Research Topics
| JOSEPH O'NEILLSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
One-year follow-up of family versus child CBT for anxiety disorders: Exploring the roles of child age and parental intrusivenessJeffrey J Wood
UCLA, Los Angeles, CA, USA
Child Psychiatry Hum Dev 40:301-16. 2009..To compare the relative long-term benefit of family-focused cognitive behavioral therapy (FCBT) and child-focused cognitive behavioral therapy (CCBT) for child anxiety disorders at a 1-year follow-up...
Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorderJOSEPH O'NEILL
Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neurosciences, Los Angeles, CA 90024, USA Electronic address
J Psychiatr Res 47:494-504. 2013..Comorbid depressive symptoms in OCD patients may have contributed to metabolite effects, although baseline and post-CBT change in depression ratings varied with choline-compounds and myo-inositol rather than Glx or tNAA...- MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorderJOSEPH O'NEILL
Division of Child and Adolescent Psychiatry, Semel Institute for Neurosciences, Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, CA 90024 1759, United States
Prog Neuropsychopharmacol Biol Psychiatry 36:161-8. 2012..We therefore probed putative metabolic effects of CBT on these brain structures in pediatric OCD using proton magnetic resonance spectroscopic imaging (1H MRSI)... 
Reduction in distractibility with AF102B and THA in the macaqueJOSEPH O'NEILL
University of California Los Angeles Neuropsychiatric Institute 47 417A, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
Pharmacol Biochem Behav 76:301-6. 2003..Reaction time at best dose decreased for both drugs, but not significantly. Muscarinic agonists and cholinesterase inhibitors may reduce distractibility in primates...- 1H MRSI evidence of metabolic abnormalities in childhood-onset schizophreniaJOSEPH O'NEILL
Division of Child and Adolescent Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
Neuroimage 21:1781-9. 2004..Low NAA may reflect diminished neuronal integrity... - 1H MRSI and social communication deficits in pediatric complex partial seizuresJOSEPH O'NEILL
Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neurosciences, Los Angeles, California 90024 1759, USA
Epilepsia 52:1705-14. 2011..To investigate relationships between regional brain metabolites, social communication deficits, and seizure frequency in children and adolescents with cryptogenic epilepsy with complex partial seizures (CPS)... - Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's diseaseJOSEPH O'NEILL
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, California, USA
Mov Disord 17:917-27. 2002..64; P < 0.05). This relationship suggests that basal ganglia volumes may be influenced by dopaminergic innervation from the substantia nigra in normal and PD subjects... - Proton magnetic resonance spectroscopy and thought disorder in childhood schizophreniaRonald R Seese
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1759, United States
Schizophr Res 133:82-90. 2011..This study examined this association in language-related brain regions using proton magnetic resonance spectroscopic imaging ((1)H MRSI)... - Reduced white matter integrity in attention-deficit hyperactivity disorderLiberty S Hamilton
Laboratory of Neuro Imaging, UCLA Neuropsychiatric Institute and Hospital in Los Angeles, Geffen School of Medicine at UCLA, Los Angeles, California, USA
Neuroreport 19:1705-8. 2008..Results support that disruptions in motor and attentional networks may contribute toward ADHD pathophysiology. Future research may clarify how ADHD subtype and psychiatric comorbidities affect diffusion measures... - Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depressionMark A Frye
UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 55905, USA
Neuropsychopharmacology 32:2490-9. 2007..Lamotrigine appears to reduce glutamine levels associated with treatment remission. Further study is encouraged to determine if these MR spectroscopic markers can delineate drug mechanism of action and subsequent treatment response... - Gray-matter volume in methamphetamine dependence: cigarette smoking and changes with abstinence from methamphetamineAngelica M Morales
Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90024, USA
Drug Alcohol Depend 125:230-8. 2012..This study, therefore, attempted to account for effects of smoking and brief abstinence from methamphetamine on gray-matter measures in methamphetamine-dependent research participants... - Cigarette smoking and white matter microstructureMatthew Hudkins
Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neurosciences and Biobehavioral Studies, 760 Westwood Plaza 58 227A, Los Angeles, CA 90024 1759, USA
Psychopharmacology (Berl) 221:285-95. 2012..Adolescent smokers exhibited elevated FA at several brain regions and a positive correlation of FA in the genu corpus callosum with exposure to smoking (pack-years)... - Metabolic levels in the corpus callosum and their structural and behavioral correlates after moderate to severe pediatric TBITalin Babikian
Semel Institute for Neuroscience and Human Behavior Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, Room C8 746, Los Angeles, CA 90095, USA
J Neurotrauma 27:473-81. 2010..This will help guide the future development of targeted therapeutic agents... - (1)H MRSI of middle frontal gyrus in pediatric ADHDSharwin Tafazoli
Ahmanson Lovelace Brain Mapping Center in the Department of Neurology, 660 Charles Young Dr So Los Angeles, CA 90095, USA
J Psychiatr Res 47:505-12. 2013..Lower Cr levels may indicate attentional or executive impairments... - White matter integrity, language, and childhood onset schizophreniaKristi Clark
Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
Schizophr Res 138:150-6. 2012..Childhood-onset schizophrenia (COS) is a particularly severe form of schizophrenia, with an onset during a key time period for both cerebral pruning and myelination... - Diminished gray matter within the hypothalamus in autism disorder: a potential link to hormonal effects?Florian Kurth
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine, University of California at Los Angeles, 760 Westwood Plaza 47 417, Los Angeles, CA 90024 1759, USA
Biol Psychiatry 70:278-82. 2011..These characteristics are found irrespective of age, IQ, and gender of affected subjects. However, brain changes due to age, IQ, and gender might pose potential confounds in autism neuroimaging analyses... - Abuse of amphetamines and structural abnormalities in the brainSteven Berman
Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
Ann N Y Acad Sci 1141:195-220. 2008..Longitudinal designs in which multimodal datasets are acquired and are subjected to multivariate analyses would enhance our ability to provide general conclusions regarding the associations between amphetamine abuse and brain structure... - Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: a study using 3-Tesla proton magnetic resonance spectroscopyMark A Frye
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Psychiatry Res 154:259-65. 2007..Limitations of this study include small sample size and lack of tissue segmentation. Further study is encouraged to clarify state vs. trait aspects of NAA in bipolar disorder... - Impairment in childhood anxiety disorders: preliminary examination of the child anxiety impact scale-parent versionAudra K Langley
Division of Child and Adolescent Psychiatry, UCLA School of Medicine, Los Angeles, California, USA
J Child Adolesc Psychopharmacol 14:105-14. 2004..The results provide initial support that the CAIS-P is a reliable and valid measure for the assessment of the impact of anxiety on child and adolescent functioning... - Family cognitive behavioral therapy for child anxiety disordersJeffrey J Wood
Department of Education, University of California, Los Angeles 90095, USA
J Am Acad Child Adolesc Psychiatry 45:314-21. 2006..This study compared family-focused cognitive behavioral therapy (CBT; the Building Confidence Program) with traditional child-focused CBT with minimal family involvement for children with anxiety disorders... - Cluster analysis of the Yale Global Tic Severity Scale (YGTSS): symptom dimensions and clinical correlates in an outpatient youth sampleKatharina Kircanski
Department of Psychology, University of California Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
J Abnorm Child Psychol 38:777-88. 2010..Findings lend support to prior research on tic phenomenology, help to organize treatment goals, and suggest symptom dimensions of tic disorders for further evaluation... - Neurocognitive correlates of child obsessive compulsive disorder and Tourette syndromeSUSANNA W CHANG
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
J Clin Exp Neuropsychol 29:724-33. 2007..TS findings were less robust and may be construed tentatively as suggestive of executive function deficits. Future research is needed to delineate the influence of development on neurocognitive deficits associated with OCD and TS... - Concurrent validity of the anxiety disorders section of the Anxiety Disorders Interview Schedule for DSM-IV: child and parent versionsJeffrey J Wood
Psychology Clinic, 2191 Franz Hall, Department of Psychology, University of California, Los Angeles, CA 90095, USA
J Clin Child Adolesc Psychol 31:335-42. 2002..These results provide support for the concurrent validity of the anxiety disorders section of the ADIS-C/P... - Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutationsJohn M Ringman
UCLA Department of Neurology, Alzheimer s Disease Research Center, 10911 Weyburn Ave, Suite 200, Los Angeles, CA 90095 7226, USA
Brain 130:1767-76. 2007..Decreased FA in of the columns of the fornix is particularly robust in early FAD and may provide a biomarker for early disease in sporadic Alzheimer's disease... - Brain growth rate abnormalities visualized in adolescents with autismXue Hua
Laboratory of Neuro Imaging, University of California Los Angeles School of Medicine, Los Angeles, California, USA
Hum Brain Mapp 34:425-36. 2013..Tensor-based morphometry revealed persisting growth rate anomalies long after diagnosis, which has implications for evaluation of therapeutic effects... - Elevated glutamatergic compounds in pregenual anterior cingulate in pediatric autism spectrum disorder demonstrated by 1H MRS and 1H MRSIAnthony Bejjani
Ahmanson Lovelace Brain Mapping Center, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
PLoS ONE 7:e38786. 2012..The hyperglutamatergic state may reflect an imbalance of excitation over inhibition in the brain as proposed in recent neurodevelopmental models of ASD... - White-matter abnormalities in brain during early abstinence from methamphetamine abuseMarc C Tobias
Semel Institute for Neuroscience and Biobehavioral Studies, University of California Los Angeles, Los Angeles, CA, USA
Psychopharmacology (Berl) 209:13-24. 2010..As certain metabolic changes in the brain first manifest after early abstinence from methamphetamine, it is also possible that microstructural white-matter abnormalities are not yet present during early abstinence... - Behavioral treatments for tic suppression: habit reversal trainingJohn C Piacentini
Department of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles Los Angeles, California, USA
Adv Neurol 99:227-33. 2006
Research Grants
- 1H MRSI/Response Inhibition/Methamphetamine AbusersJOSEPH O NEILL; Fiscal Year: 2005..This project will examine the chemistry of parts of the brain thought to be responsible for inhibition and/or damaged by methamphetamine in methamphetamine addicts. ..
- Magnetic Resonance Spectroscopic Imaging of the Brain in Methamphetamine AbuseJOSEPH O NEILL; Fiscal Year: 2007..This proposal aims for a better understanding of the state of the brain during very early abstinence from methamphetamine in order to develop novel therapies and improve the success of existing therapies. ..
- Cognitive-Behavioral Therapy & Glutametergic Neurometabolites in Pediatric OCDJOSEPH O NEILL; Fiscal Year: 2009..This proposal aims for a better understanding of the brain mechanisms of cognitive-behavioral therapy (CBT) in order to develop novel therapies and improve the success of existing therapies. ..
- Cognitive-Behavioral Therapy & Glutametergic Neurometabolites in Pediatric OCDJohn C Piacentini; Fiscal Year: 2010..This proposal aims for a better understanding of the brain mechanisms of cognitive-behavioral therapy (CBT) in order to develop novel therapies and improve the success of existing therapies. ..
- Cognitive-Behavioral Therapy & Glutametergic Neurometabolites in Pediatric OCDJohn C Piacentini; Fiscal Year: 2010..This proposal aims for a better understanding of the brain mechanisms of cognitive-behavioral therapy (CBT) in order to develop novel therapies and improve the success of existing therapies. ..