G S Omenn

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint The HUPO Plasma Proteome Project: a report from the Munich congress
    Gilbert S Omenn
    Internal Medicine, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Proteomics 6:9-11. 2006
  2. doi request reprint The human eye proteome project
    Gilbert S Omenn
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109 2218, USA
    Proteomics 13:2375-6. 2013
  3. pmc Innovations in proteomic profiling of cancers: alternative splice variants as a new class of cancer biomarker candidates and bridging of proteomics with structural biology
    Gilbert S Omenn
    Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109 2218, USA
    J Proteomics 90:28-37. 2013
  4. pmc A mouse plasma peptide atlas as a resource for disease proteomics
    Qing Zhang
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genome Biol 9:R93. 2008
  5. pmc Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis
    Wei Min Gao
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Cancer 5:110. 2005
  6. ncbi request reprint Caring for the community: the role of partnerships
    G S Omenn
    University of Michigan U of M Medical School, Ann Arbor 48109 0624, USA
    Acad Med 74:782-9. 1999
  7. ncbi request reprint Strategies for plasma proteomic profiling of cancers
    Gilbert S Omenn
    Department of Internal Medicine, Center for Computational Medicine and Biology, and Proteomics Alliance for Cancer Research, University of Michigan, Ann Arbor, MI 48109 0656, USA
    Proteomics 6:5662-73. 2006
  8. ncbi request reprint Commentary on scientific peer review to inform regulatory decision making: roles and perspectives of scientists
    Gilbert S Omenn
    Internal Medicine, Human Genetics and Public Health, University of Michigan, MI 48109 0656, USA
    Risk Anal 26:37-9. 2006
  9. ncbi request reprint Human lung cancer chemoprevention strategies: Parker B. Francis lecture
    Gilbert S Omenn
    University of Michigan, Ann Arbor, MI 48109 0656, USA
    Chest 125:123S-7S. 2004
  10. ncbi request reprint The Human Proteome Organization Plasma Proteome Project pilot phase: reference specimens, technology platform comparisons, and standardized data submissions and analyses
    Gilbert S Omenn
    University of Michigan, Ann Arbor, 48109 0656, USA
    Proteomics 4:1235-40. 2004

Collaborators

Detail Information

Publications83

  1. ncbi request reprint The HUPO Plasma Proteome Project: a report from the Munich congress
    Gilbert S Omenn
    Internal Medicine, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Proteomics 6:9-11. 2006
    ..An open Workshop and a presentation in the closing plenary session of the congress focused on next phases for the Plasma Proteome Project...
  2. doi request reprint The human eye proteome project
    Gilbert S Omenn
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109 2218, USA
    Proteomics 13:2375-6. 2013
    ..As part of the Biology and Disease-driven HPP, they and their colleagues will generate fresh data and meet the stringent guidelines for protein identification and characterization as established by the HPP. ..
  3. pmc Innovations in proteomic profiling of cancers: alternative splice variants as a new class of cancer biomarker candidates and bridging of proteomics with structural biology
    Gilbert S Omenn
    Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109 2218, USA
    J Proteomics 90:28-37. 2013
    ..Here we review our work on differential expression of splice variant proteins in cancers and the feasibility of integrating proteomic analysis with structure-based conformational predictions of the differences between such isoforms...
  4. pmc A mouse plasma peptide atlas as a resource for disease proteomics
    Qing Zhang
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Genome Biol 9:R93. 2008
    ..A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis...
  5. pmc Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis
    Wei Min Gao
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    BMC Cancer 5:110. 2005
    ..We hypothesized that distinctive profiles may result from the differential expression of relatively abundant serum proteins associated with the host response...
  6. ncbi request reprint Caring for the community: the role of partnerships
    G S Omenn
    University of Michigan U of M Medical School, Ann Arbor 48109 0624, USA
    Acad Med 74:782-9. 1999
    ..He closes by emphasizing the importance of community-based research to learn about the health statuses, problems, and resources of particular communities, and presents a set of principles for such community-based research...
  7. ncbi request reprint Strategies for plasma proteomic profiling of cancers
    Gilbert S Omenn
    Department of Internal Medicine, Center for Computational Medicine and Biology, and Proteomics Alliance for Cancer Research, University of Michigan, Ann Arbor, MI 48109 0656, USA
    Proteomics 6:5662-73. 2006
    ....
  8. ncbi request reprint Commentary on scientific peer review to inform regulatory decision making: roles and perspectives of scientists
    Gilbert S Omenn
    Internal Medicine, Human Genetics and Public Health, University of Michigan, MI 48109 0656, USA
    Risk Anal 26:37-9. 2006
  9. ncbi request reprint Human lung cancer chemoprevention strategies: Parker B. Francis lecture
    Gilbert S Omenn
    University of Michigan, Ann Arbor, MI 48109 0656, USA
    Chest 125:123S-7S. 2004
    ..The most active area currently is focused on selective inhibition of arachidonic metabolism, both Cox-2 and Lox pathways...
  10. ncbi request reprint The Human Proteome Organization Plasma Proteome Project pilot phase: reference specimens, technology platform comparisons, and standardized data submissions and analyses
    Gilbert S Omenn
    University of Michigan, Ann Arbor, 48109 0656, USA
    Proteomics 4:1235-40. 2004
    ....
  11. pmc Advancement of biomarker discovery and validation through the HUPO plasma proteome project
    Gilbert S Omenn
    University of Michigan, A510 MSRB I, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0656, USA
    Dis Markers 20:131-4. 2004
    ..This international collaboration will lay the groundwork for many large-scale clinical and epidemiological studies of health and disease...
  12. ncbi request reprint Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database
    Gilbert S Omenn
    Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0656, USA
    Proteomics 5:3226-45. 2005
    ....
  13. ncbi request reprint Chemoprevention of lung cancers: lessons from CARET, the beta-carotene and retinol efficacy trial, and prospects for the future
    Gilbert S Omenn
    University of Michigan, Ann Arbor, Michigan 48109 0656, USA
    Eur J Cancer Prev 16:184-91. 2007
    ..Trials are necessary to test inferences from observational epidemiology and animal models. Multiple classes of promising agents are available for evaluation and for eventual randomized trials...
  14. ncbi request reprint Chemoprevention of lung cancer: the rise and demise of beta-carotene
    G S Omenn
    School of Public Health and Community Medicine, University of Washington, Seattle 98195 7230, USA
    Annu Rev Public Health 19:73-99. 1998
    ..continued priority for smoking prevention, smoking cessation, and avoidance of known carcinogens in the environment...
  15. ncbi request reprint HUPO 3rd annual World Congress on Proteomics. 25-27th October, 2004, Beijing, China
    Gilbert S Omenn
    University of Michigan, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0656, USA
    Expert Rev Proteomics 2:9-12. 2005
  16. ncbi request reprint The Guide to Community Preventive Services will be influential in academic health centers: education, research and links with practice
    G S Omenn
    University of Michigan Health System and Medical School, Ann Arbor 48109 0624, USA
    Am J Prev Med 18:12-4. 2000
    ..Such initiatives will improve the chances for increased investment in preventive medicine and public health...
  17. ncbi request reprint Public health genetics: an emerging interdisciplinary field for the post-genomic era
    G S Omenn
    University of Michigan, Ann Arbor 48109 0626, USA
    Annu Rev Public Health 21:1-13. 2000
    ....
  18. doi request reprint THE HUPO Human Plasma Proteome Project
    Gilbert S Omenn
    Internal Medicine, Human Genetics, Public Health and Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA
    Proteomics Clin Appl 1:769-79. 2007
    ....
  19. ncbi request reprint Prospects for pharmacogenetics and ecogenetics in the new millennium
    G S Omenn
    University of Michigan, Ann Arbor 48109 0626, USA
    Drug Metab Dispos 29:611-4. 2001
    ..In Michigan, a Governor's Commission has sought to strike an appropriate balance...
  20. doi request reprint Data management and data integration in the HUPO plasma proteome project
    Gilbert S Omenn
    Departments of Medicine and Genetics, Center for Computational Medicine and Bioinformatics, Medical School and School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Methods Mol Biol 696:247-57. 2011
    ..org, and reanalysis from the primary raw spectra at ISB/PeptideAtlas. Such human plasma proteome datasets are available for data mining comparisons with the proteomes of other organs and biofluids in health and disease...
  21. pmc Alternative splice variants, a new class of protein cancer biomarker candidates: findings in pancreatic cancer and breast cancer with systems biology implications
    Gilbert S Omenn
    University of Michigan Center for Computational Medicine and Bioinformatics and Michigan Proteomics Alliance for Cancer Research, Ann Arbor, MI 48109 2218, USA
    Dis Markers 28:241-51. 2010
    ..The same approach is being applied to human tumors, plasma, and cell line studies of other cancers...
  22. doi request reprint Overview of the symposium on public health significance of genomics and eco-genetics
    Gilbert S Omenn
    Center for Computational Medicine and Bioinformatics, Departments of Internal Medicine and Human Genetics, and School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2218, USA
    Annu Rev Public Health 31:1-8. 2010
    ....
  23. pmc Evolution in health and medicine Sackler colloquium: Evolution and public health
    Gilbert S Omenn
    Department of Internal Medicine, Medical School and School of Public Health, University of Michigan, Center for Computational Medicine and Bioinformatics, Ann Arbor, MI 48109 2218, USA
    Proc Natl Acad Sci U S A 107:1702-9. 2010
    ..The implications and applications of evolutionary understanding are important to our current programs and policies for infectious disease surveillance, gene-environment interactions, and health disparities globally...
  24. ncbi request reprint A wide range of protein isoforms in serum and plasma uncovered by a quantitative intact protein analysis system
    David E Misek
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI, USA
    Proteomics 5:3343-52. 2005
    ..IPAS provides a high resolution, high sensitivity, and quantitative approach for the analysis of serum and plasma proteins, and allows assessment of PTMs as a potential source of biomarkers...
  25. ncbi request reprint Strategies for recruitment to a population-based lung cancer prevention trial: the CARET experience with heavy smokers. Beta-Carotene and Retinol Efficacy Trial
    G E Goodman
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 7:405-12. 1998
    ..A major limitation of this study was that the pool of minorities that was reached was small...
  26. ncbi request reprint Data management and preliminary data analysis in the pilot phase of the HUPO Plasma Proteome Project
    Marcin Adamski
    University of Michigan, Ann Arbor, MI 48109 2218, USA
    Proteomics 5:3246-61. 2005
    ..Recommendations of the PPP for future large-scale proteomics endeavors are described...
  27. ncbi request reprint Discovery of cancer biomarkers through the use of mouse models
    Rork Kuick
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI, USA
    Cancer Lett 249:40-8. 2007
    ..Proteomic studies of mouse models of cancer allow assessment of the range of changes in plasma proteins that occur with tumor development and may lead to the identification of potential cancer markers applicable to humans...
  28. ncbi request reprint Challenges in deriving high-confidence protein identifications from data gathered by a HUPO plasma proteome collaborative study
    David J States
    University of Michigan, 100 Washtenaw Rd, Palmer Commons 2035B, Ann Arbor, Michigan 48109, USA
    Nat Biotechnol 24:333-8. 2006
    ....
  29. pmc Quantitative proteomic profiling of prostate cancer reveals a role for miR-128 in prostate cancer
    Amjad P Khan
    The Michigan Center for Translational Pathology, Universityof Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 9:298-312. 2010
    ..Taken together, our profiles of the proteomic alterations of prostate cancer progression revealed miR-128 as a potentially important negative regulator of prostate cancer cell invasion...
  30. pmc Novel gene and gene model detection using a whole genome open reading frame analysis in proteomics
    Damian Fermin
    Bioinformatics Program, University of Michigan, Ann Arbor, MI 48109, USA
    Genome Biol 7:R35. 2006
    ....
  31. pmc Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer
    Rajasree Menon
    Center for Computational Medicine and Biology and Pediatric Endocrinology, University of Michigan, 100 Washtenaw Avenue, Palmer Commons, Ann Arbor, MI 48109, USA
    Cancer Res 69:300-9. 2009
    ..Our results show that, in a mouse model for human pancreatic cancer, novel and differentially expressed alternative splice isoforms are detectable in plasma and may be a source of candidate biomarkers...
  32. ncbi request reprint Development of natural protein microarrays for diagnosing cancer based on an antibody response to tumor antigens
    Ji Qiu
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Proteome Res 3:261-7. 2004
    ..008). Microarrays of tumor-derived proteins provide the means for uncovering a repertoire of tumor antigens that have induced an antibody response in patients with specific cancers...
  33. ncbi request reprint Lobe of origin and histologic type of lung cancer associated with asbestos exposure in the Carotene and Retinol Efficacy Trial (CARET)
    C A Brodkin
    University of Washington, Department of Environmental Health, Seattle, USA
    Am J Ind Med 32:582-91. 1997
    ..19; 95% CI = 0.06-0.62). We conclude that neither anatomic site nor histologic cell type of tumors distinguishes effectively between smoking and asbestos as causal factors in development of lung cancer...
  34. pmc ConceptGen: a gene set enrichment and gene set relation mapping tool
    Maureen A Sartor
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 26:456-63. 2010
    ..Accomplishing these tasks requires a unified framework for agglomeration of data from various genomic resources, novel visualizations, and user functionality...
  35. ncbi request reprint Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation
    Chad J Creighton
    Bioinformatics Program, Department of Pathology, University of Michigan, 4237 Med Sci I, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Mol Cancer Res 3:119-29. 2005
    ..Thus, analysis of tumor xenografts by gene expression profiling has the potential for identifying genes involved in tumor development that may not be expressed in cancer cells grown in vitro...
  36. ncbi request reprint Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotype
    Venkateshwar G Keshamouni
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Michigan Proteomics Consortium, National Resource for Proteomics and Pathways, University of Michigan, Ann Arbor, Michigan, 48109, USA
    J Proteome Res 5:1143-54. 2006
    ....
  37. ncbi request reprint Homocyst(e)ine and coronary heart disease: pharmacoeconomic support for interventions to lower hyperhomocyst(e)inaemia
    Brahmajee K Nallamothu
    Department of Internal Medicine, University of Michigan Medical School, B1F245 University Hospital, Ann Arbor, MI 49109 0022, USA
    Pharmacoeconomics 20:429-42. 2002
    ....
  38. pmc Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine
    Randolph M Nesse
    Department of Psychiatry and Psychology, University of Michigan, Room 3018, East Hall, 530 Church Street, Ann Arbor, MI 48104, USA
    Proc Natl Acad Sci U S A 107:1800-7. 2010
    ..Evolutionary biology is not just another topic vying for inclusion in the curriculum; it is an essential foundation for a biological understanding of health and disease...
  39. doi request reprint Modeling dynamic changes in type 1 diabetes progression: quantifying beta-cell variation after the appearance of islet-specific autoimmune responses
    Patrick Nelson
    University of Michigan, Department of Mathematics, Center for Computational Medicine and Bioinformatics, 100 Washtenaw Ave, Ann Arbor, MI 48109 2218, USA
    Math Biosci Eng 6:753-78. 2009
    ..Finally, we discuss the robustness of the model and its ability to assist experimentalists in designing studies to test complicated theories about the disease...
  40. pmc Coupled global and targeted proteomics of human embryonic stem cells during induced differentiation
    Anastasia K Yocum
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 7:750-67. 2008
    ....
  41. doi request reprint 7(th) HUPO World Congress of Proteomics: launching the second phase of the HUPOPlasma Proteome Project (PPP-2) 16-20 August 2008, Amsterdam, The Netherlands
    Gilbert S Omenn
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 2218, USA
    Proteomics 9:4-6. 2009
    ..Plasma is expected to be the common pathway for biomarker development and application through collaboration and integration with other HUPO initiatives...
  42. pmc Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice
    Chad Creighton
    Bioinformatics Program, Human Genetics, and Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Genome Biol 4:R46. 2003
    ..Global gene-expression profiles of the tumors were determined, based on analysis of expression of human genes, and compared with expression profiles of the cell lines grown in culture...
  43. pmc Metscape: a Cytoscape plug-in for visualizing and interpreting metabolomic data in the context of human metabolic networks
    Jing Gao
    National Center for Integrative Biomedical Informatics, University of Michigan, Ann Arbor, MI 48109, USA
    Bioinformatics 26:971-3. 2010
    ..Color and size of the nodes are used to visualize these dynamic changes. Metscape can display the entire metabolic network or any of the pathway-specific networks that exist in the database...
  44. pmc Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes
    Michael P Morran
    Laboratory of Immunogenetics, The Brehm Center for Diabetes Research, 1000 Wall Street, Ann Arbor, Michigan 48105
    Endocrinology 151:2528-37. 2010
    ....
  45. doi request reprint Temporal quantitative proteomics by iTRAQ 2D-LC-MS/MS and corresponding mRNA expression analysis identify post-transcriptional modulation of actin-cytoskeleton regulators during TGF-beta-Induced epithelial-mesenchymal transition
    Venkateshwar G Keshamouni
    Divisions of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, 48109, USA
    J Proteome Res 8:35-47. 2009
    ..These results are the first demonstration of post-transcriptional regulation of cytoskeletal remodelling and a key role for cofilin1 during TGF-beta-induced EMT...
  46. pmc The relative merits of population-based and targeted prevention strategies
    Donna M Zulman
    Robert Wood Johnson Clinical Scholars Program, University of Michigan, 6312 Medical Science Building I, 1150 W Medical Center Drive, Ann Arbor, MI 48109 5604, USA
    Milbank Q 86:557-80. 2008
    ..The use of multivariable risk prediction tools, however, may affect the relative merits of this strategy...
  47. pmc Proteomic characterization of novel alternative splice variant proteins in human epidermal growth factor receptor 2/neu-induced breast cancers
    Rajasree Menon
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109 2218, USA
    Cancer Res 70:3440-9. 2010
    ..The cancer-associated differentially expressed splice variant proteins offer novel biomarker candidates that may function in breast cancer progression or metastasis...
  48. ncbi request reprint Predictors of serum selenium in cigarette smokers and the lack of association with lung and prostate cancer risk
    G E Goodman
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 10:1069-76. 2001
    ..In the CARET population of current and former smokers consuming an ad libitum diet, the serum concentration of selenium was not a risk factor for either lung cancer or prostate cancer...
  49. pmc Proteomics approaches to identify tumor antigen directed autoantibodies as cancer biomarkers
    Yuji Imafuku
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Dis Markers 20:149-53. 2004
    ..This work has resulted in the identification of numerous cancer biomarker candidates. Large clinical studies are currently planned to establish their value in early cancer diagnosis...
  50. ncbi request reprint Genetic advances will influence the practice of medicine: examples from cancer research and care of cancer patients
    Gilbert S Omenn
    University of Michigan Health System, Ann Arbor, 48109 0626, USA
    Genet Med 4:15S-20S. 2002
    ..Physicians also can help put new technologies in cultural and ethical context...
  51. ncbi request reprint The new millennium: values, perceptions of risk, and the key roles of science and technology
    G S Omenn
    University of Michigan, Ann Arbor 48109-0626, USA
    Health Phys 80:328-32. 2001
    ....
  52. ncbi request reprint Intact-protein-based high-resolution three-dimensional quantitative analysis system for proteome profiling of biological fluids
    Hong Wang
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 4:618-25. 2005
    ..IPAS provides a combination of comprehensive profiling and quantitative analysis, with a substantial dynamic range, for disease-related applications...
  53. pmc Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases
    Adaikkalam Vellaichamy
    Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA
    PLoS ONE 4:e7075. 2009
    ..Thus, data derived from multiple proteomics platforms and transcript data coupled with informatics analysis provides a deeper insight into the functional consequences of androgen action in prostate cancer...
  54. ncbi request reprint Humoral response profiling reveals pathways to prostate cancer progression
    Barry S Taylor
    Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 7:600-11. 2008
    ..Thus, in addition to functioning as markers in prostate cancer detection, humoral response profiles can serve as powerful tools revealing pathway dysregulation that might otherwise be suppressed by the complexity of the cancer proteome...
  55. pmc An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer
    Xiao Song Wang
    Michigan Center for Translational Pathology, Ann Arbor, Michigan, USA
    Nat Biotechnol 27:1005-11. 2009
    ..Knockdown of NFE2 decreased proliferation and invasion of H1792 cells. Together, these results present a systematic analysis of gene fusions in cancer and describe key characteristics that assist in new fusion discovery...
  56. pmc "Topological significance" analysis of gene expression and proteomic profiles from prostate cancer cells reveals key mechanisms of androgen response
    Adaikkalam Vellaichamy
    Departments of Pathology, Internal Medicine, Human Genetics, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS ONE 5:e10936. 2010
    ....
  57. ncbi request reprint Assessment of human cancer risk: challenges for alternative approaches
    G S Omenn
    The University of Michigan, Ann Arbor 48109 0626, USA
    Toxicol Pathol 29:5-12. 2001
    ..The Lave-Omenn value-of-information model provides a useful way to assess the social costs and benefits of different strategies for testing large numbers of chemicals...
  58. ncbi request reprint Potential clinical and economic effects of homocyst(e)ine lowering
    B K Nallamothu
    Division of General Medicine, University of Michigan Medical Center, 3116 Taubman Center, Ann Arbor, MI 48109 0376, USA
    Arch Intern Med 160:3406-12. 2000
    ..However, the benefits expected from lowering homocyst(e)ine levels with folic acid and vitamin B(12) supplementation have yet to be demonstrated in clinical trials...
  59. doi request reprint Immunology and genetics of type 1 diabetes
    Michael P Morran
    Department of Internal Medicine, Division of Metabolism, Laboratory of Immunogenetics, Brehm Center for Type 1 Diabetes Research and Analysis, University of Michigan Medical School, Ann Arbor, MI, USA
    Mt Sinai J Med 75:314-27. 2008
    ..In silico research can aid the comprehension of the etiology of complex disease pathways, including Type I diabetes, in order to and help predict the outcome of therapeutic strategies aimed at preserving beta-cell function...
  60. ncbi request reprint The crucial role of the public health sciences in the postgenomic era
    Gilbert S Omenn
    University of Michigan Health System, Ann Arbor, 48109 0626, USA
    Genet Med 4:21S-26S. 2002
    ..These linkages depend upon the public health sciences: epidemiology, biostatistics, environmental health sciences, pathobiology, health sciences research, and clinical prevention trials...
  61. pmc Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor
    Biaoyang Lin
    Department of Urology, University of Washington, Seattle, WA, USA
    PLoS ONE 4:e6589. 2009
    ..The AR can act either as a promoter or a tumor suppressor depending on cell types. The AR proliferative response program has been well studied, but its prohibitive response program has not yet been thoroughly studied...
  62. pmc Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
    Arun Sreekumar
    The Michigan Center for Translational Pathology, Ann Arbor, USA
    Nature 457:910-4. 2009
    ..Here, by profiling the metabolomic alterations of prostate cancer progression, we reveal sarcosine as a potentially important metabolic intermediary of cancer cell invasion and aggressivity...
  63. ncbi request reprint Exploring the human plasma proteome
    Gilbert S Omenn
    Proteomics 5:3223, 3225. 2005
  64. ncbi request reprint Streamlining IRB review in multisite trials through single-study IRB Cooperative Agreements: experience of the Beta-Carotene and Retinol Efficacy Trial (CARET)
    Mark D Thornquist
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Control Clin Trials 23:80-6. 2002
    ..We describe our experience and make recommendations for other multisite clinical trials...
  65. ncbi request reprint Predictors of lung cancer among asbestos-exposed men in the {beta}-carotene and retinol efficacy trial
    Mark R Cullen
    Occupational and Environmental Medicine Program and the Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Epidemiol 161:260-70. 2005
    ..Residual confounding by subclinical asbestosis, exposure to unmeasured lung carcinogens, or differences in smoking are unlikely to explain these observations better than a carcinogenic effect of asbestos per se...
  66. ncbi request reprint Do we want our data raw? Including binary mass spectrometry data in public proteomics data repositories
    Lennart Martens
    Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    Proteomics 5:3501-5. 2005
    ..Finally, some suggestions are made for both immediate and future storage of MS data in public repositories...
  67. ncbi request reprint Physical activity in relation to all-site and lung cancer incidence and mortality in current and former smokers
    Catherine M Alfano
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M3 B232, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:2233-41. 2004
    ..Prospective studies using more sophisticated measures of physical activity assessed at multiple time points during follow-up are needed to corroborate these associations...
  68. ncbi request reprint An evaluation, comparison, and accurate benchmarking of several publicly available MS/MS search algorithms: sensitivity and specificity analysis
    Eugene A Kapp
    Joint ProteomicS Laboratory, Ludwig Institute for Cancer Research Melbourne Branch Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Proteomics 5:3475-90. 2005
    ..e., the use of multiple (at least two) search algorithms to reduce the number of FPs. complement...
  69. ncbi request reprint The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements
    Gary E Goodman
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Bldg M, M1 B514, Seattle, WA 98109, USA
    J Natl Cancer Inst 96:1743-50. 2004
    ....
  70. ncbi request reprint A functional annotation of subproteomes in human plasma
    Peipei Ping
    Department of Physiology and Medicine, Division of Cardiology, Cardiovascular Research Laboratories, University of California, Los Angeles, CA, USA
    Proteomics 5:3506-19. 2005
    ..The HPPP-organized, multi-laboratory effort, as described herein, resulted in much synergy and was essential to the success of this project...
  71. ncbi request reprint International collaboration in clinical chemistry and laboratory medicine: the Human Proteome Organization (HUPO) Plasma Proteome Project
    Gilbert S Omenn
    Clin Chem Lab Med 42:1-2. 2004
  72. ncbi request reprint Microarrays of tumor cell derived proteins uncover a distinct pattern of prostate cancer serum immunoreactivity
    Kerri Bouwman
    The Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, MI 49503, USA
    Proteomics 3:2200-7. 2003
    ..These results suggest that microarrays of fractionated proteins could be a powerful tool for tumor antigen discovery and cancer diagnosis...
  73. ncbi request reprint Report from the 2nd Annual US HUPO Meeting on the HUPO Human Plasma Proteome Project
    Gilbert S Omenn
    Expert Rev Proteomics 3:165-8. 2006
  74. ncbi request reprint Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of the beta-carotene and retinol efficacy trial (CARET)
    Marian L Neuhouser
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 12:350-8. 2003
    ..However, persons who use beta-carotene supplements do not benefit from the protective compounds in plant foods...
  75. ncbi request reprint Standards for plasma and serum proteomics in early cancer detection: a needs assessment report from the national institute of standards and technology--National Cancer Institute Standards, Methods, Assays, Reagents and Technologies Workshop, August 18-19,
    Peter E Barker
    NIST National Cancer Institute Cancer Biomarker Reference Laboratory, NIST Mass Spectrometry Data Center, Analytical Chemistry Division, NIST, Gaithersburg, MD 20899 8311, USA
    Clin Chem 52:1669-74. 2006
    ..This report summarizes the discussion and recommendations for proteomics reference materials...
  76. ncbi request reprint The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trial
    Gary E Goodman
    The Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 12:518-26. 2003
    ..There was no statistically significant association between serum carotenoids and prostate cancer. Our findings provide additional support for the association between physiological levels of dietary micronutrients and cancer incidence...
  77. pmc Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera
    Ji Qiu
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Clin Oncol 26:5060-6. 2008
    ....
  78. ncbi request reprint Immunoassay and antibody microarray analysis of the HUPO Plasma Proteome Project reference specimens: systematic variation between sample types and calibration of mass spectrometry data
    Brian B Haab
    The Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Proteomics 5:3278-91. 2005
    ..Continued developments in antibody-based methods will further advance the scientific goals of the PPP...
  79. doi request reprint Development and validation of sandwich ELISA microarrays with minimal assay interference
    Rachel M Gonzalez
    Pacific Northwest National Laboratory, 902 Battelle Boulevard, P7 56, Richland, Washington 99354, USA
    J Proteome Res 7:2406-14. 2008
    ..Overall, this research demonstrates the importance of a stringent screening protocol and the value of optimizing the antibody and antigen concentrations when designing chips for ELISA microarrays...
  80. doi request reprint Human Proteinpedia enables sharing of human protein data
    Suresh Mathivanan
    Nat Biotechnol 26:164-7. 2008
  81. ncbi request reprint Biorepositories: let's not lose what we have so carefully gathered!
    Gary E Goodman
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 15:599-601. 2006
  82. ncbi request reprint Evidence for excess colorectal cancer incidence among asbestos-exposed men in the Beta-Carotene and Retinol Efficacy Trial
    Oluremi A Aliyu
    Cancer Center, Yale University School of Medicine, New Haven, CT, USA
    Am J Epidemiol 162:868-78. 2005
    ..Nonetheless, these data suggest that colorectal cancer risk is elevated among men occupationally exposed to asbestos, especially those with evidence of nonmalignant asbestos-associated radiographic changes...
  83. pmc A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury
    Wei Min Gao
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    J Neurotrauma 24:43-53. 2007
    ..These initial results with conventional gel-based proteomics show new protein changes that may ultimately help to understand pathophysiological differences between iTBI and nTBI...