Research Topics
Species | J H OmensSummaryAffiliation: University of California Country: USA Publications
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Publications
Complex distributions of residual stress and strain in the mouse left ventricle: experimental and theoretical modelsJ H Omens
Department of Medicine, University of California San Diego, 0613J 9500 Gilman Drive, La Jolla, CA 92093 0613, USA
Biomech Model Mechanobiol 1:267-77. 2003..These results imply a more complex distribution of residual stress and strain in ventricular myocardium than previously thought...- Comparison of two techniques for measuring two-dimensional strain in rat left ventriclesJ H Omens
Department of Medicine Cardiology, University of California, San Diego, La Jolla 92093 0613, USA
Am J Physiol 271:H1256-61. 1996.... - Relationship between passive tissue strain and collagen uncoiling during healing of infarcted myocardiumJ H Omens
Department of Medicine Cardiology, University of California, San Diego, La Jolla 92093 0613, USA
Cardiovasc Res 33:351-8. 1997..Hence collagen uncoiling and tissue strain were measured during passive loading in normal tissue, and in healing infarct tissue... - Muscle LIM protein deficiency leads to alterations in passive ventricular mechanicsJeffrey H Omens
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Am J Physiol Heart Circ Physiol 282:H680-7. 2002.... - Stress and strain as regulators of myocardial growthJ H Omens
Department of Medicine, University of California, San Diego, La Jolla 92093 0613, USA
Prog Biophys Mol Biol 69:559-72. 1998..But other studies do not agree with this result, and other modes of hypertrophy may be regulated by different factors or combinations of factors... - Left ventricular geometric remodeling and residual stress in the rat heartJ H Omens
Department of Bioengineering, University of California, San Diego, La Jolla 92093, USA
J Biomech Eng 120:715-9. 1998..Collagen area fraction increased with age. Hence physiologic ventricular remodeling in rats decreases myocardial residual strain in proportion to the relative reduction in wall thickness-radius ratio... - Transmural distribution of three-dimensional systolic strains in stunned myocardiumR Mazhari
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, California, USA
Circulation 104:336-41. 2001..Perhaps systolic fiber dysfunction rather than the degree of perfusion deficit during the preceding ischemic period may be the main determinant of myocardial dysfunction during reperfusion... - Flow-function relations during graded coronary occlusions in the dog: effects of transmural location and segment orientationA D McCulloch
Department of Bioengineering, University of California San Diego, La Jolla 92093 0412, USA
Cardiovasc Res 37:636-45. 1998..The aim of this study was to determine the effects of fiber orientation and transmural location on the relationships between regional myocardial flow and three-dimensional systolic wall strain during graded coronary artery occlusions... - Myocardial mechanics and collagen structure in the osteogenesis imperfecta murine (oim)S M Weis
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
Circ Res 87:663-9. 2000..In addition to supporting and organizing myocytes, myocardial collagen contributes directly to ventricular stiffness at high and low loads and can influence stress-free state and myofiber architecture... - Age-associated cardiac dysfunction in Drosophila melanogasterG Paternostro
The Burnham Institute, La Jolla, CA 92037, USA
Circ Res 88:1053-8. 2001.... - Passive ventricular mechanics in tight-skin miceJ H Omens
Department of Medicine, University of California at San Diego, La Jolla 92093
Am J Physiol 266:H1169-76. 1994.... - Regional septal dysfunction in a three-dimensional computational model of focal myofiber disarrayT P Usyk
Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California, La Jolla, California 92093-0412, USA
Am J Physiol Heart Circ Physiol 281:H506-14. 2001.... 
Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70S U Trost
Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0618, USA
J Clin Invest 101:855-62. 1998..Thus, we conclude that expression of HSP70 protects against postischemic myocardial dysfunction as shown by better preserved myocardial function...- Cardiac resynchronization: insight from experimental and computational modelsR C P Kerckhoffs
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
Prog Biophys Mol Biol 97:543-61. 2008..In this paper, we focus on to what extent animal experiments and mathematical models can help in order to understand the pathophysiology of asynchrony to further improve CRT... - Improvement in pump function with endocardial biventricular pacing increases with activation time at the left ventricular pacing site in failing canine heartsElliot J Howard
Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0613, USA
Am J Physiol Heart Circ Physiol 301:H1447-55. 2011..At the anterolateral wall, end-systolic transmural function was greater with local ENDO compared with EPI pacing. ENDO pacing and intrinsic activation delay may have important implications for management of DYSS heart failure... - Ventricular filling slows epicardial conduction and increases action potential duration in an optical mapping study of the isolated rabbit heartDerrick Sung
Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA
J Cardiovasc Electrophysiol 14:739-49. 2003.... - Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injuryChristopher K Means
Department of Pharmacology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0636, USA
Am J Physiol Heart Circ Physiol 292:H2944-51. 2007..Our data demonstrate that activation of S1P(2) and S1P(3) receptors plays a significant role in protecting cardiomyocytes from I/R damage in vivo and implicate the release of S1P and receptor-mediated Akt activation in this process... - Transmural dispersion of myofiber mechanics: implications for electrical heterogeneity in vivoHiroshi Ashikaga
Department of Medicine and Bioengineering, University of California, San Diego, La Jolla, California, USA
J Am Coll Cardiol 49:909-16. 2007..We investigated whether transmural mechanics could yield insight into the transmural electrical sequence... - High-resolution longitudinal MRI of the transition to heart failurePeter N Costandi
Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0613, USA
Magn Reson Med 57:714-20. 2007.... - Asynchrony of ventricular activation affects magnitude and timing of fiber stretch in late-activated regions of the canine heartBenjamin A Coppola
UCSD School of Medicine, Department of Cardiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Am J Physiol Heart Circ Physiol 293:H754-61. 2007..The increased shortening of these regions appears to be because of a reduced afterload rather than an effect of length-dependent activation in this preparation... - The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathyRalph Knoll
Institute of Molecular Medicine, Department of Medicine, University of California at San Diego, La Jolla 92093, USA
Cell 111:943-55. 2002..We propose that a Z disc MLP/T-cap complex is a key component of the in vivo cardiomyocyte stretch sensor machinery, and that defects in the complex can lead to human DCM and associated heart failure... - Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structureHiroshi Ashikaga
Department of Medicine and Bioengineering, University of California, San Diego, La Jolla, CA, USA
Am J Physiol Heart Circ Physiol 295:H610-8. 2008..Our data in the early activated region also suggest that myocardial volume change is caused not by the intramyocardial tissue pressure but by direct impingement of the contracting myocytes on the microvasculature... - Effects of biglycan deficiency on myocardial infarct structure and mechanicsPatrick H Campbell
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
Mol Cell Biomech 5:27-35. 2008..Null-expression of biglycan may alter collagen fibril ultrastructure, and thereby influence scar mechanics and remodeling... - Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytesJeffrey G Jacot
Department of Bioengineering, University of California, San Diego, USA
Biophys J 95:3479-87. 2008..On very stiff substrates, this adaptation seems to involve RhoA kinase... - Computational modeling for bedside applicationRoy C P Kerckhoffs
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, CA 92093 0412, USA
Heart Fail Clin 4:371-8. 2008..Models, therefore, will provide insight as to why specific interventions succeed or fail... - Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shearIlka Lorenzen-Schmidt
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0613, USA
Cell Biochem Biophys 46:113-22. 2006..The results suggest that the beta-adrenergic signaling pathway and integrin activation, which are known to interact, may play an important role in the response mechanism... - Role of diastolic properties in the transition to failure in a mouse model of the cardiac dilatationPeter N Costandi
Dept of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0613, USA
Am J Physiol Heart Circ Physiol 291:H2971-9. 2006..Though initially compensatory, this process may exhaust itself and consequently transition to a maladaptive course... - Time-dependent remodeling of transmural architecture underlying abnormal ventricular geometry in chronic volume overload heart failureHiroshi Ashikaga
Dept. of Medicine, Univ. of California, San Diego, 9500 Gilman Dr, 0613J, La Jolla, CA 92093, USA
Am J Physiol Heart Circ Physiol 287:H1994-2002. 2004..These results suggest that the temporal progression of ventricular remodeling may be anatomically designed at the level of regional laminar architecture... - Deficiency of actinin-associated LIM protein alters regional right ventricular function and hypertrophic remodelingIlka Lorenzen-Schmidt
Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla 92093, CA, USA
Ann Biomed Eng 33:888-96. 2005..In summary, the results are consistent with the view that disruption of ALP is associated with diminished RV contractile function as well as altered hypertrophic remodeling... - Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathyIlka Lorenzen-Schmidt
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
J Mol Cell Cardiol 39:241-50. 2005..These results indicate that the progression to heart failure in the MLPKO model may be driven by diastolic myocardial dysfunction and abnormal passive properties rather than systolic dysfunction... - A role for decorin in the remodeling of myocardial infarctionSara M Weis
Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093, USA
Matrix Biol 24:313-24. 2005..This might contribute to aneurysmal ventricular dilatation, remote hypertrophy, and depressed ventricular function... - Etanercept or intravenous immunoglobulin attenuates expression of genes involved in post-myocardial infarction remodelingDevorah Gurantz
Department of Medicine, Division of Cardiology, University of California, San Diego, Medical Center, 200 W Arbor Drive, San Diego, California, CA 92103-8411, USA
Cardiovasc Res 67:106-15. 2005..These findings raise the possibility that initiation of immunomodulatory therapy post-MI could be beneficial in preventing the later development of heart failure... - Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophyKeith L Herrmann
Whitaker Institute of Biomedical Engineering, University of California-San Diego, La Jolla, California 92093, USA
Am J Physiol Heart Circ Physiol 284:H1277-84. 2003.... - Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomersSindhu M Gopalan
Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0412, USA
Biotechnol Bioeng 81:578-87. 2003.... - Transmural mechanics at left ventricular epicardial pacing siteHiroshi Ashikaga
Department of Medicine, University of California-San Diego, 9500 Gilman Drive, 0613J, La Jolla, CA 92093, USA
Am J Physiol Heart Circ Physiol 286:H2401-7. 2004..These findings suggest that normal sheet extension and wall thickening immediately after activation may require normal transmural activation sequence, whereas sheet shear deformation may be determined by local anatomy... - Transmural left ventricular mechanics underlying torsional recoil during relaxationHiroshi Ashikaga
Department of Medicine, University of California, San Diego, La Jolla 92093, USA
Am J Physiol Heart Circ Physiol 286:H640-7. 2004..Predominant epicardial stretch along myofibers during isovolumic relaxation appears to drive global torsional recoil to aid early diastolic filling... - Diastolic dysfunction in volume-overload hypertrophy is associated with abnormal shearing of myolaminar sheetsHiroshi Ashikaga
Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1061, Bldg 10, B1D416, Bethesda, MD 20892 1061, USA
Am J Physiol Heart Circ Physiol 288:H2603-10. 2005..These results provide the first evidence that changes in motion of radially oriented laminar sheets may play an important functional role in pathology of diastolic dysfunction in this model... 
Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technologyJacob D Feala
Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, 0412, La Jolla, CA 92093 0412, USA
Ann N Y Acad Sci 1123:169-77. 2008..We discuss the possible applications of a genome-wide cardiac phenotype data set in systems biology analyses of hypoxic metabolism, using genome-scale interaction networks and constraint-based metabolic models...- Myocyte shearing, myocardial sheets, and microtubulesAndrew D McCulloch
Circ Res 98:1-3. 2006
Research Grants
- Cardiomyocyte mechanotransduction through the integrin complexROBERT SCOTT ROSS; Fiscal Year: 2010....
- MECHANICAL REGULATION OF DILATED CARDIOMYOPATHYJeffrey Omens; Fiscal Year: 2004..We propose that these regional structural changes accompanies dilatory heart failure, and are mechanisms behind the reduction in fiber shortening and the ability of the wall to thicken during systole. ..
- TRANSMURAL DEFORMATIONJeffrey Omens; Fiscal Year: 2007..We will test the hypothesis that minimizing the 'prestretch' tissue area can be used as an algorithm to select pacing sites which improve global and regional function in the failing heart. ..