S Oparil

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Moderate versus intensive treatment of hypertension with amlodipine/valsartan for patients uncontrolled on angiotensin receptor blocker monotherapy
    Suzanne Oparil
    Department of Medicine Cardiovascular, University of Alabama at Birmingham, Birmingham, Alabama 35294 1150, USA
    J Hypertens 29:161-70. 2011
  2. ncbi request reprint Triple therapy with olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide in adult patients with hypertension: The TRINITY multicenter, randomized, double-blind, 12-week, parallel-group study
    Suzanne Oparil
    University of Alabama at Birmingham, 35294 0007, USA
    Clin Ther 32:1252-69. 2010
  3. doi request reprint Efficacy of an olmesartan medoxomil-based treatment algorithm in patients stratified by age, race, or sex
    Suzanne Oparil
    Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Clin Hypertens (Greenwich) 12:3-13. 2010
  4. ncbi request reprint A double-blind, randomized study evaluating losartan potassium monotherapy or in combination with hydrochlorothiazide versus placebo in obese patients with hypertension
    S Oparil
    University of Alabama Birmingham, Birmingham, AL 35294 0007, USA
    Curr Med Res Opin 24:1101-14. 2008
  5. pmc Long-term efficacy of a combination of amlodipine and olmesartan medoxomil ± hydrochlorothiazide in patients with hypertension stratified by age, race and diabetes status: a substudy of the COACH trial
    S Oparil
    Division of Cardiovascular Diseases, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294 0007, USA
    J Hum Hypertens 24:831-8. 2010
  6. ncbi request reprint Estrogen-induced vasoprotection is estrogen receptor dependent: evidence from the balloon-injured rat carotid artery model
    S Bakir
    The Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, USA
    Circulation 101:2342-4. 2000
  7. ncbi request reprint Estrogen restores endothelial cell function in an experimental model of vascular injury
    C R White
    University of Alabama at Birmingham, Department of Medicine, Vascular Biology, and Hypertension Program, 35294 0007, USA
    Circulation 96:1624-30. 1997
  8. ncbi request reprint Efficacy and safety of losartan/hydrochlorothiazide in patients with severe hypertension
    S Oparil
    University of Alabama at Birmingham, Community Health Sciences, USA
    Am J Cardiol 87:721-6. 2001
  9. doi request reprint Relationships between metrics of visit-to-visit variability of blood pressure
    E B Levitan
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Hum Hypertens 27:589-93. 2013
  10. ncbi request reprint Sexually dimorphic response of the balloon-injured rat carotid artery to hormone treatment
    S Oparil
    University of Alabama at Birmingham, USA
    Circulation 95:1301-7. 1997

Detail Information

Publications50

  1. pmc Moderate versus intensive treatment of hypertension with amlodipine/valsartan for patients uncontrolled on angiotensin receptor blocker monotherapy
    Suzanne Oparil
    Department of Medicine Cardiovascular, University of Alabama at Birmingham, Birmingham, Alabama 35294 1150, USA
    J Hypertens 29:161-70. 2011
    ..We investigated whether initiating intensive treatment with combination amlodipine/valsartan was superior to moderate treatment with amlodipine/valsartan in patients previously uncontrolled on ARB monotherapy...
  2. ncbi request reprint Triple therapy with olmesartan medoxomil, amlodipine besylate, and hydrochlorothiazide in adult patients with hypertension: The TRINITY multicenter, randomized, double-blind, 12-week, parallel-group study
    Suzanne Oparil
    University of Alabama at Birmingham, 35294 0007, USA
    Clin Ther 32:1252-69. 2010
    ..Patients with hypertension may require a combination of > or =2 antihypertensive agents to achieve blood pressure (BP) control...
  3. doi request reprint Efficacy of an olmesartan medoxomil-based treatment algorithm in patients stratified by age, race, or sex
    Suzanne Oparil
    Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    J Clin Hypertens (Greenwich) 12:3-13. 2010
    ....
  4. ncbi request reprint A double-blind, randomized study evaluating losartan potassium monotherapy or in combination with hydrochlorothiazide versus placebo in obese patients with hypertension
    S Oparil
    University of Alabama Birmingham, Birmingham, AL 35294 0007, USA
    Curr Med Res Opin 24:1101-14. 2008
    ..The objective of this study was to evaluate the effects of losartan +/- hydrochlorothiazide (HCTZ) versus placebo in obese patients with systolic and diastolic hypertension...
  5. pmc Long-term efficacy of a combination of amlodipine and olmesartan medoxomil ± hydrochlorothiazide in patients with hypertension stratified by age, race and diabetes status: a substudy of the COACH trial
    S Oparil
    Division of Cardiovascular Diseases, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294 0007, USA
    J Hum Hypertens 24:831-8. 2010
    ..3% of Blacks, 67.8% of non-Blacks, 26.9% of patients with diabetes and 72.9% of patients without diabetes. The combination of AML + OM ± HCTZ was efficacious, safe and well tolerated by these subgroups...
  6. ncbi request reprint Estrogen-induced vasoprotection is estrogen receptor dependent: evidence from the balloon-injured rat carotid artery model
    S Bakir
    The Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, USA
    Circulation 101:2342-4. 2000
    ..This study used ICI 182,780, a nonselective ER antagonist, to test the hypothesis that the vasoprotective effect of E2 in the rat carotid injury model is ER mediated...
  7. ncbi request reprint Estrogen restores endothelial cell function in an experimental model of vascular injury
    C R White
    University of Alabama at Birmingham, Department of Medicine, Vascular Biology, and Hypertension Program, 35294 0007, USA
    Circulation 96:1624-30. 1997
    ..The goal of the present study was to determine whether estrogen restores endothelial cell function in balloon-injured rat carotid arteries...
  8. ncbi request reprint Efficacy and safety of losartan/hydrochlorothiazide in patients with severe hypertension
    S Oparil
    University of Alabama at Birmingham, Community Health Sciences, USA
    Am J Cardiol 87:721-6. 2001
    ..In conclusion, losartan/ HCTZ, alone or as part of a regimen with other standard antihypertensive agents, is effective and well tolerated in the treatment of patients with severe hypertension...
  9. doi request reprint Relationships between metrics of visit-to-visit variability of blood pressure
    E B Levitan
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Hum Hypertens 27:589-93. 2013
    ..d., SDIM, CV), one of the metrics of variability between consecutive visits (SV, ARV), and one or more of the metrics of extreme values at a single visit (maximum, peak size, trough size)...
  10. ncbi request reprint Sexually dimorphic response of the balloon-injured rat carotid artery to hormone treatment
    S Oparil
    University of Alabama at Birmingham, USA
    Circulation 95:1301-7. 1997
    ....
  11. ncbi request reprint Comparative efficacy of olmesartan, losartan, valsartan, and irbesartan in the control of essential hypertension
    S Oparil
    Division of Cardiovascular Disease, University of Alabama, Birmingham, AL 35294, USA
    J Clin Hypertens (Greenwich) 3:283-91, 318. 2001
    ..3 mm Hg). All drugs were well tolerated. The authors conclude that olmesartan, at its starting dose, is more effective than the starting doses of the other ARBs tested in reducing cuff DBP in patients with essential hypertension...
  12. ncbi request reprint Mibefradil, a T-channel-selective calcium antagonist: clinical trials in hypertension
    S Oparil
    University of Alabama at Birmingham, 35294, USA
    Am J Hypertens 11:88S-94S. 1998
    ..Overall, mibefradil was better tolerated than the comparison drugs. Mibefradil, at the recommended doses of 50 to 100 mg/day, is safe and effective for the treatment of mild-to-moderate hypertension...
  13. ncbi request reprint Estrogen-induced vasoprotection is independent of inducible nitric oxide synthase expression: evidence from the mouse carotid artery ligation model
    T Tolbert
    Departments of Medicine, Division of Cardiovascular Diseases, Division of Transplantation, University of Alabama at Birmingham, USA
    Circulation 104:2740-5. 2001
    ..This study tested the hypothesis that E(2) reduces neointima formation after vascular injury via a mechanism that is dependent on modulation of iNOS expression...
  14. ncbi request reprint Treating multiple-risk hypertensive populations
    S Oparil
    Vascular Biology and Hypertension Program, University of Alabama Birmingham, 35294, USA
    Am J Hypertens 12:121S-129S. 1999
    ....
  15. pmc Spironolactone reduces severity of obstructive sleep apnoea in patients with resistant hypertension: a preliminary report
    K Gaddam
    Division of Cardiovascular Diseases, Ochsner Clinic Foundation, New Orleans, LA, USA
    J Hum Hypertens 24:532-7. 2010
    ..If confirmed in a randomized assessment, it will support aldosterone-mediated chronic fluid retention as an important mediator of OSA severity in patients with resistant hypertension...
  16. ncbi request reprint Newly emerging pharmacologic differences in angiotensin II receptor blockers
    S Oparil
    University of Alabama at Birmingham, USA
    Am J Hypertens 13:18S-24S. 2000
    ....
  17. ncbi request reprint Arthur C. Corcoran Memorial Lecture. Hormones and vasoprotection
    S Oparil
    Department of Medicine, University of Alabama at Birmingham, Vascular Biology and Hypertension Program, USA
    Hypertension 33:170-6. 1999
    ..These fundamental studies will establish more rational strategies for therapeutic intervention in vascular diseases, including the basis for future gene therapy...
  18. ncbi request reprint Dose-response characteristics of mibefradil, a novel calcium antagonist, in the treatment of essential hypertension
    S Oparil
    University of Alabama at Birmingham, 35294, USA
    Am J Hypertens 10:735-42. 1997
    ..The appropriate therapeutic dose range of mibefradil in the management of mild-to-moderate essential hypertension is 50 to 100 mg...
  19. ncbi request reprint Efficacy of perindopril in the treatment of systemic hypertension
    S Oparil
    Vascular Biology and Hypertension Program of the Division of Cardiovascular Disease, University of Alabama School of Medicine, Birmingham, Alabama 35294, USA
    Am J Cardiol 88:3i-12i. 2001
    ..Both of these effects are at least partly independent of its ability to lower BP. Perindopril is safe and well tolerated in patients with hypertension. Rates of adverse events and discontinuation because of such events are low...
  20. ncbi request reprint Genetic variation in angiotensin-converting enzyme does not prevent development of cardiac hypertrophy or upregulation of angiotensin II in response to aortocaval fistula
    G J Perry
    Birmingham VA Medical Center, University of Alabama at Birmingham, USA
    Circulation 103:1012-6. 2001
    ..We investigated the effect of genetic variation in angiotensin-converting enzyme (ACE) on the development of cardiac hypertrophy and left ventricular (LV) dysfunction in response to volume overload...
  21. ncbi request reprint Estrogen depletion induces NaCl-sensitive hypertension in female spontaneously hypertensive rats
    Z Fang
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1934-9. 2001
    ..Furthermore, these results demonstrate that dietary phytoestrogens can have a major impact on the interpretation of studies into the physiological role of estrogen in females...
  22. ncbi request reprint Estrogen attenuates the adventitial contribution to neointima formation in injured rat carotid arteries
    S Oparil
    Cardiovasc Res 44:608-14. 1999
    ....
  23. ncbi request reprint Dietary salt reduction in hypertension--what is the evidence and why is it still controversial?
    G S Chrysant
    University of Alabama at Birmingham, Department of Medicine, Vascular Biology and Hypertension Program, 35294 0012, USA
    Prog Cardiovasc Dis 42:23-38. 1999
    ..This paper will review the definition and methods used in determining salt sensitivity, the evidence linking sodium intake and target organ damage, and modern studies of salt and blood pressure...
  24. ncbi request reprint Fenoldopam: a new parenteral antihypertensive: consensus roundtable on the management of perioperative hypertension and hypertensive crises
    S Oparil
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Am J Hypertens 12:653-64. 1999
    ..It was concluded that fenoldopam offers significant advantages as a parenterally administered agent for the management of blood pressure in both hypertensive emergencies and in the perioperative setting...
  25. ncbi request reprint Managing the patient with hard-to-control hypertension
    S Oparil
    Division of Cardiovascular Disease, University of Alabama School of Medicine, Birmingham, USA
    Am Fam Physician 57:1007-14, 1019-20. 1998
    ..In many patients, these factors must be dealt with before blood pressure can be controlled...
  26. ncbi request reprint Comparative antihypertensive efficacy of olmesartan: comparison with other angiotensin II receptor antagonists
    S Oparil
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Dept of Medicine, University of Alabama at Birmingham, 1034 Zeigler Research Building, Birmingham, AL 35294, USA
    J Hum Hypertens 16:S17-23. 2002
    ..Preliminary evidence suggests that olmesartan, an A II receptor blocker currently being evaluated for approval for clinical use, may provide antihypertensive efficacy that is superior to other members of the class...
  27. ncbi request reprint [Calcium antagonists in cardiovascular disease. Clinical evidence from morbidity and mortality trials]
    S Oparil
    Université d Alabama, Departement de Medecine, Biologie Vasculaire et Hypertension, Birmingham, USA
    Drugs 59:25-37. 2000
    ..To date, these trials in progress have provided no evidence to support these concerns...
  28. ncbi request reprint Cardiovascular effects of estrogen
    T Tolbert
    The University of Alabama at Birmingham, Department of Medicine, 35294 0007, USA
    Am J Hypertens 14:186S-193S. 2001
    ..The relevant observational and prospective data on HRT in cardiovascular disease prevention are reviewed, and the cardiovascular effects of estrogen are discussed...
  29. ncbi request reprint Nontraditional cardiovascular risk factors
    S Oparil
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Am J Med Sci 317:193-207. 1999
    ..The strength of the associations of the newer risk factors with cardiovascular therapy are currently being tested. This review will briefly discuss evidence that these risk factors are related to cardiovascular disease...
  30. ncbi request reprint Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function
    B Tian
    Department of Medicine, University of Alabama at Birmingham, 35294 0007, USA
    Hypertension 30:128-33. 1997
    ....
  31. ncbi request reprint The neointimal response to endovascular injury is increased in obese Zucker rats
    J Shelton
    Departments of Medicine, Vascular Biology and Hypertension Program of the Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Diabetes Obes Metab 5:415-23. 2003
    ..Restenosis after revascularization procedures is accelerated in persons with type 2 diabetes...
  32. ncbi request reprint Tyrosine kinase receptor activation inhibits NPR-C in lung arterial smooth muscle cells
    J Z Sun
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Physiol Lung Cell Mol Physiol 281:L155-63. 2001
    ..These results suggest that FGF-1, FGF-2, and PDGF-BB play a role in the signal transduction pathway linking hypoxia to altered NPR-C expression in lung...
  33. ncbi request reprint Management of the hypertensive patient with coronary artery disease
    S Oparil
    University of Alabama at Birmingham, 35294, USA
    Am J Hypertens 12:56S-62S. 1999
    ..Choosing a long-acting agent that achieves high plasma drug levels during critical hours may reduce the risk for cardiovascular morbidity and mortality...
  34. ncbi request reprint Alcohol consumption and cardiovascular risk in hypertensives with left ventricular hypertrophy: the LIFE study
    H M Reims
    Department of Cardiology, Ullevaal University Hospital, Oslo, Norway
    J Hum Hypertens 18:381-9. 2004
    ..Alcohol reduces the risk of myocardial infarction, while the risk of stroke tends to increase with high intake...
  35. ncbi request reprint Rationale and design for the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). ALLHAT Research Group
    B R Davis
    University of Texas School of Public Health, Houston, USA
    Am J Hypertens 9:342-60. 1996
    ..The mean duration of treatment and follow-up is planned to be 6 years. Further features of the rationale, design, objectives, treatment program, and study organization of ALLHAT are described in this article...
  36. doi request reprint Telmisartan, ramipril, or both in patients at high risk for vascular events
    Salim Yusuf
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
    N Engl J Med 358:1547-59. 2008
    ..We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes...
  37. ncbi request reprint Blood pressure and metabolic responses to moderate sodium restriction in isradipine-treated hypertensive patients
    D A McCarron
    Oregon Health Sciences University, Portland 97201, USA
    Am J Hypertens 10:68-76. 1997
    ..The antihypertensive action of isradipine was not enhanced by dietary sodium chloride restriction, and the lipoprotein profile was least favorable with sodium chloride restriction...
  38. ncbi request reprint The effect of antihypertensive drugs on the fetus
    T Rosenthal
    Chorley Hypertension Research Institute, Chaim Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Israel
    J Hum Hypertens 16:293-8. 2002
    ....
  39. ncbi request reprint The Losartan Intervention For Endpoint reduction (LIFE) in Hypertension study: rationale, design, and methods. The LIFE Study Group
    B Dahlof
    Ostra University Hospital, Goteborg, Sweden
    Am J Hypertens 10:705-13. 1997
    ..On April 30, 1997, when inclusion was stopped, 9,218 patients had been randomized...
  40. ncbi request reprint Comprehensive nutrition plan improves cardiovascular risk factors in essential hypertension
    D A McCarron
    Department of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Am J Hypertens 11:31-40. 1998
    ..Compared with typical dietary therapy, the comprehensive CCNW meal plan has significantly greater effects on multiple cardiovascular risk factors while yielding greater compliance and improved quality of life...
  41. ncbi request reprint Once-daily treatment of patients with hypertension: a placebo-controlled study of amlodipine and benazepril vs amlodipine or benazepril alone
    J Pool
    The Methodist Hospital, Houston, TX, USA
    J Hum Hypertens 15:495-8. 2001
    ..CONCLUSIONS: Therapy with amlodipine 5 mg/benazepril 10 mg was well tolerated and was superior to amlodipine 5 mg, benazepril 10 mg, and placebo in reducing sitting diastolic blood pressure in patients with essential hypertension...
  42. ncbi request reprint Lowering of blood pressure and predictors of response in patients with left ventricular hypertrophy: the LIFE study. Losartan Intervention For Endpoint
    S E Kjeldsen
    Ullevaal University Hospital, Oslo, Norway
    Am J Hypertens 13:899-906. 2000
    ..It has been possible to keep most of these patients with complicated hypertension taking blinded study drug for 12 months...
  43. ncbi request reprint A comparison of the angiotensin II antagonists valsartan and losartan in the treatment of essential hypertension
    T Hedner
    Klinfarm Sahlgrenska Sjukhuset, , Sweden
    Am J Hypertens 12:414-7. 1999
    ..Valsartan (80/160 mg) monotherapy in this trial was as effective and well tolerated as 50/100 mg losartan in treating mild to moderate essential hypertension, and at 160 mg has a significantly higher responder rate than 100 mg losartan...
  44. ncbi request reprint Isolation of two distinct type I angiotensin II receptor genes
    T S Elton
    Department of Medicine, University of Alabama, Birmingham 35294
    Biochem Biophys Res Commun 184:1067-73. 1992
    ..The first of these genes corresponds to the published rat vascular complementary DNA sequence; the second, corresponds to a novel receptor not previously described...
  45. ncbi request reprint Altered stores of atrial natriuretic peptide in specific brain nuclei of NaCl-sensitive spontaneously hypertensive rats
    H K Jin
    Department of Medicine, University of Alabama, Birmingham 35294
    Am J Hypertens 4:449-55. 1991
    ..These alterations in ANP content in SHR-S may be related to the reduced release of norepinephrine from nerve terminals in AHA and to the presumed central defect in baroreceptor function...
  46. ncbi request reprint Dietary Ca2+ prevents NaCl-sensitive hypertension in spontaneously hypertensive rats by a sympatholytic mechanism
    S Oparil
    Department of Medicine, University of Alabama, Birmingham 35294
    Am J Hypertens 3:179S-188S. 1990
    ....
  47. ncbi request reprint Central mechanisms of hypertension
    S Oparil
    Department of Medicine, University of Alabama, Birmingham 35294
    Am J Hypertens 2:477-85. 1989
    ..These findings are consistent with the hypothesis that decreased noradrenergic activity of sympathoinhibitory neurons in the AHA may mediate the exacerbation in hypertension that occurs in SHR-S during dietary NaCl supplementation...
  48. ncbi request reprint Factors affecting blood pressure responses to diet: the Vanguard study
    L M Resnick
    Hypertension Center, New York-Presbyterian Hospital/Cornell University Medical Center, New York 10021, USA
    Am J Hypertens 13:956-65. 2000
    ....
  49. ncbi request reprint Effects of acute and chronic blockade of neutral endopeptidase with Sch 34826 on NaCl-sensitive hypertension in spontaneously hypertensive rats
    H Jin
    Department of Medicine, University of Alabama, Birmingham
    Am J Hypertens 5:210-8. 1992
    ..This effect was associated with increased urine volume and urinary sodium, ANP, and cyclic GMP in 8% NaCl fed SHR-S.(ABSTRACT TRUNCATED AT 250 WORDS)..
  50. doi request reprint Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial
    S Yusuf
    Lancet 372:1174-83. 2008
    ..We therefore assessed whether the angiotensin-receptor blocker telmisartan would be effective in patients intolerant to ACE inhibitors with cardiovascular disease or diabetes with end-organ damage...