependent: evidence from the balloon-injured rat carotid artery model
    S Bakir
    The Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, USA
    Circulation 101:2342-4. 2000
    ..This study used ICI 182,780, a nonselective ER antagonist, to test the hypothesis that the vasoprotective effect of E2 in the rat carotid injury model is ER mediated...
  25. doi request reprint Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial
    George L Bakris
    Hypertensive Diseases Unit, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Lancet 375:1173-81. 2010
    ..We assessed the effects of these drug combinations on progression of chronic kidney disease...
  26. ncbi request reprint Dietary compliance and cardiovascular risk reduction with a prepared meal plan compared with a self-selected diet
    J A Metz
    Department of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Am J Clin Nutr 66:373-85. 1997
    ..The prepared meal plan is a simple and effective strategy for meeting the many nutrient recommendations for CVD risk reduction and improving dietary compliance and CVD endpoints...
  27. pmc Inhibition of transforming growth factor-beta signaling induces left ventricular dilation and dysfunction in the pressure-overloaded heart
    Jason A Lucas
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Heart Circ Physiol 298:H424-32. 2010
    ....
  28. ncbi request reprint Altered stores of atrial natriuretic peptide in specific brain nuclei of NaCl-sensitive spontaneously hypertensive rats
    H K Jin
    Department of Medicine, University of Alabama, Birmingham 35294
    Am J Hypertens 4:449-55. 1991
    ..These alterations in ANP content in SHR-S may be related to the reduced release of norepinephrine from nerve terminals in AHA and to the presumed central defect in baroreceptor function...
  29. ncbi request reprint Dietary NaCl loading enhances antihypertensive effect of guanabenz in spontaneously hypertensive rats
    H K Jin
    Department of Medicine, University of Alabama, Birmingham 35294
    Am J Hypertens 2:435-9. 1989
    ..1). Guanabenz tended to reduce plasma NE levels in 8% NaCl fed SHR-S (.1 greater than P greater than .05), but not in 1% NaCl fed rats (P greater than .1).(ABSTRACT TRUNCATED AT 250 WORDS)..
  30. ncbi request reprint Sexually dimorphic response of the balloon-injured rat carotid artery to hormone treatment
    S Oparil
    University of Alabama at Birmingham, USA
    Circulation 95:1301-7. 1997
    ....
  31. ncbi request reprint Estrogen depletion induces NaCl-sensitive hypertension in female spontaneously hypertensive rats
    Z Fang
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1934-9. 2001
    ..Furthermore, these results demonstrate that dietary phytoestrogens can have a major impact on the interpretation of studies into the physiological role of estrogen in females...
  32. ncbi request reprint Effects of pressure overload on extracellular matrix expression in the heart of the atrial natriuretic peptide-null mouse
    Dajun Wang
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hypertension 42:88-95. 2003
    ..These results support the hypothesis that atrial natriuretic peptide protects against pressure overload-induced cardiac hypertrophy and remodeling by negative modulation of genes involved in extracellular matrix deposition...
  33. pmc The transcription factor ETS-1 mediates proinflammatory responses and neointima formation in carotid artery endoluminal vascular injury
    Wenguang Feng
    Division of Nephrology and Hypertension, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hypertension 55:1381-8. 2010
    ..This study unveils the role of ETS-1 as a mediator of inflammation and neointima formation in a model of carotid artery balloon injury and may result in the development of novel strategies in the treatment of vascular injury...
  34. ncbi request reprint Dietary Ca2+ prevents NaCl-sensitive hypertension in spontaneously hypertensive rats by a sympatholytic mechanism
    S Oparil
    Department of Medicine, University of Alabama, Birmingham 35294
    Am J Hypertens 3:179S-188S. 1990
    ....
  35. ncbi request reprint Estrogen-induced vasoprotection is independent of inducible nitric oxide synthase expression: evidence from the mouse carotid artery ligation model
    T Tolbert
    Departments of Medicine, Division of Cardiovascular Diseases, Division of Transplantation, University of Alabama at Birmingham, USA
    Circulation 104:2740-5. 2001
    ..This study tested the hypothesis that E(2) reduces neointima formation after vascular injury via a mechanism that is dependent on modulation of iNOS expression...
  36. ncbi request reprint A double-blind, randomized study evaluating losartan potassium monotherapy or in combination with hydrochlorothiazide versus placebo in obese patients with hypertension
    S Oparil
    University of Alabama Birmingham, Birmingham, AL 35294 0007, USA
    Curr Med Res Opin 24:1101-14. 2008
    ..The objective of this study was to evaluate the effects of losartan +/- hydrochlorothiazide (HCTZ) versus placebo in obese patients with systolic and diastolic hypertension...
  37. ncbi request reprint Effects of acute and chronic blockade of neutral endopeptidase with Sch 34826 on NaCl-sensitive hypertension in spontaneously hypertensive rats
    H Jin
    Department of Medicine, University of Alabama, Birmingham
    Am J Hypertens 5:210-8. 1992
    ..This effect was associated with increased urine volume and urinary sodium, ANP, and cyclic GMP in 8% NaCl fed SHR-S.(ABSTRACT TRUNCATED AT 250 WORDS)..
  38. ncbi request reprint Genetic variation in angiotensin-converting enzyme does not prevent development of cardiac hypertrophy or upregulation of angiotensin II in response to aortocaval fistula
    G J Perry
    Birmingham VA Medical Center, University of Alabama at Birmingham, USA
    Circulation 103:1012-6. 2001
    ..We investigated the effect of genetic variation in angiotensin-converting enzyme (ACE) on the development of cardiac hypertrophy and left ventricular (LV) dysfunction in response to volume overload...
  39. ncbi request reprint Efficacy and safety of losartan/hydrochlorothiazide in patients with severe hypertension
    S Oparil
    University of Alabama at Birmingham, Community Health Sciences, USA
    Am J Cardiol 87:721-6. 2001
    ..In conclusion, losartan/ HCTZ, alone or as part of a regimen with other standard antihypertensive agents, is effective and well tolerated in the treatment of patients with severe hypertension...
  40. ncbi request reprint The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report
    Aram V Chobanian
    Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
    JAMA 289:2560-72. 2003
    ..Empathy builds trust and is a potent motivator. Finally, in presenting these guidelines, the committee recognizes that the responsible physician's judgment remains paramount...
  41. ncbi request reprint Endothelin-A receptor blockade in porcine pulmonary hypertension
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Res 52:913-21. 2002
    ..Differences in response to ET(A) blockade in pulmonary hypertension may be seen depending on the etiology (hypoxia versus infection-associated), and the specific ET(A) antagonist used...
  42. ncbi request reprint Dietary salt supplementation selectively downregulates NPR-C receptor expression in kidney independently of ANP
    Ju Zhong Sun
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Renal Physiol 282:F220-7. 2002
    ....
  43. doi request reprint Relationships between metrics of visit-to-visit variability of blood pressure
    E B Levitan
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Hum Hypertens 27:589-93. 2013
    ..d., SDIM, CV), one of the metrics of variability between consecutive visits (SV, ARV), and one or more of the metrics of extreme values at a single visit (maximum, peak size, trough size)...
  44. ncbi request reprint Ganglion atrial natriuretic peptide in NaCl sensitive spontaneously hypertensive rats
    H Jin
    Department of Medicine, University of Alabama, Birmingham
    Am J Hypertens 5:806-10. 1992
    ..abstract truncated at 250 words)..
  45. ncbi request reprint Mibefradil, a T-channel-selective calcium antagonist: clinical trials in hypertension
    S Oparil
    University of Alabama at Birmingham, 35294, USA
    Am J Hypertens 11:88S-94S. 1998
    ..Overall, mibefradil was better tolerated than the comparison drugs. Mibefradil, at the recommended doses of 50 to 100 mg/day, is safe and effective for the treatment of mild-to-moderate hypertension...
  46. pmc Loss of Thy-1 inhibits alveolar development in the newborn mouse lung
    Teodora Nicola
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Am J Physiol Lung Cell Mol Physiol 296:L738-50. 2009
    ..Thy-1(-/-) mice given 1D11 had improved alveolar development and lung function. These data support the hypothesis that hypoxia, by reducing Thy-1, increases TGF-beta activation, and thereby inhibits normal alveolar development...
  47. pmc Severity of obstructive sleep apnea is related to aldosterone status in subjects with resistant hypertension
    Carolina C Gonzaga
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, AL, USA
    J Clin Sleep Med 6:363-8. 2010
    ..This investigation examines the relationship between aldosterone status and OSA in patients with resistant hypertensive-with and without hyperaldosteronism...
  48. pmc Estrogen and mechanisms of vascular protection
    Dongqi Xing
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Arterioscler Thromb Vasc Biol 29:289-95. 2009
    ....
  49. ncbi request reprint Blood pressure and NaCl-sensitive hypertension are influenced by angiotensin-converting enzyme gene expression in transgenic mice
    Scott H Carlson
    Vascular Biology and Hypertension Program of the Department of Medicine, University of Alabama at Birmingham, USA
    Hypertension 39:214-8. 2002
    ....
  50. ncbi request reprint The neointimal response to endovascular injury is increased in obese Zucker rats
    J Shelton
    Departments of Medicine, Vascular Biology and Hypertension Program of the Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Diabetes Obes Metab 5:415-23. 2003
    ..Restenosis after revascularization procedures is accelerated in persons with type 2 diabetes...
  51. ncbi request reprint Comprehensive nutrition plan improves cardiovascular risk factors in essential hypertension
    D A McCarron
    Department of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Am J Hypertens 11:31-40. 1998
    ..Compared with typical dietary therapy, the comprehensive CCNW meal plan has significantly greater effects on multiple cardiovascular risk factors while yielding greater compliance and improved quality of life...
  52. pmc Spironolactone reduces severity of obstructive sleep apnoea in patients with resistant hypertension: a preliminary report
    K Gaddam
    Division of Cardiovascular Diseases, Ochsner Clinic Foundation, New Orleans, LA, USA
    J Hum Hypertens 24:532-7. 2010
    ..If confirmed in a randomized assessment, it will support aldosterone-mediated chronic fluid retention as an important mediator of OSA severity in patients with resistant hypertension...
  53. ncbi request reprint Dose-response characteristics of mibefradil, a novel calcium antagonist, in the treatment of essential hypertension
    S Oparil
    University of Alabama at Birmingham, 35294, USA
    Am J Hypertens 10:735-42. 1997
    ..The appropriate therapeutic dose range of mibefradil in the management of mild-to-moderate essential hypertension is 50 to 100 mg...
  54. ncbi request reprint Newly emerging pharmacologic differences in angiotensin II receptor blockers
    S Oparil
    University of Alabama at Birmingham, USA
    Am J Hypertens 13:18S-24S. 2000
    ....
  55. ncbi request reprint Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts
    Peng Li
    Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
    Circ Res 102:185-92. 2008
    ..We postulate that this process contributes to the antifibrogenic effects of the natriuretic peptide in heart...
  56. ncbi request reprint Volume overload results in exaggerated cardiac hypertrophy in the atrial natriuretic peptide knockout mouse
    Tatsuhiko Mori
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cardiovasc Res 61:771-9. 2004
    ..The effect of ANP deficiency on the response to volume overload has not previously been studied. We hypothesised that ANP deficient mice would develop excess cardiac hypertrophy in response to volume overload stress...
  57. pmc Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent
    Dongqi Xing
    Vascular Biology and Hypertension Program, The University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Pathol 172:22-30. 2008
    ..The exaggerated response to vascular injury provoked by CRP in OVX CRPtg depends on Fc gamma RI and probably requires its expression by F4/80+ cells...
  58. doi request reprint Renin inhibition: should it supplant ACE inhibitors and ARBS in high risk patients?
    Krishna K Gaddam
    Vascular Biology and Hypertension Program, Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Curr Opin Nephrol Hypertens 17:484-90. 2008
    ..In this review, we discuss the potential advantages and disadvantages of this newest antihypertensive class over other available RAAS antagonists...
  59. doi request reprint Have the renin-angiotensin-aldosterone system perturbations in cardiovascular disease been exhausted?
    Sulaf J Mansur
    Jefferson Clinic PC, Birmingham, AL, USA
    Curr Cardiol Rep 12:450-63. 2010
    ....
  60. pmc Rapid reversal of left ventricular hypertrophy and intracardiac volume overload in patients with resistant hypertension and hyperaldosteronism: a prospective clinical study
    Krishna Gaddam
    Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Hypertension 55:1137-42. 2010
    ..In subjects with high aldosterone, mineralocorticoid receptor blockade induces a prominent diuretic effect compared with a greater vasodilatory effect in subjects with normal aldosterone status...
  61. ncbi request reprint Estrogen treatment abrogates neointima formation in human C-reactive protein transgenic mice
    Dajun Wang
    Division of Cardiovascular Disease, University of Alabama, Birmingham, Alabama 35294 0006, USA
    Arterioscler Thromb Vasc Biol 25:2094-9. 2005
    ..Herein we tested the hypothesis that E2 modulates vascular injury in the CRPtg mouse...
  62. ncbi request reprint Fibroblast growth factor mediates hypoxia-induced endothelin-- a receptor expression in lung artery smooth muscle cells
    Peng Li
    Department of Medicine, University of Alabama at Birmingham at Alabama, Birmingham, AL 35294, USA
    J Appl Physiol (1985) 95:643-51; discussion 863. 2003
    ....
  63. ncbi request reprint ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells
    Peng Li
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Appl Physiol (1985) 102:390-8. 2007
    ..Blocking nuclear translocation and subsequent binding of pSmad2 and pSmad3 to TGF-beta-Smad response elements in ECM genes may be responsible for the inhibitory effects of ANP on TGF-beta-induced expression of ECM molecules...
  64. pmc Atrial natriuretic peptide attenuates the development of pulmonary hypertension in rats adapted to chronic hypoxia
    H Jin
    Division of Cardiovascular Disease, University of Alabama, Birmingham 35294
    J Clin Invest 85:115-20. 1990
    ..The data demonstrate that chronic infusion of exogenous ANP at a dose that does not affect MPAP or RV weight in air-control rats attenuates the development of pulmonary hypertension and RV enlargement in rats adapted to chronic hypoxia...
  65. ncbi request reprint Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function
    B Tian
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Hypertension 30:128-33. 1997
    ....
  66. ncbi request reprint Tyrosine kinase receptor activation inhibits NPR-C in lung arterial smooth muscle cells
    J Z Sun
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Physiol Lung Cell Mol Physiol 281:L155-63. 2001
    ..These results suggest that FGF-1, FGF-2, and PDGF-BB play a role in the signal transduction pathway linking hypoxia to altered NPR-C expression in lung...
  67. ncbi request reprint Differential ANG II generation in plasma and tissue of mice with decreased expression of the ACE gene
    Chih Chang Wei
    Birmingham Veteran Affairs Medical Center and Division of Cardiovascular Disease, Department of Medicine, Vascular Biology and Hypertension Program, University of Alabama, Birmingham, Alabama 35294, USA
    Am J Physiol Heart Circ Physiol 282:H2254-8. 2002
    ..These data suggest that ACE is essential to ANG II formation in the vascular space, whereas chymase may provide an important mechanism in maintaining steady-state ANG II levels in tissue...
  68. ncbi request reprint Pressure-independent enhancement of cardiac hypertrophy in atrial natriuretic peptide-deficient mice
    Ji An Feng
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Clin Exp Pharmacol Physiol 30:343-9. 2003
    ..5. These findings indicate that ANP deletion results in cardiomyocyte hypertrophy and biventricular hypertrophy independent of blood pressure, supporting the concept that ANP has direct antihypertrophic effects in the heart...
  69. doi request reprint ASH Position Paper: Dietary approaches to lower blood pressure
    Lawrence J Appel
    Department of Medicine, Division of General Internal Medicine, Johns Hopkins University, Baltimore, MD 21205 2223, USA
    J Clin Hypertens (Greenwich) 11:358-68. 2009
    ..The current challenge is designing and implementing effective clinical and public health interventions that lead to sustained dietary changes among individuals and more broadly in the general population...
  70. ncbi request reprint Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells
    Peng Li
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Appl Physiol (1985) 97:1550-8; discussion 1549. 2004
    ..These differences in signaling suggest that PN and OPN may play different roles in pulmonary vascular remodeling under pathophysiological conditions...
  71. ncbi request reprint Estrogen attenuates integrin-beta(3)-dependent adventitial fibroblast migration after inhibition of osteopontin production in vascular smooth muscle cells
    G Li
    Departments of Medicine, Vascular Biology and Hypertension Program, and Surgery, Division of Transplantation, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Circulation 101:2949-55. 2000
    ..In addition, the relative functional roles of beta(1)- and beta(3)-integrin-matrix interactions were examined...
  72. ncbi request reprint What do international guidelines say about therapy?
    R B Thakkar
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham School of Medicine, 35294, USA
    J Hypertens Suppl 19:S23-31. 2001
    ....
  73. ncbi request reprint Cardiovascular effects of estrogen
    T Tolbert
    The University of Alabama at Birmingham, Department of Medicine, 35294 0007, USA
    Am J Hypertens 14:186S-193S. 2001
    ..The relevant observational and prospective data on HRT in cardiovascular disease prevention are reviewed, and the cardiovascular effects of estrogen are discussed...
  74. doi request reprint The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: findings from NHANES III, 1988 to 1994
    Paul Muntner
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hypertension 57:160-6. 2011
    ..In this population-based study of US adults, higher levels of short-term visit-to-visit variability in systolic blood pressure were associated with increased all-cause mortality...
  75. ncbi request reprint Aldosterone excess and resistance to 24-h blood pressure control
    Eduardo Pimenta
    Vascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Hypertens 25:2131-7. 2007
    ..Aldosterone excess has been reported to be a common cause of resistant hypertension. To what degree this represents true treatment resistance is unknown...
  76. pmc C-reactive protein-mediated vascular injury requires complement
    Fadi G Hage
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Ala, USA
    Arterioscler Thromb Vasc Biol 30:1189-95. 2010
    ..We now test the hypothesis that complement is required for this effect...
  77. ncbi request reprint Hypertensive therapy: Part I
    Veronica Franco
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham 35294, USA
    Circulation 109:2953-8. 2004
  78. ncbi request reprint Fibroblast growth factor receptor-1 signaling induces osteopontin expression and vascular smooth muscle cell-dependent adventitial fibroblast migration in vitro
    Guohong Li
    Department of Medicine, Division of Transplantation, University of Alabama at Birmingham, Ala, USA
    Circulation 106:854-9. 2002
    ....
  79. doi request reprint Reduction of blood pressure in patients with treatment-resistant hypertension
    Maria Czarina Acelajado
    University of Alabama at Birmingham, 35294 2041, USA
    Expert Opin Pharmacother 10:2959-71. 2009
    ..Resistant hypertension is a common clinical problem, and patients with resistant hypertension have increased cardiovascular risk. It is a subset of the hypertensive population that is little studied and poorly characterized...
  80. ncbi request reprint Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodeling
    Yiu Fai Chen
    Vascular Biology and Hypertension Program, Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, 35296, USA
    Life Sci 79:1357-65. 2006
    ....
  81. ncbi request reprint Mechanisms and treatment of resistant hypertension
    Eduardo Pimenta
    Departamento de Hipertensão Arterial e Nefrologia, Instituto Dante Pazzanese de Cardiologia, Sao Paulo, SP, Brasil
    Arq Bras Cardiol 88:683-92. 2007
  82. pmc Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Am J Physiol Lung Cell Mol Physiol 295:L86-95. 2008
    ..These data support the conclusion that TGF-beta plays an important role in hypoxia-induced pulmonary vascular adaptation and IAD in the newborn animal model...
  83. ncbi request reprint Mechanisms and treatment of resistant hypertension
    Eduardo Pimenta
    Vascular Biology and Hypertension Program, University of Alabama at Birmingham, 933 19th Street South, Birmingham, AL 35294, USA
    J Clin Hypertens (Greenwich) 10:239-44. 2008
    ..Recent studies indicate that the addition of spironolactone to standard treatment induces significant BP reduction in most patients with resistant hypertension...
  84. ncbi request reprint Atrial natriuretic peptide dose-dependently inhibits pressure overload-induced cardiac remodeling
    Veronica Franco
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, ZRB 1024, 703 19th St S, Birmingham, AL 35294, USA
    Hypertension 44:746-50. 2004
    ....
  85. ncbi request reprint Relation of dietary salt and aldosterone to urinary protein excretion in subjects with resistant hypertension
    Eduardo Pimenta
    Vascular Biology and Hypertension Program, University of Alabama at Birmingham, AL, USA
    Hypertension 51:339-44. 2008
    ..003) was observed in subjects with high Ualdo but not in subjects with normal Ualdo (r=0.18; P value not significant). These results suggest that aldosterone excess and high dietary salt combine to increase urinary protein excretion...
  86. ncbi request reprint Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteries
    Andrew P Miller
    Vascular Biology and Hypertension Program, University of Alabama at Birmingham, 1047 Zeigler Research Bldg, 703 19th St S, Birmingham, AL 35294 0007, USA
    Circulation 110:1664-9. 2004
    ....
  87. pmc Characterization of resistant hypertension: association between resistant hypertension, aldosterone, and persistent intravascular volume expansion
    Krishna K Gaddam
    Vascular Biology and Hypertension Program, University of Alabama at Birmingham, 933 19th St S, Community Health Services Bldg 115, Birmingham, AL 35294, USA
    Arch Intern Med 168:1159-64. 2008
    ..Resistant hypertension is a common clinical problem and greatly increases the risk of target organ damage...
  88. ncbi request reprint Hypertensive therapy: Part II
    Veronica Franco
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham 35294, USA
    Circulation 109:3081-8. 2004
  89. pmc Role of oxygen availability in CFTR expression and function
    Jennifer S Guimbellot
    Department of Genetics, Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Am J Respir Cell Mol Biol 39:514-21. 2008
    ..Environmental factors that induce hypoxic signaling regulate CFTR mRNA and epithelial Cl(-) transport in vitro and in vivo...
  90. ncbi request reprint Salt sensitivity, a determinant of blood pressure, cardiovascular disease and survival
    Veronica Franco
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Am Coll Nutr 25:247S-255S. 2006
    ..Increased attention to strategies that reduce salt sensitivity, i.e. improvement in diet quality and weight loss, particularly in high risk persons, is urgently needed...
  91. ncbi request reprint Drugs targeting the renin-angiotensin-aldosterone system
    Mohammad Amin Zaman
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Rev Drug Discov 1:621-36. 2002
    ....
  92. ncbi request reprint Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation
    Dongqi Xing
    Department of Medicine, University of Alabama at Birmingham, UAB Station, Birmingham, AL 35294, USA
    Am J Physiol Heart Circ Physiol 292:H2607-12. 2007
    ..E2 inhibits activated RASMC proinflammatory mediator expression and neutrophil chemotactic activity through an ER beta-dependent mechanism...
  93. ncbi request reprint Do angiotensin receptor antagonists have benefits beyond blood pressure lowering?
    Suzanne Oparil
    UAB Vascular Biology and Hypertension Program, Room 1047 ZRB, 703 South 19th Street, Birmingham, AL 35294, USA
    Curr Hypertens Rep 4:219-20. 2002
  94. doi request reprint Triple therapy with olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide in adult patients with hypertension: The TRINITY multicenter, randomized, double-blind, 12-week, parallel-group study
    Suzanne Oparil
    University of Alabama at Birmingham, 35294 0007, USA
    Clin Ther 32:1252-69. 2010
    ..Patients with hypertension may require a combination of > or =2 antihypertensive agents to achieve blood pressure (BP) control...
  95. ncbi request reprint Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null mice
    Veronica Franco
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, AL 35294, USA
    Clin Exp Pharmacol Physiol 33:773-9. 2006
    ..The mechanism whereby ANP deficiency leads to excess hypertrophy, fibrosis and early failure following TAC is increased profibrotic signals resulting from excess or unopposed MR activation, rather than increased levels of aldosterone...
  96. ncbi request reprint Estradiol and progestins differentially modulate leukocyte infiltration after vascular injury
    Dongqi Xing
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, UAB Station, Birmingham, AL 35294, USA
    Circulation 109:234-41. 2004
    ..This study tested the hypothesis that E2 inhibits the migration of inflammatory cells, particularly granulocytes, into the rat carotid arteries after acute endoluminal injury and that MPA blocks this effect...
  97. ncbi request reprint Aged rats lose vasoprotective and anti-inflammatory actions of estrogen in injured arteries
    Andrew P Miller
    Department of Medicine, University of Alabama at Birmingham 35294 0007, USA
    Menopause 14:251-60. 2007
    ..Trials of E2 in elderly postmenopausal women have not confirmed a vasoprotective effect. This study tested the hypothesis that responsiveness to E2 is lost in injured arteries of aged (12-mo-old) OVX rats...
  98. ncbi request reprint Hormone replacement therapy and inflammation: interactions in cardiovascular disease
    Andrew P Miller
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, 1047 Zeigler Research Bldg, 703 19th St South, Birmingham, AL 35294 0007, USA
    Hypertension 42:657-63. 2003
    ..Insights from fundamental mechanistic studies in animal models are needed to delineate the cellular/molecular events that determine whether these hormones protect or injure blood vessels...
  99. doi request reprint Efficacy of an olmesartan medoxomil-based treatment algorithm in patients stratified by age, race, or sex
    Suzanne Oparil
    Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Clin Hypertens (Greenwich) 12:3-13. 2010
    ....
  100. doi request reprint Hypertension in the elderly
    Maria Czarina Acelajado
    Vascular Biology and Hypertension Program of Division of Cardiovascular Disease, Department of Medicine, School of Medicine, University of Alabama at Birmingham, USA
    Clin Geriatr Med 25:391-412. 2009
    ..The concomitant intake of certain medications that counter the effects of antihypertensive drugs and the frequent occurrence of orthostatic hypotension complicate treatment in older patients and drive down blood pressure control rates...
  101. pmc Role of matrix metalloproteinase-2 in newborn mouse lungs under hypoxic conditions
    Namasivayam Ambalavanan
    Department of Pediatrics, Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Pediatr Res 63:26-32. 2008
    ..We conclude that hypoxia reduces the postnatal MMP-2 increase in the lung, which may contribute to abnormal pulmonary arterial remodeling and impaired alveolarization...

Research Grants12

  1. Estrogen Modulates Injury-Induced Inflammation
    Suzanne Oparil; Fiscal Year: 2007
    ..These fundamental mechanistic studies will enhance our understanding of the pathobiology of vascular disease, particularly as it occurs in aging women, and will provide the basis for development of novel therapeutic strategies. ..
  2. MECHANISMS OF HYPERTENSION AND CARDIOVASCULAR DISEASES
    Suzanne Oparil; Fiscal Year: 2007
    ..Ours is the only Program in Alabama that provides highly integrated, "bench to the bedside" training in cardiovascular science for M.D. and Ph.D. prepared trainees. (End of Abstract) ..
  3. ADVENTITIAL RESPONSE TO VASCULAR INJURY: ESTROGEN
    Suzanne Oparil; Fiscal Year: 2003
    ..These fundamental mechanistic studies will establish more rational strategies for therapeutic intervention in vascular diseases, including the basis for future gene therapy. ..
  4. O-GlyNAcylation: Novel Mechanism of Estrogen-Induced Vasoprotection
    Suzanne Oparil; Fiscal Year: 2010
    ....