Isaac G Onyango

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Activation of p38 and N-acetylcysteine-sensitive c-Jun NH2-terminal kinase signaling cascades is required for induction of apoptosis in Parkinson's disease cybrids
    Isaac G Onyango
    Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Cell Neurosci 28:452-61. 2005
  2. ncbi request reprint Mitochondrial dysfunction and oxidative stress in Parkinson's disease
    Isaac G Onyango
    Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, VA, USA
    Neurochem Res 33:589-97. 2008
  3. ncbi request reprint Endogenous oxidative stress in sporadic Alzheimer's disease neuronal cybrids reduces viability by increasing apoptosis through pro-death signaling pathways and is mimicked by oxidant exposure of control cybrids
    Isaac G Onyango
    Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Neurobiol Dis 19:312-22. 2005
  4. ncbi request reprint Altered intracellular signaling and reduced viability of Alzheimer's disease neuronal cybrids is reproduced by beta-amyloid peptide acting through receptor for advanced glycation end products (RAGE)
    Isaac G Onyango
    Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cell Neurosci 29:333-43. 2005
  5. ncbi request reprint Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H2O2-induced neuronal death
    Isaac G Onyango
    Department of Neuroscience, University of Virginia School of Medicine, PO Box 801392, Charlottesville, VA 22908, USA
    Neurobiol Dis 20:141-54. 2005
  6. ncbi request reprint Oxidative stress, mitochondrial dysfunction, and stress signaling in Alzheimer's disease
    Isaac G Onyango
    Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA
    Curr Alzheimer Res 3:339-49. 2006

Detail Information

Publications6

  1. ncbi request reprint Activation of p38 and N-acetylcysteine-sensitive c-Jun NH2-terminal kinase signaling cascades is required for induction of apoptosis in Parkinson's disease cybrids
    Isaac G Onyango
    Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Cell Neurosci 28:452-61. 2005
    ..PD mitochondrial genes expressed in cybrids stimulate pro-apoptotic cell signaling and biochemistry through oxidative stress. These results support development of antioxidative therapeutics for PD...
  2. ncbi request reprint Mitochondrial dysfunction and oxidative stress in Parkinson's disease
    Isaac G Onyango
    Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, VA, USA
    Neurochem Res 33:589-97. 2008
    ..We review recent advances and current understanding of the genetic factors, molecular mechanisms and animal models of PD...
  3. ncbi request reprint Endogenous oxidative stress in sporadic Alzheimer's disease neuronal cybrids reduces viability by increasing apoptosis through pro-death signaling pathways and is mimicked by oxidant exposure of control cybrids
    Isaac G Onyango
    Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Neurobiol Dis 19:312-22. 2005
    ..Exposure of CTL cybrids to H2O2 decreased viability and activated in a NAC-sensitive manner, the same intracellular signaling pathways active under basal conditions in SAD cybrids...
  4. ncbi request reprint Altered intracellular signaling and reduced viability of Alzheimer's disease neuronal cybrids is reproduced by beta-amyloid peptide acting through receptor for advanced glycation end products (RAGE)
    Isaac G Onyango
    Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cell Neurosci 29:333-43. 2005
    ..This SAD phenotype is produced by endogenously generated Abeta and can be replicated by exogenous Abeta acting through RAGE...
  5. ncbi request reprint Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H2O2-induced neuronal death
    Isaac G Onyango
    Department of Neuroscience, University of Virginia School of Medicine, PO Box 801392, Charlottesville, VA 22908, USA
    Neurobiol Dis 20:141-54. 2005
    ....
  6. ncbi request reprint Oxidative stress, mitochondrial dysfunction, and stress signaling in Alzheimer's disease
    Isaac G Onyango
    Center for the Study of Neurodegenerative Diseases, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA
    Curr Alzheimer Res 3:339-49. 2006
    ....