Research Topics
| G S OmennSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
A mouse plasma peptide atlas as a resource for disease proteomicsQing Zhang
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Genome Biol 9:R93. 2008..A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis...
Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysisWei Min Gao
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
BMC Cancer 5:110. 2005..We hypothesized that distinctive profiles may result from the differential expression of relatively abundant serum proteins associated with the host response...
The HUPO Plasma Proteome Project: a report from the Munich congressGilbert S Omenn
Internal Medicine, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
Proteomics 6:9-11. 2006..An open Workshop and a presentation in the closing plenary session of the congress focused on next phases for the Plasma Proteome Project...- Chemoprevention of lung cancers: lessons from CARET, the beta-carotene and retinol efficacy trial, and prospects for the futureGilbert S Omenn
University of Michigan, Ann Arbor, Michigan 48109 0656, USA
Eur J Cancer Prev 16:184-91. 2007..Trials are necessary to test inferences from observational epidemiology and animal models. Multiple classes of promising agents are available for evaluation and for eventual randomized trials... - Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available databaseGilbert S Omenn
Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0656, USA
Proteomics 5:3226-45. 2005.... - Strategies for plasma proteomic profiling of cancersGilbert S Omenn
Department of Internal Medicine, Center for Computational Medicine and Biology, and Proteomics Alliance for Cancer Research, University of Michigan, Ann Arbor, MI 48109 0656, USA
Proteomics 6:5662-73. 2006.... - Human lung cancer chemoprevention strategies: Parker B. Francis lectureGilbert S Omenn
University of Michigan, Ann Arbor, MI 48109 0656, USA
Chest 125:123S-7S. 2004..The most active area currently is focused on selective inhibition of arachidonic metabolism, both Cox-2 and Lox pathways... - The Human Proteome Organization Plasma Proteome Project pilot phase: reference specimens, technology platform comparisons, and standardized data submissions and analysesGilbert S Omenn
University of Michigan, Ann Arbor, 48109 0656, USA
Proteomics 4:1235-40. 2004.... - Advancement of biomarker discovery and validation through the HUPO plasma proteome projectGilbert S Omenn
University of Michigan, A510 MSRB I, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0656, USA
Dis Markers 20:131-4. 2004..This international collaboration will lay the groundwork for many large-scale clinical and epidemiological studies of health and disease... 
THE HUPO Human Plasma Proteome ProjectGilbert S Omenn
Internal Medicine, Human Genetics, Public Health and Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA
Proteomics Clin Appl 1:769-79. 2007....- HUPO 3rd annual World Congress on Proteomics. 25-27th October, 2004, Beijing, ChinaGilbert S Omenn
University of Michigan, 1150 W. Medical Center Dr, Ann Arbor, MI 48109-0656, USA
Expert Rev Proteomics 2:9-12. 2005 - Evolution in health and medicine Sackler colloquium: Evolution and public healthGilbert S Omenn
Department of Internal Medicine, Medical School and School of Public Health, University of Michigan, Center for Computational Medicine and Bioinformatics, Ann Arbor, MI 48109 2218, USA
Proc Natl Acad Sci U S A 107:1702-9. 2010..The implications and applications of evolutionary understanding are important to our current programs and policies for infectious disease surveillance, gene-environment interactions, and health disparities globally... - Chemoprevention of lung cancer: the rise and demise of beta-caroteneG S Omenn
School of Public Health and Community Medicine, University of Washington, Seattle 98195 7230, USA
Annu Rev Public Health 19:73-99. 1998..continued priority for smoking prevention, smoking cessation, and avoidance of known carcinogens in the environment... - Caring for the community: the role of partnershipsG S Omenn
University of Michigan U of M Medical School, Ann Arbor 48109 0624, USA
Acad Med 74:782-9. 1999..He closes by emphasizing the importance of community-based research to learn about the health statuses, problems, and resources of particular communities, and presents a set of principles for such community-based research... - The Guide to Community Preventive Services will be influential in academic health centers: education, research and links with practiceG S Omenn
University of Michigan Health System and Medical School, Ann Arbor 48109 0624, USA
Am J Prev Med 18:12-4. 2000..Such initiatives will improve the chances for increased investment in preventive medicine and public health... - Public health genetics: an emerging interdisciplinary field for the post-genomic eraG S Omenn
University of Michigan, Ann Arbor 48109 0626, USA
Annu Rev Public Health 21:1-13. 2000.... - Commentary on scientific peer review to inform regulatory decision making: roles and perspectives of scientistsGilbert S Omenn
Internal Medicine, Human Genetics and Public Health, University of Michigan, MI 48109-0656, USA
Risk Anal 26:37-9. 2006 - Data management and data integration in the HUPO plasma proteome projectGilbert S Omenn
Departments of Medicine and Genetics, Center for Computational Medicine and Bioinformatics, Medical School and School of Public Health, University of Michigan, Ann Arbor, MI, USA
Methods Mol Biol 696:247-57. 2011..org, and reanalysis from the primary raw spectra at ISB/PeptideAtlas. Such human plasma proteome datasets are available for data mining comparisons with the proteomes of other organs and biofluids in health and disease... - Prospects for pharmacogenetics and ecogenetics in the new millenniumG S Omenn
University of Michigan, Ann Arbor 48109 0626, USA
Drug Metab Dispos 29:611-4. 2001..In Michigan, a Governor's Commission has sought to strike an appropriate balance... - Alternative splice variants, a new class of protein cancer biomarker candidates: findings in pancreatic cancer and breast cancer with systems biology implicationsGilbert S Omenn
University of Michigan Center for Computational Medicine and Bioinformatics and Michigan Proteomics Alliance for Cancer Research, Ann Arbor, MI 48109 2218, USA
Dis Markers 28:241-51. 2010..The same approach is being applied to human tumors, plasma, and cell line studies of other cancers... - Overview of the symposium on public health significance of genomics and eco-geneticsGilbert S Omenn
Center for Computational Medicine and Bioinformatics, Departments of Internal Medicine and Human Genetics, and School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2218, USA
Annu Rev Public Health 31:1-8. 2010.... - A wide range of protein isoforms in serum and plasma uncovered by a quantitative intact protein analysis systemDavid E Misek
Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI, USA
Proteomics 5:3343-52. 2005..IPAS provides a high resolution, high sensitivity, and quantitative approach for the analysis of serum and plasma proteins, and allows assessment of PTMs as a potential source of biomarkers... - Data management and preliminary data analysis in the pilot phase of the HUPO Plasma Proteome ProjectMarcin Adamski
University of Michigan, Ann Arbor, MI 48109-2218, USA
Proteomics 5:3246-61. 2005..Recommendations of the PPP for future large-scale proteomics endeavors are described... - Challenges in deriving high-confidence protein identifications from data gathered by a HUPO plasma proteome collaborative studyDavid J States
University of Michigan, 100 Washtenaw Rd, Palmer Commons 2035B, Ann Arbor, Michigan 48109, USA
Nat Biotechnol 24:333-8. 2006.... - Discovery of cancer biomarkers through the use of mouse modelsRork Kuick
Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI, USA
Cancer Lett 249:40-8. 2007..Proteomic studies of mouse models of cancer allow assessment of the range of changes in plasma proteins that occur with tumor development and may lead to the identification of potential cancer markers applicable to humans... - Quantitative proteomic profiling of prostate cancer reveals a role for miR-128 in prostate cancerAmjad P Khan
The Michigan Center for Translational Pathology, Universityof Michigan Medical School, Ann Arbor, Michigan 48109, USA
Mol Cell Proteomics 9:298-312. 2010..Taken together, our profiles of the proteomic alterations of prostate cancer progression revealed miR-128 as a potentially important negative regulator of prostate cancer cell invasion... - Novel gene and gene model detection using a whole genome open reading frame analysis in proteomicsDamian Fermin
Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
Genome Biol 7:R35. 2006..These findings suggest that annotation of the genome is not yet complete and that proteomics has the potential to further add to our understanding of gene structures... - Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancerRajasree Menon
Center for Computational Medicine and Biology and Pediatric Endocrinology, University of Michigan, 100 Washtenaw Avenue, Palmer Commons, Ann Arbor, MI 48109, USA
Cancer Res 69:300-9. 2009..Our results show that, in a mouse model for human pancreatic cancer, novel and differentially expressed alternative splice isoforms are detectable in plasma and may be a source of candidate biomarkers... - Development of natural protein microarrays for diagnosing cancer based on an antibody response to tumor antigensJi Qiu
Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
J Proteome Res 3:261-7. 2004..008). Microarrays of tumor-derived proteins provide the means for uncovering a repertoire of tumor antigens that have induced an antibody response in patients with specific cancers... - Lobe of origin and histologic type of lung cancer associated with asbestos exposure in the Carotene and Retinol Efficacy Trial (CARET)C A Brodkin
University of Washington, Department of Environmental Health, Seattle, USA
Am J Ind Med 32:582-91. 1997..19; 95% CI = 0.06-0.62). We conclude that neither anatomic site nor histologic cell type of tumors distinguishes effectively between smoking and asbestos as causal factors in development of lung cancer... - Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotypeVenkateshwar G Keshamouni
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Michigan Proteomics Consortium, National Resource for Proteomics and Pathways, University of Michigan, Ann Arbor, Michigan, 48109, USA
J Proteome Res 5:1143-54. 2006.... - Homocyst(e)ine and coronary heart disease: pharmacoeconomic support for interventions to lower hyperhomocyst(e)inaemiaBrahmajee K Nallamothu
Department of Internal Medicine, University of Michigan Medical School, B1F245 University Hospital, Ann Arbor, MI 49109 0022, USA
Pharmacoeconomics 20:429-42. 2002.... - ConceptGen: a gene set enrichment and gene set relation mapping toolMaureen A Sartor
Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
Bioinformatics 26:456-63. 2010..We demonstrate the functionalities of ConceptGen using gene expression data modeling TGF-beta-induced epithelial-mesenchymal transition and metabolomics data comparing metastatic versus localized prostate cancers... - Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into miceChad Creighton
Bioinformatics Program, Human Genetics, and Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Genome Biol 4:R46. 2003..Global gene-expression profiles of the tumors were determined, based on analysis of expression of human genes, and compared with expression profiles of the cell lines grown in culture... - Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicineRandolph M Nesse
Department of Psychiatry and Psychology, University of Michigan, Room 3018, East Hall, 530 Church Street, Ann Arbor, MI 48104, USA
Proc Natl Acad Sci U S A 107:1800-7. 2010..Evolutionary biology is not just another topic vying for inclusion in the curriculum; it is an essential foundation for a biological understanding of health and disease... - Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetesMichael P Morran
Laboratory of Immunogenetics, The Brehm Center for Diabetes Research, 1000 Wall Street, Ann Arbor, Michigan 48105
Endocrinology 151:2528-37. 2010.... - Proteomic characterization of novel alternative splice variant proteins in human epidermal growth factor receptor 2/neu-induced breast cancersRajasree Menon
Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109 2218, USA
Cancer Res 70:3440-9. 2010..The cancer-associated differentially expressed splice variant proteins offer novel biomarker candidates that may function in breast cancer progression or metastasis... - Metscape: a Cytoscape plug-in for visualizing and interpreting metabolomic data in the context of human metabolic networksJing Gao
National Center for Integrative Biomedical Informatics, University of Michigan, Ann Arbor, MI 48109, USA
Bioinformatics 26:971-3. 2010..AVAILABILITY: Metscape can be installed from within Cytoscape 2.6.x under 'Network and Attribute I/O' category. For more information, please visit http://metscape.ncibi.org/tryplugin.html... - Coupled global and targeted proteomics of human embryonic stem cells during induced differentiationAnastasia K Yocum
Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Cell Proteomics 7:750-67. 2008.... - The relative merits of population-based and targeted prevention strategiesDonna M Zulman
Robert Wood Johnson Clinical Scholars Program, University of Michigan, 6312 Medical Science Building I, 1150 W Medical Center Drive, Ann Arbor, MI 48109 5604, USA
Milbank Q 86:557-80. 2008..The use of multivariable risk prediction tools, however, may affect the relative merits of this strategy... - Temporal quantitative proteomics by iTRAQ 2D-LC-MS/MS and corresponding mRNA expression analysis identify post-transcriptional modulation of actin-cytoskeleton regulators during TGF-beta-Induced epithelial-mesenchymal transitionVenkateshwar G Keshamouni
Divisions of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, 48109, USA
J Proteome Res 8:35-47. 2009..These results are the first demonstration of post-transcriptional regulation of cytoskeletal remodelling and a key role for cofilin1 during TGF-beta-induced EMT... - 7(th) HUPO World Congress of Proteomics: launching the second phase of the HUPOPlasma Proteome Project (PPP-2) 16-20 August 2008, Amsterdam, The NetherlandsGilbert S Omenn
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 2218, USA
Proteomics 9:4-6. 2009..Plasma is expected to be the common pathway for biomarker development and application through collaboration and integration with other HUPO initiatives... - Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formationChad J Creighton
Bioinformatics Program, Department of Pathology, University of Michigan, 4237 Med Sci I, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
Mol Cancer Res 3:119-29. 2005..Thus, analysis of tumor xenografts by gene expression profiling has the potential for identifying genes involved in tumor development that may not be expressed in cancer cells grown in vitro... - Modeling dynamic changes in type 1 diabetes progression: quantifying beta-cell variation after the appearance of islet-specific autoimmune responsesPatrick Nelson
University of Michigan, Department of Mathematics, Center for Computational Medicine and Bioinformatics, 100 Washtenaw Ave, Ann Arbor, MI 48109 2218, USA
Math Biosci Eng 6:753-78. 2009..Finally, we discuss the robustness of the model and its ability to assist experimentalists in designing studies to test complicated theories about the disease... - Proteomics approaches to identify tumor antigen directed autoantibodies as cancer biomarkersYuji Imafuku
Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
Dis Markers 20:149-53. 2004..This work has resulted in the identification of numerous cancer biomarker candidates. Large clinical studies are currently planned to establish their value in early cancer diagnosis... - Genetic advances will influence the practice of medicine: examples from cancer research and care of cancer patientsGilbert S Omenn
University of Michigan Health System, Ann Arbor, 48109-0626, USA
Genet Med 4:15S-20S. 2002..Physicians also can help put new technologies in cultural and ethical context... - The new millennium: values, perceptions of risk, and the key roles of science and technologyG S Omenn
University of Michigan, Ann Arbor 48109-0626, USA
Health Phys 80:328-32. 2001.... - Humoral response profiling reveals pathways to prostate cancer progressionBarry S Taylor
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Mol Cell Proteomics 7:600-11. 2008..Thus, in addition to functioning as markers in prostate cancer detection, humoral response profiles can serve as powerful tools revealing pathway dysregulation that might otherwise be suppressed by the complexity of the cancer proteome... - Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetasesAdaikkalam Vellaichamy
Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA
PLoS ONE 4:e7075. 2009..Thus, data derived from multiple proteomics platforms and transcript data coupled with informatics analysis provides a deeper insight into the functional consequences of androgen action in prostate cancer... - An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancerXiao Song Wang
Michigan Center for Translational Pathology, Ann Arbor, Michigan, USA
Nat Biotechnol 27:1005-11. 2009..Knockdown of NFE2 decreased proliferation and invasion of H1792 cells. Together, these results present a systematic analysis of gene fusions in cancer and describe key characteristics that assist in new fusion discovery... - Intact-protein-based high-resolution three-dimensional quantitative analysis system for proteome profiling of biological fluidsHong Wang
Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
Mol Cell Proteomics 4:618-25. 2005..IPAS provides a combination of comprehensive profiling and quantitative analysis, with a substantial dynamic range, for disease-related applications... - "Topological significance" analysis of gene expression and proteomic profiles from prostate cancer cells reveals key mechanisms of androgen responseAdaikkalam Vellaichamy
Departments of Pathology, Internal Medicine, Human Genetics, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA
PLoS ONE 5:e10936. 2010.... - Potential clinical and economic effects of homocyst(e)ine loweringB K Nallamothu
Division of General Medicine, University of Michigan Medical Center, 3116 Taubman Center, Ann Arbor, MI 48109 0376, USA
Arch Intern Med 160:3406-12. 2000..However, the benefits expected from lowering homocyst(e)ine levels with folic acid and vitamin B(12) supplementation have yet to be demonstrated in clinical trials... - Assessment of human cancer risk: challenges for alternative approachesG S Omenn
The University of Michigan, Ann Arbor 48109 0626, USA
Toxicol Pathol 29:5-12. 2001..The Lave-Omenn value-of-information model provides a useful way to assess the social costs and benefits of different strategies for testing large numbers of chemicals... - Immunology and genetics of type 1 diabetesMichael P Morran
Department of Internal Medicine, Division of Metabolism, Laboratory of Immunogenetics, Brehm Center for Type 1 Diabetes Research and Analysis, University of Michigan Medical School, Ann Arbor, MI, USA
Mt Sinai J Med 75:314-27. 2008..In silico research can aid the comprehension of the etiology of complex disease pathways, including Type I diabetes, in order to and help predict the outcome of therapeutic strategies aimed at preserving beta-cell function... - Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptorBiaoyang Lin
Department of Urology, University of Washington, Seattle, WA, USA
PLoS ONE 4:e6589. 2009..The AR can act either as a promoter or a tumor suppressor depending on cell types. The AR proliferative response program has been well studied, but its prohibitive response program has not yet been thoroughly studied... - The crucial role of the public health sciences in the postgenomic eraGilbert S Omenn
University of Michigan Health System, Ann Arbor, 48109-0626, USA
Genet Med 4:21S-26S. 2002..These linkages depend upon the public health sciences: epidemiology, biostatistics, environmental health sciences, pathobiology, health sciences research, and clinical prevention trials... - Metabolomic profiles delineate potential role for sarcosine in prostate cancer progressionArun Sreekumar
The Michigan Center for Translational Pathology, Ann Arbor, USA
Nature 457:910-4. 2009..Here, by profiling the metabolomic alterations of prostate cancer progression, we reveal sarcosine as a potentially important metabolic intermediary of cancer cell invasion and aggressivity... - A functional annotation of subproteomes in human plasmaPeipei Ping
Department of Physiology and Medicine, Division of Cardiology, Cardiovascular Research Laboratories, University of California, Los Angeles, CA, USA
Proteomics 5:3506-19. 2005..The HPPP-organized, multi-laboratory effort, as described herein, resulted in much synergy and was essential to the success of this project... - Do we want our data raw? Including binary mass spectrometry data in public proteomics data repositoriesLennart Martens
Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
Proteomics 5:3501-5. 2005..Finally, some suggestions are made for both immediate and future storage of MS data in public repositories... - Immunoassay and antibody microarray analysis of the HUPO Plasma Proteome Project reference specimens: systematic variation between sample types and calibration of mass spectrometry dataBrian B Haab
The Van Andel Research Institute, Grand Rapids, MI 49503, USA
Proteomics 5:3278-91. 2005..Continued developments in antibody-based methods will further advance the scientific goals of the PPP... - Physical activity in relation to all-site and lung cancer incidence and mortality in current and former smokersCatherine M Alfano
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M3-B232, Seattle, WA 98109-1024, USA
Cancer Epidemiol Biomarkers Prev 13:2233-41. 2004..Prospective studies using more sophisticated measures of physical activity assessed at multiple time points during follow-up are needed to corroborate these associations... - Exploring the human plasma proteomeGilbert S Omenn
Proteomics 5:3223, 3225. 2005 - The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplementsGary E Goodman
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Bldg M, M1 B514, Seattle, WA 98109, USA
J Natl Cancer Inst 96:1743-50. 2004.... - Streamlining IRB review in multisite trials through single-study IRB Cooperative Agreements: experience of the Beta-Carotene and Retinol Efficacy Trial (CARET)Mark D Thornquist
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Control Clin Trials 23:80-6. 2002..We describe our experience and make recommendations for other multisite clinical trials... - Report from the 2nd Annual US HUPO Meeting on the HUPO Human Plasma Proteome ProjectGilbert S Omenn
Expert Rev Proteomics 3:165-8. 2006 - An evaluation, comparison, and accurate benchmarking of several publicly available MS/MS search algorithms: sensitivity and specificity analysisEugene A Kapp
Joint ProteomicS Laboratory, Ludwig Institute for Cancer Research (Melbourne Branch)/Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Proteomics 5:3475-90. 2005..e., the use of multiple (at least two) search algorithms to reduce the number of FPs. complement... - International collaboration in clinical chemistry and laboratory medicine: the Human Proteome Organization (HUPO) Plasma Proteome ProjectGilbert S Omenn
Clin Chem Lab Med 42:1-2. 2004 - Standards for plasma and serum proteomics in early cancer detection: a needs assessment report from the national institute of standards and technology--National Cancer Institute Standards, Methods, Assays, Reagents and Technologies Workshop, August 18-19,Peter E Barker
NIST-National Cancer Institute Cancer Biomarker Reference Laboratory, NIST Mass Spectrometry Data Center, Analytical Chemistry Division, NIST, Gaithersburg, MD 20899-8311, USA
Clin Chem 52:1669-74. 2006..This report summarizes the discussion and recommendations for proteomics reference materials... - Microarrays of tumor cell derived proteins uncover a distinct pattern of prostate cancer serum immunoreactivityKerri Bouwman
The Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
Proteomics 3:2200-7. 2003..These results suggest that microarrays of fractionated proteins could be a powerful tool for tumor antigen discovery and cancer diagnosis... - The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trialGary E Goodman
The Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer Epidemiol Biomarkers Prev 12:518-26. 2003..There was no statistically significant association between serum carotenoids and prostate cancer. Our findings provide additional support for the association between physiological levels of dietary micronutrients and cancer incidence... - Human Proteinpedia enables sharing of human protein dataSuresh Mathivanan
Nat Biotechnol 26:164-7. 2008 - Development and validation of sandwich ELISA microarrays with minimal assay interferenceRachel M Gonzalez
Pacific Northwest National Laboratory, 902 Battelle Boulevard, P7 56, Richland, Washington 99354, USA
J Proteome Res 7:2406-14. 2008..Overall, this research demonstrates the importance of a stringent screening protocol and the value of optimizing the antibody and antigen concentrations when designing chips for ELISA microarrays... - Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of the beta-carotene and retinol efficacy trial (CARET)Marian L Neuhouser
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 12:350-8. 2003..However, persons who use beta-carotene supplements do not benefit from the protective compounds in plant foods... - Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer seraJi Qiu
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Clin Oncol 26:5060-6. 2008.... - Predictors of lung cancer among asbestos-exposed men in the {beta}-carotene and retinol efficacy trialMark R Cullen
Occupational and Environmental Medicine Program and the Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA
Am J Epidemiol 161:260-70. 2005..Residual confounding by subclinical asbestosis, exposure to unmeasured lung carcinogens, or differences in smoking are unlikely to explain these observations better than a carcinogenic effect of asbestos per se... - Evidence for excess colorectal cancer incidence among asbestos-exposed men in the Beta-Carotene and Retinol Efficacy TrialOluremi A Aliyu
Cancer Center, Yale University School of Medicine, New Haven, CT, USA
Am J Epidemiol 162:868-78. 2005..Nonetheless, these data suggest that colorectal cancer risk is elevated among men occupationally exposed to asbestos, especially those with evidence of nonmalignant asbestos-associated radiographic changes... - Biorepositories: let's not lose what we have so carefully gathered!Gary E Goodman
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Epidemiol Biomarkers Prev 15:599-601. 2006 - A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injuryWei Min Gao
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
J Neurotrauma 24:43-53. 2007..These initial results with conventional gel-based proteomics show new protein changes that may ultimately help to understand pathophysiological differences between iTBI and nTBI...