BERT W O'MALLEY

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi Gene therapy principles and strategies for head and neck cancer
    B W O'Malley
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA
    Adv Otorhinolaryngol 56:279-88. 2000
  2. ncbi Molecular disruption of the MRN(95) complex induces radiation sensitivity in head and neck cancer
    BERT W O'MALLEY
    Department of Otolaryngology Head and Neck Cancer, University of Maryland School of Medicine, Baltimore, USA
    Laryngoscope 113:1588-94. 2003
  3. doi Selective neck dissection and deintensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania transoral robotic surgery trial
    Gregory S Weinstein
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 120:1749-55. 2010
  4. ncbi Spatial distribution of tumor vaccine improves efficacy
    Marion Couch
    Department of Otolarynology Head and Neck Surgery, Johns Hopkins Hospital, Johns Hopkins Outpatient Center, Baltimore, Maryland 21287 0901, USA
    Laryngoscope 113:1401-5. 2003
  5. ncbi Combination radiation and adenovirus-mediated P16(INK4A) gene therapy in a murine model for head and neck cancer
    Juong G Rhee
    Department of Radiation Oncology, University of Maryland School of Medicine, BRB 6013, 655 West Baltimore Street, Baltimore, MD 21201, USA
    ORL J Otorhinolaryngol Relat Spec 65:144-54. 2003
  6. pmc Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivo
    Jeffrey S Wolf
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Clin Cancer Res 13:1601-10. 2007
  7. ncbi Lactoferrin inhibits growth of malignant tumors of the head and neck
    Jeffrey S Wolf
    Otolaryngology Head and Neck Surgery, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    ORL J Otorhinolaryngol Relat Spec 65:245-9. 2003
  8. doi Transoral robotic surgery for parapharyngeal space tumors
    BERT W O'MALLEY
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 72:332-6. 2010
  9. doi Gene therapy for head and neck cancer
    Waleed M Abuzeid
    Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Adv Otorhinolaryngol 70:141-51. 2011
  10. doi Endoscopic resection of advanced anterior skull base lesions: oncologically safe?
    Marc A Cohen
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 71:123-8. 2009

Research Grants

  1. Human and Murine Models of BRCA1 Tumorigenesis
    BERT O MALLEY; Fiscal Year: 2007
  2. Adenovirus Limitations and Tumor Targeted Gene Therapy
    BERT O MALLEY; Fiscal Year: 2007
  3. Molecular Analysis of OSCC Tumor Invasion
    BERT W O apos MALLEY; Fiscal Year: 2010

Detail Information

Publications15

  1. ncbi Gene therapy principles and strategies for head and neck cancer
    B W O'Malley
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA
    Adv Otorhinolaryngol 56:279-88. 2000
    ..In conjunction with the evolution of molecular diagnostics, gene therapy strategies may provide the means for preventing the malignant progression of premalignant head and neck lesions upon early diagnosis...
  2. ncbi Molecular disruption of the MRN(95) complex induces radiation sensitivity in head and neck cancer
    BERT W O'MALLEY
    Department of Otolaryngology Head and Neck Cancer, University of Maryland School of Medicine, Baltimore, USA
    Laryngoscope 113:1588-94. 2003
    ..Disruption the MRN(95) complex and thus DNA repair should result in enhanced tumor killing after classic external-beam radiation therapy...
  3. doi Selective neck dissection and deintensified postoperative radiation and chemotherapy for oropharyngeal cancer: a subset analysis of the University of Pennsylvania transoral robotic surgery trial
    Gregory S Weinstein
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Laryngoscope 120:1749-55. 2010
    ....
  4. ncbi Spatial distribution of tumor vaccine improves efficacy
    Marion Couch
    Department of Otolarynology Head and Neck Surgery, Johns Hopkins Hospital, Johns Hopkins Outpatient Center, Baltimore, Maryland 21287 0901, USA
    Laryngoscope 113:1401-5. 2003
    ..Genetically engineered tumor cells were used as a vaccine in a murine model to compare tumor formation after inoculating multiple sites versus a single site. The effect of vaccinating draining lymph node basins was evaluated...
  5. ncbi Combination radiation and adenovirus-mediated P16(INK4A) gene therapy in a murine model for head and neck cancer
    Juong G Rhee
    Department of Radiation Oncology, University of Maryland School of Medicine, BRB 6013, 655 West Baltimore Street, Baltimore, MD 21201, USA
    ORL J Otorhinolaryngol Relat Spec 65:144-54. 2003
    ..Our data suggest that Ad-P16 gene therapy may prove effective in treating human HNSCC that is refractory to radiation therapy...
  6. pmc Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivo
    Jeffrey S Wolf
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Clin Cancer Res 13:1601-10. 2007
    ..Human lactoferrin is a naturally occurring glycoprotein that inhibits cancer growth. Our purpose was to evaluate recombinant human lactoferrin as a chemotherapeutic agent against head and neck squamous cell carcinoma...
  7. ncbi Lactoferrin inhibits growth of malignant tumors of the head and neck
    Jeffrey S Wolf
    Otolaryngology Head and Neck Surgery, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    ORL J Otorhinolaryngol Relat Spec 65:245-9. 2003
    ..These properties offer hope for its use as a primary or adjuvant chemotherapeutic agent. Further investigation focused on mechanism and delivery is needed...
  8. doi Transoral robotic surgery for parapharyngeal space tumors
    BERT W O'MALLEY
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 72:332-6. 2010
    ..To evaluate the outcomes of patients with parapharyngeal space (PPS) tumors treated with a transoral robotic surgery (TORS) approach...
  9. doi Gene therapy for head and neck cancer
    Waleed M Abuzeid
    Department of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Adv Otorhinolaryngol 70:141-51. 2011
    ..Cells. Translational research has been conducted in each of these areas, culminating in clinical trials and the implementation of gene therapy as a viable therapeutic modality for head and neck cancers...
  10. doi Endoscopic resection of advanced anterior skull base lesions: oncologically safe?
    Marc A Cohen
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    ORL J Otorhinolaryngol Relat Spec 71:123-8. 2009
    ..2) Understand the difference in patient morbidity with endoscopic surgery compared to traditional CFR...
  11. ncbi Genetically engineered tumor cell vaccine in a head and neck cancer model
    Marion Couch
    Department of Otolaryngology Head and Neck Surgery, Outpatient Center, Johns Hopkins Hospital, Room 624, 601 North Caroline Street, Baltimore, MD 21287 0901, USA
    Laryngoscope 113:552-6. 2003
    ..Using a murine model, a novel tumor vaccine for head and neck squamous cell carcinoma expressing the granulocyte-macrophage colony stimulating factor (GM-CSF) gene was evaluated for its ability to protect against tumor challenge...
  12. ncbi Effects of insulin-like growth factor-1 gene transfer on myosin heavy chains in denervated rat laryngeal muscle
    Paul W Flint
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 N Caroline Street, Baltimore, MD 21287, USA
    Laryngoscope 114:368-71. 2004
    ....
  13. ncbi Microvascular reconstruction of cranial base defects: An evaluation of complication and survival rates to justify the use of this repair
    Jason Newman
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Otolaryngol Head Neck Surg 132:381-4. 2006
    ....
  14. ncbi Transoral robotic surgery: radical tonsillectomy
    Gregory S Weinstein
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Arch Otolaryngol Head Neck Surg 133:1220-6. 2007
    ..To describe and show the feasibility of a new surgical technique for transoral robotic surgery (TORS) radical tonsillectomy...
  15. ncbi Malignant peripheral primitive neuroectodermal tumor-peripheral neuroepithelioma of the head and neck: a clinicopathologic study of five cases and review of the literature
    Nikolaos G Nikitakis
    Department of Diagnostic Sciences and Pathology, Dental School, University of Maryland, Baltimore, 666 W Baltimore Street, Room 4 C 02, Baltimore, Maryland 21201 1586, USA
    Head Neck 25:488-98. 2003
    ..Here, we focus on one particular member of the PNET family, the malignant peripheral PNET (pPNET) or peripheral neuroepithelioma of head and neck...

Research Grants12

  1. Human and Murine Models of BRCA1 Tumorigenesis
    BERT O MALLEY; Fiscal Year: 2007
    ..abstract_text> ..
  2. Adenovirus Limitations and Tumor Targeted Gene Therapy
    BERT O MALLEY; Fiscal Year: 2007
    ..This platform of information will also prove valuable to investigators who wish to circumvent limitations by developing and using alternative strategies such as FGF adenovirus retargeting. ..
  3. Molecular Analysis of OSCC Tumor Invasion
    BERT W O apos MALLEY; Fiscal Year: 2010
    ..The accurate and reliable lymph node metastasis gene signature identified in this proposal will have a profound clinical utility for reducing osee patient mortality and morbidity. ..