J H Omens

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Complex distributions of residual stress and strain in the mouse left ventricle: experimental and theoretical models
    J H Omens
    Department of Medicine, University of California San Diego, 0613J 9500 Gilman Drive, La Jolla, CA 92093 0613, USA
    Biomech Model Mechanobiol 1:267-77. 2003
  2. ncbi request reprint Comparison of two techniques for measuring two-dimensional strain in rat left ventricles
    J H Omens
    Department of Medicine Cardiology, University of California, San Diego, La Jolla 92093 0613, USA
    Am J Physiol 271:H1256-61. 1996
  3. ncbi request reprint Relationship between passive tissue strain and collagen uncoiling during healing of infarcted myocardium
    J H Omens
    Department of Medicine Cardiology, University of California, San Diego, La Jolla 92093 0613, USA
    Cardiovasc Res 33:351-8. 1997
  4. ncbi request reprint Muscle LIM protein deficiency leads to alterations in passive ventricular mechanics
    Jeffrey H Omens
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Am J Physiol Heart Circ Physiol 282:H680-7. 2002
  5. ncbi request reprint Stress and strain as regulators of myocardial growth
    J H Omens
    Department of Medicine, University of California, San Diego, La Jolla 92093 0613, USA
    Prog Biophys Mol Biol 69:559-72. 1998
  6. ncbi request reprint Left ventricular geometric remodeling and residual stress in the rat heart
    J H Omens
    Department of Bioengineering, University of California, San Diego, La Jolla 92093, USA
    J Biomech Eng 120:715-9. 1998
  7. ncbi request reprint Transmural distribution of three-dimensional systolic strains in stunned myocardium
    R Mazhari
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, California, USA
    Circulation 104:336-41. 2001
  8. ncbi request reprint Flow-function relations during graded coronary occlusions in the dog: effects of transmural location and segment orientation
    A D McCulloch
    Department of Bioengineering, University of California San Diego, La Jolla 92093 0412, USA
    Cardiovasc Res 37:636-45. 1998
  9. ncbi request reprint Myocardial mechanics and collagen structure in the osteogenesis imperfecta murine (oim)
    S M Weis
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Circ Res 87:663-9. 2000
  10. ncbi request reprint Age-associated cardiac dysfunction in Drosophila melanogaster
    G Paternostro
    The Burnham Institute, La Jolla, CA 92037, USA
    Circ Res 88:1053-8. 2001

Research Grants

  1. Cardiomyocyte mechanotransduction through the integrin complex
    ROBERT SCOTT ROSS; Fiscal Year: 2010
  2. MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    Jeffrey Omens; Fiscal Year: 2001
  3. MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    Jeffrey Omens; Fiscal Year: 2002
  4. MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    Jeffrey Omens; Fiscal Year: 2003
  5. MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    Jeffrey Omens; Fiscal Year: 2004
  6. TRANSMURAL DEFORMATION
    Jeffrey Omens; Fiscal Year: 2005
  7. TRANSMURAL DEFORMATION
    Jeffrey Omens; Fiscal Year: 2006
  8. TRANSMURAL DEFORMATION
    Jeffrey Omens; Fiscal Year: 2007
  9. TRANSMURAL DEFORMATION
    Jeffrey Omens; Fiscal Year: 2008

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Complex distributions of residual stress and strain in the mouse left ventricle: experimental and theoretical models
    J H Omens
    Department of Medicine, University of California San Diego, 0613J 9500 Gilman Drive, La Jolla, CA 92093 0613, USA
    Biomech Model Mechanobiol 1:267-77. 2003
    ..These results imply a more complex distribution of residual stress and strain in ventricular myocardium than previously thought...
  2. ncbi request reprint Comparison of two techniques for measuring two-dimensional strain in rat left ventricles
    J H Omens
    Department of Medicine Cardiology, University of California, San Diego, La Jolla 92093 0613, USA
    Am J Physiol 271:H1256-61. 1996
    ....
  3. ncbi request reprint Relationship between passive tissue strain and collagen uncoiling during healing of infarcted myocardium
    J H Omens
    Department of Medicine Cardiology, University of California, San Diego, La Jolla 92093 0613, USA
    Cardiovasc Res 33:351-8. 1997
    ..Hence collagen uncoiling and tissue strain were measured during passive loading in normal tissue, and in healing infarct tissue...
  4. ncbi request reprint Muscle LIM protein deficiency leads to alterations in passive ventricular mechanics
    Jeffrey H Omens
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Am J Physiol Heart Circ Physiol 282:H680-7. 2002
    ....
  5. ncbi request reprint Stress and strain as regulators of myocardial growth
    J H Omens
    Department of Medicine, University of California, San Diego, La Jolla 92093 0613, USA
    Prog Biophys Mol Biol 69:559-72. 1998
    ..But other studies do not agree with this result, and other modes of hypertrophy may be regulated by different factors or combinations of factors...
  6. ncbi request reprint Left ventricular geometric remodeling and residual stress in the rat heart
    J H Omens
    Department of Bioengineering, University of California, San Diego, La Jolla 92093, USA
    J Biomech Eng 120:715-9. 1998
    ..Collagen area fraction increased with age. Hence physiologic ventricular remodeling in rats decreases myocardial residual strain in proportion to the relative reduction in wall thickness-radius ratio...
  7. ncbi request reprint Transmural distribution of three-dimensional systolic strains in stunned myocardium
    R Mazhari
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, California, USA
    Circulation 104:336-41. 2001
    ..Perhaps systolic fiber dysfunction rather than the degree of perfusion deficit during the preceding ischemic period may be the main determinant of myocardial dysfunction during reperfusion...
  8. ncbi request reprint Flow-function relations during graded coronary occlusions in the dog: effects of transmural location and segment orientation
    A D McCulloch
    Department of Bioengineering, University of California San Diego, La Jolla 92093 0412, USA
    Cardiovasc Res 37:636-45. 1998
    ..The aim of this study was to determine the effects of fiber orientation and transmural location on the relationships between regional myocardial flow and three-dimensional systolic wall strain during graded coronary artery occlusions...
  9. ncbi request reprint Myocardial mechanics and collagen structure in the osteogenesis imperfecta murine (oim)
    S M Weis
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Circ Res 87:663-9. 2000
    ..In addition to supporting and organizing myocytes, myocardial collagen contributes directly to ventricular stiffness at high and low loads and can influence stress-free state and myofiber architecture...
  10. ncbi request reprint Age-associated cardiac dysfunction in Drosophila melanogaster
    G Paternostro
    The Burnham Institute, La Jolla, CA 92037, USA
    Circ Res 88:1053-8. 2001
    ....
  11. ncbi request reprint Passive ventricular mechanics in tight-skin mice
    J H Omens
    Department of Medicine, University of California at San Diego, La Jolla 92093
    Am J Physiol 266:H1169-76. 1994
    ....
  12. ncbi request reprint Regional septal dysfunction in a three-dimensional computational model of focal myofiber disarray
    T P Usyk
    Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California, La Jolla, California 92093-0412, USA
    Am J Physiol Heart Circ Physiol 281:H506-14. 2001
    ....
  13. pmc Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70
    S U Trost
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0618, USA
    J Clin Invest 101:855-62. 1998
    ..Thus, we conclude that expression of HSP70 protects against postischemic myocardial dysfunction as shown by better preserved myocardial function...
  14. pmc Cardiac resynchronization: insight from experimental and computational models
    R C P Kerckhoffs
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Prog Biophys Mol Biol 97:543-61. 2008
    ..In this paper, we focus on to what extent animal experiments and mathematical models can help in order to understand the pathophysiology of asynchrony to further improve CRT...
  15. pmc Improvement in pump function with endocardial biventricular pacing increases with activation time at the left ventricular pacing site in failing canine hearts
    Elliot J Howard
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0613, USA
    Am J Physiol Heart Circ Physiol 301:H1447-55. 2011
    ..At the anterolateral wall, end-systolic transmural function was greater with local ENDO compared with EPI pacing. ENDO pacing and intrinsic activation delay may have important implications for management of DYSS heart failure...
  16. ncbi request reprint Ventricular filling slows epicardial conduction and increases action potential duration in an optical mapping study of the isolated rabbit heart
    Derrick Sung
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    J Cardiovasc Electrophysiol 14:739-49. 2003
    ..Mechanical stimulation can induce electrophysiologic changes in cardiac myocytes, but how mechanoelectric feedback in the intact heart affects action potential propagation remains unclear...
  17. ncbi request reprint Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury
    Christopher K Means
    Department of Pharmacology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0636, USA
    Am J Physiol Heart Circ Physiol 292:H2944-51. 2007
    ..Our data demonstrate that activation of S1P(2) and S1P(3) receptors plays a significant role in protecting cardiomyocytes from I/R damage in vivo and implicate the release of S1P and receptor-mediated Akt activation in this process...
  18. pmc Transmural dispersion of myofiber mechanics: implications for electrical heterogeneity in vivo
    Hiroshi Ashikaga
    Department of Medicine and Bioengineering, University of California, San Diego, La Jolla, California, USA
    J Am Coll Cardiol 49:909-16. 2007
    ..We investigated whether transmural mechanics could yield insight into the transmural electrical sequence...
  19. ncbi request reprint High-resolution longitudinal MRI of the transition to heart failure
    Peter N Costandi
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0613, USA
    Magn Reson Med 57:714-20. 2007
    ....
  20. pmc Asynchrony of ventricular activation affects magnitude and timing of fiber stretch in late-activated regions of the canine heart
    Benjamin A Coppola
    UCSD School of Medicine, Department of Cardiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Am J Physiol Heart Circ Physiol 293:H754-61. 2007
    ..The increased shortening of these regions appears to be because of a reduced afterload rather than an effect of length-dependent activation in this preparation...
  21. ncbi request reprint The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy
    Ralph Knoll
    Institute of Molecular Medicine, Department of Medicine, University of California at San Diego, La Jolla 92093, USA
    Cell 111:943-55. 2002
    ..We propose that a Z disc MLP/T-cap complex is a key component of the in vivo cardiomyocyte stretch sensor machinery, and that defects in the complex can lead to human DCM and associated heart failure...
  22. pmc Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure
    Hiroshi Ashikaga
    Department of Medicine and Bioengineering, University of California, San Diego, La Jolla, CA, USA
    Am J Physiol Heart Circ Physiol 295:H610-8. 2008
    ..Our data in the early activated region also suggest that myocardial volume change is caused not by the intramyocardial tissue pressure but by direct impingement of the contracting myocytes on the microvasculature...
  23. pmc Effects of biglycan deficiency on myocardial infarct structure and mechanics
    Patrick H Campbell
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Mol Cell Biomech 5:27-35. 2008
    ..Null-expression of biglycan may alter collagen fibril ultrastructure, and thereby influence scar mechanics and remodeling...
  24. pmc Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes
    Jeffrey G Jacot
    Department of Bioengineering, University of California, San Diego, USA
    Biophys J 95:3479-87. 2008
    ..On very stiff substrates, this adaptation seems to involve RhoA kinase...
  25. pmc Computational modeling for bedside application
    Roy C P Kerckhoffs
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Heart Fail Clin 4:371-8. 2008
    ..Models, therefore, will provide insight as to why specific interventions succeed or fail...
  26. pmc Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear
    Ilka Lorenzen-Schmidt
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0613, USA
    Cell Biochem Biophys 46:113-22. 2006
    ..The results suggest that the beta-adrenergic signaling pathway and integrin activation, which are known to interact, may play an important role in the response mechanism...
  27. pmc Role of diastolic properties in the transition to failure in a mouse model of the cardiac dilatation
    Peter N Costandi
    Dept of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0613, USA
    Am J Physiol Heart Circ Physiol 291:H2971-9. 2006
    ..Though initially compensatory, this process may exhaust itself and consequently transition to a maladaptive course...
  28. pmc Time-dependent remodeling of transmural architecture underlying abnormal ventricular geometry in chronic volume overload heart failure
    Hiroshi Ashikaga
    Dept of Medicine, Univ of California, San Diego, 9500 Gilman Dr, 0613J, La Jolla, CA 92093, USA
    Am J Physiol Heart Circ Physiol 287:H1994-2002. 2004
    ..These results suggest that the temporal progression of ventricular remodeling may be anatomically designed at the level of regional laminar architecture...
  29. ncbi request reprint Deficiency of actinin-associated LIM protein alters regional right ventricular function and hypertrophic remodeling
    Ilka Lorenzen-Schmidt
    Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla 92093, CA, USA
    Ann Biomed Eng 33:888-96. 2005
    ..In summary, the results are consistent with the view that disruption of ALP is associated with diminished RV contractile function as well as altered hypertrophic remodeling...
  30. ncbi request reprint Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy
    Ilka Lorenzen-Schmidt
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    J Mol Cell Cardiol 39:241-50. 2005
    ..These results indicate that the progression to heart failure in the MLPKO model may be driven by diastolic myocardial dysfunction and abnormal passive properties rather than systolic dysfunction...
  31. ncbi request reprint A role for decorin in the remodeling of myocardial infarction
    Sara M Weis
    Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093, USA
    Matrix Biol 24:313-24. 2005
    ..This might contribute to aneurysmal ventricular dilatation, remote hypertrophy, and depressed ventricular function...
  32. ncbi request reprint Etanercept or intravenous immunoglobulin attenuates expression of genes involved in post-myocardial infarction remodeling
    Devorah Gurantz
    Department of Medicine, Division of Cardiology, University of California, San Diego, Medical Center, 200 W Arbor Drive, San Diego, California, CA 92103 8411, USA
    Cardiovasc Res 67:106-15. 2005
    ..The aim of the present study was to examine the effects of immunomodulatory therapy with recombinant soluble TNF receptor (TNFR:Fc) or intravenous immunoglobulin (IVIg) on left and right ventricular post-MI remodeling in rats...
  33. pmc Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy
    Keith L Herrmann
    Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, California 92093, USA
    Am J Physiol Heart Circ Physiol 284:H1277-84. 2003
    ....
  34. ncbi request reprint Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers
    Sindhu M Gopalan
    Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0412, USA
    Biotechnol Bioeng 81:578-87. 2003
    ....
  35. pmc Transmural mechanics at left ventricular epicardial pacing site
    Hiroshi Ashikaga
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, 0613J, La Jolla, CA 92093, USA
    Am J Physiol Heart Circ Physiol 286:H2401-7. 2004
    ..These findings suggest that normal sheet extension and wall thickening immediately after activation may require normal transmural activation sequence, whereas sheet shear deformation may be determined by local anatomy...
  36. pmc Transmural left ventricular mechanics underlying torsional recoil during relaxation
    Hiroshi Ashikaga
    Department of Medicine, University of California, San Diego, La Jolla 92093, USA
    Am J Physiol Heart Circ Physiol 286:H640-7. 2004
    ..Predominant epicardial stretch along myofibers during isovolumic relaxation appears to drive global torsional recoil to aid early diastolic filling...
  37. pmc Diastolic dysfunction in volume-overload hypertrophy is associated with abnormal shearing of myolaminar sheets
    Hiroshi Ashikaga
    Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1061, Bldg 10, B1D416, Bethesda, MD 20892 1061, USA
    Am J Physiol Heart Circ Physiol 288:H2603-10. 2005
    ..These results provide the first evidence that changes in motion of radially oriented laminar sheets may play an important functional role in pathology of diastolic dysfunction in this model...
  38. doi request reprint Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technology
    Jacob D Feala
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, 0412, La Jolla, CA 92093 0412, USA
    Ann N Y Acad Sci 1123:169-77. 2008
    ..We discuss the possible applications of a genome-wide cardiac phenotype data set in systems biology analyses of hypoxic metabolism, using genome-scale interaction networks and constraint-based metabolic models...
  39. ncbi request reprint Myocyte shearing, myocardial sheets, and microtubules
    Andrew D McCulloch
    Circ Res 98:1-3. 2006

Research Grants9

  1. Cardiomyocyte mechanotransduction through the integrin complex
    ROBERT SCOTT ROSS; Fiscal Year: 2010
    ....
  2. MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    Jeffrey Omens; Fiscal Year: 2001
    ..We propose that these regional structural changes accompanies dilatory heart failure, and are mechanisms behind the reduction in fiber shortening and the ability of the wall to thicken during systole. ..
  3. MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    Jeffrey Omens; Fiscal Year: 2002
    ..We propose that these regional structural changes accompanies dilatory heart failure, and are mechanisms behind the reduction in fiber shortening and the ability of the wall to thicken during systole. ..
  4. MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    Jeffrey Omens; Fiscal Year: 2003
    ..We propose that these regional structural changes accompanies dilatory heart failure, and are mechanisms behind the reduction in fiber shortening and the ability of the wall to thicken during systole. ..
  5. MECHANICAL REGULATION OF DILATED CARDIOMYOPATHY
    Jeffrey Omens; Fiscal Year: 2004
    ..We propose that these regional structural changes accompanies dilatory heart failure, and are mechanisms behind the reduction in fiber shortening and the ability of the wall to thicken during systole. ..
  6. TRANSMURAL DEFORMATION
    Jeffrey Omens; Fiscal Year: 2005
    ..We will test the hypothesis that minimizing the 'prestretch' tissue area can be used as an algorithm to select pacing sites which improve global and regional function in the failing heart. ..
  7. TRANSMURAL DEFORMATION
    Jeffrey Omens; Fiscal Year: 2006
    ..We will test the hypothesis that minimizing the 'prestretch' tissue area can be used as an algorithm to select pacing sites which improve global and regional function in the failing heart. ..
  8. TRANSMURAL DEFORMATION
    Jeffrey Omens; Fiscal Year: 2007
    ..We will test the hypothesis that minimizing the 'prestretch' tissue area can be used as an algorithm to select pacing sites which improve global and regional function in the failing heart. ..
  9. TRANSMURAL DEFORMATION
    Jeffrey Omens; Fiscal Year: 2008
    ..We will test the hypothesis that minimizing the 'prestretch' tissue area can be used as an algorithm to select pacing sites which improve global and regional function in the failing heart. ..