BERT W O'MALLEY

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi Gene therapy principles and strategies for head and neck cancer
    B W O'Malley
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA
    Adv Otorhinolaryngol 56:279-88. 2000
  2. ncbi Molecular disruption of the MRN(95) complex induces radiation sensitivity in head and neck cancer
    BERT W O'MALLEY
    Department of Otolaryngology Head and Neck Cancer, University of Maryland School of Medicine, Baltimore, USA
    Laryngoscope 113:1588-94. 2003
  3. ncbi The role of adenovirus-mediated retinoblastoma 94 in the treatment of head and neck cancer
    Daqing Li
    Department of Otolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 62:4637-44. 2002
  4. ncbi Combination nonviral interleukin 2 gene therapy and external-beam radiation therapy for head and neck cancer
    David Bray
    Department of Otolaryngology Head and Neck Surgery, The Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, USA
    Arch Otolaryngol Head Neck Surg 129:618-22. 2003
  5. doi Selective neck dissection and deintensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania transoral robotic surgery trial
    Gregory S Weinstein
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 120:1749-55. 2010
  6. ncbi Spatial distribution of tumor vaccine improves efficacy
    Marion Couch
    Department of Otolarynology Head and Neck Surgery, Johns Hopkins Hospital, Johns Hopkins Outpatient Center, Baltimore, Maryland 21287 0901, USA
    Laryngoscope 113:1401-5. 2003
  7. ncbi Informed consent in sinus surgery: link between demographics and patient desires
    Rodney J Taylor
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Laryngoscope 115:826-31. 2005
  8. ncbi Timing of human insulin-like growth factor-1 gene transfer in reinnervating laryngeal muscle
    Hideki Nakagawa
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, University of Maryland Medical Center, Baltimore, Maryland, USA
    Laryngoscope 114:726-32. 2004
  9. ncbi Interleukin 2 gene transfer prevents NKG2D suppression and enhances antitumor efficacy in combination with cisplatin for head and neck squamous cell cancer
    Daqing Li
    Department of Otolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 62:4023-8. 2002
  10. ncbi Combination radiation and adenovirus-mediated P16(INK4A) gene therapy in a murine model for head and neck cancer
    Juong G Rhee
    Department of Radiation Oncology, University of Maryland School of Medicine, BRB 6013, 655 West Baltimore Street, Baltimore, MD 21201, USA
    ORL J Otorhinolaryngol Relat Spec 65:144-54. 2003

Collaborators

Detail Information

Publications25

  1. ncbi Gene therapy principles and strategies for head and neck cancer
    B W O'Malley
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA
    Adv Otorhinolaryngol 56:279-88. 2000
    ..In conjunction with the evolution of molecular diagnostics, gene therapy strategies may provide the means for preventing the malignant progression of premalignant head and neck lesions upon early diagnosis...
  2. ncbi Molecular disruption of the MRN(95) complex induces radiation sensitivity in head and neck cancer
    BERT W O'MALLEY
    Department of Otolaryngology Head and Neck Cancer, University of Maryland School of Medicine, Baltimore, USA
    Laryngoscope 113:1588-94. 2003
    ..Disruption the MRN(95) complex and thus DNA repair should result in enhanced tumor killing after classic external-beam radiation therapy...
  3. ncbi The role of adenovirus-mediated retinoblastoma 94 in the treatment of head and neck cancer
    Daqing Li
    Department of Otolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 62:4637-44. 2002
    ....
  4. ncbi Combination nonviral interleukin 2 gene therapy and external-beam radiation therapy for head and neck cancer
    David Bray
    Department of Otolaryngology Head and Neck Surgery, The Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, USA
    Arch Otolaryngol Head Neck Surg 129:618-22. 2003
    ....
  5. doi Selective neck dissection and deintensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania transoral robotic surgery trial
    Gregory S Weinstein
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 120:1749-55. 2010
    ....
  6. ncbi Spatial distribution of tumor vaccine improves efficacy
    Marion Couch
    Department of Otolarynology Head and Neck Surgery, Johns Hopkins Hospital, Johns Hopkins Outpatient Center, Baltimore, Maryland 21287 0901, USA
    Laryngoscope 113:1401-5. 2003
    ..Genetically engineered tumor cells were used as a vaccine in a murine model to compare tumor formation after inoculating multiple sites versus a single site. The effect of vaccinating draining lymph node basins was evaluated...
  7. ncbi Informed consent in sinus surgery: link between demographics and patient desires
    Rodney J Taylor
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Laryngoscope 115:826-31. 2005
    ..To evaluate and understand differences in expectations according to patient demographics during the informed consent process for functional endoscopic sinus surgery (FESS)...
  8. ncbi Timing of human insulin-like growth factor-1 gene transfer in reinnervating laryngeal muscle
    Hideki Nakagawa
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, University of Maryland Medical Center, Baltimore, Maryland, USA
    Laryngoscope 114:726-32. 2004
    ..The timing of gene delivery relative to nerve repair is likely to be important, to optimize the results...
  9. ncbi Interleukin 2 gene transfer prevents NKG2D suppression and enhances antitumor efficacy in combination with cisplatin for head and neck squamous cell cancer
    Daqing Li
    Department of Otolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 62:4023-8. 2002
    ....
  10. ncbi Combination radiation and adenovirus-mediated P16(INK4A) gene therapy in a murine model for head and neck cancer
    Juong G Rhee
    Department of Radiation Oncology, University of Maryland School of Medicine, BRB 6013, 655 West Baltimore Street, Baltimore, MD 21201, USA
    ORL J Otorhinolaryngol Relat Spec 65:144-54. 2003
    ..Our data suggest that Ad-P16 gene therapy may prove effective in treating human HNSCC that is refractory to radiation therapy...
  11. pmc Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivo
    Jeffrey S Wolf
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Clin Cancer Res 13:1601-10. 2007
    ..Human lactoferrin is a naturally occurring glycoprotein that inhibits cancer growth. Our purpose was to evaluate recombinant human lactoferrin as a chemotherapeutic agent against head and neck squamous cell carcinoma...
  12. ncbi Lactoferrin inhibits growth of malignant tumors of the head and neck
    Jeffrey S Wolf
    Otolaryngology Head and Neck Surgery, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    ORL J Otorhinolaryngol Relat Spec 65:245-9. 2003
    ..These properties offer hope for its use as a primary or adjuvant chemotherapeutic agent. Further investigation focused on mechanism and delivery is needed...
  13. ncbi Informed consent in endoscopic sinus surgery: the patient perspective
    Jeffrey S Wolf
    Department of Otolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Laryngoscope 115:492-4. 2005
    ..To understand patient expectations during the informed consent process for functional endoscopic sinus surgery (FESS)...
  14. doi Transoral robotic surgery for parapharyngeal space tumors
    BERT W O'MALLEY
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 72:332-6. 2010
    ..To evaluate the outcomes of patients with parapharyngeal space (PPS) tumors treated with a transoral robotic surgery (TORS) approach...
  15. ncbi In vitro and in vivo evaluation of recombinant silk-elastinlike hydrogels for cancer gene therapy
    Zaki Megeed
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 North Penn Street, Baltimore, MD 21201, USA
    J Control Release 94:433-45. 2004
    ..These studies indicate that genetically engineered SELP hydrogels have potential as matrices for controlled nonviral and viral gene delivery...
  16. doi Gene therapy for head and neck cancer
    Waleed M Abuzeid
    Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Adv Otorhinolaryngol 70:141-51. 2011
    ..Cells. Translational research has been conducted in each of these areas, culminating in clinical trials and the implementation of gene therapy as a viable therapeutic modality for head and neck cancers...
  17. ncbi Extended pericranial flap and bone graft reconstruction in anterior skull base surgery
    Michael Rodrigues
    University of Maryland School of Medicine, University of Maryland Hospital, Baltimore, MD, USA
    Otolaryngol Head Neck Surg 131:69-76. 2004
    ..Study design Thirty-four patients underwent anterior craniofacial resection of anterior skull-based tumors of varying histology with reconstruction using an extended pericranial flap and split calvarial bone graft...
  18. ncbi Genetically engineered tumor cell vaccine in a head and neck cancer model
    Marion Couch
    Department of Otolaryngology Head and Neck Surgery, Outpatient Center, Johns Hopkins Hospital, Room 624, 601 North Caroline Street, Baltimore, MD 21287 0901, USA
    Laryngoscope 113:552-6. 2003
    ..Using a murine model, a novel tumor vaccine for head and neck squamous cell carcinoma expressing the granulocyte-macrophage colony stimulating factor (GM-CSF) gene was evaluated for its ability to protect against tumor challenge...
  19. doi Endoscopic resection of advanced anterior skull base lesions: oncologically safe?
    Marc A Cohen
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 71:123-8. 2009
    ..2) Understand the difference in patient morbidity with endoscopic surgery compared to traditional CFR...
  20. ncbi Effects of insulin-like growth factor-1 gene transfer on myosin heavy chains in denervated rat laryngeal muscle
    Paul W Flint
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 N Caroline Street, Baltimore, MD 21287, USA
    Laryngoscope 114:368-71. 2004
    ....
  21. ncbi Making image guidance work: understanding control of accuracy
    Julie Berry
    Department of Otolaryngology Head and Neck Surgery, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    Ann Otol Rhinol Laryngol 112:689-92. 2003
    ..Inaccurate registration resulted in increased mean fiducial error and lower accuracy at the target point. Understanding the registration process will enhance the utility of image-guided surgery in otolaryngology and skull base surgery...
  22. doi Sphenoid sinus anatomy and suprasellar extension of pituitary tumors
    Vijay R Ramakrishnan
    Department of Otolaryngology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurosurg 119:669-74. 2013
    ..In this paper the authors' goal was to determine if sphenoid anatomy influences pituitary tumor growth...
  23. ncbi Transoral robotic surgery: radical tonsillectomy
    Gregory S Weinstein
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Arch Otolaryngol Head Neck Surg 133:1220-6. 2007
    ..To describe and show the feasibility of a new surgical technique for transoral robotic surgery (TORS) radical tonsillectomy...
  24. ncbi Microvascular reconstruction of cranial base defects: An evaluation of complication and survival rates to justify the use of this repair
    Jason Newman
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Otolaryngol Head Neck Surg 132:381-4. 2006
    ....
  25. ncbi Malignant peripheral primitive neuroectodermal tumor-peripheral neuroepithelioma of the head and neck: a clinicopathologic study of five cases and review of the literature
    Nikolaos G Nikitakis
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, 666 W Baltimore Street, Room 4 C 02, Baltimore, Maryland 21201 1586, USA
    Head Neck 25:488-98. 2003
    ..Here, we focus on one particular member of the PNET family, the malignant peripheral PNET (pPNET) or peripheral neuroepithelioma of head and neck...

Research Grants12

  1. Adenovirus Limitations and Tumor Targeted Gene Therapy
    BERT O MALLEY; Fiscal Year: 2003
    ..This platform of information will also prove valuable to investigators who wish to circumvent limitations by developing and using alternative strategies such as FGF adenovirus retargeting. ..
  2. Molecular Analysis of OSCC Tumor Invasion
    Barry Ziober; Fiscal Year: 2009
    ..The accurate and reliable lymph node metastasis gene signature identified in this proposal will have a profound clinical utility for reducing osee patient mortality and morbidity. ..
  3. Human and Murine Models of BRCA1 Tumorigenesis
    BERT O MALLEY; Fiscal Year: 2007
    ..abstract_text> ..
  4. Adenovirus Limitations and Tumor Targeted Gene Therapy
    BERT O MALLEY; Fiscal Year: 2007
    ..This platform of information will also prove valuable to investigators who wish to circumvent limitations by developing and using alternative strategies such as FGF adenovirus retargeting. ..
  5. Human and Murine Models of BRCA1 Tumorigenesis
    BERT O MALLEY; Fiscal Year: 2006
    ..abstract_text> ..
  6. Adenovirus Limitations and Tumor Targeted Gene Therapy
    BERT O MALLEY; Fiscal Year: 2006
    ..This platform of information will also prove valuable to investigators who wish to circumvent limitations by developing and using alternative strategies such as FGF adenovirus retargeting. ..
  7. Human and Murine Models of BRCA1 Tumorigenesis
    BERT O MALLEY; Fiscal Year: 2005
    ..abstract_text> ..
  8. Adenovirus Limitations and Tumor Targeted Gene Therapy
    BERT O MALLEY; Fiscal Year: 2005
    ..This platform of information will also prove valuable to investigators who wish to circumvent limitations by developing and using alternative strategies such as FGF adenovirus retargeting. ..
  9. Adenovirus Limitations and Tumor Targeted Gene Therapy
    BERT O MALLEY; Fiscal Year: 2003
    ..This platform of information will also prove valuable to investigators who wish to circumvent limitations by developing and using alternative strategies such as FGF adenovirus retargeting. ..
  10. Adenovirus Limitations and Tumor Targeted Gene Therapy
    BERT O MALLEY; Fiscal Year: 2004
    ..This platform of information will also prove valuable to investigators who wish to circumvent limitations by developing and using alternative strategies such as FGF adenovirus retargeting. ..
  11. Molecular Analysis of OSCC Tumor Invasion
    BERT W O apos MALLEY; Fiscal Year: 2010
    ..The accurate and reliable lymph node metastasis gene signature identified in this proposal will have a profound clinical utility for reducing osee patient mortality and morbidity. ..