JOSEPH O'NEILL

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc One-year follow-up of family versus child CBT for anxiety disorders: Exploring the roles of child age and parental intrusiveness
    Jeffrey J Wood
    UCLA, Los Angeles, CA, USA
    Child Psychiatry Hum Dev 40:301-16. 2009
  2. ncbi request reprint Thalamic glutamate decreases with cigarette smoking
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience, 760 Westwood Plaza, Box 175919, Los Angeles, CA, 90024 1759, USA
    Psychopharmacology (Berl) 231:2717-24. 2014
  3. pmc White-matter abnormalities in brain during early abstinence from methamphetamine abuse
    Marc C Tobias
    Semel Institute for Neuroscience and Biobehavioral Studies, University of California Los Angeles, Los Angeles, CA, USA
    Psychopharmacology (Berl) 209:13-24. 2010
  4. pmc Elevated glutamatergic compounds in pregenual anterior cingulate in pediatric autism spectrum disorder demonstrated by 1H MRS and 1H MRSI
    Anthony Bejjani
    Ahmanson Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 7:e38786. 2012
  5. pmc Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorder
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neurosciences, Los Angeles, CA 90024, USA
    J Psychiatr Res 47:494-504. 2013
  6. doi request reprint MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, Semel Institute for Neurosciences, Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, CA 90024 1759, United States
    Prog Neuropsychopharmacol Biol Psychiatry 36:161-8. 2012
  7. ncbi request reprint 1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Neuroimage 21:1781-9. 2004
  8. ncbi request reprint Reduction in distractibility with AF102B and THA in the macaque
    JOSEPH O'NEILL
    University of California Los Angeles Neuropsychiatric Institute 47 417A, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Pharmacol Biochem Behav 76:301-6. 2003
  9. ncbi request reprint Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease
    JOSEPH O'NEILL
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, California, USA
    Mov Disord 17:917-27. 2002
  10. doi request reprint 1H MRSI and social communication deficits in pediatric complex partial seizures
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neurosciences, Los Angeles, California 90024 1759, USA
    Epilepsia 52:1705-14. 2011

Collaborators

Detail Information

Publications31

  1. pmc One-year follow-up of family versus child CBT for anxiety disorders: Exploring the roles of child age and parental intrusiveness
    Jeffrey J Wood
    UCLA, Los Angeles, CA, USA
    Child Psychiatry Hum Dev 40:301-16. 2009
    ..To compare the relative long-term benefit of family-focused cognitive behavioral therapy (FCBT) and child-focused cognitive behavioral therapy (CCBT) for child anxiety disorders at a 1-year follow-up...
  2. ncbi request reprint Thalamic glutamate decreases with cigarette smoking
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience, 760 Westwood Plaza, Box 175919, Los Angeles, CA, 90024 1759, USA
    Psychopharmacology (Berl) 231:2717-24. 2014
    ..As Glu release is mediated by nicotinic acetylcholine receptors (nAChRs), which are present at high concentrations in the thalamus, we examined the effects of smoking on thalamic Glu...
  3. pmc White-matter abnormalities in brain during early abstinence from methamphetamine abuse
    Marc C Tobias
    Semel Institute for Neuroscience and Biobehavioral Studies, University of California Los Angeles, Los Angeles, CA, USA
    Psychopharmacology (Berl) 209:13-24. 2010
    ..As certain metabolic changes in the brain first manifest after early abstinence from methamphetamine, it is also possible that microstructural white-matter abnormalities are not yet present during early abstinence...
  4. pmc Elevated glutamatergic compounds in pregenual anterior cingulate in pediatric autism spectrum disorder demonstrated by 1H MRS and 1H MRSI
    Anthony Bejjani
    Ahmanson Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 7:e38786. 2012
    ..The hyperglutamatergic state may reflect an imbalance of excitation over inhibition in the brain as proposed in recent neurodevelopmental models of ASD...
  5. pmc Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorder
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neurosciences, Los Angeles, CA 90024, USA
    J Psychiatr Res 47:494-504. 2013
    ..Comorbid depressive symptoms in OCD patients may have contributed to metabolite effects, although baseline and post-CBT change in depression ratings varied with choline-compounds and myo-inositol rather than Glx or tNAA...
  6. doi request reprint MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, Semel Institute for Neurosciences, Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, CA 90024 1759, United States
    Prog Neuropsychopharmacol Biol Psychiatry 36:161-8. 2012
    ..We therefore probed putative metabolic effects of CBT on these brain structures in pediatric OCD using proton magnetic resonance spectroscopic imaging (1H MRSI)...
  7. ncbi request reprint 1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Neuroimage 21:1781-9. 2004
    ..Low NAA may reflect diminished neuronal integrity...
  8. ncbi request reprint Reduction in distractibility with AF102B and THA in the macaque
    JOSEPH O'NEILL
    University of California Los Angeles Neuropsychiatric Institute 47 417A, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Pharmacol Biochem Behav 76:301-6. 2003
    ..Reaction time at best dose decreased for both drugs, but not significantly. Muscarinic agonists and cholinesterase inhibitors may reduce distractibility in primates...
  9. ncbi request reprint Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease
    JOSEPH O'NEILL
    Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, California, USA
    Mov Disord 17:917-27. 2002
    ..64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects...
  10. doi request reprint 1H MRSI and social communication deficits in pediatric complex partial seizures
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neurosciences, Los Angeles, California 90024 1759, USA
    Epilepsia 52:1705-14. 2011
    ..To investigate relationships between regional brain metabolites, social communication deficits, and seizure frequency in children and adolescents with cryptogenic epilepsy with complex partial seizures (CPS)...
  11. pmc Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia
    Ronald R Seese
    Division of Child and Adolescent Psychiatry, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1759, United States
    Schizophr Res 133:82-90. 2011
    ..This study examined this association in language-related brain regions using proton magnetic resonance spectroscopic imaging ((1)H MRSI)...
  12. pmc 1H MRSI of middle frontal gyrus in pediatric ADHD
    Sharwin Tafazoli
    Ahmanson Lovelace Brain Mapping Center in the Department of Neurology, 660 Charles Young Dr So Los Angeles, CA 90095, USA
    J Psychiatr Res 47:505-12. 2013
    ..Lower Cr levels may indicate attentional or executive impairments...
  13. ncbi request reprint Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression
    Mark A Frye
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 55905, USA
    Neuropsychopharmacology 32:2490-9. 2007
    ..Lamotrigine appears to reduce glutamine levels associated with treatment remission. Further study is encouraged to determine if these MR spectroscopic markers can delineate drug mechanism of action and subsequent treatment response...
  14. pmc Reduced white matter integrity in attention-deficit hyperactivity disorder
    Liberty S Hamilton
    Laboratory of Neuro Imaging, UCLA Neuropsychiatric Institute and Hospital in Los Angeles, Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Neuroreport 19:1705-8. 2008
    ..Results support that disruptions in motor and attentional networks may contribute toward ADHD pathophysiology. Future research may clarify how ADHD subtype and psychiatric comorbidities affect diffusion measures...
  15. ncbi request reprint Proton magnetic resonance spectroscopic imaging of the brain in childhood autism
    Jennifer G Levitt
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, Los Angeles, California, USA
    Biol Psychiatry 54:1355-66. 2003
    ....
  16. pmc Brain growth rate abnormalities visualized in adolescents with autism
    Xue Hua
    Laboratory of Neuro Imaging, University of California Los Angeles School of Medicine, Los Angeles, California, USA
    Hum Brain Mapp 34:425-36. 2013
    ..Tensor-based morphometry revealed persisting growth rate anomalies long after diagnosis, which has implications for evaluation of therapeutic effects...
  17. pmc Gray-matter volume in methamphetamine dependence: cigarette smoking and changes with abstinence from methamphetamine
    Angelica M Morales
    Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90024, USA
    Drug Alcohol Depend 125:230-8. 2012
    ..This study, therefore, attempted to account for effects of smoking and brief abstinence from methamphetamine on gray-matter measures in methamphetamine-dependent research participants...
  18. pmc Cigarette smoking and white matter microstructure
    Matthew Hudkins
    Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neurosciences and Biobehavioral Studies, 760 Westwood Plaza 58 227A, Los Angeles, CA 90024 1759, USA
    Psychopharmacology (Berl) 221:285-95. 2012
    ..Adolescent smokers exhibited elevated FA at several brain regions and a positive correlation of FA in the genu corpus callosum with exposure to smoking (pack-years)...
  19. pmc Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBI
    Talin Babikian
    Semel Institute for Neuroscience and Human Behavior Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, Room C8 746, Los Angeles, CA 90095, USA
    J Neurotrauma 27:473-81. 2010
    ..This will help guide the future development of targeted therapeutic agents...
  20. pmc White matter integrity, language, and childhood onset schizophrenia
    Kristi Clark
    Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Schizophr Res 138:150-6. 2012
    ..Childhood-onset schizophrenia (COS) is a particularly severe form of schizophrenia, with an onset during a key time period for both cerebral pruning and myelination...
  21. pmc Diminished gray matter within the hypothalamus in autism disorder: a potential link to hormonal effects?
    Florian Kurth
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine, University of California at Los Angeles, 760 Westwood Plaza 47 417, Los Angeles, CA 90024 1759, USA
    Biol Psychiatry 70:278-82. 2011
    ..These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, and gender might pose potential confounds in autism neuroimaging analyses...
  22. ncbi request reprint Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations
    John M Ringman
    UCLA Department of Neurology, Alzheimer s Disease Research Center, 10911 Weyburn Ave, Suite 200, Los Angeles, CA 90095 7226, USA
    Brain 130:1767-76. 2007
    ..Decreased FA in of the columns of the fornix is particularly robust in early FAD and may provide a biomarker for early disease in sporadic Alzheimer's disease...
  23. pmc White matter microstructure in subjects with attention-deficit/hyperactivity disorder and their siblings
    Katherine E Lawrence
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, USA
    J Am Acad Child Adolesc Psychiatry 52:431-440.e4. 2013
    ..However, findings remain mixed, and few studies have examined the contribution of ADHD familial liability to white matter microstructure...
  24. pmc Abuse of amphetamines and structural abnormalities in the brain
    Steven Berman
    Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
    Ann N Y Acad Sci 1141:195-220. 2008
    ..Longitudinal designs in which multimodal datasets are acquired and are subjected to multivariate analyses would enhance our ability to provide general conclusions regarding the associations between amphetamine abuse and brain structure...
  25. ncbi request reprint Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: a study using 3-Tesla proton magnetic resonance spectroscopy
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Psychiatry Res 154:259-65. 2007
    ..Limitations of this study include small sample size and lack of tissue segmentation. Further study is encouraged to clarify state vs. trait aspects of NAA in bipolar disorder...
  26. ncbi request reprint Impairment in childhood anxiety disorders: preliminary examination of the child anxiety impact scale-parent version
    Audra K Langley
    Division of Child and Adolescent Psychiatry, UCLA School of Medicine, Los Angeles, California, USA
    J Child Adolesc Psychopharmacol 14:105-14. 2004
    ..The results provide initial support that the CAIS-P is a reliable and valid measure for the assessment of the impact of anxiety on child and adolescent functioning...
  27. ncbi request reprint Family cognitive behavioral therapy for child anxiety disorders
    Jeffrey J Wood
    Department of Education, University of California, Los Angeles 90095, USA
    J Am Acad Child Adolesc Psychiatry 45:314-21. 2006
    ..This study compared family-focused cognitive behavioral therapy (CBT; the Building Confidence Program) with traditional child-focused CBT with minimal family involvement for children with anxiety disorders...
  28. pmc Cluster analysis of the Yale Global Tic Severity Scale (YGTSS): symptom dimensions and clinical correlates in an outpatient youth sample
    Katharina Kircanski
    Department of Psychology, University of California Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
    J Abnorm Child Psychol 38:777-88. 2010
    ..Findings lend support to prior research on tic phenomenology, help to organize treatment goals, and suggest symptom dimensions of tic disorders for further evaluation...
  29. ncbi request reprint Neurocognitive correlates of child obsessive compulsive disorder and Tourette syndrome
    SUSANNA W CHANG
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    J Clin Exp Neuropsychol 29:724-33. 2007
    ..TS findings were less robust and may be construed tentatively as suggestive of executive function deficits. Future research is needed to delineate the influence of development on neurocognitive deficits associated with OCD and TS...
  30. ncbi request reprint Concurrent validity of the anxiety disorders section of the Anxiety Disorders Interview Schedule for DSM-IV: child and parent versions
    Jeffrey J Wood
    Psychology Clinic, 2191 Franz Hall, Department of Psychology, University of California, Los Angeles, CA 90095, USA
    J Clin Child Adolesc Psychol 31:335-42. 2002
    ..These results provide support for the concurrent validity of the anxiety disorders section of the ADIS-C/P...
  31. ncbi request reprint Behavioral treatments for tic suppression: habit reversal training
    John C Piacentini
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles Los Angeles, California, USA
    Adv Neurol 99:227-33. 2006

Research Grants7

  1. 1H MRSI/Response Inhibition/Methamphetamine Abusers
    JOSEPH O NEILL; Fiscal Year: 2005
    ..This project will examine the chemistry of parts of the brain thought to be responsible for inhibition and/or damaged by methamphetamine in methamphetamine addicts. ..
  2. Magnetic Resonance Spectroscopic Imaging of the Brain in Methamphetamine Abuse
    JOSEPH O NEILL; Fiscal Year: 2007
    ..This proposal aims for a better understanding of the state of the brain during very early abstinence from methamphetamine in order to develop novel therapies and improve the success of existing therapies. ..
  3. Cognitive-Behavioral Therapy & Glutametergic Neurometabolites in Pediatric OCD
    JOSEPH O NEILL; Fiscal Year: 2009
    ..This proposal aims for a better understanding of the brain mechanisms of cognitive-behavioral therapy (CBT) in order to develop novel therapies and improve the success of existing therapies. ..
  4. Cognitive-Behavioral Therapy & Glutametergic Neurometabolites in Pediatric OCD
    John C Piacentini; Fiscal Year: 2010
    ..This proposal aims for a better understanding of the brain mechanisms of cognitive-behavioral therapy (CBT) in order to develop novel therapies and improve the success of existing therapies. ..
  5. Cognitive-Behavioral Therapy & Glutametergic Neurometabolites in Pediatric OCD
    John C Piacentini; Fiscal Year: 2010
    ..This proposal aims for a better understanding of the brain mechanisms of cognitive-behavioral therapy (CBT) in order to develop novel therapies and improve the success of existing therapies. ..